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180 results on '"Patel, Ela"'

13. Glial changes are associated with cerebrovascular integrity in hyperhomocysteinemia‐induced VCID in mouse and human brain

Author

Weekman, Erica M, primary, Winder, Zachary, additional, Rogers, Colin B, additional, Abner, Erin L, additional, Sudduth, Tiffany L, additional, Price, Brittani R., additional, Woolums, Abigail, additional, Hawthorne, Danielle, additional, IV, Charles E Seaks, additional, Patel, Ela, additional, Dugan, Adam, additional, Fister, Shuling X, additional, Wasek, Brandi, additional, Bottiglieri, Teodoro, additional, Fardo, David W., additional, and Wilcock, Donna M., additional

Published
2023
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14. Peritoneal Flap Following Lymph Node Dissection in Robotic Radical Prostatectomy: A Novel "Bunching" Technique.

Author

Gamal, Ahmed, Moschovas, Marcio Covas, Jaber, Abdel Rahman, Saikali, Shady, Sandri, Marco, Patel, Ela, Patel, Evan, Rogers, Travis, and Patel, Vipul

Subjects
PREVENTION of surgical complications, PERITONEUM surgery, SURGICAL robots, LYMPHADENECTOMY, PELVIS, RADICAL prostatectomy, LYMPHOCELE, BLOOD loss estimation, TREATMENT effectiveness, SURGICAL flaps, SUTURING, COMPARATIVE studies, TIME, EVALUATION
Abstract

Simple Summary: Symptomatic lymphocele can occur in 2–8% of patients following PLND in RARP, and the condition can add significant morbidities, such as fever, lower abdominal pain, deep venous thrombosis (DVT), and lower urinary tract symptoms. The literature has outlined diverse techniques for preventing the formation of lymphoceles, including ligature, clipping, or the mono/bipolar sealing of lymphatic vessels. Nevertheless, there exists ongoing controversy and debate regarding the efficacy of these varied approaches. Recent studies suggest that incorporating a peritoneal flap (PF) may reduce the risk of lymphoceles by enhancing the absorption of lymph fluid through the peritoneum. We described a novel technique for peritoneal flap creation that involves bunching the bladder peritoneum and suturing it to the periosteum of the pubic bone to secure it in place. Our technique has been shown to be effective in elimination of symptomatic lymphocele formation. The bunching technique is safe, feasible, does not add significant morbidities, and does not require a learning curve. Background: Pelvic lymph node dissection (PLND) is recommended while performing robot-assisted radical prostatectomy (RARP) for patients with localized intermediate or high-risk prostate cancer. However, symptomatic lymphoceles can occur after surgery, adding significant morbidity to patients. Our objective is to describe a novel Peritoneal Bladder Flap Bunching technique (PBFB) to reduce the risk of clinically significant lymphoceles in patients undergoing RARP and PLND. Methods: We evaluated 2267 patients who underwent RARP with PLND, dividing them into two groups: Group 1, comprising 567 patients who had the peritoneal flap (PBFB), and Group 2, comprising 1700 patients without the flap; propensity score matching carried out at a 1:3 ratio. Variables analyzed included estimated blood loss (EBL), operative time, postoperative complications, lymphocele formation, and the development of symptomatic lymphocele. Results: The two groups exhibited similar preoperative characteristics after matching. There was no statistically significant difference in the occurrence of lymphoceles between the flap group and the non-flap group, with rates of 24% and 20.9%, respectively (p = 0.14). However, none of the patients in the flap group (0%) developed symptomatic lymphoceles, whereas 2.2% of patients in the non-flap group experienced symptomatic lymphoceles (p = 0.01). Conclusion: We have demonstrated a modified technique for a peritoneal flap (PBFB) with the initial elimination of postoperative symptomatic lymphoceles and promising short-term outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Brain pathologies in extreme old age

Author

Neltner, Janna H., Abner, Erin L., Jicha, Gregory A., Schmitt, Frederick A., Patel, Ela, Poon, Leonard W., Marla, Gearing, Green, Robert C., Davey, Adam, Johnson, Mary Ann, Jazwinski, S. Michal, Kim, Sangkyu, Davis, Daron, Woodard, John L., Kryscio, Richard J., Van Eldik, Linda J., and Nelson, Peter T.

Published
2016
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22. Oncologic outcomes with and without amniotic membranes in robotic-assisted radical prostatectomy: A propensity score matched analysis

Author

Noël, Jonathan, primary, Stirt, Daniel, additional, Moschovas, Marcio Covas, additional, Reddy, Sunil, additional, Jaber, Abdel Rahman, additional, Sandri, Marco, additional, Bhat, Seetharam, additional, Rogers, Travis, additional, Ahmed, Subuhee, additional, Mascarenhas, Anya, additional, Patel, Ela, additional, and Patel, Vipul, additional

Published
2022
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25. Examining the association between blood‐based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort

Author

Winder, Zachary, primary, Sudduth, Tiffany L., additional, Anderson, Sonya, additional, Patel, Ela, additional, Neltner, Janna, additional, Martin, Barbara J., additional, Snyder, Katherine E., additional, Abner, Erin L., additional, Jicha, Gregory A., additional, Nelson, Peter T., additional, and Wilcock, Donna M., additional

Published
2022
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26. Genetic expression changes and pathologic findings associated with hyperhomocysteinemia in human autopsy brain tissue

Author

Weekman, Erica M., primary, Winder, Zach, additional, Rogers, Colin B., additional, Abner, Erin L., additional, Sudduth, Tiffany L., additional, Patel, Ela, additional, Dugan, Adam J., additional, Fister, Shuling X., additional, Wasek, Brandi, additional, Nelson, Peter T., additional, Jicha, Gregory A., additional, Bottiglieri, Teodoro, additional, Fardo, David W., additional, and Wilcock, Donna M., additional

Published
2022
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27. Examining the association between blood‐based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort.

Author

Winder, Zachary, Sudduth, Tiffany L., Anderson, Sonya, Patel, Ela, Neltner, Janna, Martin, Barbara J., Snyder, Katherine E., Abner, Erin L., Jicha, Gregory A., Nelson, Peter T., and Wilcock, Donna M.

Abstract

Introduction: Clinically, detection of disease‐causing pathology associated with Alzheimer's disease (AD) and vascular contributions to cognitive impairment and dementia (VCID) is limited to magnetic resonance imaging and positron emission tomography scans, which are expensive and not widely accessible. Here, we assess angiogenic, inflammatory, and AD‐related plasma biomarkers to determine their relationships with human post mortem neuropathology. Method: Plasma samples were analyzed using a digital immunoassay and pathological evaluation was performed by University of Kentucky Alzheimer's Disease Research Center neuropathologists. The association of plasma markers with neuropathology was estimated via proportional odds and logistic regressions adjusted for age. Results: Included cases (N = 90) showed increased tau/amyloid beta (Aβ)42 ratio, glial fibrillary acidic protein (GFAP), vascular endothelial growth factor A (VEGF‐A), and placental growth factor (PlGF) were positively associated with higher level of AD neuropathological change, while higher Aβ42/Aβ40 ratio was inversely associated. Higher PlGF, VEGF‐A, and interleukin 6 were inversely associated with chronic cerebrovascular disease, while Aβ42/Aβ40 ratio was positively associated. Discussion: Our results provide support for the continued study of plasma biomarkers as a clinical screening tool for AD and VCID pathology. [ABSTRACT FROM AUTHOR]

Published
2023
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39. p38 Kinase Is Activated in the Alzheimer's Disease Brain

Author

Hensley, Kenneth, Floyd, Robert A., Zheng, Nai-Ying, Nael, Raha, Robinson, Kent A., Nguyen, Xuan, Pye, Quentin N., Stewart, Charles A., Geddes, James, Markesbery, William R., Patel, Ela, Johnson, Gail V. W., and Bing, Guoying

Published
1999

40. In aged human brains without detected neuritic amyloid plaques, the severity of NFT pathology, and APOE genotype, are each associated with non-neuritic Aβ plaques

Author

Abner, Erin L., Neltner, Janna H., Jicha, Gregory A., Patel, Ela, Anderson, Sonya, Wilcock, Donna M., Van Eldik, Linda J., and Nelson, Peter T.

Subjects
Aged, 80 and over, Male, Aging, Silver Staining, Amyloid beta-Peptides, Brain, Neurofibrillary Tangles, Plaque, Amyloid, tau Proteins, Article, Apolipoproteins E, Humans, Female, Aged
Abstract

Data from a large autopsy series were analyzed to address questions pertinent to primary age-related tauopathy (PART) and Alzheimer's disease (AD): what factors are associated with increased severity of neurofibrillary degeneration in brains that lack neuritic amyloid plaques?; is there an association between Apolipoprotein E (APOE) alleles and PART pathologic severity independent of amyloid-β (Aβ) deposits?; and, how do the stains used to detect plaques and tangles impact the experimental results? Neuropathologic data were evaluated from elderly research volunteers whose brain autopsies were performed at University of Kentucky Alzheimer's Disease Center (UK-ADC; N = 145 subjects). All of the included subjects' brains lacked neuritic amyloid plaques according to the CERAD diagnostic criteria and the average final MMSE score before death was 26.8±4.6 stdev. The study incorporated evaluation of tissue with both silver histochemical stains and immunohistochemical stains to compare results; the immunohistochemical stains (Aβ and phospho-tau) were scanned and quantified using digital pathologic methods. Immunohistochemical stains provided important advantages over histochemical stains due to sensitivity and detectability via digital methods. When AD-type pathology was in its presumed earliest phases, neocortical parenchymal Aβ deposits were associated with increased medial temporal lobe neurofibrillary tangles. The observation supports the NIA-AA consensus recommendation for neuropathologic diagnoses, because even these "diffuse" Aβ deposits signal that AD pathobiologic mechanisms are occurring. Further, the data were most compatible with the hypothesis that the APOEɛ4 allele exerts its effect(s) via driving Aβ deposition, i.e., an "upstream" influence, rather than being associated directly with Aβ- independent PART pathology.

Published
2018

44. Detergent Insoluble Proteins and Inclusion Body-Like Structures Immunoreactive for PRKDC/DNA-PK/DNA-PKcs, FTL, NNT, and AIFM1 in the Amygdala of Cognitively Impaired Elderly Persons

Author

Gal, Jozsef, primary, Chen, Jing, additional, Katsumata, Yuriko, additional, Fardo, David W, additional, Wang, Wang-Xia, additional, Artiushin, Sergey, additional, Price, Douglas, additional, Anderson, Sonya, additional, Patel, Ela, additional, Zhu, Haining, additional, and Nelson, Peter T, additional

Published
2017
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45. The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases

Author

Nelson, Peter T, primary, Abner, Erin L, additional, Patel, Ela, additional, Anderson, Sonya, additional, Wilcock, Donna M, additional, Kryscio, Richard J, additional, Van Eldik, Linda J, additional, Jicha, Gregory A, additional, Gal, Zsombor, additional, Nelson, Ruth S, additional, Nelson, Bela G, additional, Gal, Jozsef, additional, Azam, Md. Tofial, additional, Fardo, David W, additional, and Cykowski, Matthew D, additional

Published
2017
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49. Disease-related microglia heterogeneity in the hippocampus of Alzheimer’s disease, dementia with Lewy bodies, and hippocampal sclerosis of aging

Author

Bachstetter, Adam D., primary, Van Eldik, Linda J., additional, Schmitt, Frederick A., additional, Neltner, Janna H., additional, Ighodaro, Eseosa T., additional, Webster, Scott J., additional, Patel, Ela, additional, Abner, Erin L., additional, Kryscio, Richard J,, additional, and Nelson, Peter T., additional

Published
2015
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50. Modeling the Association between 43 Different Clinical and Pathological Variables and the Severity of Cognitive Impairment in a Large Autopsy Cohort of Elderly Persons

Author

Nelson, Peter T., Abner, Erin L., Schmitt, Frederick A., Kryscio, Richard J., Jicha, Gregory A., Smith, Charles D., Davis, Daron G., Poduska, John W., Patel, Ela, Mendiondo, Marta S., and Markesbery, William R.

Subjects
Aged, 80 and over, Cerebral Cortex, Male, Aging, Models, Statistical, Databases, Factual, Brain, Neuropsychological Tests, Hippocampus, Immunohistochemistry, Article, Cohort Studies, DNA-Binding Proteins, Apolipoproteins E, Alzheimer Disease, Linear Models, Humans, Female, Autopsy, Cognition Disorders, Aged
Abstract

We evaluated the association between mini-mental status examination (MMSE) scores proximal to death and the values of 43 different clinical and pathological parameters. Studies were performed using data from 334 elderly, longitudinally evaluated research subjects who had undergone autopsy and satisfied inclusion criteria from an initial study group of 501. Interindividual variance in MMSE scores was used as a surrogate for the severity of cognitive impairment linked to aging (CILA). A statistical linear regression-based model provided a framework for assessing the parameters with significant, direct impact on CILA severity. Strong association between CILA and Alzheimer's disease (AD) pathology, especially isocortical neurofibrillary tangles, was evident. The pattern of association between AD lesion densities with cognitive impairment severity was biologically informative, with neuritic plaques having more impact in relatively high-functioning individuals. Abundant isocortical Lewy bodies tended to be an additive pathology correlating with final MMSE scores approximately 10 points lower. In a subset of cases we found evidence for association between TDP-43-related pathology and CILA severity, independent of AD or hippocampal sclerosis. There was no support for independent association between CILA severity and most evaluated indices including diffuse plaques, argyrophilic grains, heart disease, education level, apolipoprotein E alleles or diabetes.

Published
2008

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