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Aim/Background: Alcohol-induced liver necrosis requires effective treatment. This study tests Polyherbal Extract's hepatoprotective effects on alcohol-induced liver necrosis in rats. The extract's impact on inflammatory pathways, serum liver enzymes (AST, ALT and ALP), bilirubin and histopathological changes are examined to determine mechanisms. Materials and Methods: We tested Polyherbal Extract's hepatoprotective effect in rats with ethanol-induced liver injury, which mimics human liver necrosis. To assess liver health, multiple Polyherbal Extract dosage groups were carefully established. In conventional and untreated groups, liver damage progression was monitored. Polyherbal Extract's liver and immune effects were assessed by inflammatory pathways. Bilirubin, AST, ALT and ALP showed hepatoprotection. The entire histology showed liver architecture changes. This integrated experimental design examines Polyherbal Extract's potential hepatoprotective mechanisms in alcohol-induced liver necrosis using ethanol-induced liver damage, diverse treatment groups, phytochemical analysis, toxicity assessment and parameter measurements. Results: This study found Polyherbal Extract's hepatoprotective effects promising. Its therapeutic potential was confirmed by phytochemical analysis. The acute toxicity study confirmed the extract's safety at specified dosages, supporting its therapeutic use. In liver function, Polyherbal Extract was effective. Compared to toxins, treated groups had significantly lower AST, ALT and ALP levels. Bilirubin levels decreased dose-dependently, indicating the extract's liver health benefits. Histopathological findings were useful at higher extract doses. Hepatocellular necrosis and inflammatory cell infiltration decreased in treated groups, suggesting the extract may reduce liver tissue structural damage. Conclusion: The Polyherbal Extract demonstrated promising hepatoprotective effects against alcohol-induced liver necrosis in the rat model. The reduction in liver enzymes, bilirubin levels and histopathological improvements, along with its safety profile, suggest its potential as an effective hepatoprotective agent. Further investigations into its mechanisms and clinical applications are warranted. [ABSTRACT FROM AUTHOR]