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1. Incidence and clinical outcomes of perforations during mechanical thrombectomy for medium vessel occlusion in acute ischemic stroke: A retrospective, multicenter, and multinational study.

Author

Dmytriw, Adam, Musmar, Basel, Salim, Hamza, Ghozy, Sherief, Siegler, James, Kobeissi, Hassan, Shaikh, Hamza, Khalife, Jane, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh, Heit, Jeremy, Regenhardt, Robert, Cancelliere, Nicole, Bernstock, Joshua, Naamani, Kareem, Amllay, Abdelaziz, Meyer, Lukas, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Saleme, Suzana, Mounayer, Charbel, Fiehler, Jens, Kühn, Anna, Puri, Ajit, Dyzmann, Christian, Kan, Peter, Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Marotta, Thomas, Stapleton, Christopher, Rabinov, James, Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard, Tan, Benjamin, Gopinathan, Anil, Martinez-Gutierrez, Juan, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Chervak, Lina, Vagal, Achala, Adeeb, Nimer, Cuellar-Saenz, Hugo, Tjoumakaris, Stavropoula, Jabbour, Pascal, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Filipe, João, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor, Möhlenbruch, Markus, Jesser, Jessica, Costalat, Vincent, Ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Aziz, Yasmin, Gory, Benjamin, Stracke, Christian, Hecker, Constantin, Kadirvel, Ramanathan, Killer-Oberpfalzer, Monika, Griessenauer, Christoph, Thomas, Ajith, Hsieh, Cheng-Yang, Liebeskind, David, Alexandru Radu, Răzvan, Alexandre, Andrea, Tancredi, Illario, Faizy, Tobias, Fahed, Robert, Weyland, Charlotte, Lubicz, Boris, Patel, Aman, Pereira, Vitor, and Guenego, Adrien

Subjects
AIS, MT, MeVo, Stroke, mechanical thrombectomy, perforation, Humans, Ischemic Stroke, Male, Retrospective Studies, Female, Aged, Middle Aged, Incidence, Thrombectomy, Treatment Outcome, Aged, 80 and over
Abstract

BACKGROUND: Mechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium vessel occlusion (MeVO) remain less explored. This multicenter, retrospective study aims to investigate the incidence and clinical outcomes of vessel perforations (confirmed by extravasation during an angiographic series) during MT for AIS caused by MeVO. METHODS: Data were collected from 37 academic centers across North America, Asia, and Europe between September 2017 and July 2021. A total of 1373 AIS patients with MeVO underwent MT. Baseline characteristics, procedural details, and clinical outcomes were analyzed. RESULTS: The incidence of vessel perforation was 4.8% (66/1373). Notably, our analysis indicates variations in perforation rates across different arterial segments: 8.9% in M3 segments, 4.3% in M2 segments, and 8.3% in A2 segments (p = 0.612). Patients with perforation had significantly worse outcomes, with lower rates of favorable angiographic outcomes (TICI 2c-3: 23% vs 58.9%, p

Published
2024

6. Multicenter evaluation of mechanical thrombectomy for distal medium vessel occlusions with National Institute of Health Stroke Scale Scores ≥ 6 and ≤ 6

Author

Kühn, Anna Luisa, Puri, Ajit S., Salim, Hamza Adel, Musmar, Basel, Ghozy, Sherief, Siegler, James, Shaikh, Hamza, Khalife, Jane, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N., Heit, Jeremy J., Regenhardt, Robert W., Diestro, Jose Danilo Bengzon, Cancelliere, Nicole M., Sweid, Ahmad, Naamani, Kareem El, Hasan, Zuha, Gopinathan, Anil, Amllay, Abdelaziz, Meyer, Lukas, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Saleme, Suzana, Mounayer, Charbel, Fiehler, Jens, Dyzmann, Christian, Kan, Peter T., Singh, Jasmeet, Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Marotta, Thomas R., Stapleton, Christopher J., Rabinov, James D., Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard LL., Tan, Benjamin Y. Q., Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Tjoumakaris, Stavropoula I., Jabbour, Pascal, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Filipe, João Pedro, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R., Möhlenbruch, Markus A., Jesser, Jessica, Costalat, Vincent, ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Chervak, Lina, Aziz, Yasmin, Gory, Benjamin, Stracke, Christian Paul, Hecker, Constantin, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J., Thomas, Ajith, Hsieh, Cheng-Yang, Liebeskind, David S., Radu, Răzvan Alexandru, Alexandre, Andrea M., Fahed, Robert, Tancredi, Illario, Faizy, Tobias D., Weyland, Charlotte, Lubicz, Boris, Patel, Aman B., Pereira, Vitor Mendes, Guenego, Adrien, and Dmytriw, Adam A.

Published
2024
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7. First pass effect as an independent predictor of functional outcomes in medium vessel occlusions: An analysis of an international multicenter study.

Author

Radu, Răzvan, Costalat, Vincent, Fahed, Robert, Ghozy, Sherief, Siegler, James, Shaikh, Hamza, Khalife, Jane, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh, Heit, Jeremy, Sweid, Ahmad, El Naamani, Kareem, Regenhardt, Robert, Diestro, Jose, Cancelliere, Nicole, Amllay, Abdelaziz, Meyer, Lukas, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Saleme, Suzana, Mounayer, Charbel, Fiehler, Jens, Kühn, Anna, Puri, Ajit, Dyzmann, Christian, Kan, Peter, Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Kyheng, Maéva, Marotta, Thomas, Stapleton, Christopher, Rabinov, James, Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard, Tan, Benjamin, Martinez-Gutierrez, Juan, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Tjoumakaris, Stavropoula, Jabbour, Pascal, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Pedro Filipe, João, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor, Möhlenbruch, Markus, Jesser, Jessica, Tancredi, Illario, Ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Chervak, Lina, Aziz, Yasmin, Gory, Benjamin, Paul Stracke, Christian, Hecker, Constantin, Killer-Oberpfalzer, Monika, Griessenauer, Christoph, Thomas, Ajith, Hsieh, Cheng-Yang, Liebeskind, David, Alexandre, Andrea, Faizy, Tobias, Weyland, Charlotte, Patel, Aman, Pereira, Vitor, Lubicz, Boris, Dmytriw, Adam, and Guenego, Adrien

Subjects
MeVO, Stroke, outcomes research, reperfusion, thrombectomy, Humans, Stroke, Brain Ischemia, Retrospective Studies, Thrombectomy, Treatment Outcome, Intracranial Hemorrhages
Abstract

INTRODUCTION: First pass effect (FPE), achievement of complete recanalization (mTICI 2c/3) with a single pass, is a significant predictor of favorable outcomes for endovascular treatment (EVT) in large vessel occlusion stroke (LVO). However, data concerning the impact on functional outcomes and predictors of FPE in medium vessel occlusions (MeVO) are scarce. PATIENTS AND METHODS: We conducted an international retrospective study on MeVO cases. Multivariable logistic modeling was used to establish independent predictors of FPE. Clinical and safety outcomes were compared between the two study groups (FPE vs non-FPE) using logistic regression models. Good outcome was defined as modified Rankin Scale 0-2 at 3 months. RESULTS: Eight hundred thirty-six patients with a final mTICI ⩾ 2b were included in this analysis. FPE was observed in 302 patients (36.1%). In multivariable analysis, hypertension (aOR 1.55, 95% CI 1.10-2.20) and lower baseline NIHSS score (aOR 0.95, 95% CI 0.93-0.97) were independently associated with an FPE. Good outcomes were more common in the FPE versus non-FPE group (72.8% vs 52.8%), and FPE was independently associated with favorable outcome (aOR 2.20, 95% CI 1.59-3.05). 90-day mortality and intracranial hemorrhage (ICH) were significantly lower in the FPE group, 0.43 (95% CI, 0.25-0.72) and 0.55 (95% CI, 0.39-0.77), respectively. CONCLUSION: Over 2/3 of patients with MeVOs and FPE in our cohort had a favorable outcome at 90 days. FPE is independently associated with favorable outcomes, it may reduce the risk of any intracranial hemorrhage, and 3-month mortality.

Published
2024

9. Comparative Efficacy of Flow Diverter Devices in the Treatment of Carotid Sidewall Intracranial Aneurysms: a Retrospective, Multicenter Study

Author

Dmytriw, Adam A., Salim, Hamza Adel, Musmar, Basel, Cancelliere, Nicole M., Griessenauer, Christoph J., Regenhardt, Robert W., Jones, Jesse, Tutino, Vincent, Hasan, Zuha, Limbucci, Nicola, Lay, Sovann V., Spears, Julian, Rabinov, James D., Harrigan, Mark R., Siddiqui, Adnan H., Levy, Elad I., Stapleton, Christopher J., Renieri, Leonardo, Cognard, Christophe, Shaikh, Hamza, Kühn, Anna Luisa, Möhlenbruch, Markus A., Tjoumakaris, Stavropoula I., Jabbour, Pascal, Taussky, Philipp, Settecase, Fabio, Heran, Manraj K. S., Nguyen, Anh, Volders, David, Harker, Pablo, Devia, Diego A., Puri, Ajit S., Psychogios, Marios, Puentes, Juan C., Leone, Giuseppe, Buono, Giuseppe, Tarantino, Margherita, Muto, Mario, Briganti, Francesco, Dalal, Shamsher, Gontu, Vamsi, Alcedo Guardia, Rodolfo E., Vicenty-Padilla, Juan C., Brouwer, Patrick, Schmidt, Matthias H., Schirmer, Clemens, Pickett, Gwynedd E., Andersson, Tommy, Söderman, Michael, Marotta, Thomas R., Cuellar-Saenz, Hugo, Thomas, Ajith J., Patel, Aman B., Mendes Pereira, Vitor, and Adeeb, Nimer

Published
2024
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11. Outcomes with General Anesthesia Compared to Conscious Sedation for Endovascular Treatment of Medium Vessel Occlusions: Results of an International Multicentric Study

Author

Radu, Răzvan Alexandru, Costalat, Vincent, Romoli, Michele, Musmar, Basel, Siegler, James E., Ghozy, Sherief, Khalife, Jane, Salim, Hamza, Shaikh, Hamza, Adeeb, Nimer, Cuellar-Saenz, Hugo H., Thomas, Ajith J., Kadirvel, Ramanathan, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N., Heit, Jeremy J., Regenhardt, Robert W., Bernstock, Joshua D., Patel, Aman B., Rabinov, James D., Stapleton, Christopher J., Cancelliere, Nicole M., Marotta, Thomas R., Mendes Pereira, Vitor, El Naamani, Kareem, Amllay, Abdelaziz, Tjoumakaris, Stavropoula I., Jabbour, Pascal, Meyer, Lukas, Fiehler, Jens, Faizy, Tobias D., Guerreiro, Helena, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Mounayer, Charbel, Kühn, Anna Luisa, Puri, Ajit S., Dyzmann, Christian, Kan, Peter T., Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard L. L., Tan, Benjamin YQ, Gopinathan, Anil, Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Chervak, Lina M., Vagal, Achala, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Alexandre, Andrea M., Filipe, João Pedro, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R., YMD, Markus A., Jesser, Jessica, Weyland, Charlotte, ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Aziz, Yasmin, Gory, Benjamin, Paul Stracke, Christian, Hecker, Constantin, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J., Hsieh, Cheng-Yang, Liebeskind, David S., Tancredi, Illario, Fahed, Robert, Lubicz, Boris, Essibayi, Muhammed Amir, Baker, Amanda, Altschul, David, Scarcia, Luca, Kalsoum, Erwah, Dmytriw, Adam A., and Guenego, Adrien

Published
2024
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13. Long-Term Follow-Up of Cerebral Aneurysms Completely Occluded at 6 Months After Intervention with the Woven EndoBridge (WEB) Device: a Retrospective Multicenter Observational Study

Author

El Naamani, Kareem, Mastorakos, Panagiotis, Adeeb, Nimer, Lan, Mathews, Castiglione, James, Khanna, Omaditya, Diestro, Jose Danilo Bengzon, McLellan, Rachel M., Dibas, Mahmoud, Vranic, Justin E., Aslan, Assala, Cuellar-Saenz, Hugo H., Guenego, Adrien, Carnevale, Joseph, Saliou, Guillaume, Ulfert, Christian, Möhlenbruch, Markus, Foreman, Paul M., Vachhani, Jay A., Hafeez, Muhammad U., Waqas, Muhammad, Tutino, Vincent M., Rabinov, James D., Ren, Yifan, Michelozzi, Caterina, Spears, Julian, Panni, Pietro, Griessenauer, Christoph J., Asadi, Hamed, Regenhardt, Robert W., Stapleton, Christopher J., Ghozy, Sherief, Siddiqui, Adnan, Patel, Nirav J., Kan, Peter, Boddu, Srikanth, Knopman, Jared, Aziz-Sultan, Mohammad A., Zanaty, Mario, Ghosh, Ritam, Abbas, Rawad, Amllay, Abdelaziz, Tjoumakaris, Stavropoula I., Gooch, Michael R., Cancelliere, Nicole M., Herial, Nabeel A., Rosenwasser, Robert H., Zarzour, Hekmat, Schmidt, Richard F., Pereira, Vitor Mendes, Patel, Aman B., Jabbour, Pascal, and Dmytriw, Adam A.

Published
2024
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17. HyenaDNA: Long-Range Genomic Sequence Modeling at Single Nucleotide Resolution

Author

Nguyen, Eric, Poli, Michael, Faizi, Marjan, Thomas, Armin, Birch-Sykes, Callum, Wornow, Michael, Patel, Aman, Rabideau, Clayton, Massaroli, Stefano, Bengio, Yoshua, Ermon, Stefano, Baccus, Stephen A., and Ré, Chris

Subjects
Computer Science - Machine Learning, Quantitative Biology - Genomics
Abstract

Genomic (DNA) sequences encode an enormous amount of information for gene regulation and protein synthesis. Similar to natural language models, researchers have proposed foundation models in genomics to learn generalizable features from unlabeled genome data that can then be fine-tuned for downstream tasks such as identifying regulatory elements. Due to the quadratic scaling of attention, previous Transformer-based genomic models have used 512 to 4k tokens as context (<0.001% of the human genome), significantly limiting the modeling of long-range interactions in DNA. In addition, these methods rely on tokenizers or fixed k-mers to aggregate meaningful DNA units, losing single nucleotide resolution where subtle genetic variations can completely alter protein function via single nucleotide polymorphisms (SNPs). Recently, Hyena, a large language model based on implicit convolutions was shown to match attention in quality while allowing longer context lengths and lower time complexity. Leveraging Hyena's new long-range capabilities, we present HyenaDNA, a genomic foundation model pretrained on the human reference genome with context lengths of up to 1 million tokens at the single nucleotide-level - an up to 500x increase over previous dense attention-based models. HyenaDNA scales sub-quadratically in sequence length (training up to 160x faster than Transformer), uses single nucleotide tokens, and has full global context at each layer. We explore what longer context enables - including the first use of in-context learning in genomics. On fine-tuned benchmarks from the Nucleotide Transformer, HyenaDNA reaches state-of-the-art (SotA) on 12 of 18 datasets using a model with orders of magnitude less parameters and pretraining data. On the GenomicBenchmarks, HyenaDNA surpasses SotA on 7 of 8 datasets on average by +10 accuracy points. Code at https://github.com/HazyResearch/hyena-dna., Comment: NeurIPS 2023 (Spotlight)

Published
2023

18. The impact of hypertension on clinical outcomes in moyamoya disease: a multicenter, propensity score-matched analysis

Author

Musmar, Basel, Roy, Joanna M., Abdalrazeq, Hammam, Atallah, Elias, Naamani, Kareem El, Chen, Ching-Jen, Jabre, Roland, Saad, Hassan, Grossberg, Jonathan A., Dmytriw, Adam A., Patel, Aman B., Khorasanizadeh, Mirhojjat, Ogilvy, Christopher S, Thomas, Ajith J., Monteiro, Andre, Siddiqui, Adnan, Cortez, Gustavo M., Hanel, Ricardo A., Porto, Guilherme, Spiotta, Alejandro M., Piscopo, Anthony J., Hasan, David M., Ghorbani, Mohammad, Weinberg, Joshua, Nimjee, Shahid M., Bekelis, Kimon, Salem, Mohamed M., Burkhardt, Jan-Karl, Zetchi, Akli, Matouk, Charles, Howard, Brian M., Lai, Rosalind, Du, Rose, Abbas, Rawad, Sioutas, Georgios S, Amllay, Abdelaziz, Munoz, Alfredo, Herial, Nabeel A., Tjoumakaris, Stavropoula I., Gooch, Michael Reid, Rosenwasser, Robert H., and Jabbour, Pascal

Published
2024
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20. Dual Layer vs Single Layer Woven EndoBridge Device in the Treatment of Intracranial Aneurysms: A Propensity Score-Matched Analysis

Author

Dmytriw, Adam A., Salim, Hamza, Musmar, Basel, Aslan, Assala, Cancelliere, Nicole M., McLellan, Rachel M., Algin, Oktay, Ghozy, Sherief, Dibas, Mahmoud, Lay, Sovann V., Guenego, Adrien, Renieri, Leonardo, Carnevale, Joseph, Saliou, Guillaume, Mastorakos, Panagiotis, Naamani, Kareem El, Shotar, Eimad, Premat, Kevin, Möhlenbruch, Markus, Kral, Michael, Doron, Omer, Chung, Charlotte, Salem, Mohamed M., Lylyk, Ivan, Foreman, Paul M., Vachhani, Jay A., Shaikh, Hamza, Župančić, Vedran, Hafeez, Muhammad U., Catapano, Joshua, Waqas, Muhammad, Tutino, Vincent M., Ibrahim, Mohamed K., Mohammed, Marwa A., Imamoglu, Cetin, Bayrak, Ahmet, Rabinov, James D., Ren, Yifan, Schirmer, Clemens M., Piano, Mariangela, Kühn, Anna L., Michelozzi, Caterina, Elens, Stéphanie, Starke, Robert M., Hassan, Ameer E., Ogilvie, Mark, Sporns, Peter, Jones, Jesse, Brinjikji, Waleed, Nawka, Marie T., Psychogios, Marios, Ulfert, Christian, Diestro, Jose Danilo Bengzon, Pukenas, Bryan, Burkhardt, Jan-Karl, Huynh, Thien, Martinez-Gutierrez, Juan Carlos, Essibayi, Muhammed Amir, Sheth, Sunil A., Spiegel, Gary, Tawk, Rabih, Lubicz, Boris, Panni, Pietro, Puri, Ajit S., Pero, Guglielmo, Nossek, Erez, Raz, Eytan, Killer-Oberfalzer, Monika, Griessenauer, Christoph J., Asadi, Hamed, Siddiqui, Adnan, Brook, Allan L., Altschul, David, Ducruet, Andrew F., Albuquerque, Felipe C., Regenhardt, Robert W., Stapleton, Christopher J., Kan, Peter, Kalousek, Vladimir, Lylyk, Pedro, Boddu, Srikanth, Knopman, Jared, Aziz-Sultan, Mohammad A., Tjoumakaris, Stavropoula I., Clarençon, Frédéric, Limbucci, Nicola, Cuellar-Saenz, Hugo H., Jabbour, Pascal M., Pereira, Vitor Mendes, Patel, Aman B., and Adeeb, Nimer

Published
2024
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21. Characterizing coma in large vessel occlusion stroke

Author

Young, Michael J., Awad, Amine, Andreev, Alexander, Bonkhoff, Anna K., Schirmer, Markus D., Dmytriw, Adam A., Vranic, Justin E., Rabinov, James D., Doron, Omer, Stapleton, Christopher J., Das, Alvin S., Edlow, Brian L., Singhal, Aneesh B., Rost, Natalia S., Patel, Aman B., and Regenhardt, Robert W.

Published
2024
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22. Use of the pRESET LITE thrombectomy device in combined approach for medium vessel occlusions: A multicenter evaluation

Author

Wang, Maud, Henkes, Hans, Ghozy, Sherief, Siegler, James E., Shaikh, Hamza, Khalife, Jane, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N., Heit, Jeremy J., Sweid, Ahmad, Naamani, Kareem El, Regenhardt, Robert W., Diestro, Jose Danilo Bengzon, Cancelliere, Nicole M., Amllay, Abdelaziz, Meyer, Lukas, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Saleme, Suzana, Mounayer, Charbel, Fiehler, Jens, Kühn, Anna Luisa, Puri, Ajit S., Dyzmann, Christian, Kan, Peter T., Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Weyland, Charlotte, Marotta, Thomas R., Stapleton, Christopher J., Rabinov, James D., Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard LL., Tan, Benjamin Y. Q., Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Tjoumakaris, Stavropoula I., Jabbour, Pascal, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Filipe, João Pedro, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R., Möhlenbruch, Markus A., Jesser, Jessica, Costalat, Vincent, ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Chervak, Lina M., Aziz, Yasmin, Gory, Benjamin, Stracke, Christian Paul, Hecker, Constantin, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J., Thomas, Ajith J., Hsieh, Cheng-Yang, Liebeskind, David S., Radu, Răzvan Alexandru, Alexandre, Andrea M., Tancredi, Illario, Faizy, Tobias D., Patel, Aman B., Pereira, Vitor Mendes, Fahed, Robert, Lubicz, Boris, Dmytriw, Adam A., and Guenego, Adrien

Published
2024
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25. International controlled study of revascularization and outcomes following COVID‐positive mechanical thrombectomy

Author

Dmytriw, Adam A, Ghozy, Sherief, Sweid, Ahmad, Piotin, Michel, Bekelis, Kimon, Sourour, Nader, Raz, Eytan, Vela‐Duarte, Daniel, Linfante, Italo, Dabus, Guilherme, Kole, Max, Martínez‐Galdámez, Mario, Nimjee, Shahid M, Lopes, Demetrius K, Hassan, Ameer E, Kan, Peter, Ghorbani, Mohammad, Levitt, Michael R, Escalard, Simon, Missios, Symeon, Shapiro, Maksim, Clarençon, Fréderic, Elhorany, Mahmoud, Tahir, Rizwan A, Youssef, Patrick P, Pandey, Aditya S, Starke, Robert M, Naamani, Kareem El, Abbas, Rawad, Mansour, Ossama Y, Galvan, Jorge, Billingsley, Joshua T, Mortazavi, Abolghasem, Walker, Melanie, Dibas, Mahmoud, Settecase, Fabio, Heran, Manraj KS, Kuhn, Anna L, Puri, Ajit S, Menon, Bijoy K, Sivakumar, Sanjeev, Mowla, Ashkan, D'Amato, Salvatore, Zha, Alicia M, Cooke, Daniel, Vranic, Justin E, Regenhardt, Robert W, Rabinov, James D, Stapleton, Christopher J, Goyal, Mayank, Wu, Hannah, Cohen, Jake, Turkel‐Parella, David, Xavier, Andrew, Waqas, Muhammad, Tutino, Vincent, Siddiqui, Adnan, Gupta, Gaurav, Nanda, Anil, Khandelwal, Priyank, Tiu, Cristina, Portela, Pere C, de la Ossa, Natalia Perez, Urra, Xabier, Lera, Mercedes, Arenillas, Juan F, Ribo, Marc, Requena, Manuel, Piano, Mariangela, Pero, Guglielmo, Sousa, Keith, Al‐Mufti, Fawaz, Hashim, Zafar, Nayak, Sanjeev, Renieri, Leonardo, Du, Rose, Aziz‐Sultan, Mohamed A, Liebeskind, David, Nogueira, Raul G, Abdalkader, Mohamad, Nguyen, Thanh N, Vigilante, Nicholas, Siegler, James E, Grossberg, Jonathan A, Saad, Hassan, Gooch, Michael R, Herial, Nabeel A, Rosenwasser, Robert H, Tjoumakaris, Stavropoula, Patel, Aman B, Tiwari, Ambooj, Jabbour, Pascal, and Investigators, North American Neurovascular COVID‐19 Consortium Society of Vascular and Interventional Neurology

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Stroke, Clinical Research, Good Health and Well Being, Brain Ischemia, COVID-19, Cross-Sectional Studies, Endovascular Procedures, Humans, Male, Retrospective Studies, Thrombectomy, Treatment Outcome, large vessel occlusion, morbidity, mortality, stroke, North American Neurovascular COVID-19 (NAN-C) Consortium &amp, Society of Vascular and Interventional Neurology (SVIN) Investigators, Neurology & Neurosurgery, Clinical sciences
Abstract

Background and purposePrevious studies suggest that mechanisms and outcomes in patients with COVID-19-associated stroke differ from those in patients with non-COVID-19-associated strokes, but there is limited comparative evidence focusing on these populations. The aim of this study, therefore, was to determine if a significant association exists between COVID-19 status with revascularization and functional outcomes following thrombectomy for large vessel occlusion (LVO), after adjustment for potential confounding factors.MethodsA cross-sectional, international multicenter retrospective study was conducted in consecutively admitted COVID-19 patients with concomitant acute LVO, compared to a control group without COVID-19. Data collected included age, gender, comorbidities, clinical characteristics, details of the involved vessels, procedural technique, and various outcomes. A multivariable-adjusted analysis was conducted.ResultsIn this cohort of 697 patients with acute LVO, 302 had COVID-19 while 395 patients did not. There was a significant difference (p

Published
2022

26. Off-Label use of Woven EndoBridge device for intracranial brain aneurysm treatment: Modeling of occlusion outcome

Author

Dibas, Mahmoud, Spears, Julian, Sundararajan, Sri Hari, Al Balush, Ali, Vranic, Justin E., Inoue, Yasuaki, Mirshahi, Shervin, Alotaibi, Naif M., Harker, Pablo, Tutino, Vincent M., Sporns, Peter, Brehm, Alex, Essibayi, Muhammed Amir, Jabal, Mohamed Sobhi, Musmar, Basel, Adeeb, Nimer, Salim, Hamza, Aslan, Assala, Cancelliere, Nicole M., McLellan, Rachel M., Algin, Oktay, Ghozy, Sherief, Lay, Sovann V., Guenego, Adrien, Renieri, Leonardo, Carnevale, Joseph, Saliou, Guillaume, Mastorakos, Panagiotis, Naamani, Kareem El, Shotar, Eimad, Premat, Kevin, Möhlenbruch, Markus, Kral, Michael, Doron, Omer, Chung, Charlotte, Salem, Mohamed M, Lylyk, Ivan, Foreman, Paul M., Vachhani, Jay A., Shaikh, Hamza, Župančić, Vedran, Hafeez, Muhammad U., Catapano, Joshua, Waqas, Muhammad, Yavuz, Kivilcim, Gunes, Yasin Celal, Rabinov, James D., Ren, Yifan, Schirmer, Clemens M., Piano, Mariangela, Kühn, Anna L., Michelozzi, Caterina, Starke, Robert M., Hassan, Ameer, Ogilvie, Mark, Nguyen, Anh, Jones, Jesse, Brinjikji, Waleed, Nawka, Marie T., Psychogios, Marios, Ulfert, Christian, Diestro, Jose Danilo Bengzon, Pukenas, Bryan, Burkhardt, Jan-Karl, Huynh, Thien, Gutierrez, Juan Carlos Martinez, Sheth, Sunil A., Spiegel, Gary, Tawk, Rabih, Lubicz, Boris, Panni, Pietro, Puri, Ajit S., Pero, Guglielmo, Nossek, Erez, Raz, Eytan, Killer-Oberfalzer, Monika, Griessenauer, Christoph J., Asadi, Hamed, Siddiqui, Adnan, Brook, Allan L., Haranhalli, Neil, Ducruet, Andrew F., Albuquerque, Felipe C., Regenhardt, Robert W., Stapleton, Christopher J., Kan, Peter, Kalousek, Vladimir, Lylyk, Pedro, Boddu, Srikanth, Knopman, Jared, Aziz-Sultan, Mohammad A., Tjoumakaris, Stavropoula I., Clarençon, Frédéric, Limbucci, Nicola, Cuellar-Saenz, Hugo H., Jabbour, Pascal M, Pereira, Vitor Mendes, Patel, Aman B., Altschul, David, and Dmytriw, Adam A.

Published
2024
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28. Pretreatment factors associated with symptomatic stroke in Moyamoya disease patients: A multicenter study

Author

Musmar, Basel, Roy, Joanna M., Salim, Hamza Adel, Kaul, Anand, Atallah, Elias, Naamani, Kareem El, Chen, Ching-Jen, Jabre, Roland, Saad, Hassan, Grossberg, Jonathan A., Dmytriw, Adam A., Patel, Aman B., Khorasanizadeh, Mirhojjat, Ogilvy, Christopher S., Thomas, Ajith J., Monteiro, Andre, Siddiqui, Adnan, Cortez, Gustavo M., Hanel, Ricardo A., Porto, Guilherme, Spiotta, Alejandro M., Piscopo, Anthony J., Hasan, David M., Ghorbani, Mohammad, Weinberg, Joshua, Nimjee, Shahid M., Bekelis, Kimon, Salem, Mohamed M., Burkhardt, Jan-Karl, Zetchi, Akli, Matouk, Charles, Howard, Brian M., Lai, Rosalind, Du, Rose, Abbas, Rawad, Sioutas, Georgios S., Amllay, Abdelaziz, Munoz, Alfredo, Herial, Nabeel A., Tjoumakaris, Stavropoula I., Gooch, Michael Reid, Rosenwasser, Robert H., and Jabbour, Pascal

Published
2024
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29. Characteristics of a COVID-19 Cohort With Large Vessel Occlusion: A Multicenter International Study

Author

Jabbour, Pascal, Dmytriw, Adam A, Sweid, Ahmad, Piotin, Michel, Bekelis, Kimon, Sourour, Nader, Raz, Eytan, Linfante, Italo, Dabus, Guilherme, Kole, Max, Martínez-Galdámez, Mario, Nimjee, Shahid M, Lopes, Demetrius K, Hassan, Ameer E, Kan, Peter, Ghorbani, Mohammad, Levitt, Michael R, Escalard, Simon, Missios, Symeon, Shapiro, Maksim, Clarençon, Frédéric, Elhorany, Mahmoud, Vela-Duarte, Daniel, Tahir, Rizwan A, Youssef, Patrick P, Pandey, Aditya S, Starke, Robert M, Naamani, Kareem El, Abbas, Rawad, Hammoud, Bassel, Mansour, Ossama Y, Galvan, Jorge, Billingsley, Joshua T, Mortazavi, Abolghasem, Walker, Melanie, Dibas, Mahmoud, Settecase, Fabio, Heran, Manraj KS, Kuhn, Anna L, Puri, Ajit S, Menon, Bijoy K, Sivakumar, Sanjeev, Mowla, Ashkan, D'Amato, Salvatore, Zha, Alicia M, Cooke, Daniel, Goyal, Mayank, Wu, Hannah, Cohen, Jake, Turkel-Parrella, David, Xavier, Andrew, Waqas, Muhammad, Tutino, Vincent M, Siddiqui, Adnan, Gupta, Gaurav, Nanda, Anil, Khandelwal, Priyank, Tiu, Cristina, Portela, Pere C, de la Ossa, Natalia Perez, Urra, Xabier, de Lera, Mercedes, Arenillas, Juan F, Ribo, Marc, Requena, Manuel, Piano, Mariangela, Pero, Guglielmo, De Sousa, Keith, Al-Mufti, Fawaz, Hashim, Zafar, Nayak, Sanjeev, Renieri, Leonardo, Aziz-Sultan, Mohamed A, Nguyen, Thanh N, Feineigle, Patricia, Patel, Aman B, Siegler, James E, Badih, Khodr, Grossberg, Jonathan A, Saad, Hassan, Gooch, M Reid, Herial, Nabeel A, Rosenwasser, Robert H, Tjoumakaris, Stavropoula, and Tiwari, Ambooj

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Neurosciences, Clinical Research, Brain Disorders, Stroke, Good Health and Well Being, Brain Ischemia, COVID-19, Cerebral Infarction, Humans, Retrospective Studies, Thrombectomy, Treatment Outcome, SARS-CoV-2, Central nervous system, Cerebrovascular disease, Hypercoagulable, Neurology & Neurosurgery, Clinical sciences, Biological psychology
Abstract

BackgroundThe mechanisms and outcomes in coronavirus disease (COVID-19)-associated stroke are unique from those of non-COVID-19 stroke.ObjectiveTo describe the efficacy and outcomes of acute revascularization of large vessel occlusion (LVO) in the setting of COVID-19 in an international cohort.MethodsWe conducted an international multicenter retrospective study of consecutively admitted patients with COVID-19 with concomitant acute LVO across 50 comprehensive stroke centers. Our control group constituted historical controls of patients presenting with LVO and receiving a mechanical thrombectomy between January 2018 and December 2020.ResultsThe total cohort was 575 patients with acute LVO; 194 patients had COVID-19 while 381 patients did not. Patients in the COVID-19 group were younger (62.5 vs 71.2; P < .001) and lacked vascular risk factors (49, 25.3% vs 54, 14.2%; P = .001). Modified thrombolysis in cerebral infarction 3 revascularization was less common in the COVID-19 group (74, 39.2% vs 252, 67.2%; P < .001). Poor functional outcome at discharge (defined as modified Ranklin Scale 3-6) was more common in the COVID-19 group (150, 79.8% vs 132, 66.7%; P = .004). COVID-19 was independently associated with a lower likelihood of achieving modified thrombolysis in cerebral infarction 3 (odds ratio [OR]: 0.4, 95% CI: 0.2-0.7; P < .001) and unfavorable outcomes (OR: 2.5, 95% CI: 1.4-4.5; P = .002).ConclusionCOVID-19 was an independent predictor of incomplete revascularization and poor outcomes in patients with stroke due to LVO. Patients with COVID-19 with LVO were younger, had fewer cerebrovascular risk factors, and suffered from higher morbidity/mortality rates.

Published
2022

31. Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations

Author

Zhao, Shujuan, Mekbib, Kedous Y., van der Ent, Martijn A., Allington, Garrett, Prendergast, Andrew, Chau, Jocelyn E., Smith, Hannah, Shohfi, John, Ocken, Jack, Duran, Daniel, Furey, Charuta G., Hao, Le Thi, Duy, Phan Q., Reeves, Benjamin C., Zhang, Junhui, Nelson-Williams, Carol, Chen, Di, Li, Boyang, Nottoli, Timothy, Bai, Suxia, Rolle, Myron, Zeng, Xue, Dong, Weilai, Fu, Po-Ying, Wang, Yung-Chun, Mane, Shrikant, Piwowarczyk, Paulina, Fehnel, Katie Pricola, See, Alfred Pokmeng, Iskandar, Bermans J., Aagaard-Kienitz, Beverly, Moyer, Quentin J., Dennis, Evan, Kiziltug, Emre, Kundishora, Adam J., DeSpenza, Jr., Tyrone, Greenberg, Ana B. W., Kidanemariam, Seblewengel M., Hale, Andrew T., Johnston, James M., Jackson, Eric M., Storm, Phillip B., Lang, Shih-Shan, Butler, William E., Carter, Bob S., Chapman, Paul, Stapleton, Christopher J., Patel, Aman B., Rodesch, Georges, Smajda, Stanislas, Berenstein, Alejandro, Barak, Tanyeri, Erson-Omay, E. Zeynep, Zhao, Hongyu, Moreno-De-Luca, Andres, Proctor, Mark R., Smith, Edward R., Orbach, Darren B., Alper, Seth L., Nicoli, Stefania, Boggon, Titus J., Lifton, Richard P., Gunel, Murat, King, Philip D., Jin, Sheng Chih, and Kahle, Kristopher T.

Published
2023
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32. Acute ischaemic stroke associated with SARS-CoV-2 infection in North America

Author

Dmytriw, Adam A, Dibas, Mahmoud, Phan, Kevin, Efendizade, Aslan, Johanna, Ospel, Schirmer, Clemens, Settecase, Fabio, Heran, Manraj KS, Kühn, Anna Luisa, Puri, Ajit S, Menon, Bijoy K, Sivakumar, Sanjeev, Mowla, Askan, Vela-Duarte, Daniel, Linfante, Italo, Dabus, Guilherme C, Regenhardt, Robert W, D'Amato, Salvatore, Rosenthal, Joseph A, Zha, Alicia, Talukder, Nafee, Sheth, Sunil A, Hassan, Ameer E, Cooke, Daniel L, Leung, Lester Y, Malek, Adel M, Voetsch, Barbara, Sehgal, Siddharth, Wakhloo, Ajay K, Goyal, Mayank, Wu, Hannah, Cohen, Jake, Ghozy, Sherief, Turkel-Parella, David, Farooq, Zerwa, Vranic, Justin, Rabinov, James D, Stapleton, Christopher J, Minhas, Ramandeep, Velayudhan, Vinodkumar, Chaudhry, Zeshan Ahmed, Xavier, Andrew, Bullrich, Maria Bres, Pandey, Sachin, Sposato, Luciano A, Johnson, Stephen A, Gupta, Gaurav, Khandelwal, Priyank, Ali, Latisha, Liebeskind, David S, Farooqui, Mudassir, Ortega-Gutierrez, Santiago, Nahab, Fadi, Jillella, Dinesh V, Chen, Karen, Aziz-Sultan, Mohammad Ali, Abdalkader, Mohamad, Kaliaev, Artem, Nguyen, Thanh N, Haussen, Diogo C, Nogueira, Raul G, Haq, Israr Ul, Zaidat, Osama O, Sanborn, Emma, Leslie-Mazwi, Thabele M, Patel, Aman B, Siegler, James E, and Tiwari, Ambooj

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Stroke, Clinical Research, Neurosciences, Good Health and Well Being, Brain Ischemia, COVID-19, Humans, Ischemic Stroke, Middle Aged, Retrospective Studies, SARS-CoV-2, Thrombectomy, Treatment Outcome, stroke, interventional, North American Neurovascular COVID-19 (NAN-C) Consortium & Society of Vascular and Interventional Neurology (SVIN) Investigators, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences
Abstract

BackgroundTo analyse the clinical characteristics of COVID-19 with acute ischaemic stroke (AIS) and identify factors predicting functional outcome.MethodsMulticentre retrospective cohort study of COVID-19 patients with AIS who presented to 30 stroke centres in the USA and Canada between 14 March and 30 August 2020. The primary endpoint was poor functional outcome, defined as a modified Rankin Scale (mRS) of 5 or 6 at discharge. Secondary endpoints include favourable outcome (mRS ≤2) and mortality at discharge, ordinal mRS (shift analysis), symptomatic intracranial haemorrhage (sICH) and occurrence of in-hospital complications.ResultsA total of 216 COVID-19 patients with AIS were included. 68.1% (147/216) were older than 60 years, while 31.9% (69/216) were younger. Median [IQR] National Institutes of Health Stroke Scale (NIHSS) at presentation was 12.5 (15.8), and 44.2% (87/197) presented with large vessel occlusion (LVO). Approximately 51.3% (98/191) of the patients had poor outcomes with an observed mortality rate of 39.1% (81/207). Age >60 years (aOR: 5.11, 95% CI 2.08 to 12.56, p

Published
2022

33. The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms: Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium

Author

Dmytriw, Adam A., Dibas, Mahmoud, Ghozy, Sherief, Adeeb, Nimer, Diestro, Jose Danilo Bengzon, Phan, Kevin, Cuellar-Saenz, Hugo H., Sweid, Ahmad, Lay, Sovann V., Guenego, Adrien, Renieri, Leonardo, Al Balushi, Ali, Saliou, Guillaume, Möhlenbruch, Markus, Regenhardt, Robert W., Vranic, Justin E., Lylyk, Ivan, Foreman, Paul M., Vachhani, Jay A., Župančić, Vedran, Hafeez, Muhammad U., Rutledge, Caleb, Waqas, Muhammad, Tutino, Vincent M., Rabinov, James D., Ren, Yifan, Schirmer, Clemens M., Piano, Mariangela, Kühn, Anna L., Michelozzi, Caterina, Elens, Stéphanie, Starke, Robert M., Hassan, Ameer, Salehani, Arsalaan, Sporns, Peter, Jones, Jesse, Psychogios, Marios, Spears, Julian, Lubicz, Boris, Panni, Pietro, Puri, Ajit S., Pero, Guglielmo, Griessenauer, Christoph J., Asadi, Hamed, Stapleton, Christopher J., Siddiqui, Adnan, Ducruet, Andrew F., Albuquerque, Felipe C., Du, Rose, Kan, Peter, Kalousek, Vladimir, Lylyk, Pedro, Boddu, Srikanth, Tjoumakaris, Stavropoula, Knopman, Jared, Aziz-Sultan, Mohammad A., Limbucci, Nicola, Jabbour, Pascal, Cognard, Christophe, and Patel, Aman B.

Published
2023
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34. Pathogenic Roles for RNASET2 in Clear Cell Renal Cell Carcinoma

Author

Peak, Taylor, Tian, Yijun, Patel, Aman, Shaw, Tim, Obermayer, Alyssa, Laborde, Jose, Kim, Youngchul, Johnson, Joseph, Stewart, Paul, Fang, Bin, Teer, Jamie K., Koomen, John, Berglund, Anders, Marchion, Doug, Francis, Natasha, Echevarria, Paola Ramos, Dhillon, Jasreman, Clark, Noel, Chang, Andrew, Sexton, Wade, Zemp, Logan, Chahoud, Jad, Wang, Liang, and Manley, Brandon

Published
2024
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36. Correction to: The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms: Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium

Author

Dmytriw, Adam A., Dibas, Mahmoud, Ghozy, Sherief, Adeeb, Nimer, Diestro, Jose Danilo Bengzon, Phan, Kevin, Cuellar-Saenz, Hugo H., Sweid, Ahmad, Lay, Sovann V., Guenego, Adrien, Renieri, Leonardo, Al Balushi, Ali, Saliou, Guillaume, Möhlenbruch, Markus, Regenhardt, Robert W., Vranic, Justin E., Lylyk, Ivan, Foreman, Paul M., Vachhani, Jay A., Župančić, Vedran, Hafeez, Muhammad U., Rutledge, Caleb, Waqas, Muhammad, Tutino, Vincent M., Rabinov, James D., Ren, Yifan, Schirmer, Clemens M., Piano, Mariangela, Kühn, Anna L., Michelozzi, Caterina, Elens, Stéphanie, Starke, Robert M., Hassan, Ameer, Salehani, Arsalaan, Sporns, Peter, Jones, Jesse, Psychogios, Marios, Spears, Julian, Lubicz, Boris, Panni, Pietro, Puri, Ajit S., Pero, Guglielmo, Griessenauer, Christoph J., Asadi, Hamed, Stapleton, Christopher J., Siddiqui, Adnan, Ducruet, Andrew F., Albuquerque, Felipe C., Du, Rose, Kan, Peter, Kalousek, Vladimir, Lylyk, Pedro, Boddu, Srikanth, Tjoumakaris, Stavropoula, Jared Knopman, Aziz-Sultan, Mohammad A., Limbucci, Nicola, Jabbour, Pascal, Cognard, Christophe, and Patel, Aman B.

Published
2023
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37. Age and Acute Ischemic Stroke Outcome in North American Patients With COVID‐19

Author

Dmytriw, Adam A, Dibas, Mahmoud, Schirmer, Clemens M, Settecase, Fabio, Heran, Manraj KS, Efendizade, Aslan, Kühn, Anna Luisa, Puri, Ajit S, Ospel, Johanna, Menon, Bijoy, Sivakumar, Sanjeev, Mowla, Ashkan, Vela‐Duarte, Daniel, Linfante, Italo, Dabus, Guilherme, Regenhardt, Robert W, Patel, Aman B, Leslie‐Mazwi, Thabele, D’Amato, Salvatore, Rosenthal, Joseph, Zha, Alicia, Talukder, Nafee, Sheth, Sunil, Cooke, Daniel, Leung, Lester Y, Malek, Adel, Voetsch, Barbara, Sehgal, Siddharth, Wakhloo, Ajay K, Wu, Hannah, Cohen, Jake, Turkel‐Parella, David, Xavier, Andrew, Tiwari, Ambooj, and Consortium, the North American Neurovascular COVID‐19

Subjects
Clinical Research, Brain Disorders, Stroke, Rehabilitation, Good Health and Well Being, Adult, Age Factors, Aged, Aged, 80 and over, COVID-19, Canada, Female, Humans, Ischemic Stroke, Male, Middle Aged, Prospective Studies, United States, acute ischemic stroke, age outcomes, COVID-19 pandemic, SARS-CoV-2, North American Neurovascular COVID‐19 (NAN‐C) Consortium, COVID‐19 pandemic, SARS‐CoV‐2, Cardiorespiratory Medicine and Haematology
Abstract

Background Acute ischemic stroke (AIS) in the context of COVID-19 has received considerable attention for its propensity to affect patients of all ages. We aimed to evaluate the effect of age on functional outcome and mortality following an acute ischemic event. Methods and Results A prospectively maintained database from comprehensive stroke centers in Canada and the United States was analyzed for patients with AIS from March 14 to September 30, 2020 who tested positive for SARS-CoV-2. The primary outcome was Modified Rankin Scale score at discharge, and the secondary outcome was mortality. Baseline characteristics, laboratory values, imaging, and thrombectomy workflow process times were assessed. Among all 126 patients with COVID-19 who were diagnosed with AIS, the median age was 63 years (range, 27-94). There were 35 (27.8%) patients with AIS in the aged ≤55 years group, 47 (37.3%) in the aged 56 to 70 group, and 44 (34.9%) in the aged >70 group. Intravenous tissue plasminogen activator and thrombectomy rates were comparable across these groups, (P=0.331 and 0.212, respectively). There was a significantly lower rate of mortality between each group favoring younger age (21.9% versus 45.0% versus 48.8%, P=0.047). After multivariable adjustment for possible confounders, a 1-year increase in age was significantly associated with fewer instances of a favorable outcome of Modified Rankin Scale 0 to 2 (odds ratio [OR], 0.95; 95 CI%, 0.90-0.99; P=0.048) and higher mortality (OR, 1.06; 95 CI%, 1.02-1.10; P=0.007). Conclusions AIS in the context of COVID-19 affects young patients at much greater rates than pre-pandemic controls. Nevertheless, instances of poor functional outcome and mortality are closely tied to increasing age.

Published
2021

40. The Impact of Dual Antiplatelet Therapy Duration on Unruptured Aneurysm Occlusion After Flow Diversion: A Multicenter Study

Author

Vranic, Justin E., Harker, Pablo, Stapleton, Christopher J., Regenhardt, Robert W., Dmytriw, Adam A., Doron, Omer M., Alotaibi, Naif M., Leslie-Mazwi, Thabele M., Gupta, Rajiv, Berglar, Inka K., Tan, Can Ozan, Koch, Matthew J., Raymond, Scott B., Mascitelli, Justin R., Patterson, T. Tyler, Seinfeld, Joshua, White, Andrew, Case, David, Roark, Christopher, Gandhi, Chirag D., Al-Mufti, Fawaz, Cooper, Jared, Matouk, Charles, Sujijantarat, Nanthiya, Devia, Diego A., Ocampo-Navia, Maria I., Villamizar-Torres, Daniel E., Puentes, Juan C., and Patel, Aman B.

Published
2023
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41. Cerebral Vasospasm

Author

Muñoz, William, Stapleton, Christopher J., Patel, Aman B., Mascitelli, Justin R., editor, and Binning, Mandy J., editor

Published
2022
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