1. Neuropsychiatric complications and associated management in adolescent and young adult cancer survivors: An All of Us study
- Author
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Agapito, Ivann, Ng, Ding Quan, Milam, Joel, Ziogas, Argyrios, Anton‐Culver, Hoda, and Chan, Alexandre
- Subjects
Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Pediatric ,Pain Research ,Clinical Research ,Cancer ,Neurosciences ,Neurodegenerative ,Peripheral Neuropathy ,Management of diseases and conditions ,7.1 Individual care needs ,Neurological ,Good Health and Well Being ,Humans ,Adolescent ,Young Adult ,United States ,Adult ,Cancer Survivors ,Fatigue Syndrome ,Chronic ,Population Health ,Neoplasms ,Memory Disorders ,Epilepsy ,adolescent and young adult cancer ,All of Us ,matched controls ,neuropsychiatric ,past medical history ,survivor ,All of Us ,Biochemistry and Cell Biology ,Oncology and carcinogenesis - Abstract
BackgroundAbout 4.5% of new cancer cases affect adolescent and young adult aged between 15 and 39 years in the United States (US). However, the effect of neuropsychiatric conditions on long-term adolescent and young adult cancer (AYAC) survivors has not been formally investigated. Thus, the impact and management of late neuropsychiatric complications in AYAC survivors compared to non-cancer-matched controls (NCMC) in the US were evaluated using the All of Us (AoU) Research Program.MethodsParticipants in the AoU Controlled Tier Dataset (v6) diagnosed with cancer between ages 15 and 39 were identified from electronic health records and surveys. AYAC survivors were matched with NCMC using the optimal pair-matching algorithm at a 1:4 ratio. Data on past diagnoses, current follow-up care, and treatment patterns of neuropsychiatric complications were collected.ResultsAnalysis was performed on 788 AYAC survivors and 3152 NCMC. AYAC survivors, with an average of 8.8 years since their first cancer diagnosis, were more likely than NCMC to receive a diagnosis of neuropathy, memory loss and epilepsy (p
- Published
- 2023