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1. Mutant p53 gains oncogenic functions through a chromosomal instability-induced cytosolic DNA response

Author

Zhao, Mei, Wang, Tianxiao, Gleber-Netto, Frederico O., Chen, Zhen, McGrail, Daniel J., Gomez, Javier A., Ju, Wutong, Gadhikar, Mayur A., Ma, Wencai, Shen, Li, Wang, Qi, Tang, Ximing, Pathak, Sen, Raso, Maria Gabriela, Burks, Jared K., Lin, Shiaw-Yih, Wang, Jing, Multani, Asha S., Pickering, Curtis R., Chen, Junjie, Myers, Jeffrey N., and Zhou, Ge

Published
2024
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2. 3D genomics across the tree of life reveals condensin II as a determinant of architecture type

Author

Hoencamp, Claire, Dudchenko, Olga, Elbatsh, Ahmed MO, Brahmachari, Sumitabha, Raaijmakers, Jonne A, van Schaik, Tom, Sedeño Cacciatore, Ángela, Contessoto, Vinícius G, van Heesbeen, Roy GHP, van den Broek, Bram, Mhaskar, Aditya N, Teunissen, Hans, St Hilaire, Brian Glenn, Weisz, David, Omer, Arina D, Pham, Melanie, Colaric, Zane, Yang, Zhenzhen, Rao, Suhas SP, Mitra, Namita, Lui, Christopher, Yao, Weijie, Khan, Ruqayya, Moroz, Leonid L, Kohn, Andrea, St Leger, Judy, Mena, Alexandria, Holcroft, Karen, Gambetta, Maria Cristina, Lim, Fabian, Farley, Emma, Stein, Nils, Haddad, Alexander, Chauss, Daniel, Mutlu, Ayse Sena, Wang, Meng C, Young, Neil D, Hildebrandt, Evin, Cheng, Hans H, Knight, Christopher J, Burnham, Theresa LU, Hovel, Kevin A, Beel, Andrew J, Mattei, Pierre-Jean, Kornberg, Roger D, Warren, Wesley C, Cary, Gregory, Gómez-Skarmeta, José Luis, Hinman, Veronica, Lindblad-Toh, Kerstin, Di Palma, Federica, Maeshima, Kazuhiro, Multani, Asha S, Pathak, Sen, Nel-Themaat, Liesl, Behringer, Richard R, Kaur, Parwinder, Medema, René H, van Steensel, Bas, de Wit, Elzo, Onuchic, José N, Di Pierro, Michele, Lieberman Aiden, Erez, and Rowland, Benjamin D

Subjects
Human Genome, Genetics, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Adenosine Triphosphatases, Algorithms, Animals, Biological Evolution, Cell Nucleolus, Cell Nucleus, Centromere, Chromosomes, Chromosomes, Human, DNA-Binding Proteins, Eukaryota, Genome, Genome, Human, Genomics, Heterochromatin, Humans, Interphase, Mitosis, Models, Biological, Multiprotein Complexes, Telomere, General Science & Technology
Abstract

We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional (3D) genome architectures at the chromosome scale. Each type appears and disappears repeatedly during eukaryotic evolution. The type of genome architecture that an organism exhibits correlates with the absence of condensin II subunits. Moreover, condensin II depletion converts the architecture of the human genome to a state resembling that seen in organisms such as fungi or mosquitoes. In this state, centromeres cluster together at nucleoli, and heterochromatin domains merge. We propose a physical model in which lengthwise compaction of chromosomes by condensin II during mitosis determines chromosome-scale genome architecture, with effects that are retained during the subsequent interphase. This mechanism likely has been conserved since the last common ancestor of all eukaryotes.

Published
2021

4. Stakeholder-driven principles for advancing equity through shared measurement

Author

Hilliard-Boone, Tandrea, Firminger, Kirsten, Dutta, Tania, Cowans, Tamika, DePatie, Holly, Maurer, Maureen, Schultz, Ellen, Castro-Reyes, Paige, Richmond, Al, Muhammad, Michael, Pathak-Sen, Ela, and Powell, Wizdom

Subjects
Social service -- Evaluation, Public health administration -- Evaluation, Business, Health care industry
Abstract

Objective: To advance equity by developing stakeholder-driven principles of shared measurement, which is using a common set of measurable goals that reflect shared priorities across communities and systems, such as health care, public health, and human and social services. Data Sources: From October 2019 to July 2021, we collected primary data from leaders in cross-systems alignment, measurement, and community engagement-including community members and community-based organization leaders-across the United States. Study Design: In partnership with equity and community engagement experts, we conducted a mixed-methods study that included multiple formative research activities and culminated in a six-week, stakeholder-engaged modified-Delphi process. Data Collection: Formative data collection occurred through an environmental scan, interviews, focus groups, and an online survey. Principles were developed using a virtual modified Delphi with iterative rapid-analysis. Feedback on the final principles was collected through virtual focus groups, an online feedback form, and during virtual presentations. Principal Findings: We developed a set of five guiding principles. Measurement that aligns systems with communities toward equitable outcomes: (1) Requires upfront investment in communities; (2) Is co-created by communities; (3) Creates accountability to communities for addressing root causes of inequities and repairing harm; (4) Focuses on a holistic and comprehensive view of communities that highlights assets and historical context; and (5) Reflects long-term efforts to build trust. Using an equity-focused process resulted in principles with broad applicability. Conclusions: Leaders across systems and communities can use these shared measurement principles to reimagine and transform how systems create equitable health by centering the needs and priorities of the communities they serve, particularly communities that historically have been harmed the most by inequities. Intentionally centering equity across all project activities was essential to producing principles that could guide others in advancing equity. KEYWORDS community health, community participation, Delphi technique, health equity, intersectoral collaboration, measurement, social determinants of health What is known on this topic * Achieving health equity requires creating aligned systems that work together with communities to meet their goals and needs. * A shared measurement system is essential to align efforts around outcomes, evaluate collective progress, improve the quality and credibility of data, and reduce costs associated with collecting and reporting data. What this study adds * Building shared measurement into systems' structure enables sustained progress toward equitable outcomes through redistribution of power, building partnerships, creating accountability to communities, and facilitating co-learning. * Five guiding principles show how community members, community-based organizations, system leaders, service providers, and policy makers can use shared measurement to align decisions, policies, and practices toward equitable health and well-being. * We found that how we approached the work--with the intention of centering equity across all project activities--was essential to producing principles that could themselves guide others in advancing equity., 1 | INTRODUCTION Achieving lasting and meaningful improvements in individual and population health requires aligning efforts across various systems--organizations, programs, and activities--within communities that directly influence the health and well-being [...]

Published
2022
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10. Stakeholder‐driven principles for advancing equity through shared measurement

Author

Tandrea Hilliard‐Boone, Kirsten Firminger, Tania Dutta, Tamika Cowans, Holly DePatie, Maureen Maurer, Ellen Schultz, Paige Castro‐Reyes, Al Richmond, Michael Muhammad, Ela Pathak‐Sen, and Wizdom Powell

Subjects
Health Policy, Humans, Public Health, United States
Abstract

To advance equity by developing stakeholder-driven principles of shared measurement, which is using a common set of measurable goals that reflect shared priorities across communities and systems, such as health care, public health, and human and social services.From October 2019 to July 2021, we collected primary data from leaders in cross-systems alignment, measurement, and community engagement-including community members and community-based organization leaders-across the United States.In partnership with equity and community engagement experts, we conducted a mixed-methods study that included multiple formative research activities and culminated in a six-week, stakeholder-engaged modified-Delphi process.Formative data collection occurred through an environmental scan, interviews, focus groups, and an online survey. Principles were developed using a virtual modified Delphi with iterative rapid-analysis. Feedback on the final principles was collected through virtual focus groups, an online feedback form, and during virtual presentations.We developed a set of five guiding principles. Measurement that aligns systems with communities toward equitable outcomes: (1) Requires upfront investment in communities; (2) Is co-created by communities; (3) Creates accountability to communities for addressing root causes of inequities and repairing harm; (4) Focuses on a holistic and comprehensive view of communities that highlights assets and historical context; and (5) Reflects long-term efforts to build trust. Using an equity-focused process resulted in principles with broad applicability.Leaders across systems and communities can use these shared measurement principles to reimagine and transform how systems create equitable health by centering the needs and priorities of the communities they serve, particularly communities that historically have been harmed the most by inequities. Intentionally centering equity across all project activities was essential to producing principles that could guide others in advancing equity.

Published
2022

11. Abstract 2585: Mutant p53 gains oncogenic functions through a cytosolic DNA response

Author

Zhao, Mei, primary, Wang, Tianxiao, additional, Gleber-Netto, Frederico O., additional, Chen, Zhen, additional, McGrail, Daniel J., additional, Gomez, Javier A., additional, Ju, Wutong, additional, Gadhikar, Mayur A., additional, Ma, Wencai, additional, Shen, Li, additional, Tang, Ximing, additional, Pathak, Sen, additional, Raso, Maria G., additional, Burks, Jared, additional, Lin, Shiaw-Yih, additional, Wang, Jing, additional, Multani, Asha S., additional, Pickering, Curtis R., additional, Chen, Junjie, additional, Myers, Jeffrey N., additional, and Zhou, Ge, additional

Published
2023
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12. Supplementary Figure Legends from Genomic Heterogeneity of Translocation Renal Cell Carcinoma

Author

Malouf, Gabriel G., primary, Monzon, Federico A., primary, Couturier, Jérôme, primary, Molinié, Vincent, primary, Escudier, Bernard, primary, Camparo, Philippe, primary, Su, Xiaoping, primary, Yao, Hui, primary, Tamboli, Pheroze, primary, Lopez-Terrada, Dolores, primary, Picken, Maria, primary, Garcia, Marileila, primary, Multani, Asha S., primary, Pathak, Sen, primary, Wood, Christopher G., primary, and Tannir, Nizar M., primary

Published
2023
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13. Supplementary Figure 1 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma

Author

Malouf, Gabriel G., primary, Monzon, Federico A., primary, Couturier, Jérôme, primary, Molinié, Vincent, primary, Escudier, Bernard, primary, Camparo, Philippe, primary, Su, Xiaoping, primary, Yao, Hui, primary, Tamboli, Pheroze, primary, Lopez-Terrada, Dolores, primary, Picken, Maria, primary, Garcia, Marileila, primary, Multani, Asha S., primary, Pathak, Sen, primary, Wood, Christopher G., primary, and Tannir, Nizar M., primary

Published
2023
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14. Supplementary Figure 2 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma

Author

Malouf, Gabriel G., primary, Monzon, Federico A., primary, Couturier, Jérôme, primary, Molinié, Vincent, primary, Escudier, Bernard, primary, Camparo, Philippe, primary, Su, Xiaoping, primary, Yao, Hui, primary, Tamboli, Pheroze, primary, Lopez-Terrada, Dolores, primary, Picken, Maria, primary, Garcia, Marileila, primary, Multani, Asha S., primary, Pathak, Sen, primary, Wood, Christopher G., primary, and Tannir, Nizar M., primary

Published
2023
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15. Supplementary Tables 1 - 3 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma

Author

Malouf, Gabriel G., primary, Monzon, Federico A., primary, Couturier, Jérôme, primary, Molinié, Vincent, primary, Escudier, Bernard, primary, Camparo, Philippe, primary, Su, Xiaoping, primary, Yao, Hui, primary, Tamboli, Pheroze, primary, Lopez-Terrada, Dolores, primary, Picken, Maria, primary, Garcia, Marileila, primary, Multani, Asha S., primary, Pathak, Sen, primary, Wood, Christopher G., primary, and Tannir, Nizar M., primary

Published
2023
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16. Supplementary Figure 3 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma

Author

Malouf, Gabriel G., primary, Monzon, Federico A., primary, Couturier, Jérôme, primary, Molinié, Vincent, primary, Escudier, Bernard, primary, Camparo, Philippe, primary, Su, Xiaoping, primary, Yao, Hui, primary, Tamboli, Pheroze, primary, Lopez-Terrada, Dolores, primary, Picken, Maria, primary, Garcia, Marileila, primary, Multani, Asha S., primary, Pathak, Sen, primary, Wood, Christopher G., primary, and Tannir, Nizar M., primary

Published
2023
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17. Data from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis

Author

Sung, Shian-Ying, primary, Hsieh, Chia-Ling, primary, Law, Andrew, primary, Zhau, Haiyen E., primary, Pathak, Sen, primary, Multani, Asha S., primary, Lim, Sharon, primary, Coleman, Ilsa M., primary, Wu, Li-Chin, primary, Figg, William D., primary, Dahut, William L., primary, Nelson, Peter, primary, Lee, Jae K., primary, Amin, Mahul B., primary, Lyles, Robert, primary, Johnstone, Peter A.J., primary, Marshall, Fray F., primary, and Chung, Leland W.K., primary

Published
2023
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19. Supplementary Legends 1-9 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis

Author

Sung, Shian-Ying, primary, Hsieh, Chia-Ling, primary, Law, Andrew, primary, Zhau, Haiyen E., primary, Pathak, Sen, primary, Multani, Asha S., primary, Lim, Sharon, primary, Coleman, Ilsa M., primary, Wu, Li-Chin, primary, Figg, William D., primary, Dahut, William L., primary, Nelson, Peter, primary, Lee, Jae K., primary, Amin, Mahul B., primary, Lyles, Robert, primary, Johnstone, Peter A.J., primary, Marshall, Fray F., primary, and Chung, Leland W.K., primary

Published
2023
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20. Supplementary Data 6-9 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis

Author

Sung, Shian-Ying, primary, Hsieh, Chia-Ling, primary, Law, Andrew, primary, Zhau, Haiyen E., primary, Pathak, Sen, primary, Multani, Asha S., primary, Lim, Sharon, primary, Coleman, Ilsa M., primary, Wu, Li-Chin, primary, Figg, William D., primary, Dahut, William L., primary, Nelson, Peter, primary, Lee, Jae K., primary, Amin, Mahul B., primary, Lyles, Robert, primary, Johnstone, Peter A.J., primary, Marshall, Fray F., primary, and Chung, Leland W.K., primary

Published
2023
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21. Supplementary Data 1-5 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis

Author

Sung, Shian-Ying, primary, Hsieh, Chia-Ling, primary, Law, Andrew, primary, Zhau, Haiyen E., primary, Pathak, Sen, primary, Multani, Asha S., primary, Lim, Sharon, primary, Coleman, Ilsa M., primary, Wu, Li-Chin, primary, Figg, William D., primary, Dahut, William L., primary, Nelson, Peter, primary, Lee, Jae K., primary, Amin, Mahul B., primary, Lyles, Robert, primary, Johnstone, Peter A.J., primary, Marshall, Fray F., primary, and Chung, Leland W.K., primary

Published
2023
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25. Effectiveness of public deliberation methods for gathering input on issues in healthcare: Results from a randomized trial

Author

Carman, Kristin L., Mallery, Coretta, Maurer, Maureen, Wang, Grace, Garfinkel, Steve, Yang, Manshu, Gilmore, Dierdre, Windham, Amy, Ginsburg, Marjorie, Sofaer, Shoshanna, Gold, Marthe, Pathak-Sen, Ela, Davies, Todd, Siegel, Joanna, Mangrum, Rikki, Fernandez, Jessica, Richmond, Jennifer, Fishkin, James, and Siu Chao, Alice

Published
2015
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39. 3D genomics across the tree of life reveals condensin II as a determinant of architecture type

Author

European Commission, Dutch Research Council, Dutch Cancer Society, Welch Foundation, Sao Paulo Research Foundation, Cancer Research UK, University of Western Australia, National Institutes of Health (US), Illumina, European Research Council, Ministerio de Economía y Competitividad (España), Hoencamp, Claire, Dudchenko, Olga, Elbatsh, Ahmed M. O., Schaik, Tom van, Sedeño Cacciatore, Ángela, Contessoto, Vinícius G., Van Heesbeen, Roy G. H. P, Van den Broek, Bram, Mhaskar, Aditya N., Teunissen, Hans, Glenn St Hilaire, Brian, Weisz, David, Omer, Arina D., Pham, Melanie, Colaric, Zane, Yang, Zhenzhen, Rao, Suhas S. P., Mitra, Namita, Lui, Christopher, Yao, Weijie, Khan, Ruqayya, Moroz, Leonid L., Kohn, Andrea, Leger, Judy St., Mena, Alexandria, Holcroft, Karen, Gambetta, Maria Cristina, Lim, Fabian, Farley, Emma, Stein, Nils, Haddad, Alexander, Chauss, Daniel, Sena Mutlu, Ayse, Wang, Meng C., Young, Neil D., Hildebrandt, Evin, Chen, Hans H., Knight, Christopher J., Burnham, Theresa L. U., Hovel, Kevin A., Beel, Andrew J., Mattei, Pierre-Jean, Kornberg, Roger D., Warren, Wesley C., Cary, Gregory, Gómez-Skarmeta, José Luis, Hinman, Verónica, Lindblad-Toh, Kerstin, Palma, Federica Di, Maeshima, Kazuhiro, Multani, Asha S., Pathak, Sen, Nel-Themaat, Liesl, Behringer, Richard R., Kaur, Parwinder, Medem, René H., Steensel, Bas van, Wit, Elzo de, Onuchic, José N., Pierro, Michele Di, Lieberman Aiden, Erez, Rowland, Benjamin D., European Commission, Dutch Research Council, Dutch Cancer Society, Welch Foundation, Sao Paulo Research Foundation, Cancer Research UK, University of Western Australia, National Institutes of Health (US), Illumina, European Research Council, Ministerio de Economía y Competitividad (España), Hoencamp, Claire, Dudchenko, Olga, Elbatsh, Ahmed M. O., Schaik, Tom van, Sedeño Cacciatore, Ángela, Contessoto, Vinícius G., Van Heesbeen, Roy G. H. P, Van den Broek, Bram, Mhaskar, Aditya N., Teunissen, Hans, Glenn St Hilaire, Brian, Weisz, David, Omer, Arina D., Pham, Melanie, Colaric, Zane, Yang, Zhenzhen, Rao, Suhas S. P., Mitra, Namita, Lui, Christopher, Yao, Weijie, Khan, Ruqayya, Moroz, Leonid L., Kohn, Andrea, Leger, Judy St., Mena, Alexandria, Holcroft, Karen, Gambetta, Maria Cristina, Lim, Fabian, Farley, Emma, Stein, Nils, Haddad, Alexander, Chauss, Daniel, Sena Mutlu, Ayse, Wang, Meng C., Young, Neil D., Hildebrandt, Evin, Chen, Hans H., Knight, Christopher J., Burnham, Theresa L. U., Hovel, Kevin A., Beel, Andrew J., Mattei, Pierre-Jean, Kornberg, Roger D., Warren, Wesley C., Cary, Gregory, Gómez-Skarmeta, José Luis, Hinman, Verónica, Lindblad-Toh, Kerstin, Palma, Federica Di, Maeshima, Kazuhiro, Multani, Asha S., Pathak, Sen, Nel-Themaat, Liesl, Behringer, Richard R., Kaur, Parwinder, Medem, René H., Steensel, Bas van, Wit, Elzo de, Onuchic, José N., Pierro, Michele Di, Lieberman Aiden, Erez, and Rowland, Benjamin D.

Abstract

We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional(3D) genome architectures at the chromosome scale. Each type appears and disappears repeatedlyduring eukaryotic evolution. The type of genome architecture that an organism exhibits correlates with theabsence of condensin II subunits. Moreover, condensin II depletion converts the architecture of thehuman genome to a state resembling that seen in organisms such as fungi or mosquitoes. In this state,centromeres cluster together at nucleoli, and heterochromatin domains merge. We propose a physicalmodel in which lengthwise compaction of chromosomes by condensin II during mitosis determineschromosome-scale genome architecture, with effects that are retained during the subsequent interphase.This mechanism likely has been conserved since the last common ancestor of all eukaryotes.

Published
2021

44. Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

Author

Laud, Purnima R., Multani, Asha S., Bailey, Susan M., Ling Wu, Jin Ma, Kingsley, Charles, Lebel, Michel, Pathak, Sen, De Pinho, Ronald A., and Chang, Sandy

Subjects
Telomeres -- Research, Cell death -- Research, Cancer -- Genetic aspects, Cancer -- Research, Biological sciences
Abstract

Genetically defined mouse cells are utilized to understand the impact of WRN helicase deficiency on telomere maintenance, chromosomal stability, cellular mortality and tumorigenesis. It is indicated that the increased incidence of chromosomal instability and cancer in Werner Syndrome is found due to aberrant recombinations between sister chromatids specifically at telomeres, which promote the activation of the alternative lengthening of telomere (ALT) pathway and lead to chromosomal instability during tumorigenesis.

Published
2005

48. Public Mistrust of the U.S. Health Care System’s Profit Motives: Mixed-Methods Results from a Randomized Controlled Trial

Author

Marthe R. Gold, Kristin L. Carman, Wizdom Powell, Manshu Yang, Jennifer Richmond, Rikki Mangrum, Maureen Maurer, and Ela Pathak-Sen

Subjects
Male, Comparative Effectiveness Research, media_common.quotation_subject, Clinical Decision-Making, Decision Making, Profit (economics), law.invention, 03 medical and health sciences, 0302 clinical medicine, Nursing, Randomized controlled trial, law, Perception, Health care, Internal Medicine, Humans, Medicine, 030212 general & internal medicine, health care economics and organizations, Aged, media_common, Motivation, business.industry, Health Policy, 030503 health policy & services, Community Participation, Health services research, Health Care Costs, Middle Aged, Deliberation, United States, Socioeconomic Factors, Public Opinion, Public trust, Female, Health Services Research, 0305 other medical science, business, Attitude to Health, Delivery of Health Care, Autonomy
Abstract

Decision makers are increasingly tasked with reducing health care costs, but the public may be mistrustful of these efforts. Public deliberation helps gather input on these types of issues by convening a group of diverse individuals to learn about and discuss values-based dilemmas. To explore public perceptions of health care costs and how they intersect with medical mistrust. This mixed-methods study analyzed data from a randomized controlled trial including four public deliberation groups (n = 96) and a control group (n = 348) comprising English-speaking adults aged 18 years and older. Data were collected in 2012 in four U.S. regions. We used data from four survey items to compare attitude shifts about costs among participants in deliberation groups to participants in the control group. We qualitatively analyzed deliberation transcripts to identify themes related to attitude shifts and to provide context for quantitative results about attitude shifts. Deliberation participants were significantly more likely than control group participants to agree that doctors and patients should consider cost when making treatment decisions (β = 0.59; p

Published
2017

49. Setting Boundaries: Public Views on Limiting Patient and Physician Autonomy in Health Care Decisions

Author

Kristin L. Carman, Joanna E. Siegel, Marthe R. Gold, Marjorie Ginsburg, Shoshanna Sofaer, Maureen Maurer, Ela Pathak-Sen, Rikki Mangrum, and Jennifer Richmond

Subjects
Social Values, media_common.quotation_subject, Decision Making, 03 medical and health sciences, 0302 clinical medicine, Nursing, Social Justice, Physicians, Health care, Humans, Medicine, Moral responsibility, 030212 general & internal medicine, media_common, Physician-Patient Relations, business.industry, 030503 health policy & services, Health Policy, Community Participation, Public relations, Deliberation, Transparency (behavior), Harm, Public Opinion, Public participation, Personal Autonomy, Accountability, 0305 other medical science, business, Delivery of Health Care, Autonomy
Abstract

We obtained and qualitatively analyzed input from more than nine hundred citizens during seventy-six public deliberation sessions about patient and physician autonomy in decision making, setting health care boundaries, and the tensions among competing social values. Generally, participants resisted interference with the patient-physician relationship and believed strongly in the freedom of patient and physician to control individual medical decisions. However, during deliberation participants identified two situations where boundaries and regulations in health care were more acceptable: protecting people from harm and allocating limited resources. The core value of individual freedom was tempered in varying degrees by the values of concern for the greater good and fairness in allocating resources. Where tensions between values emerged, participants used different concepts-including accountability, transparency, trust, personal responsibility, and moral obligation-to navigate trade-offs. Fairly balancing the public's desire to protect individual freedom with their sense of responsibility for protecting the common good may be the key to developing acceptable, workable policies that promote evidence-based medical practice.

Published
2017

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