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11. Assessment of Single‐Dose Pharmacokinetics of Oxolinic Acid in Rainbow Trout and Determination of In Vitro Antibacterial Activity Against Pathogenic Bacteria From Diseased Fish.

Author

Pathak, Richa, Mallik, Sumanta Kumar, Patil, Prasanna Kumar, Shahi, Neetu, Kala, Krishna, Bhat, Raja Adil Hussain, Nadella, Ranjit Kumar, Pandey, Nityanand, and Pandey, Pramod Kumar

Subjects
*FISH farming, *RAINBOW trout, *PATHOGENIC bacteria, *DRUG efficacy, *BACTERIAL diseases
Abstract

ABSTRACT In response to the heightened risk of bacterial diseases in fish farms caused by increased demand for fish consumption and subsequent overcrowding, researchers are currently investigating the efficacy and residue management of oxolinic acid (OA) as a treatment for bacterial infections in fish. This research is crucial for gaining a comprehensive understanding of the pharmacokinetics of OA. The present study investigates pharmacokinetics of OA in juvenile rainbow trout. The fish were given a 12 mg kg−1 dose of OA through their feed, and tissue samples were collected of the liver, kidney, gill, intestine, muscle, and plasma for analysis using LC‐MS/MS. The highest concentrations of the drug were found in the gill (4096.55 μg kg−1) and intestine (11592.98 μg kg−1), with significant absorption also seen in the liver (0.36 L/h) and gill (0.07 L/h) (p < 0.05). The liver (0.21 L/h) and kidney (0.03 L/h) were found to be the most efficient (p < 0.05) at eliminating the drug. The study also confirmed the drug antimicrobial effectiveness against several bacterial pathogens, including Shewanella xiamenensis (0.25 μg mL−1), Lactococcus garvieae (1 μg mL−1), and Chryseobacterium aquaticum (4 μg mL−1). The study concludes significant variations among different fish tissues, with higher concentrations and longer half‐lives observed in the kidney and intestine. The lowest MIC value recorded against major bacterial pathogens demonstrated its therapeutic potential in aquaculture. It also emphasizes the importance of understanding OA pharmacokinetics to optimize antimicrobial therapy in aquaculture. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Biosafety, histological alterations and residue depletion of feed administered anti-parasitic drug emamectin benzoate in golden mahseer, Tor putitora (Hamilton, 1822) as a model candidate fish for sport fishery and conservation in temperate waters

Author

Mallik, Sumanta Kumar, primary, Singh, Shivam, additional, Shahi, Neetu, additional, Patil, Prasanna Kumar, additional, Kala, Krishna, additional, Pathak, Richa, additional, Giri, Abhay Kumar, additional, Das, Partha, additional, Tandel, Ritesh Shantilal, additional, Chandra, Suresh, additional, Krishna, Nanitha, additional, Ravindran, Rajisha, additional, and Pandey, Pramod Kumar, additional

Published
2023
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16. Pharmacokinetics and biosafety evaluation of a veterinary drug florfenicol in rainbow trout, Oncorhynchus mykiss (Walbaum 1792) as a model cultivable fish species in temperate water

Author

Mallik, Sumanta Kumar, primary, Shahi, Neetu, additional, Pathak, Richa, additional, Kala, Krishna, additional, Patil, Prasanna Kumar, additional, Singh, Bhupendra, additional, Ravindran, Rajisha, additional, Krishna, Nanitha, additional, and Pandey, Pramod Kumar, additional

Published
2023
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24. AMR in aquaculture

Author

Sumanta Kumar Mallik, Gupta, Manisha, Gunja, Shahi, Neetu, Pathak, Richa, Partha Das, and Saxena, Amit

Published
2021
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30. Contributors

Author

Aggarwal, Divya, Arunachalam, Nisha, Ashok, Asha, Bagchi, Sudeshna, Banerjee, Subhadeep, Barbhuiya, Rahul Islam, Barve, Swapnil, Bhardwaj, Ambika, Bhattacharya, Bhaswati, Bhattacharyya, Shalini, Bhondekar, Amol P., Bishnoi, Priya, Bodana, Vikrant, Chatterjee, Pratik, Cherwoo, Lubhan, Chhikara, Navnidhi, Chidambaram, Ramalingam, Chinchkar, Ajay V., Chowdary, Madineni Yogitha, Das, Joydeep, Dash, Kshirod Kumar, Deep, Akash, Devraj, Lavanya, Dhiman, Aishwarya, Dhivahar Sahaya Antony John, Amal, Dubey, Rashmi, Ghosh, Payel, Girthie John Britto, Claudia, Gopalakrishnan, Krishna, Gupta, Anjali, Huang, Shuting, Idrishi, Rubeka, J, Nagarajan, Jayakumar, Archanna, Jeelani, Peerzada Gh., Jinachandran, Arunima, Joshi T., Jayasree, Kamble, Meenatai G., Kanagarajan, Selvaraju, Kannan, Vishal Amith, Karuppiah, Vijay, Kaur, Gurjeet, Kehinde, Bababode Adesegun, Krishnamoorthy, Chandan, Kuldeep, Kumar, Saurav, Kumar, Ritesh, Kumar, Lokesh, Kumar, Sanjusree, Meghwal, Murlidhar, Mishra, Shivangi, Mishra, Shruti, Mossa, Abdel-Tawab, Mukherjee, Anwesha, Murugan, Shibasini, Muthukumar, Janani, Nain, Anurag, Nandi, Nishithendu Bikash, Nath, Pinku Chandra, Panda, Sangita, Panghal, Anil, Panneerselvam, Rajapandiyan, Panneerselvam, Sivasakthivelan, Panoth, Abhirami, Pathak, Richa, Paul, Utpalendu, Perumal, Suparna, Prabhakar, Pramod K., Puri, Nishtha, Rasbhara, Chiragkumar, Roy, Biplab, Sarkar, Parthendu, Selvasekaran, Pavidharshini, Sharma, Saloni, Sharma, Anupma, Sharma, Arun, Shukla, Geetanjali, Singh, Anurag, Singh, Rakhi, Singh, Nishant Veer Vikram, Suhag, Rajat, Thangavel, Kavitha, Thombare, Nandkishore, Tiwari, Ajita, Tripathy, Divya Bajpai, Tyagi, Varee, V., Harsha, V.C., Anitha Krishnan, Venkatesan, Surya Arcot, Vijayakumar, Gayathri, Wang, Yixiang, and Zheng, Haotian

Published
2023
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46. Virulence Potential, Biofilm Formation, and Antibiotic Susceptibility of Listeria monocytogenesIsolated from Cattle Housed in a Particular Gaushala (Cattle Shelter) and Organized Farm

Author

Ramanjeneya, Sunitha, Sahoo, Sudam Chandra, Pathak, Richa, Kumar, Manesh, Vergis, Jess, Malik, Satya Veer Singh, Barbuddhe, Sukhadeo B., and Rawool, Deepak B.

Abstract

AbstractObjectives:The occurrence of Listeria monocytogeneswas studied by using cultural and serological methods in cattle housed in a particular gaushala (cattle shelter) and organized dairy farm.Materials and Methods:A total of 1201 samples from cattle comprising blood (n= 207), milk (n= 203), vaginal swabs (n= 210), and serum (n= 207) from an organized farm (n= 210) and blood (n= 100), milk (n= 74), vaginal swabs (n= 100), and serum (n= 100) from a gaushala (n= 100) were collected and analyzed for L. monocytogenes.All samples excluding serum were analyzed for isolation and identification of L. monocytogenes, while the serum samples were screened for seropositivity. The isolates were further subjected to assess their virulence potential (in vitroand in vivo), biofilm formation ability, and antibiotic susceptibility patterns.Results:Four L. monocytogenesstrains were isolated from the cattle; three (0.48%) from the organized farm and one (0.36%) from the gaushala. On serological screening of cattle from the organized dairy farm, 16.42% were found to be positive for antibodies against listeriolysin O, while cattle from the gaushala revealed 36% seropositivity. Furthermore, on characterization of the isolates for their pathogenic potential and biofilm-forming ability, all were found to be pathogenic by both in vitroand in vivoassays and were weak to moderate biofilm formers. The minimum inhibition concentration (MIC) of recovered isolates revealed resistance for ampicillin by two L. monocytogenesisolates (MIC >256 μg/mL), whereas three L. monocytogenesisolates were intermediately resistant (MIC >4 μg/mL) and one resistant against amoxicillin (MIC >8 μg/mL). However, all four isolates were susceptible to gentamicin, cotrimoxazole, and erythromycin.Conclusions:Isolation of virulent and antibiotic-resistant strains of L. monocytogeneswarrants the need for epidemiological surveillance, antimicrobial susceptibility, and implementation of control measures to combat the occurrence of L. monocytogenesinfection in animals as well as humans.

Published
2019
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