840 results on '"Patrick Georges"'
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2. Ce:LYSO, from scintillator to solid-state lighting as a blue luminescent concentrator
- Author
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Lisa Lopez, Pierre Pichon, Pascal Loiseau, Bruno Viana, Rachid Mahiou, Frederic Druon, Patrick Georges, and François Balembois
- Subjects
Medicine ,Science - Abstract
Abstract Cerium-doped lutetium-yttrium oxyorthosilicate (Ce:LYSO) is a well-known single crystal scintillator used in medical imaging and security scanners. Recent development of high power UV LED, matching its absorption band, questions the possibility to use Ce:LYSO in a new way: as LED-pumped solid-state light source. Since Ce:LYSO is available in large size crystals, we investigate its potential as a luminescent concentrator. This paper reports an extensive study of the performance in close relation to the spectroscopic properties of this crystal. It gives the reasons why the Ce:LYSO crystal tested in this study is less efficient than Ce:YAG for luminescent concentration: limited quantum efficiency and high losses coming from self-absorption and from excited-state absorption are playing key roles. However, we demonstrate that a Ce:LYSO luminescent concentrator is an innovative source for solid-state lighting. Pumped by a peak power of 3400 W in quasi-continuous wave regime (40 µs, 10 Hz), a rectangular (1 × 22 × 105 mm3) Ce:LYSO crystal delivers a broadband spectrum (60 nm FWHM) centered at 430 nm. At full output aperture (20 × 1 mm2), it emits a peak power of 116 W. On a squared output surface (1 × 1 mm2) it emits 16 W corresponding to a brightness of 509 W cm–2 sr–1. This combination of spectrum power and brightness is higher than blue LEDs and opens perspectives for Ce:LYSO in the field of illumination namely for imaging.
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- 2023
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3. The Systems Measurement of Mammalian Biotas, Part Two
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Charles H. Smith, Patrick Georges, and Ngoc Nguyen
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mammals ,faunal classification ,natural systems ,evolution ,distribution patterns ,maps ,Science - Abstract
For a recent publication, the authors identified a seven-region model of mammal family distribution patterns, in which each unit contributes equally to the system’s overall statistical characteristics of diversity, despite its individual units having measurably different levels of diversity and endemism. This systemization presents a highly efficient descriptive model that can possibly be interpreted as a form of natural classification. An additional analysis of the same mode is described here, in which the seven-region model of the distribution of mammal families’ spatial affinities is shown to closely approach a most-probable-state arrangement, as assessed through combinatorics, raising some important questions about how macroevolutionary patterns might self-organize spatially. One of the possible practical applications of the overall approach is to areal representation; statistical moments of the underlying world patterns can be used to characterize faunal statuses at any individual location by relating the latter to the former. Through this approach, classical concepts such as corridors, tracks, and transition zones might be re-examined in a manner that better lends itself to hypothesis testing. An arbitrarily chosen bounded area, the conterminous United States, is treated in this fashion by way of illustration.
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- 2023
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4. Light Extraction and Brightness Enhancement of Luminescent Rectangular Slabs
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Pierre Pichon, Lisa Lopez, Maxime Nourry-Martin, Stéphane Darbon, Frederic Druon, Patrick Georges, and François Balembois
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brightness ,light guide ,luminescent concentrator ,luminescent materials ,scintillators ,Applied optics. Photonics ,TA1501-1820 ,Optics. Light ,QC350-467 - Abstract
The extraction efficiency and the brightness are critical parameters to increase the performance of luminescent rectangular slabs such as scintillators, luminescent concentrators, or diamonds with NV centers. This work explains how an additional face breaking the rectangular symmetry can improve the extraction efficiency and brightness. The study is based on a fully analytical approach corroborated experimentally with cerium‐doped yttrium aluminum garnet (Ce:YAG) slabs. The model gives an analytical expression of the extraction efficiency and the brightness of the additional face as a function of the slab parameters (dimensions, refractive index, losses). Results highlight that the extraction efficiency by an additional face can be improved even if the area of the additional face is lower than the area of the smallest face of the slab, generally chosen as the output face in a standard configuration. Therefore, the output brightness can be easily improved and controlled by the dimension of the additional face. Balancing the extraction efficiency and the brightness, a 1 × 3 × 22 mm3 Ce:YAG slab with an optimized edge face and with mirrors on the lateral faces exhibits an efficiency 1.9 times better and a brightness 5.6 higher than a Ce:YAG in a standard configuration.
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- 2022
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5. Evolution and Biogeography, and the Systems Measurement of Mammalian Biotas
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Charles H. Smith, Patrick Georges, and Ngoc Nguyen
- Subjects
mammals ,faunal regions ,classification ,natural systems ,evolution ,Spinoza ,Science - Abstract
Biological evolution is generally regarded as a stochastic or probabilistic process, per the ideas of Darwin in the nineteenth century. Even if this is true at the meso-scale, it still may, however, be impacted by overarching constraints that we have not yet identified. In this paper, we revisit the subject of mammal faunal regions with a mind to explore a potential kind of macroevolutionary influence. We first identify an optimum seven-region mammal faunal classification system based on spatial and phylogenetic data from a comprehensive 2013 review, and then examine the possibility that this classification provides supporting evidence for a Spinoza-influenced philosophical/theoretical model of the “natural system” concept developed by one of the authors in the 1980s. The hierarchical pattern of regional affinities revealed does do this.
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- 2023
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6. New Materials for Short-Pulse Amplifiers
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Frédéric Druon, François Balembois, and Patrick Georges
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Laser ,solid laser ,optical amplifier ,ultrafast laser ,diode-pumped laser ,Applied optics. Photonics ,TA1501-1820 ,Optics. Light ,QC350-467 - Abstract
Laser amplifiers seek high power, efficiency, and short pulse durations. Research laboratories in this field have focused their investigations toward new laser materials that can be efficiently diode pumped, sustain high-power pumping, and have broad emission bandwidth to achieve ultrashort pulse amplification. This is why, for more than ten years now, new Yb-doped materials have been intensively investigated. In the actual state of the art, they represent the more promising and successful materials for these kinds of applications. In this paper, we will do a short review of the last and more impacting discoveries and demonstrations in this field over the last few years.
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- 2011
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7. Higgs in a box: investigating the nature of a scientific discovery
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Woithe, Julia, Boselli, Margherita, Chatzidaki, Panagiota, Dahlkemper, Merten Nikolay, Duggan, Ruadh, Durey, Guillaume, Herff, Niklas, Horvat, Anja Kranjc, Molaro, Daniele, Scheerer, Gernot Werner, Schmeling, Sascha, Thill, Patrick Georges, Wiener, Jeff, and Zoechling, Sarah
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Physics - Physics Education ,Physics - Popular Physics - Abstract
The discovery of the Higgs boson by the ATLAS and CMS collaborations in 2012 concluded the longest search for a particle in the history of particle physics and was based on the largest and most complex physics experiments ever conducted, involving thousands of scientists and engineers from around the world. It provided crucial evidence for a theory developed in the 1960s that describes the existence of the invisible Brout-Englert-Higgs field and the effects of this field on the mass of elementary particles. After the discovery, the work on the theoretical prediction was awarded the Nobel Prize in Physics 2013. This discovery provides a prime example of modern science in the making and a fantastic opportunity to discuss important aspects of Nature of Science (NoS) in the classroom. In this article, we draw connections between a) milestones in the discovery of the Higgs boson, b) important aspects of NoS, and c) hands-on activities with mystery boxes, which are an effective tool to enable students to experience elements of scientific discovery and explicitly reflect on NoS. We hope that this supports educators in bringing lively discussions about modern physics research into their classrooms., Comment: 18 pages, 6 figures
- Published
- 2022
8. Virosome-formulated Plasmodium falciparum AMA-1 & CSP derived peptides as malaria vaccine: randomized phase 1b trial in semi-immune adults & children.
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Patrick Georges Cech, Thomas Aebi, Mwanajaa Shomari Abdallah, Maxmillian Mpina, Ester Barnabas Machunda, Nicole Westerfeld, Sabine Alexandra Stoffel, Rinaldo Zurbriggen, Gerd Pluschke, Marcel Tanner, Claudia Daubenberger, Blaise Genton, and Salim Abdulla
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Medicine ,Science - Abstract
This trial was conducted to evaluate the safety and immunogenicity of two virosome formulated malaria peptidomimetics derived from Plasmodium falciparum AMA-1 and CSP in malaria semi-immune adults and children.The design was a prospective randomized, double-blind, controlled, age-deescalating study with two immunizations. 10 adults and 40 children (aged 5-9 years) living in a malaria endemic area were immunized with PEV3B or virosomal influenza vaccine Inflexal®V on day 0 and 90.No serious or severe adverse events (AEs) related to the vaccines were observed. The only local solicited AE reported was pain at injection site, which affected more children in the Inflexal®V group compared to the PEV3B group (p = 0.014). In the PEV3B group, IgG ELISA endpoint titers specific for the AMA-1 and CSP peptide antigens were significantly higher for most time points compared to the Inflexal®V control group. Across all time points after first immunization the average ratio of endpoint titers to baseline values in PEV3B subjects ranged from 4 to 15 in adults and from 4 to 66 in children. As an exploratory outcome, we found that the incidence rate of clinical malaria episodes in children vaccinees was half the rate of the control children between study days 30 and 365 (0.0035 episodes per day at risk for PEV3B vs. 0.0069 for Inflexal®V; RR = 0.50 [95%-CI: 0.29-0.88], p = 0.02).These findings provide a strong basis for the further development of multivalent virosomal malaria peptide vaccines.ClinicalTrials.gov NCT00513669.
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- 2011
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9. Validation of a natural language processing algorithm using national reporting data to improve identification of anesthesia-related ADVerse evENTs: The “ADVENTURE” study
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Mertes, Paul M, Morgand, Claire, Barach, Paul, Jurkolow, Geoffrey, Assmann, Karen E., Dufetelle, Edouard, Susplugas, Vincent, Alauddin, Bilal, Yavordios, Patrick Georges, Tourres, Jean, Dumeix, Jean-Marc, and Capdevila, Xavier
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- 2024
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10. Diversity of benthic macroinvertebrates in the Algerian East Coast
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Hiba Rezzag Mahcene, Mohamed Said Ramdani, Abdelhak Sebbih, Tarik Meziane, Françoise Denis, Ouided Maamcha, Patrick Georges Thiery Moanono, and Tarek Daas
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General Medicine - Published
- 2022
11. Poster zum Beitrag 'Die Entdeckung des Higgs-Bosons'
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Zoechling, Sarah Maria, Boselli, Margherita, Chatzidaki, Panagiota, Dahlkemper, Merten Nikolay, Duggan, Ruadh, Durey, Guillaume, Herff, Niklas, Kranjc Horvat, Anja, Molaro, Daniele, Scheerer, Gernot Werner, Schmeling, Sascha, Thill, Patrick Georges, Wiener, Jeff, and Woithe, Julia
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Education and Outreach - Abstract
Dieses Poster ist ein Begleitmaterial zum Beitrag "Die Entdeckung des Higgs-Bosons". This poster is supporting material for an article on the discovery of the Higgs boson.
- Published
- 2023
12. Music information visualization and classical composers discovery: an application of network graphs, multidimensional scaling, and support vector machines
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Patrick Georges and Aylin Seckin
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General Social Sciences ,Library and Information Sciences ,Computer Science Applications - Abstract
This article illustrates different information visualization techniques applied to a database of classical composers and visualizes both the macrocosm of the Common Practice Period and the microcosms of twentieth century classical music. It uses data on personal (composer-to-composer) musical influences to generate and analyze network graphs. Data on style influences and composers ‘ecological’ data are then combined to composer-to-composer musical influences to build a similarity/distance matrix, and a multidimensional scaling analysis is used to locate the relative position of composers on a map while preserving the pairwise distances. Finally, a support-vector machines algorithm is used to generate classification maps. This article falls into the realm of an experiment in music education, not musicology. The ultimate objective is to explore parts of the classical music heritage and stimulate interest in discovering composers. In an age offering either inculcation through lists of prescribed composers and compositions to explore, or music recommendation algorithms that automatically propose works to listen to next, the analysis illustrates an alternative path that might promote the active rather than passive discovery of composers and their music in a less restrictive way than inculcation through prescription.
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- 2022
13. Higgs in a Box: Investigating the Nature of a Scientific Discovery
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Woithe, Julia, primary, Boselli, Margherita, additional, Chatzidaki, Panagiota, additional, Dahlkemper, Merten Nikolay, additional, Duggan, Ruadh, additional, Durey, Guillaume, additional, Herff, Niklas, additional, Horvat, Anja Kranjc, additional, Molaro, Daniele, additional, Scheerer, Gernot Werner, additional, Schmeling, Sascha, additional, Thill, Patrick Georges, additional, Wiener, Jeff, additional, and Zoechling, Sarah, additional
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- 2022
- Full Text
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14. Dual-wavelength-pumping of mid-infrared Tm:YLF laser at 2.3 µm: demonstration of pump seeding and recycling processes
- Author
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Hippolyte Dupont, Lauren Guillemot, Pavel Loiko, Alain Braud, Jean-Louis Doualan, Patrice Camy, Patrick Georges, Frédéric Druon, Laboratoire Charles Fabry / Lasers, Laboratoire Charles Fabry (LCF), Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre de recherche sur les Ions, les MAtériaux et la Photonique (CIMAP - UMR 6252), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Matériaux Avancés (IRMA), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), and Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)
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[PHYS]Physics [physics] ,Atomic and Molecular Physics, and Optics - Abstract
Upconversion pumping of thulium lasers emitting around 2.3 µm (the 3H4 → 3H5 transition) has recently attracted a lot of attention as it is compatible with the mature Yb-laser technology. To explore this possibility, we built a mid-infrared Tm:LiYF4 laser pumped by an Yb:CaF2 laser at 1.05 µm delivering an output power of 110 mW at 2.31 µm for a maximum incident pump power of 2.0 W. A strong absorption issue appeared in the Tm laser: the slope efficiency vs. the incident pump power was 7.6% while that vs. the absorbed pump power reached 29%. To overcome this issue, a dual-wavelength pumping at 0.78 µm and 1.05 µm was explored (combining both the direct and upconversion pumping schemes). The reciprocal interplay between the two pumps was studied to evaluate their benefits in terms of the pump absorption and laser efficiency. We observed an interesting decrease of the laser threshold for upconversion pumping when adding a small fraction of the direct pump revealing a seeding effect for the excited-state absorption from the metastable 3F4 level. A recycling process of this manifold by excited-state absorption in the 3F4 → 3F2,3 loop was also observed. The pump absorption seeding is a viable route for the development of low-threshold upconversion pumped thulium lasers.
- Published
- 2022
15. Diversity of benthic macroinvertebrates in the Algerian East Coast
- Author
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Rezzag Mahcene, Hiba, primary, Ramdani, Mohamed Said, additional, Sebbih, Abdelhak, additional, Meziane, Tarik, additional, Denis, Françoise, additional, Maamcha, Ouided, additional, Moanono, Patrick Georges Thiery, additional, and Daas, Tarek, additional
- Published
- 2022
- Full Text
- View/download PDF
16. LED-pumped Cr:LiSAF laser system operating at 100 Hz based on a multipass amplifier
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Hussein Taleb, Catherine Le Blanc, Elio Thellier, Pierre Pichon, Frédéric Druon, François Balembois, and Patrick Georges
- Subjects
Atomic and Molecular Physics, and Optics - Abstract
The LED-pumping technology is used for the first time, to the best of our knowledge, to develop a complete master oscillator power amplifier (MOPA) system including a multipass amplifier. A pumping head using an original slab architecture is developed integrating a Cr:LiSAF slab pumped by 2112 blue LEDs via a Ce:YAG luminescent concentrator. The slab configuration enables the reaching of a large number of passes—up to 22—together with access to efficient cooling, allowing for a repetition rate scale up. For 22 passes, the amplifier delivers pulses with energy up to 2.4 mJ at 10-Hz repetition rate with a gain of 4.36 at 825 nm. A complete study of the MOPA is described, concluding in nearly constant performances versus the repetition rate, up to 100 Hz.
- Published
- 2022
17. Higgs in a box: investigating the nature of a scientific discovery
- Author
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Julia Woithe, Margherita Boselli, Panagiota Chatzidaki, Merten Nikolay Dahlkemper, Ruadh Duggan, Guillaume Durey, Niklas Herff, Anja Kranjc Horvat, Daniele Molaro, Gernot Werner Scheerer, Sascha Schmeling, Patrick Georges Thill, Jeff Wiener, and Sarah Zoechling
- Subjects
Physics Education (physics.ed-ph) ,General Mathematics ,Physics - Physics Education ,FOS: Physical sciences ,General Physics and Astronomy ,Popular Physics (physics.pop-ph) ,Physics - Popular Physics ,Education and Outreach ,Education - Abstract
The discovery of the Higgs boson by the ATLAS and CMS collaborations in 2012 concluded the longest search for a particle in the history of particle physics and was based on the largest and most complex physics experiments ever conducted, involving thousands of scientists and engineers from around the world. It provided crucial evidence for a theory developed in the 1960s that describes the existence of the invisible Brout-Englert-Higgs field and the effects of this field on the mass of elementary particles. After the discovery, the work on the theoretical prediction was awarded the Nobel Prize in Physics 2013. This discovery provides a prime example of modern science in the making and a fantastic opportunity to discuss important aspects of Nature of Science (NoS) in the classroom. In this article, we draw connections between a) milestones in the discovery of the Higgs boson, b) important aspects of NoS, and c) hands-on activities with mystery boxes, which are an effective tool to enable students to experience elements of scientific discovery and explicitly reflect on NoS. We hope that this supports educators in bringing lively discussions about modern physics research into their classrooms., 18 pages, 6 figures
- Published
- 2022
18. Tm:CALGO lasers at 2.32 µm: cascade lasing and upconversion pumping
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Hippolyte Dupont, Pavel Loiko, Aleksey Tyazhev, Luidgi Giordano, Zhongben Pan, Hongwei Chu, Dechun Li, Bruno Viana, Ammar Hideur, Lauren Guillemot, Alain Braud, Patrice Camy, Patrick Georges, and Frédéric Druon
- Subjects
Atomic and Molecular Physics, and Optics - Abstract
We report on the first laser operation of a disordered Tm:CaGdAlO4 crystal on the 3H4 → 3H5 transition. Under direct pumping at 0.79 µm, it generates 264 mW at 2.32 µm with a slope efficiency of 13.9% and 22.5% vs. incident and absorbed pump power, respectively, and a linear polarization (σ). Two strategies to overcome the bottleneck effect of the metastable 3F4 Tm3+ state leading to the ground-state bleaching are exploited: cascade lasing on the 3H4 → 3H5 and 3F4 → 3H6 transitions and dual-wavelength pumping at 0.79 and 1.05 µm combining the direct and upconversion pumping schemes. The cascade Tm-laser generates a maximum output power of 585 mW at 1.77 µm (3F4 → 3H6) and 2.32 µm (3H4 → 3H5) with a higher slope efficiency of 28.3% and a lower laser threshold of 1.43 W, out of which 332 mW are achieved at 2.32 µm. Under dual-wavelength pumping, further power scaling to 357 mW at at 2.32 µm is observed at the expense of increased laser threshold. To support the upconversion pumping experiment, excited-state absorption spectra of Tm3+ ions for the 3F4 → 3F2,3 and 3F4 → 3H4 transitions are measured for polarized light. Tm3+ ions in CaGdAlO4 exhibit broadband emission at 2.3 - 2.5 µm making this crystal promising for ultrashort pulse generation.
- Published
- 2023
19. Excited-state absorption and upconversion pumping of Tm3+-doped potassium lutetium double tungstate
- Author
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Aleksey Tyazhev, Pavel Loiko, Lauren Guillemot, Alexandre Kouta, Rosa Maria Solé, Xavier Mateos, Magdalena Aguiló, Francesc Díaz, Hippolyte Dupont, Patrick Georges, Frédéric Druon, Alain Braud, Patrice Camy, and Ammar Hideur
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Atomic and Molecular Physics, and Optics - Abstract
We report on a bulk thulium laser operating on the 3H4 → 3H5 transition with pure upconversion pumping at 1064 nm by an ytterbium fiber laser (addressing the 3F4 → 3F2,3 excited-state absorption (ESA) transition of Tm3+ ions) generating 433 mW at 2291 nm with a slope efficiency of 7.4% / 33.2% vs. the incident / absorbed pump power, respectively, and linear laser polarization representing the highest output power ever extracted from any bulk 2.3 µm thulium laser with upconversion pumping. As a gain material, a Tm3+-doped potassium lutetium double tungstate crystal is employed. The polarized ESA spectra of this material in the near-infrared are measured by the pump-probe method. The possible benefits of dual-wavelength pumping at 0.79 and 1.06 µm are also explored, indicating a positive effect of co-pumping at 0.79 µm on reducing the threshold pump power for upconversion pumping.
- Published
- 2023
20. Second harmonic generation in the presence of walk-off and group velocity mismatch
- Author
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Marc Hanna, Michele Natile, Yoann Zaouter, Manuel Joffre, and Patrick Georges
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Statistical and Nonlinear Physics ,Atomic and Molecular Physics, and Optics - Abstract
We study a second harmonic generation interaction geometry in the case where both group velocity mismatch and walk-off have significant impacts. This results in a frequency-converted beam exhibiting a pulse front tilt. Using the global response function of the crystal, we provide an analytical model that allows to predict the spatiotemporal structure of the second harmonic wave packet and verify its validity using numerical simulations and a simple experiment. Distinctive features of this geometry are the suppression of back-conversion and the ability to conserve the fundamental bandwidth in space and time domains. Subsequent compensation of the pulse front tilt should allow efficient generation of ultrashort pulses in the deep ultraviolet.
- Published
- 2023
21. Enhanced-efficiency of a mid-IR intrapulse difference-frequency generation
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Quentin Bournet, Florent Guichard, Michele Natile, Yoann Zaouter, Frédéric Druon, Marc Hanna, and Patrick Georges
- Published
- 2022
22. Low-threshold Highly Efficient Backward Wave OPO
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Kjell Martin Mølster, Marie Guionie, Patrick Mutter, Jean-Baptiste Dherbecourt, Jean-Michel Melkonian, Xavier Délen, Andrius Zukauskas, Carlota Canalias, Fredrik Laurell, Patrick Georges, Myriam Raybaut, Antoine Godard, and Valdas Pasiskevicius
- Abstract
Cavity-free, precision-tunable source of a nanosecond, mJ-level, pulses consisting of backward optical parametric oscillator pumped by diode-seeded laser amplifier shows a record threshold of 19 MW/cm2 and an optical-to-optical efficiency exceeding 70%.
- Published
- 2022
23. Tunable, Broadband Mid-Infrared Source Based on Amplified Intrapulse Difference Frequency Generation
- Author
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Quentin Bournet, Florent Guichard, Michele Natile, Yoann Zaouter, Manuel Joffre, Adeline Bonvalet, Frederic Druon, Marc Hanna, and Patrick Georges
- Abstract
We report on an ultra-broadband mid-infrared source based on intrapulse difference-frequency-generation with time-delay and chirp optimizations of the pump and signal pulses, delivering 600 nJ, 50 fs pulses at 8.6 µm and 250 kHz repetition-rate.
- Published
- 2022
24. Excited-State Absorption and Upconversion Pumping of Monoclinic Tm:KLu(WO4)2 Crystals
- Author
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Aleksey Tyazhev, Pavel Loiko, Lauren Guillemot, Alexandre Kouta, Rosa Maria Solé, Xavier Mateos, Magdalena Aguiló, Francesc Díaz, Hippolyte Dupont, Patrick Georges, Frédéric Druon, Alain Braud, Ammar Hideur, and Patrice Camy
- Abstract
Excited-state absorption of Tm3+ ions (3F4→3F2,3 and 3H4) in the KLu(WO4)2 crystal is studied. Mid-infrared laser operation (3H4→3H5) is achieved with this crystal under upconversion pumping at 1.06 μm yielding 433 mW at 2291 nm. © 2022 The Author(s)
- Published
- 2022
25. Improvement of 1 µm upconversion pumping of mid-infrared Tm:YLF laser at 2.3 µm by dual-wavelength-pumping
- Author
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Hippolyte Dupont, Lauren Guillemot, Pavel Loiko, Alain Braud, Jean-Louis Doualan, Patrice Camy, Patrick Georges, and Frédéric Druon
- Abstract
We present studies about upconversion pumping at 1.05 µm for Tm:YLF lasers emitting at 2.3 μm. To improve the performance of this pump, we explore the possibility dual pumping with 780 nm.
- Published
- 2022
26. Non-Competitive Cascade Lasing at 1.8 and 2.3 µm Using a Tm:CALGO Crystal
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Hippolyte Dupont, Pavel Loiko, Zhongben Pan, Hongwei Chu, Dechun Li, Bruno Viana, Ammar Hideur, Alain Braud, Lauren Guillemot, Patrice Camy, Patrick Georges, and Frédéric Druon
- Abstract
Cascade lasing in a Tm:CALGO crystal at 1.8 µm (3F4→3H6) and 2.3 μm (3H4→3H5) is demonstrated with the originality of lacking a competition between the two laser channels, owing to dual-wavelength (direct and upconversion) pumping.
- Published
- 2022
27. Precisely tunable narrowband mid-infrared mJ pulses from a backward wave optical parametric oscillator
- Author
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Kjell Martin Mølster, Marie Guionie, Patrick Mutter, Jean-Baptiste Dherbecourt, Jean-Michel Melkonian, Xavier Délen, Andrius Zukauskas, Carlota Canalias, Fredrik Laurell, Patrick Georges, Myriam Raybaut, Antoine Godard, and Valdas Pasiskevicius
- Abstract
Precision-tunable mJ, nanosecond pulses at 1981.1 nm and 2145.6 nm are generated at 5kHz repetition with an efficiency of 70% in a cavity-free arrangement using a PPRKTP BWOPO pumped by a narrowband DPSSL at 1030nm.
- Published
- 2022
28. Coherent combination of micropulse tapered amplifiers at 828 nm for direct-detection LIDAR applications
- Author
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Qin Liu, Sylvie Janicot, Patrick Georges, and Gaëlle Lucas-Leclin
- Subjects
Atomic and Molecular Physics, and Optics - Abstract
We report on the design of a compact master oscillator power amplifier (MOPA) diode laser architecture at 828 nm suitable for direct-detection LIDARs, specifically applied to water vapor differential absorption LIDARs. Coherent beam combination of two pulsed high-brightness tapered amplifiers (1 μs, 10 kHz), seeded by a DBR laser diode, is demonstrated. The phase dynamics during the pulses have been thoroughly investigated. The main limitation to the CBC efficiency is quantified. The maximum combined pulse energy reaches 10.3 μJ with combining efficiency above 82% ± 5%.
- Published
- 2023
29. Le neuromarketing en action: Parler et vendre au cerveau
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Michel Badoc, Patrick Georges
- Published
- 2012
30. Influence of the Mekin hydroelectric dam on the distribution of benthic macroinvertebrates of the Dja stream: South Cameroon region
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Rodrigue Nanfack Dongmo, Cecile Rita Boudem Tsane, Raoul Polycarpe Tuekam Kayo, Patrick Georges Thiery Moanono, Brillant Nonga Tang, Serge Hubert Zébazé Togouet, and Paul Bertrand Sob Nangou
- Subjects
Upstream and downstream (DNA) ,Hydrology ,education.field_of_study ,Benthic macroinvertebrates ,Physico-chemistry ,Dja River ,Mekin Hydroelectric dam ,Benthic zone ,Hydroelectricity ,Population ,Biodiversity ,Sampling (statistics) ,Environmental science ,Standard methods ,education ,Invertebrate - Abstract
This work was conducted with the aim of studying the biodiversity of benthic macroinvertebrates in the Dja River and determining the effect of the Mekin hydroelectric dam on their population in relation to the physico-chemical quality of the water. The study ran from May to October 2020 and samplings were carried out on a monthly basis in four different sampling stations located upstream and downstream of the dam. The physico-chemical analyses were done according to standard methods, while the benthic macrofauna was collected using a turbid net of 400 µm mesh size over a total area of about 6 m2per station. Physico-chemical analyses revealed a decreasing evolution from upstream to downstream of the dam of nitrogen forms (NO3-(1.67mg/L-0.41mg/L); NH4+(0.31 mg/L-0.21 mg/L) with p>0.05); Electrical Conductivity (21.45µS/Cm-17.1µS/Cm with pTrithemis dorsalis(96.05%); while downstream, Heteroptera was largely abundant and highly represented byPoissoniasp1. (79.78%). These results revealed that restoration of the upstream of the dam impacted by organic pollution and physical degradation of the environment is recommended.
- Published
- 2021
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- View/download PDF
31. Light recycling in LED-pumped Ce:YAG luminescent concentrators
- Author
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Maxime Nourry-Martin, Stephane Darbon, Pierre Pichon, Frédéric Druon, François Balembois, Patrick Georges, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire Charles Fabry / Lasers, Laboratoire Charles Fabry (LCF), and Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Brightness ,Materials science ,business.industry ,Drop (liquid) ,Irradiance ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Concentrator ,01 natural sciences ,7. Clean energy ,Atomic and Molecular Physics, and Optics ,law.invention ,010309 optics ,Photometry (optics) ,Luminous flux ,Optics ,law ,0103 physical sciences ,[SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic ,0210 nano-technology ,Luminescence ,business ,Light-emitting diode - Abstract
We report the development of a high-brightness, high-power Ce:YAG luminescent concentrator pumped by 2240 blue LEDs in quasi-continuous wave operation (10 µs, 10 Hz). Using light confinement and recycling in the three space dimensions, the parallelepiped (1mm×14×mm×200mm) Ce:YAG emits a power of 145 W from a square output surface (1 × 1mm2) corresponding to a brightness of 4.6 kW/cm2/sr. This broadband yellow source has a unique combination of luminous flux (7.6 104 lm) and brightness (2.4 104 cd/mm2) and overcomes many other visible incoherent sources by one order of magnitude. This paper also proposes a deep understanding of the performance drop compared to a linear behavior when the pump power increases. Despite excited state absorption was unexpected for this low doped Ce:YAG pumped at a low irradiance level, we demonstrated that it affects the performance by tripling the losses in the concentrator. This effect is particularly important for small output surfaces corresponding to strong light recycling in the concentrator and to average travel distances inside the medium reaching meters.
- Published
- 2021
32. Efficient and high-throughput ablation of platinum using high-repetition rate radially and azimuthally polarized sub-picosecond laser pulses
- Author
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André, Loescher, Paul, Oldorf, Rigo, Peters, Wolfgang, Pallmann, Bojan, Resan, Fabien, Lesparre, Patrick, Beaure d'Augères, Xavier, Delen, Francois, Balembois, Patrick, Georges, Roswitha, Giedl-Wagner, Ronny De, Loor, Thomas, Graf, and Marwan Abdou, Ahmed
- Abstract
A highly productive ablation process of 100 nm thick platinum films with a processed area rate of up to 378 cm
- Published
- 2021
33. Simple carrier-envelope phase control and stabilization scheme for difference frequency generation-based systems
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Michele Natile, Marc Hanna, Patrick Georges, Yoann Zaouter, Florent Guichard, Laboratoire Charles Fabry / Lasers, Laboratoire Charles Fabry (LCF), and Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Physics ,Optical amplifier ,[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics] ,business.industry ,Carrier-envelope phase ,Phase (waves) ,02 engineering and technology ,Laser pumping ,Feedback loop ,021001 nanoscience & nanotechnology ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,010309 optics ,Amplitude ,Optics ,0103 physical sciences ,Modulation (music) ,Astrophysics::Solar and Stellar Astrophysics ,0210 nano-technology ,business ,Phase modulation - Abstract
International audience; We report about a setup for carrier-envelope phase (CEP) control and stabilization in passive systems based on difference frequency generation (DFG). The principle of this approach relies on the amplitude to phase modulation transfer in the white-light generation process. A small modulation of the pump laser intensity is used to obtain a DFG output modulated in CEP. This technique is demonstrated in a CEP-stable system pumped by an Yb-doped fiber amplifier. It is first characterized by measuring CEP modulations produced by applying arbitrary waveforms. The CEP actuator is then used for slow drifts correction in a feedback loop. The results show the capability of this simple approach for OPA/OPCPA CEP-stabilized setups.
- Published
- 2021
34. 100 fs LED-pumped Cr:LiSAF regenerative amplifier
- Author
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Frédéric Druon, François Balembois, Hussein Taleb, Pierre Pichon, and Patrick Georges
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Materials science ,business.industry ,Amplifier ,Physics::Optics ,Pulse duration ,Laser ,Semiconductor laser theory ,law.invention ,Regenerative amplification ,law ,Femtosecond ,Optoelectronics ,business ,Diode ,Light-emitting diode - Abstract
Transition metal-doped gain media such as Ti:sapphire, Cr:LiSAF and Alexandrite are the most appropriated crystals for femtosecond laser chains with pulse duration below 100 fs. However, because of a low gain and an absorption band in the green/red region, these materials are difficult to pump directly with diodes. Hence, the main issue for a femtosecond laser chain is the complexity and the high cost of the pump sources for the amplifiers. One innovative solution is to take advantage of the compactness, robustness, and low price of the light-emitting diodes (LED) to pump transition metal-doped gain media. In this work, we report, to our best knowledge, the first femtosecond amplifier pumped by LED. For this demonstration, we choose the Cr:LiSAF crystal for its combination of high absorption, large emission cross section and relatively long radiative lifetime. We then present a LED-pumped Cr:LiSAF regenerative amplifier in a femtosecond laser chain.
- Published
- 2021
35. Visualizing music similarity: clustering and mapping 500 classical music composers
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Patrick Georges and Ngoc Nguyen
- Subjects
Computer science ,business.industry ,General Social Sciences ,Library and Information Sciences ,computer.software_genre ,Computer Science Applications ,Hierarchical clustering ,Classical music ,Distance matrix ,Similarity (network science) ,Graph (abstract data type) ,Music information retrieval ,Artificial intelligence ,Multidimensional scaling ,business ,Cluster analysis ,computer ,Natural language processing - Abstract
This paper applies clustering techniques and multi-dimensional scaling (MDS) analysis to a 500 × 500 composers’ similarity/distance matrix. The objective is to visualize or translate the similarity matrix into dendrograms and maps of classical (European art) music composers. We construct dendrograms and maps for the Baroque, Classical, and Romantic periods, and a map that represents seven centuries of European art music in one single graph. Finally, we also use linear and non-linear canonical correlation analyses to identify variables underlying the dimensions generated by the MDS methodology.
- Published
- 2019
36. Enhanced extreme ultraviolet high-harmonic generation from chromium-doped magnesium oxide
- Author
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Willem Boutu, A. Hamdou, Viktoria Nefedova, Francisco Navarrete, Nicolas Tancogne-Dejean, Uwe Thumm, Patrick Georges, Gaëtan Jargot, Dominik Franz, Shatha Kaassamani, Hamed Merdji, Sven Fröhlich, Rana Nicolas, Marc Hanna, Marcelo F. Ciappina, D. Gauthier, Laboratoire Interactions, Dynamiques et Lasers (ex SPAM) (LIDyl), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Kansas State University, Institut für Physik [Rostock], Universität Rostock, Max Planck Institute for the Structure and Dynamics of Matter (MPSD), Laboratoire Charles Fabry / Lasers, Laboratoire Charles Fabry (LCF), Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Barcelona Institute of Science and Technology (BIST), ANR-17-CE30-0008,PACHA,Harmoniques laser dans les cristaux assistées par la plasmonique(2017), and Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
010302 applied physics ,Semiconductor Bloch equations ,[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics] ,Materials science ,Physics and Astronomy (miscellaneous) ,Doping ,Physics::Optics ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Laser ,01 natural sciences ,Molecular physics ,law.invention ,Crystal ,Condensed Matter::Materials Science ,law ,Vacancy defect ,Extreme ultraviolet ,Condensed Matter::Superconductivity ,0103 physical sciences ,Physics::Atomic and Molecular Clusters ,High harmonic generation ,0210 nano-technology ,Anisotropy - Abstract
International audience; High-order harmonic generation (HHG) from crystals is emerging as a new ultrashort source of coherent extreme ultraviolet (XUV) light. Doping the crystal structure can offer a new way to control the source properties. Here, we present a study of HHG enhancement in the XUV spectral region from an ionic crystal, using dopant-induced vacancy defects, driven by a laser centered at a wavelength of 1.55 lm. Our numerical simulations based on solutions of the semiconductor Bloch equations and density-functional theory are supported by our experimental observations and demonstrate an increase in the XUV high harmonic yield from doped bulk magnesium oxide (MgO) compared to undoped MgO, even at a low defect concentration. The anisotropy of the harmonic emission as a function of the laser polarization shows that the pristine crystal's symmetry is preserved. Our study paves the way toward the control of HHG in solids with complex defects caused by transition-metal doping.
- Published
- 2021
37. Single-pass tapered semiconductor optical amplifiers and modules for efficient coherent beam combining
- Author
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Jonas Hamperl, Gunnar Blume, Paul Crump, M Elattar, A. Maaβdorf, David Feise, Patrick Georges, Gaëlle Lucas-Leclin, Arnim Ginolas, Philipp Albrodt, J. Fricke, Günther Tränkle, and Katrin Paschke
- Subjects
Optical amplifier ,Semiconductor ,Materials science ,Fabrication ,business.industry ,Amplifier ,Energy conversion efficiency ,Optoelectronics ,Near and far field ,Laser beam quality ,business ,Beam (structure) - Abstract
We present progress in high power GaAs-based single-pass semiconductor tapered optical amplifiers and modules tailored for coherent beam combining (CBC) in master-oscillator power-amplifier configuration. Amplifier design is first studied, by varying device geometry and epitaxial structure in 976nm devices. Epitaxial structures with large vertical near field and low wave-guiding from the active region enable higher CBC efficiency. However, changes to in-plane geometry did not improve performance. Overall, CBC of tapered amplifiers is stable, reproducible and robust, motivating next the development of 1064nm CBC-ready stand-alone sub-modules. Design, construction and test results from the pilot-series fabrication of these amplifier modules are presented.
- Published
- 2021
38. Improved employee selection and staffing through meta programmes
- Author
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Patrick Georges, D.
- Published
- 1996
- Full Text
- View/download PDF
39. Nonlinear beam matching to gas-filled multipass cells
- Author
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Patrick Georges, Xavier Délen, Louis Daniault, Marc Hanna, Florent Guichard, Nour Daher, Rodrigo Lopez-Martens, Laboratoire Charles Fabry / Lasers, Laboratoire Charles Fabry (LCF), Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'optique appliquée (LOA), École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), and Amplitude Systèmes
- Subjects
[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics] ,Materials science ,Computer simulation ,business.industry ,Compression (physics) ,Laser ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,law.invention ,010309 optics ,Nonlinear system ,Optics ,law ,Ionization ,0103 physical sciences ,Femtosecond ,Electrical and Electronic Engineering ,Current (fluid) ,010306 general physics ,business ,Constant (mathematics) - Abstract
International audience; Gas-filled multipass cells are an appealing alternative to capillaries to implement nonlinear temporal compression of high energy femtosecond lasers. Here, we provide an analytic expression for stationary beam coupling to multipass cells that takes into account nonlinear propagation. This allows a constant beam size on the mirrors and at the cell waist, thereby making the optical design more accurate, for example to avoid optical damage or significant ionization. The analysis is validated using spatio-temporal numerical simulations of the propagation in a near-concentric configuration. This is particularly important for multipass cells that are operated in a highly nonlinear regime, which is the current trend since it allows a lower number of roundtrips, relaxing the constraint on mirror coatings performance.
- Published
- 2021
40. Incoherent light source exceeding the brightness of 18 suns using light recycling in LED-pumped luminescent concentrators
- Author
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Pierre Pichon, Frédéric Druon, Patrick Georges, Maxime Nourry-Martin, François Balembois, and Stephane Darbon
- Subjects
Brightness ,Materials science ,Light source ,Optics ,business.industry ,Laser pumping ,Suns in alchemy ,Luminescence ,business ,Refractive index ,Order of magnitude - Abstract
Blue-LED-pumped Ce: YAG luminescent concentrators are counting among the brightest incoherent light sources. This work shows that light recycling allows to enhance their brightness by one order of magnitude reaching 4.6 kW/cm²/sr.
- Published
- 2021
41. Generation of optically synchronized pump-signal beams for ultrafast OPCPA via the optical Kerr effect
- Author
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Frédéric Druon, Dimitris N. Papadopoulos, Christina Alexandridi, Patrick Georges, Luc Martin, F. Mathieu, Xavier Délen, Laboratoire pour l'utilisation des lasers intenses (LULI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Charles Fabry / Lasers, Laboratoire Charles Fabry (LCF), and Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Chirped pulse amplification ,Physics ,[PHYS]Physics [physics] ,Kerr effect ,business.industry ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Laser ,01 natural sciences ,Signal ,Atomic and Molecular Physics, and Optics ,law.invention ,Pulse (physics) ,010309 optics ,Synchronization (alternating current) ,Optics ,law ,Shutter ,0103 physical sciences ,0210 nano-technology ,business ,Ultrashort pulse - Abstract
In recent years, multi-petawatt laser installations have achieved unprecedented peak powers, opening new horizons to laser–matter interaction studies. Ultra-broadband and extreme temporal contrast pulse requirements make optical parametric chirped pulse amplification (OPCPA) in the few-picosecond regime the key technology in these systems. To guarantee high fidelity output, however, OPCPA requires excellent synchronization between pump and signal pulses. Here, we propose a new highly versatile architecture for the generation of optically synchronized pump–signal pairs based on the Kerr shutter effect. We obtained > 550 µ J pump pulses of 12 ps duration at 532 nm optically synchronized with a typical ultrashort CPA source at 800 nm. As a proof-of-principle demonstration, our system was also used for amplification of ∼ 20 µ J ultra-broadband pulses based on an OPCPA setup.
- Published
- 2021
42. Harnessing subcellular-resolved organ distribution of cationic copolymer-functionalized fluorescent nanodiamonds for optimal delivery of therapeutic siRNA to a xenografted tumor in mice
- Author
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Zamira Díaz-Riascos, Patrick Georges, Sandra Claveau, Xavier Délen, Jean-Rémi Bertrand, Petr Cigler, Alexandre Papine, Marek Kindermann, François Treussart, Òscar Tirado Martínez, Ibane Abasolo Olaortua, Roser López-Alemany, Laboratoire Lumière, Matière et Interfaces (LuMIn), CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay), Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques (METSY), Institut Gustave Roussy (IGR)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Vectorologie et thérapeutiques anti-cancéreuses [Villejuif] (UMR 8203), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS), Institut Gustave Roussy (IGR), Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB / CAS), Czech Academy of Sciences [Prague] (CAS), University of Chemistry and Technology Prague (UCT Prague), IMSTAR, IMSTAR S.A., Vall d’Hebron Research Institute (VHIR), Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III [Madrid] (ISC)-ministerio de ciencia e innovacion, Laboratoire Charles Fabry / Lasers, Laboratoire Charles Fabry (LCF), Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and Institut d'Investigació Biomèdica de Bellvitge [Barcelone] (IDIBELL)
- Subjects
Biodistribution ,Small interfering RNA ,[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Quantitative Biology - Quantitative Methods ,Fluorescence ,Nanodiamonds ,Mice ,[SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication ,In vivo ,Neoplasms ,Fluorescence microscope ,Animals ,General Materials Science ,Tissue Distribution ,RNA, Small Interfering ,Nanodiamond ,Tissues and Organs (q-bio.TO) ,biodistribution ,Quantitative Methods (q-bio.QM) ,Oncogene ,cationic copolymer ,Chemistry ,time-delayed epifluorescence ,Quantitative Biology - Tissues and Organs ,[CHIM.MATE]Chemical Sciences/Material chemistry ,021001 nanoscience & nanotechnology ,3. Good health ,0104 chemical sciences ,FOS: Biological sciences ,Biophysics ,Nanomedicine ,fluorescent nanodiamond ,0210 nano-technology ,high-throughput quantifications ,in vivo siRNA delivery - Abstract
Diamond nanoparticles (nanodiamonds) can transport active drugs in cultured cells as well as in vivo. However, in the latter case, methods allowing to determine their bioavailability accurately are still lacking. Nanodiamond can be made fluorescent with a perfectly stable emission and a lifetime ten times longer than the one of tissue autofluorescence. Taking advantage of these properties, we present an automated quantification method of fluorescent nanodiamonds (FND) in histological sections of mouse organs and tumor, after systemic injection. We use a home-made time-delayed fluorescence microscope comprising a custom pulsed laser source synchronized on the master clock of a gated intensified array detector. This setup allows to obtain ultra-high-resolution images 120 Mpixels of whole mouse organs sections, with subcellular resolution and single-particle sensitivity. As a proof-of-principle experiment, we quantified the biodistribution and aggregation state of new cationic FNDs able to transport small interfering RNA inhibiting the oncogene responsible for Ewing sarcoma. Image analysis showed a low yield of nanodiamonds in the tumor after intravenous injection. Thus, for the in vivo efficacy assay we injected the nanomedicine into the tumor. We achieved a 28-fold inhibition of the oncogene. This method can readily be applied to other nanoemitters with $\approx$100 ns lifetime., Comment: Nanoscale, Royal Society of Chemistry, 2021
- Published
- 2021
- Full Text
- View/download PDF
43. Le médecin, seconde victime ?
- Author
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Bouaziz, Hervé and Yavordios, Patrick-Georges
- Published
- 2020
- Full Text
- View/download PDF
44. Le médecin, seconde victime ?
- Author
-
Patrick-Georges Yavordios, Hervé Bouaziz, and Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)
- Subjects
03 medical and health sciences ,0302 clinical medicine ,Anesthesiology and Pain Medicine ,030503 health policy & services ,[SDV]Life Sciences [q-bio] ,Emergency Medicine ,030212 general & internal medicine ,Emergency Nursing ,0305 other medical science ,3. Good health - Abstract
Resume Au-dela du patient, une erreur medicale peut affecter la vie personnelle et professionnelle du ou des medecins concernes. Toutes les enquetes montrent que les soignants sont plus ou moins durablement et gravement affectes a la suite d’une erreur medicale ayant eu des consequences serieuses. A l’occasion d’un evenement adverse grave, une assistance doit etre portee aux medecins concernes. Cette assistance porte a a fois sur la tracabilite et l’analyse des faits, mais aussi sur la communication avec les familles et concerne la prise en charge psychologique des praticiens. L’institution et les membres de l’equipe soignante ont un role immediat a jouer dans ce processus.
- Published
- 2020
45. Comparison of multi-pass and regenerative strategies for energetic high-gain amplifiers based on Yb:CaF
- Author
-
Frédéric, Druon, Kévin, Genevrier, Patrick, Georges, and Dimitris N, Papadopoulos
- Abstract
Yb-doped materials, due to their high saturation fluence and consequently their low gain, represent a challenging choice for high-energy amplifiers. In this Letter, we study two original amplifier designs adapted to a large number of passes capable of operating in the 100 mJ energy range at repetition rates up to 100 Hz using
- Published
- 2020
46. Hybrid master oscillator power amplifier single-frequency, nanosecond, multi-mJ, 5 kHz at 1030 nm
- Author
-
Jean-Michel Melkonian, Myriam Raybaut, Jean-Baptiste Dherbecourt, Antoine Godard, Xavier Délen, Patrick Georges, Thomas Hamoudi, DPHY, ONERA, Université Paris Saclay [Palaiseau], ONERA-Université Paris-Saclay, Laboratoire Charles Fabry / Lasers, Laboratoire Charles Fabry (LCF), and Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Ytterbium ,Materials science ,chemistry.chemical_element ,02 engineering and technology ,01 natural sciences ,Tunable laser ,010309 optics ,Master oscillator ,[SPI]Engineering Sciences [physics] ,0103 physical sciences ,Bulk crystal ,[PHYS]Physics [physics] ,business.industry ,Amplifier ,Pulsed laser ,Nanosecond ,021001 nanoscience & nanotechnology ,chemistry ,Modulation ,Optical parametric oscillator ,Optoelectronics ,0210 nano-technology ,business ,Single frequency laser - Abstract
We demonstrate that the combination of Ytterbium doped-fiber and bulk crystals amplifiers, in a Master Oscillator Power Amplifier configuration (MOPA) allows obtaining 3.6 mJ, 15 ns, single-frequency pulses and 5 kHz repetition rate.
- Published
- 2020
47. Trade Policy Renegotiations: The Case of the North American Free Trade Agreement (NAFTA) and Canada’s Options under Donald Trump
- Author
-
Patrick Georges
- Published
- 2020
48. High repetition rate CEP-stable Yb-doped fiber amplifier
- Author
-
Marc Hanna, Patrick Georges, Anna Golinelli, Michele Natile, Yoann Zaouter, Florent Guichard, Amplitude Laser Group, Laboratoire Charles Fabry / Lasers, Laboratoire Charles Fabry (LCF), and Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
- Subjects
[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics] ,Materials science ,Repetition (rhetorical device) ,business.industry ,Doping ,Fiber amplifier ,Optoelectronics ,business ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2020
49. High repetition rate CEP-stable Yb-doped laser source for attoscience
- Author
-
Florent Guichard, Marc Hanna, Yoann Zaouter, Anna Golinelli, Patrick Georges, R. Chiche, and Michele Natile
- Subjects
Materials science ,Repetition (rhetorical device) ,business.industry ,Laser source ,Doping ,Optoelectronics ,business - Abstract
We report on the CEP-stabilization of an ultrashort pulses Yb-doped source delivering 75 microjoules, 60 fs at 100 kHz with a measured every shot CEP noise lower than 320 mrad over 1s.
- Published
- 2020
50. Enhanced intrapulse difference frequency generation in the mid-infrared by a spectrally dependent polarization state
- Author
-
Ioachim Pupeza, Christina Hofer, Manuel Joffre, Patrick Georges, Quentin Bournet, Yoann Zaouter, Michele Natile, Florent Guichard, Marc Hanna, Frédéric Druon, Adeline Bonvalet, Hanna, Marc, Laboratoire Charles Fabry / Lasers, Laboratoire Charles Fabry (LCF), Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Optique et Biosciences (LOB), and École polytechnique (X)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
[PHYS.PHYS.PHYS-OPTICS] Physics [physics]/Physics [physics]/Optics [physics.optics] ,Physics ,[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics] ,Frequency generation ,Optics ,business.industry ,State (functional analysis) ,Polarization (waves) ,business ,Atomic and Molecular Physics, and Optics - Abstract
We present a technique to optimize the intrapulse difference frequency generation efficiency for mid-infrared generation. The approach employs a multi-order wave plate that is designed to selectively rotate the polarization state of the incoming spectral components on the relevant orthogonal axes for subsequent nonlinear interaction. We demonstrate a significant increase of the mid-infrared average power generated, of a factor ≥2.5 compared with the conventional scheme, owing to an optimally distributed number of photons enrolled in the difference frequency generation process.
- Published
- 2022
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