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5. Primary ciliary dyskinesia: A multicenter survey on clinical practice and patient management in Italy

Author

Ullmann, Nicola, primary, Santamaria, Francesca, additional, Allegorico, Annalisa, additional, Fainardi, Valentina, additional, Borrelli, Melissa, additional, Ferraro, Valentina A., additional, Proietti, Elena, additional, Parisi, Giuseppe F., additional, Romagnoli, Vittorio, additional, Lucca, Francesca, additional, Gallucci, Marcella, additional, Mappa, Luigi, additional, Lelli, Mara, additional, Amato, Doriana, additional, Petrarca, Laura, additional, Cimino, Giuseppe, additional, Sacco, Oliviero, additional, Calogero, Claudia, additional, Patria, Maria Francesca, additional, Acquafredda, Angelo, additional, Ferlisi, Annalisa, additional, Maschio, Massimo, additional, Kantar, Ahmad, additional, and Cutrera, Renato, additional

Published
2023
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7. The effect of component-resolved diagnosis on specific immunotherapy prescription in children with hay fever

Author

Stringari, Giovanna, Tripodi, Salvatore, Caffarelli, Carlo, Dondi, Arianna, Asero, Riccardo, Di Rienzo Businco, Andrea, Bianchi, Annamaria, Candelotti, Paolo, Ricci, Giampaolo, Bellini, Federica, Maiello, Nunzia, Miraglia del Giudice, Michele, Frediani, Tullio, Sodano, Simona, Dello Iacono, Iride, Macrì, Francesco, Peparini, Ilaria, Povesi Dascola, Carlotta, Patria, Maria Francesca, Varin, Elena, Peroni, Diego, Comberiati, Pasquale, Chini, Loredana, Moschese, Viviana, Lucarelli, Sandra, Bernardini, Roberto, Pingitore, Giuseppe, Pelosi, Umberto, Tosca, Mariangela, Cirisano, Anastasia, Faggian, Diego, Travaglini, Alessandro, Plebani, Mario, and Matricardi, Paolo Maria

Published
2014
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8. When and how ruling out cystic fibrosis in adult patients with bronchiectasis

Author

Gramegna, Andrea, Aliberti, Stefano, Seia, Manuela, Porcaro, Luigi, Bianchi, Vera, Castellani, Carlo, Melotti, Paola, Sorio, Claudio, Consalvo, Enza, Franceschi, Elisa, Amati, Francesco, Contarini, Martina, Gaffuri, Michele, Roncoroni, Luca, Vigone, Barbara, Bellofiore, Angela, Del Monaco, Cesare, Oriano, Martina, Terranova, Leonardo, Patria, Maria Francesca, Marchisio, Paola, Assael, Baroukh M., and Blasi, Francesco

Published
2018
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10. Caregivers' Attitudes Toward COVID-19 Vaccination in Children and Adolescents With a History of SARS-CoV-2 Infection

Author

Buonsenso, Danilo, Valentini, Piero, Macchi, Marina, Folino, Francesco, Pensabene, Carola, Patria, Maria Francesca, Agostoni, Carlo, Castaldi, Silvana, Lecce, Maurizio, Giannì, Maria Lorella, Marchisio, Paola, Milani, Gregorio P, Valentini, Piero (ORCID:0000-0001-6095-9510), Buonsenso, Danilo, Valentini, Piero, Macchi, Marina, Folino, Francesco, Pensabene, Carola, Patria, Maria Francesca, Agostoni, Carlo, Castaldi, Silvana, Lecce, Maurizio, Giannì, Maria Lorella, Marchisio, Paola, Milani, Gregorio P, and Valentini, Piero (ORCID:0000-0001-6095-9510)

Abstract

Background: Limited data are available on the attitudes of caregivers toward COVID-19 vaccination in children and adolescents with a history of SARS-CoV-2 infection or Long Covid symptoms. The aim of this study was to investigate the vaccine hesitancy among caregivers of children and adolescents with a documented history of SARS-CoV-2 infection and to explore the possible associations between COVID-19 manifestations and the acceptance of the vaccine. Methods: Caregivers of children or adolescents with a microbiologically confirmed diagnosis of SARS-CoV-2 infection evaluated in two University Hospitals were interviewed. Results: We were able to contact 132 caregivers and 9 declined to participate. 68 caregivers (56%) were in favor of COVID-19 vaccination for their child. In the multiple logistic regression, child's age (OR 1.17, 95%CI 1.06-1.28) and hospitalization due to COVID-19 (OR 3.25, 95%CI 1.06-9.95) were positively associated with being in favor of COVID-19 vaccination. On the contrary, the occurrence of child's Long Covid was associated with a higher likelihood of being against the vaccination (OR 0.28, 95%CI 0.10-0.80). Conclusions: This preliminary study shows that only about half of the interviewed parents of children and adolescents with a previous SARS-CoV-2 infection are willing to vaccinate them to prevent a repeated COVID-19 infection. These findings might help healthcare workers to provide tailored information to caregivers of children with a previous SARS-CoV-2 infection.

Published
2022

12. Therapeutic Strategies for COVID-19 Lung Disease in Children

Author

Gatti, Elisabetta, primary, Piotto, Marta, additional, Lelii, Mara, additional, Pensabene, Mariacarola, additional, Madini, Barbara, additional, Cerrato, Lucia, additional, Hassan, Vittoria, additional, Aliberti, Stefano, additional, Bosis, Samantha, additional, Marchisio, Paola, additional, and Patria, Maria Francesca, additional

Published
2022
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13. Early weaning is beneficial to prevent atopic dermatitis occurrence in young children

Author

Turati, F., Bertuccio, P., Galeone, C., Pelucchi, C., Naldi, L., Bach, J.-F., La Vecchia, C., Chatenoud, L., Agostinis, Fabio, Carminati, Stefania, Neri, Iria, Patrizi, Annalisa, Starace, Michela, Berti, Samantha, Gola, Maria Francesca, Gola, Massimo, Martelli, Alberto, Origgi, Daniela, Serradori, Lorenza, Burroni, Anna Graziella, Ciccarese, Giulia, Brena, Michela, Colonna, Cristiana, Gelmetti, Carlo, Esposito, Susanna, Montinaro, Valentina, Patria, Maria Francesca, Rios, Walter Peves, Tagliabue, Claudia, Fontana, Elena, Fortina, Anna Belloni, Peccianti, Camilla, Pellegrino, Michele, Trovato, Emanuele, Landro, Anna Di, Menchini, Massimo, Quadri, Vera, Testagrossa, Oriana, Boner, Attilio, Comberiati, Pasquale, and Peroni, Diego

Published
2016
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15. Therapeutic strategies for COVID-19 lung disease in children

Author

Gatti, Elisabetta, primary, MARTA, PIOTTO, additional, Lelii, Mara, additional, Pensabene, Mariacarola, additional, Madini, Barbara, additional, Cerrato, Lucia, additional, Hassan, Vittoria, additional, Aliberti, Stefano, additional, Bosis, Samantha, additional, Marchisio, Paola, additional, and Patria, Maria Francesca, additional

Published
2021
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16. Pollen-induced allergic rhinitis in 1360 Italian children: Comorbidities and determinants of severity

Author

Dondi, Arianna, Tripodi, Salvatore, Panetta, Valentina, Asero, Riccardo, Businco, Andrea Di Rienzo, Bianchi, Annamaria, Carlucci, Antonio, Ricci, Giampaolo, Bellini, Federica, Maiello, Nunzia, del Giudice, Michele Miraglia, Frediani, Tullio, Sodano, Simona, Dello Iacono, Iride, Macrì, Francesco, Massaccesi, Valerio, Caffarelli, Carlo, Rinaldi, Laura, Patria, Maria Francesca, Varin, Elena, Peroni, Diego, Chinellato, Iolanda, Chini, Loredana, Moschese, Viviana, Lucarelli, Sandra, Bernardini, Roberto, Pingitore, Giuseppe, Pelosi, Umberto, Tosca, Mariangela, Paravati, Francesco, La Grutta, Stefania, Meglio, Paolo, Calvani, Mauro, Plebani, Mario, and Matricardi, Paolo Maria

Published
2013
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23. House dust mite allergy in Italy. Diagnostic and clinical relevance of Der p 23 (and of minor allergens): A real life, multicenter study

Author

Celi, Giorgio, Brusca, Ignazio, Scala, Enrico, Villalta, Danilo, Pastorello, Elide, Farioli, Laura, Cortellini, Gabriele, Deleonardi, Gaia, Galati, Pietro, Losappio, Laura, Manzotti, Giuseppina, Pirovano, Barbara, Muratore, Lionello, Murzilli, Francesco, Cucinelli, Francesco, Musarra, Antonino, Cilia, Marcello, Nucera, Eleonora, Aruanno, Arianna, Ria, Francesco, Patria, Maria Francesca, Varin, Elena, Polillo, Battista Roberto, Sargentini, Vittorio, Quercia, Oliviero, Uasuf, Carina Gabriela, Zampogna, Stefania, Carollo, Michela, Graci, Stefania, Amato, Stefano, Mistrello, Gianni, Asero, Riccardo, Nucera, Eleonora (ORCID:0000-0002-0565-7680), Ria, Francesco (ORCID:0000-0002-8444-0307), Celi, Giorgio, Brusca, Ignazio, Scala, Enrico, Villalta, Danilo, Pastorello, Elide, Farioli, Laura, Cortellini, Gabriele, Deleonardi, Gaia, Galati, Pietro, Losappio, Laura, Manzotti, Giuseppina, Pirovano, Barbara, Muratore, Lionello, Murzilli, Francesco, Cucinelli, Francesco, Musarra, Antonino, Cilia, Marcello, Nucera, Eleonora, Aruanno, Arianna, Ria, Francesco, Patria, Maria Francesca, Varin, Elena, Polillo, Battista Roberto, Sargentini, Vittorio, Quercia, Oliviero, Uasuf, Carina Gabriela, Zampogna, Stefania, Carollo, Michela, Graci, Stefania, Amato, Stefano, Mistrello, Gianni, Asero, Riccardo, Nucera, Eleonora (ORCID:0000-0002-0565-7680), and Ria, Francesco (ORCID:0000-0002-8444-0307)

Abstract

House dust mites (HDM) area major cause of respiratory allergy and of perennial asthmaworldwide. 32 allergens for Dermatophagoidesfarinae(D2) and 21 for Dermatophagoides pteronyssinus(D1) have been detectedso farand novel allergens are still being reported(1). Der p 23, a gut-derived peritrophin present in the outer membrane of mite feces (2),has been recognized as a major allergen (2,3).Der p 1, Der p 2, Der p 23, and Der p 10(tropomyosin)are theonly allergens currently available for the component-resolved diagnosis of HDMallergyon ImmunoCAP.The clinical relevance of Der p 23 is only partially defined, and the prevalence and relevance of the exclusive sensitization to allergensother than groups1, 2, 10, and 23 has received little attention so far. We addressed these aspects ina large multicenter study.

Published
2019

24. When and how ruling out cystic fibrosis in adult patients with bronchiectasis

Author

Gramegna, Andrea, primary, Aliberti, Stefano, additional, Seia, Manuela, additional, Porcaro, Luigi, additional, Bianchi, Vera, additional, Castellani, Carlo, additional, Melotti, Paola, additional, Sorio, Claudio, additional, Consalvo, Enza, additional, Franceschi, Elisa, additional, Amati, Francesco, additional, Contarini, Martina, additional, Gaffuri, Michele, additional, Roncoroni, Luca, additional, Vigone, Barbara, additional, Bellofiore, Angela, additional, Del Monaco, Cesare, additional, Oriano, Martina, additional, Terranova, Leonardo, additional, Patria, Maria Francesca, additional, Marchisio, Paola, additional, Assael, Baroukh M., additional, and Blasi, Francesco, additional

Published
2019
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25. Familial Sleep Disorders in Unknown Genetic Syndrome

Author

Lelii, Mara, additional, Baggi, Elena, additional, Senatore, Laura, additional, Bedeschi, Maria Francesca, additional, Dilena, Robertino, additional, Iascone, Maria, additional, Gangi, Silvana, additional, Marchisio, Paola, additional, and Patria, Maria Francesca, additional

Published
2019
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28. House dust mite allergy in Italy—Diagnostic and clinical relevance of Der p 23 (and of minor allergens): A real‐life, multicenter study

Author

Celi, Giorgio, primary, Brusca, Ignazio, additional, Scala, Enrico, additional, Villalta, Danilo, additional, Pastorello, Elide, additional, Farioli, Laura, additional, Cortellini, Gabriele, additional, Deleonardi, Gaia, additional, Galati, Pietro, additional, Losappio, Laura, additional, Manzotti, Giuseppina, additional, Pirovano, Barbara, additional, Muratore, Lionello, additional, Murzilli, Francesco, additional, Cucinelli, Francesco, additional, Musarra, Antonino, additional, Cilia, Marcello, additional, Nucera, Eleonora, additional, Aruanno, Arianna, additional, Ria, Francesco, additional, Patria, Maria Francesca, additional, Varin, Elena, additional, Polillo, Battista Roberto, additional, Sargentini, Vittorio, additional, Quercia, Oliviero, additional, Gabriela Uasuf, Carina, additional, Zampogna, Stefania, additional, Carollo, Michela, additional, Graci, Stefania, additional, Amato, Stefano, additional, Mistrello, Gianni, additional, and Asero, Riccardo, additional

Published
2019
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29. Severe asthma features in children: A case–control online survey

Author

Montella, Silvia, Baraldi, Eugenio, Cazzato, Salvatore, Aralla, Raffaele, Berardi, Mariangela, Brunetti, Luigia Maria, Cardinale, Fabio, Cutrera, Renato, De Benedictis, Fernando Maria, Di Palmo, Emanuela, Di Pillo, Sabrina, Fenu, Grazia, La Grutta, Stefania, Lombardi, Enrico, Piacentini, Giorgio, Santamaria, Francesca, Ullmann, Nicola, Rusconi, Franca, Terraciano, Luigi, Esposito, Susanna, Patria, Maria Francesca, Marseglia, Gian Luigi, Licari, Amelia, Boccaccino, Alfredo, Tenero, Laura, Pifferi, Massimo, Di Cicco, Maria Elisa, Franceschini, Fabrizio, Duse, Marzia, Indinnimeo, Luciana, Consilvio, Nicola Pietro, Brunetti, Luigia, Natale, Maria Pia, Cappiello, Annarita, Ferrante, Giuliana, Montella, S, Baraldi, E, Cazzato, S, Aralla, R, Berardi, M, Brunetti, L, Cardinale, F, Cutrera, R, Benedictis, F, Palmo, E, Pillo, S, Fenu, G, La Grutta, S, Lombardi, E, Piacentini, G, Santamaria, F, Ullmann, N, Rusconi, F, Montella, Silvia, Baraldi, Eugenio, Cazzato, Salvatore, Aralla, Raffaele, Berardi, Mariangela, Brunetti, Luigia Maria, Cardinale, Fabio, Cutrera, Renato, de Benedictis, Fernando Maria, di Palmo, Emanuela, Di Pillo, Sabrina, Fenu, Grazia, La Grutta, Stefania, Lombardi, Enrico, Piacentini, Giorgio, Santamaria, Francesca, Ullmann, Nicola, and Rusconi, Franca

Subjects
Quality of life, Male, Pediatrics, medicine.medical_specialty, Allergy, Adolescent, macromolecular substances, Severity of Illness Index, Atopy, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Severity of illness, medicine, Humans, Asthma, Children, Lung function, Pediatrics, Perinatology and Child Health, 030212 general & internal medicine, Child, Respiratory Function Test, business.industry, Research, Case-control study, Case-Control Studies, Female, Italy, Quality of Life, Respiratory Function Tests, Odds ratio, Perinatology and Child Health, medicine.disease, respiratory tract diseases, 030228 respiratory system, Exhaled nitric oxide, business, Case-Control Studie, Human
Abstract

Background Very few studies have explored the distinguishing features of severe asthma in childhood in Europe, and only one study was conducted in Southern Europe. The aim of this study was to provide a detailed characterization of children with severe asthma treated in specialized pediatric asthma centers across Italy. Methods We conducted a web-based data collection of family, environmental, clinical and laboratory characteristics of 41 patients aged 6–17 years with severe asthma, defined according to the recent guidelines of the European Respiratory Society and the American Thoracic Society, and 78 age-matched peers with non-severe persistent asthma. The patients have been enrolled from 16 hospital-based pediatric pulmonology and allergy centers in Northern, Central, and Southern Italy. Logistic regression analysis assessed the relationship between patients’ characteristics and severe asthma or non-severe persistent asthma. Results Features independently and significantly associated with severe asthma included lifetime sensitization to food allergens [Odds ratio (OR), 4.73; 95 % Confidence Interval (CI), 1.21–18.53; p = 0.03], lifetime hospitalization for asthma (OR, 3.71; 95 % CI, 1.11–12.33; p = 0.03), emergency-department visits for asthma during the past year (OR = 11.98; 95 % CI, 2.70–53.11; p = 0.001), and symptoms triggered by physical activity (OR = 12.78; 95 % CI, 2.66–61.40; p = 0.001). Quality-of-life score was worse in patients with severe asthma than in subjects with non-severe persistent asthma (5.9 versus 6.6, p = 0.005). Self-perception of wellbeing was compromised in more than 40 % of patients in both groups. Children with severe asthma had lower spirometric z scores than non-severe asthmatic peers (all p

Published
2016

34. Streptococcus pneumoniae colonisation in children and adolescents with asthma: impact of the heptavalent pneumococcal conjugate vaccine and evaluation of potential effect of thirteen-valent pneumococcal conjugate vaccine

Author

Esposito, Susanna, primary, Terranova, Leonardo, additional, Patria, Maria Francesca, additional, Marseglia, Gian Luigi, additional, Miraglia del Giudice, Michele, additional, Bodini, Alessandro, additional, Martelli, Alberto, additional, Baraldi, Eugenio, additional, Mazzina, Oscar, additional, Tagliabue, Claudia, additional, Licari, Amelia, additional, Ierardi, Valentina, additional, Lelii, Mara, additional, and Principi, Nicola, additional

Published
2015
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35. Impact of genetic polymorphisms on paediatric atopic dermatitis

Author

Esposito, Susanna, primary, Patria, Maria Francesca, additional, Spena, Silvia, additional, Codecà, Claudio, additional, Tagliabue, Claudia, additional, Zampiero, Alberto, additional, Lelii, Mara, additional, Montinaro, Valentina, additional, Pelucchi, Claudio, additional, and Principi, Nicola, additional

Published
2015
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43. Streptococcus pneumoniae colonisation in children and adolescents with asthma: impact of the heptavalent pneumococcal conjugate vaccine and evaluation of potential effect of thirteen-valent pneumococcal conjugate vaccine.

Author

Esposito, Susanna, Terranova, Leonardo, Patria, Maria Francesca, Marseglia, Gian Luigi, del Giudice, Michele Miraglia, Bodini, Alessandro, Martelli, Alberto, Baraldi, Eugenio, Mazzina, Oscar, Tagliabue, Claudia, Licari, Amelia, Ierardi, Valentina, Lelii, Mara, Principi, Nicola, and Miraglia Del Giudice, Michele

Subjects
STREPTOCOCCUS pneumoniae, ASTHMA in children, PNEUMOCOCCAL vaccines, RESPIRATORY diseases, CHRONIC diseases, LUNG diseases, BACTERIAL colonies, ASTHMA prevention, NASOPHARYNX microbiology, STREPTOCOCCAL disease prevention, ASTHMA, CLINICAL trials, COMPARATIVE studies, CLINICAL drug trials, RESEARCH methodology, MEDICAL cooperation, RESEARCH, STREPTOCOCCAL diseases, STREPTOCOCCUS, VACCINES, EVALUATION research, PHYSIOLOGY
Abstract

Background: The main aim of this study was to evaluate Streptococcus pneumoniae carriage in a group of school-aged children and adolescents with asthma because these results might indicate the theoretical risk of invasive pneumococcal disease (IPD) of such patients and the potential protective efficacy of the 13-valent pneumococcal conjugate vaccine (PCV13).Methods: Oropharyngeal samples were obtained from 423 children with documented asthma (300 males, 70.9%), and tested for the autolysin-A-encoding (lytA) and the wzg (cpsA) gene of S. pneumoniae by means of real-time polymerase chain reaction.Results: S. pneumoniae was identified in the swabs of 192 subjects (45.4%): 48.4% of whom were aged <10 years, 46.9% aged 10-14 years, and 4.7% aged ≥15 years (p < 0.001). Carriage was significantly less frequent among the children who had received recent antibiotic therapy (odds ratio [OR 0.41]; 95% confidence interval [95% CI] 0.22-0.76). Multivariate analyses showed no association between carriage and vaccination status, with ORs of 1.05 (95% CI 0.70-1.58) for carriers of any pneumococcal serotype, 1.08 (95% CI 0.72-1.62) for carriers of any of the serotypes included in 7-valent pneumococcal conjugate vaccine (PCV7), and 0.76 (95% CI 0.45-1.28) for carriers of any of the six additional serotypes of PCV13. Serotypes 19 F, 4 and 9 V were the most frequently identified serotypes in vaccinated subjects.Conclusions: These results showed that carriage of S. pneumoniae is relatively common in all school-aged children and adolescents with asthma, regardless of the severity of disease and the administration of PCV7 in the first years of life. This highlights the problem of the duration of the protection against colonisation provided by pneumococcal conjugate vaccine, and the importance of re-colonization by the same pneumococcal serotypes included in the previously used vaccine. [ABSTRACT FROM AUTHOR]

Published
2016
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45. Prevalence and Clinical Relevance of IgE Sensitization to Profilin in Childhood: A Multicenter Study.

Author

asero, Riccardo, Tripodi, Salvatore, Dondi, arianna, Di Rienzo Businco, andrea, Sfika, Ifigenia, Bianchi, annamaria, Candelotti, Paolo, Caffarelli, Carlo, Povesi Dascola, Carlotta, Ricci, Giampaolo, Calamelli, Elisabetta, Maiello, Nunzia, Miraglia del Giudice, Michele, Frediani, Tullio, Frediani, Simone, Macrì, Francesco, Moretti, Matteo, Dello Iacono, Iride, Patria, Maria Francesca, and Varin, Elena

Subjects
HAY fever in children, IMMUNOGLOBULIN E, PROFILIN, SENSITIZATION (Neuropsychology), POLLEN
Abstract

Background: Little is known about the prevalence and clinical relevance of hypersensitivity to the plant panallergen profilin in children. Objectives: The present study aimed to investigate prevalence, risk factors and clinical relevance of profilin sensitization in a large cohort of Italian children of different ages living in different geographic areas. Methods: Children with pollen allergy enrolled by 16 pediatric outpatient clinics sited in three main geographic areas of Italy were studied. SPT were carried out with commercial pollen extracts and a commercial purified date palm pollen profilin. IgE specific for allergenic pollen molecules, Phl p 12 (grass profilin) and Pru p 3 (peach lipid transfer protein) were tested by ImmunoCAP FEIA. Results: IgE to Phl p 12 (≥0.35 kU/l) was observed in 296 of the 1,271 participants (23%), including 17 of the 108 (16%) preschool children. Profilin SPT was positive (≥3 mm) in 320/1,271 (25%) participants. The two diagnostic methods were concordant in 1,151 (91%, p < 0.0001) cases. Phl p 12 IgE prevalence declined from northern to southern Italy and was directly associated with IgE to Phl p 1 and/or Phl p 5 and Ole e 1. Among children with IgE to Phl p 12, OAS was provoked by kiwi, melon, watermelon, banana, apricot and cucumber. Conclusions: Profilin sensitization is very frequent among pollen-allergic children, occurs at a very young age and contributes to the development of childhood OAS with a typical pattern of offending foods. Pediatricians should always consider IgE sensitization to profilin while examining pollen-allergic children, even if they are at preschool age. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2015
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48. Severe asthma (SA) compared to non severe persistent asthma (PA) in children: An Italian on-line database

Author

Monteila, Silvia, Baraldi, Eugenio, Cazzato, Salvatore, Araila, Raffaele, Berardi, Mariangela, Brunetti, Luigia Maria, Calogero, Claudia, Cappiello, Anna Rita, Cardinale, Fabio, Di Cicco, Maria Elisa, Di Paimo, Emanuela, Di Pillo, Sabrina, Duse, Marzia, Fenu, Grazia, Ferrante, Giuliana, Franceschini, Fabrizio, Amelia Licari, Marrazzo, Giuseppina, Natale, Maria Pia, Patria, Maria Francesca, Piacentini, Giorgio, Ragazzo, Vincenzo, Ullmann, Nicola, and Rusconi, Franca

Subjects
Asthma - Management, Epidemiology, Children, Epidemiology, Asthma - Management, Children

49. Prevalence and Clinical Relevance of IgE Sensitization to Profilin in Childhood: A Multicenter Study

Author

Dondi, A, Tripodi, S, Panetta, V, Asero, R, Businco, Ad, Bianchi, A, Carlucci, A, Ricci, G, Bellini, F, Maiello, N, del Giudice, Mm, Frediani, T, Sodano, S, Dello Iacono, I, Macrì, F, Massaccesi, V, Caffarelli, C, Rinaldi, L, Patria, Mf, Varin, E, Peroni, Diego, Chinellato, I, Chini, L, Moschese, V, Lucarelli, S, Bernardini, R, Pingitore, G, Pelosi, U, Tosca, M, Paravati, F, La Grutta, S, Meglio, P, Calvani, M, Plebani, M, Matricardi, Pm, Asero, Riccardo, Tripodi, Salvatore, Dondi, Arianna, Di Rienzo Businco, Andrea, Sfika, Ifigenia, Bianchi, Annamaria, Candelotti, Paolo, Caffarelli, Carlo, Povesi Dascola, Carlotta, Ricci, Giampaolo, Calamelli, Elisabetta, Maiello, Nunzia, MIRAGLIA DEL GIUDICE, Michele, Frediani, Tullio, Frediani, Simone, Macri, Francesco, Moretti, Matteo, Iacono, Iride Dello, Patria, Maria Francesca, Varin, Elena, Peroni, Diego, Comberiati, Pasquale, Chini, Loredana, Moschese, Viviana, Lucarelli, Sandra, Bernardini, Roberto, Pingitore, Giuseppe, Pelosi, Umberto, Tosca, Mariangela, Cirisano, Anastasia, Faggian, Diego, Plebani, Mario, Verga, Carmen, Matricardi, Paolo Maria, and Del Giudice, Michele Miraglia

Subjects
Male, Allergy, Profilin, Prevalence, Immunoglobulin E, Allergic rhinitis, Children, Component-resolved diagnosis, IgE, Oral allergy syndrome, Panallergens, Pollen, Allergens, Antigens, Plant, Carrier Proteins, Child, Cross Reactions, Cucumis sativus, Female, Fruit, Humans, Hypersensitivity, Italy, Poaceae, Profilins, Rhinitis, Allergic, Seasonal, Risk Factors, Skin Tests, Immunology and Allergy, Immunology, Medicine (all), Epidemiology, Outpatient clinic, Sensitization, Rhinitis, Skin Test, biology, Allergen, food and beverages, General Medicine, medicine.anatomical_structure, Cross Reaction, Human, medicine.medical_specialty, Allergic rhinitis, Children, Component-resolved diagnosis, IgE , Oral allergy syndrome, Panallergens, Pollen, Profilin, Socio-culturale, macromolecular substances, Component-resolved diagnosi, Allergic, Allergic rhiniti, medicine, Antigens, Settore MED/38 - Pediatria Generale e Specialistica, Seasonal, business.industry, Risk Factor, Plant, medicine.disease, Cucumis sativu, biology.protein, Panallergen, Carrier Protein, business
Abstract

Background: Little is known about the prevalence and clinical relevance of hypersensitivity to the plant panallergen profilin in children. Objectives: The present study aimed to investigate prevalence, risk factors and clinical relevance of profilin sensitization in a large cohort of Italian children of different ages living in different geographic areas. Methods: Children with pollen allergy enrolled by 16 pediatric outpatient clinics sited in three main geographic areas of Italy were studied. SPT were carried out with commercial pollen extracts and a commercial purified date palm pollen profilin. IgE specific for allergenic pollen molecules, Phl p 12 (grass profilin) and Pru p 3 (peach lipid transfer protein) were tested by ImmunoCAP FEIA. Results: IgE to Phl p 12 (≥0.35 kU/l) was observed in 296 of the 1,271 participants (23%), including 17 of the 108 (16%) preschool children. Profilin SPT was positive (≥3 mm) in 320/1,271 (25%) participants. The two diagnostic methods were concordant in 1,151 (91%, p < 0.0001) cases. Phl p 12 IgE prevalence declined from northern to southern Italy and was directly associated with IgE to Phl p 1 and/or Phl p 5 and Ole e 1. Among children with IgE to Phl p 12, OAS was provoked by kiwi, melon, watermelon, banana, apricot and cucumber. Conclusions: Profilin sensitization is very frequent among pollen-allergic children, occurs at a very young age and contributes to the development of childhood OAS with a typical pattern of offending foods. Pediatricians should always consider IgE sensitization to profilin while examining pollen-allergic children, even if they are at preschool age.

Published
2015
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50. Streptococcus pneumoniae colonisation in children and adolescents with asthma: Impact of the heptavalent pneumococcal conjugate vaccine and evaluation of potential effect of thirteen-valent pneumococcal conjugate vaccine

Author

Mara Lelii, Oscar Mazzina, Eugenio Baraldi, Gian Luigi Marseglia, Susanna Esposito, Arabella Martelli, Alessandro Bodini, Maria Francesca Patria, Valentina Ierardi, Michele Miraglia Del Giudice, Leonardo Terranova, Amelia Licari, Nicola Principi, Claudia Tagliabue, Esposito, Susanna, Terranova, Leonardo, Patria, Maria Francesca, Marseglia, Gian Luigi, MIRAGLIA DEL GIUDICE, Michele, Bodini, Alessandro, Martelli, Alberto, Baraldi, Eugenio, Mazzina, Oscar, Tagliabue, Claudia, Licari, Amelia, Ierardi, Valentina, Lelii, Mara, and Principi, Nicola

Subjects
0301 basic medicine, Male, Heptavalent Pneumococcal Conjugate Vaccine, PCV13, medicine.disease_cause, Pneumococcal conjugate vaccine, Asthma, Asthmatic children, Chronic respiratory disease, PCV7, Pneumococcal colonisation, Pulmonary disease, Streptococcus pneumoniae, Infectious Diseases, 0302 clinical medicine, Medical microbiology, vaccine, Nasopharynx, 030212 general & internal medicine, Child, Streptococcus, Pneumococcal infections, Child, Preschool, Female, Research Article, medicine.drug, Human, medicine.medical_specialty, Adolescent, Pneumococcal Infection, Pneumococcal Infections, 03 medical and health sciences, medicine, Humans, Vaccines, Conjugate, business.industry, medicine.disease, Streptococcus, asthma, vaccine, 030104 developmental biology, Carriage, Immunology, Drug Evaluation, business
Abstract

Background The main aim of this study was to evaluate Streptococcus pneumoniae carriage in a group of school-aged children and adolescents with asthma because these results might indicate the theoretical risk of invasive pneumococcal disease (IPD) of such patients and the potential protective efficacy of the 13-valent pneumococcal conjugate vaccine (PCV13). Methods Oropharyngeal samples were obtained from 423 children with documented asthma (300 males, 70.9 %), and tested for the autolysin-A-encoding (lytA) and the wzg (cpsA) gene of S. pneumoniae by means of real-time polymerase chain reaction. Results S. pneumoniae was identified in the swabs of 192 subjects (45.4 %): 48.4 % of whom were aged

Published
2016

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