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44 results on '"Patel, H.R."'

16. Salvage Treatments for the Local Recurrence of Prostate Cancer After Radiotherapy – Results of an International Multidisciplinary Survey

Author

Chirila, M.E., primary, Brausi, M., additional, Chatterjee, P., additional, Gordon, K., additional, Kacso, G., additional, Kettache, R.H., additional, Li, B., additional, Ma, W.K., additional, Martinez, D.A., additional, Mazibuko, T., additional, Murgic, J., additional, Patel, H.R., additional, de Reijke, T.M., additional, Riedl, C., additional, Turner, S., additional, Zilli, T., additional, Poortmans, P., additional, and Roach, M., additional

Published
2021
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17. Equitable expanded carrier screening needs Indigenous clinical and population genomic data

Author

Easteal, S., Arkell, R.M., Balboa, R.F., Bellingham, S.A., Brown, A.D., Calma, T., Cook, M.C., Davis, M., Dawkins, H.J.S., Dinger, M.E., Dobbie, M.S., Farlow, A., Gwynne, K.G., Hermes, A., Hoy, W.E., Jenkins, M.R., Jiang, S.H., Kaplan, W., Leslie, S., Llamas, B., Mann, G.J., McMorran, B.J., McWhirter, R.E., Meldrum, C.J., Nagaraj, S.H., Newman, S.J., Nunn, J.S., Ormond-Parker, L., Orr, N.J., Paliwal, D., Patel, H.R., Pearson, G., Pratt, G.R., Rambaldini, B., Russell, L.W., Savarirayan, R., Silcocks, M., Skinner, J.C., Souilmi, Y., Vinuesa, C.G., Baynam, G., Easteal, S., Arkell, R.M., Balboa, R.F., Bellingham, S.A., Brown, A.D., Calma, T., Cook, M.C., Davis, M., Dawkins, H.J.S., Dinger, M.E., Dobbie, M.S., Farlow, A., Gwynne, K.G., Hermes, A., Hoy, W.E., Jenkins, M.R., Jiang, S.H., Kaplan, W., Leslie, S., Llamas, B., Mann, G.J., McMorran, B.J., McWhirter, R.E., Meldrum, C.J., Nagaraj, S.H., Newman, S.J., Nunn, J.S., Ormond-Parker, L., Orr, N.J., Paliwal, D., Patel, H.R., Pearson, G., Pratt, G.R., Rambaldini, B., Russell, L.W., Savarirayan, R., Silcocks, M., Skinner, J.C., Souilmi, Y., Vinuesa, C.G., and Baynam, G.

Abstract

Expanded carrier screening (ECS) for recessive monogenic diseases requires prior knowledge of genomic variation, including DNA variants that cause disease. The composition of pathogenic variants differs greatly among human populations, but historically, research about monogenic diseases has focused mainly on people with European ancestry. By comparison, less is known about pathogenic DNA variants in people from other parts of the world. Consequently, inclusion of currently underrepresented Indigenous and other minority population groups in genomic research is essential to enable equitable outcomes in ECS and other areas of genomic medicine. Here, we discuss this issue in relation to the implementation of ECS in Australia, which is currently being evaluated as part of the national Government’s Genomics Health Futures Mission. We argue that significant effort is required to build an evidence base and genomic reference data so that ECS can bring significant clinical benefit for many Aboriginal and/or Torres Strait Islander Australians. These efforts are essential steps to achieving the Australian Government’s objectives and its commitment “to leveraging the benefits of genomics in the health system for all Australians.” They require culturally safe, community-led research and community involvement embedded within national health and medical genomics programs to ensure that new knowledge is integrated into medicine and health services in ways that address the specific and articulated cultural and health needs of Indigenous people. Until this occurs, people who do not have European ancestry are at risk of being, in relative terms, further disadvantaged.

Published
2020

22. Role of miRNAs and alternative mRNA 3′-end cleavage and polyadenylation of their mRNA targets in cardiomyocyte hypertrophy

Author

Soetanto, R., primary, Hynes, C.J., additional, Patel, H.R., additional, Humphreys, D.T., additional, Evers, M., additional, Duan, G., additional, Parker, B.J., additional, Archer, S.K., additional, Clancy, J.L., additional, Graham, R.M., additional, Beilharz, T.H., additional, Smith, N.J., additional, and Preiss, T., additional

Published
2016
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23. Nonmyeloablative Allogeneic Stem-Cell Transplantation for Metastatic Renal Cell Cancer: A Review and Update

Author

Erotocritou, P., Ahmed, H., Patel, S.S., Shergill, I., Patel, H.R., Shah, P.M., and Arya, M.

Subjects
Article Subject
Abstract

Metastatic renal cell carcinoma (RCC) is resistant to conventional chemotherapy and radiotherapy. However, immunotherapy appears to be effective in 15—20% of cases, with interleukin-2 becoming the standard therapy for this disease. As a consequence of the immune susceptibility of RCC, other avenues of immunotherapy are being explored, such as nonmyeloablative allogeneic stem cell transplantation (NST). A number of trials have shown NST to be effective in varying degrees, causing partial or complete regression. Although nonmyeloablative conditioning is safer than myeloablative conditioning, its role has yet to be clearly proven as many studies have shown variable effect. Alongside this limitation, transplant-related toxicity also forms obstacles. Regardless of the limitation of NST, further refinement of the technique, with appropriate patient selection, may lead to this being an effective therapeutic choice for a significant number of individuals.

Published
2006
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35. Evaluation of Steady Flow Through a Six-Lobe Sand Cartridge Filter by the Boudnary Perturbation Method.

Author

Patel, H.R., Hariharan, S.I., and Chase, G.G.

Subjects
FILTERS & filtration, SAND, FLUID mechanics, WATER, PERTURBATION theory
Abstract

Deals with a study which determined the steady-state pressure profile for radial flow of water through sand cartridge filters used in the oil industry. Boundary perturbation method for the pressure profile of consolidated sand filter; Use of the Darcy's law in describing the pressure-velocity relationship; Solution for the six-lobed geometry.

Published
2002
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37. GUT-HORMONE PROFILE IN CŒLIAC DISEASE

Author

Besterman, H.S., Bloom, S.R., Sarson, D.L., Blackburn, A.M., Johnston, D.I., Patel, H.R., Stewart, J.S., Modigliani, R., Guerin, S., and Mallinson, C.N.

Abstract

Patients with cœliac disease have a highly significant reduction in the release of secretin and gastric inhibitory polypeptide from the upper small intestine, but a greatly increased release of enteroglucagon, and also of neurotensin, from the lower part of the small intestine. The release of gastrin and pancreatic polypeptide, from the antrum and pancreas respectively, is, however, normal. Thus the pattern of hormone release reflects the location of the mucosal lesion. The gut-hormone profile may also help to characterise other gastrointestinal diseases.

Published
1978
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