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Objective: To compare clinicopathological characteristics of patients with papillary thyroid carcinoma in association with the presence or absence of chronic lymphocytic thyroiditis in tertiary care hospital who underwent thyroidectomy. Material and Method: This was a cross sectional retrospective study carried out by the Department of pathology, NAMO Medical Institute of Medical Science, Silvassa. In the present study, histopathological record of patients who underwent for total thyroidectomy were reviewed NAMO Medical Institute of Medical Science, Shree Vinoba Bhave Hospital, Silvassa, during the period of December 2019- December 2022. Total 20 cases of thyroidectomy specimen with papillary carcinoma were included in the present study. Following variables were taken in the present study: Age and gender of patient, presence of chronic lymphocytic thyroditis, type of thyroid malignancy, tumor size and lymph node metastasis. The cancer other than papillary carcinoma and benign thyroid lesion were not included in the present study. Result: Total 200 Thyroidectomy were done within December 2019-december 2022 (3 years period), from which 170 (85%) cases were benign thyroid lesion which were excluded from the study. Only 30 (15%) cases were malignant thyroid lesion from which 20 (66.67%) cases were of papillary carcinoma of thyroid, 6 (20%) cases were of follicular carcinoma, 1 (3.33%) case was of medullar carcinoma, and 3 (10%) cases were others like lymphoma and poorly differentiated malignancy. Among the 20 patients, there were 16 (80%) men and 4 (20%) women. Mean age was 48.23+12.54 years. The mean tumor size was 2.5+0.97 cm. Based on univariate analysis, the mean age of patients with and without CLT was 40.45+10.64 and 46.6+11.18 years, respectively (P-value=0.143). Predominance of female gender was observed in patients without CLT compared to patients with CLT. The mean tumor size was smaller in patients with CLT than patients without CLT (1.7+0.88 cm vs 2.2+0.92 cm, respectively; P=0.033). Conclusion: The chronic lymphocytic Thyroiditis is positively associated with papillary carcinoma of Thyroiditis. The influence of Thyroiditis on prognosis of well differentiated thyroid epithelial malignancy needs to be evaluated on the larger sample size. [ABSTRACT FROM AUTHOR]

Background: Prostate cancer (PCa) is one of the most common cancer in men globally. Prostate-specific antigen (PSA) is used for screening and biopsy is used to confirm the diagnosis. Inflammatory markers serve as non-invasive predictors of PCa. Thus, this study was performed to evaluate the role of PSA, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and red cell distribution width (RDW) in predicting PCa. Materials and Methods: This was a retrospective, observational study carried out at a tertiary care hospital for a period of two years and eight months from Oct 2019 to June 2022. It included the biopsy samples of all the male patients who underwent the transrectal ultrasound guided prostate biopsy. The samples were evaluated by the histopathology section of the pathology department. In the patients suffering from confirmed prostatic carcinoma (PCa), the levels of PSA, lymphocyte, neutrophil and platelet counts before the biopsy were noted. Gleason scores were graded. NLR, PLR and RDW were evaluated. Among the non-PCa, the samples were categorized into two groups based on histological results -- Prostatitis and Benign prostatic hyperplasia (BPH). Unpaired t-test and Mann Whitney U test were used as test of significance. P value < 0.05 was considered significant. Results: Total 73 biopsy samples were evaluated. The average age of the patients was 66.48 ± 5.8 years. 55 out of 73 were non-PCa and 16 were classified as prostatic adenocarcinoma. All of the 55 non-PCa patients were classified as benign prostatic hypertrophy. PSA values were significantly higher in PCa as compared toBPH patients (p< 0.001). There was no statistically significant difference in the median NLR, PLR and RDW in the BPH and PCa group. Majority (37.5%, n =6) patients were categorised into grade 3 Gleason score followed by 5 (31.25%) patients in grade 4. Also, the correlation between Gleason score and PSA, NLR, PLR and RDW was statistically insignificant in PCa patients. Conclusion: Significantly high PSA levels are seen in PCa but it is not specific for PCa. Inflammatory markers NLR, PLR, RDW does not serve as reliable indicators for diagnosis of PCa. [ABSTRACT FROM AUTHOR]