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4. Comprehensive Characterization of Cardiac, Skeletal and Diaphragmatic Myotoxicity Using CMR in Patients with Immune Checkpoint Inhibitor Therapy and Relation to Outcomes

Author

Charpentier, Etienne, primary, boussouar, samia, additional, Bretagne, Marie, additional, Bouazizi, Khaoula, additional, Kachenoura, Nadjia, additional, Nguyen, Lan Anh, additional, Pasi, Nicoletta, additional, Edhery, Stephane, additional, allenbach, yves, additional, Similowski, Thomas, additional, Kerneis, Mathieu, additional, Baldassarre, Lauren, additional, Salem, Joe-Elie, additional, and Redheuil, Alban, additional

Published
2024
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9. Kiosk 5R-TA-04 - Comprehensive Characterization of Cardiac, Skeletal and Diaphragmatic Myotoxicity Using CMR in Patients with Immune Checkpoint Inhibitor Therapy and Relation to Outcomes

Author

Charpentier, Etienne, boussouar, samia, Bretagne, Marie, Bouazizi, Khaoula, Kachenoura, Nadjia, Nguyen, Lan Anh, Pasi, Nicoletta, Edhery, Stephane, allenbach, yves, Similowski, Thomas, Kerneis, Mathieu, Baldassarre, Lauren, Salem, Joe-Elie, and Redheuil, Alban

Published
2024
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12. COVID‐19 and its Severity in Bariatric Surgery‐Operated Patients

Author

Charpentier, Etienne, Redheuil, Alban, Bourron, Olivier, Boussouar, Samia, Lucidarme, Olivier, Zarai, Mohamed, Kachenoura, Nadjia, Bouazizi, Khaoula, Salem, Joe-Elie, Hekimian, Guillaume, Kerneis, Matthieu, Amoura, Zahir, Allenbach, Yves, Hatem, Stephane, Jeannin, Anne-Caroline, Andreelli, Fabrizio, Phan, Franck, Tilmont, Romain, Chenu, Romain, Meyfroit, Louise, Pasi, Nicoletta, Larbi-Messaoud, Schahrazed, Laroche, Suzanne, Ciangura, Cécile, Popelier, Marc, Jacqueminet, Sophie, Halbron, Marine, Hartemann, Agnès, Service de Nutrition [CHU Pitié-Salpétrière], Institut E3M [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche en Nutrition Humaine d'Ile-de-France (CRNH-IDF), Institut de Veille Sanitaire (INVS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut National Agronomique Paris-Grignon (INA P-G)-CETAF-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Sorbonne Paris Nord, Nutrition et obésités: approches systémiques (nutriomics) (UMR-S 1269 INSERM - Sorbonne Université), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de chirurgie digestive et viscérale [CHU Pitié-Salpêtrière], Nutrition et obésités: approches systémiques (UMR-S 1269) (Nutriomics), Institut de Veille Sanitaire (INVS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut National Agronomique Paris-Grignon (INA P-G)-CETAF-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Sorbonne Paris Nord, Gestionnaire, Hal Sorbonne Université, Service de nutrition [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut de Veille Sanitaire (INVS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Sorbonne Paris Nord-Institut National Agronomique Paris-Grignon (INA P-G)-Sorbonne Université (SU)-CETAF-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), [SDV]Life Sciences [q-bio], Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), 030209 endocrinology & metabolism, Type 2 diabetes, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Weight loss, Diabetes mellitus, Severity of illness, medicine, 030212 general & internal medicine, Risk factor, Nutrition and Dietetics, business.industry, Retrospective cohort study, medicine.disease, Obesity, 3. Good health, Surgery, [SDV] Life Sciences [q-bio], medicine.symptom, business
Abstract

International audience; Objective: Obesity is a major risk factor for severe forms of coronavirus disease (COVID-19), but little is known about the post-bariatric surgery (BS) setting. The prevalence of likely COVID-19 and its risk factors in patients followed up after BS was assessed.Methods: A total of 738 patients who underwent BS and were followed up at a university medical center were surveyed. A retrospective comparison of characteristics at baseline, 1 year after BS, and at the time of lockdown was performed between patients with COVID-19-likely events (CL) based on a combination of reported symptoms and those for whom COVID-19 was unlikely.Results: CL occurred in 62 (8.4%) patients, among whom 4 (6.4%) had a severe form requiring hospitalization and 1 (1.6%) died. The CL group had a higher proportion of persistent type 2 diabetes (T2D) at last follow-up (36.2% vs. 20.3%, P = 0.01). BMI at the time of lockdown was lower in the CL group (30.2 ± 5.1 vs. 32.8 ± 6.5 kg/m2 ; P < 0.01) with higher percent weight loss since BS in the CL group. Severe forms of COVID-19 requiring hospitalization were associated with persistent T2D at the last follow-up visit.Conclusions: In BS patients, CL were associated with persistent T2D and lower BMI.

Published
2020
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15. Quantitative magnetic resonance imaging measures of three‐dimensional aortic morphology in healthy aging and hypertension

Author

Dietenbeck, Thomas, primary, Houriez‐‐Gombaud‐Saintonge, Sophia, additional, Charpentier, Etienne, additional, Gencer, Umit, additional, Giron, Alain, additional, Gallo, Antonio, additional, Boussouar, Samia, additional, Pasi, Nicoletta, additional, Soulat, Gilles, additional, Mousseaux, Elie, additional, Redheuil, Alban, additional, and Kachenoura, Nadjia, additional

Published
2021
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18. Diagnostic performance of chest computed tomography during the epidemic wave of COVID-19 varied as a function of time since the beginning of the confinement in France

Author

Boussouar, Samia, primary, Wagner, Mathilde, additional, Donciu, Victoria, additional, Pasi, Nicoletta, additional, Salem, Joe Elie, additional, Renard-Penna, Raphaele, additional, Marot, Stéphane, additional, Freund, Yonathan, additional, Redheuil, Alban, additional, and Lucidarme, Olivier, additional

Published
2020
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21. Ascending aorta dilatation rates in patients with tricuspid and bicuspid aortic stenosis: the COFRASA/GENERAC study

Author

Kerneis, Caroline, primary, Pasi, Nicoletta, additional, Arangalage, Dimitri, additional, Nguyen, Virginia, additional, Mathieu, Tiffany, additional, Verdonk, Constance, additional, Codogno, Isabelle, additional, Ou, Phalla, additional, Duval, Xavier, additional, Tubiana, Sarah, additional, Cimadevilla, Claire, additional, Vahanian, Alec, additional, and Messika-Zeitoun, David, additional

Published
2017
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22. Usefulness of Late Iodine Enhancement on Spectral CT in Acute Myocarditis

Author

Bouleti, Claire, primary, Baudry, Guillaume, additional, Iung, Bernard, additional, Arangalage, Dimitri, additional, Abtan, Jérémie, additional, Ducrocq, Gregory, additional, Steg, Philippe-Gabriel, additional, Vahanian, Alec, additional, Henry-Feugeas, Marie-Cécile, additional, Pasi, Nicoletta, additional, Chillon, Sylvie, additional, Pitocco, Francesca, additional, Laissy, Jean-Pierre, additional, and Ou, Phalla, additional

Published
2017
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23. New insights on tuberculous aortitis

Author

Delaval, Laure, primary, Goulenok, Tiphaine, additional, Achouh, Paul, additional, Saadoun, David, additional, Gaudric, Julien, additional, Pellenc, Quentin, additional, Kahn, Jean-Emmanuel, additional, Pasi, Nicoletta, additional, van Gysel, Damien, additional, Bruneval, Patrick, additional, Papo, Thomas, additional, and Sacre, Karim, additional

Published
2017
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26. Tertiary Lymphoid Organs in Takayasu Arteritis

Author

Clement, Marc, primary, Galy, Adrien, additional, Bruneval, Patrick, additional, Morvan, Marion, additional, Hyafil, Fabien, additional, Benali, Khadija, additional, Pasi, Nicoletta, additional, Deschamps, Lydia, additional, Pellenc, Quentin, additional, Papo, Thomas, additional, Nicoletti, Antonino, additional, and Sacre, Karim, additional

Published
2016
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28. Ascending aorta dilatation rates in patients with tricuspid and bicuspid aortic stenosis: the COFRASA/GENERAC study.

Author

Kerneis, Caroline, Pasi, Nicoletta, Arangalage, Dimitri, Nguyen, Virginia, Mathieu, Tiffany, Verdonk, Constance, Codogno, Isabelle, Ou, Phalla, Duval, Xavier, Tubiana, Sarah, Cimadevilla, Claire, Vahanian, Alec, and Messika-Zeitoun, David

Subjects
AGE distribution, AORTA, AORTIC aneurysms, AORTIC stenosis, VASODILATION, COMPUTED tomography, ECHOCARDIOGRAPHY, LONGITUDINAL method, MITRAL valve, SEX distribution, TRICUSPID valve, SEVERITY of illness index, BODY surface area, SINUS of valsalva
Abstract

Background Ascending aorta (AA) dilatation is common in aortic valve stenosis (AS) but data regarding AA progression, its determinants and impact of valve anatomy [bicuspid (BAV), or tricuspid (TAV)] are scarce. Methods and Results Asymptomatic AS patients enrolled in a prospective cohort (COFRASA/GENERAC) with at least 2 years of follow-up were considered in the present analysis. A transthoracic echocardiography (TTE) and a computed tomography (CT) scan were performed at inclusion and yearly thereafter. We enrolled 195 patients [mean gradient 22 ± 11 mmHg, 42 BAV patients (22%)]. Mean aorta diameters assessed using TTE were 35 ± 4 and 36 ± 5mm at the sinuses of Valsalva and tubular level, respectively. Ascending aorta diameter was >40mm in 29% of patients (24% in TAV vs. 52% in BAV, P < 0.01). Determinants of AA diameters were age, sex, BSA, and BAV, but not AS severity. After a mean follow-up of 3.8 ± 1.5years, AA enlargement rate assessed using TTE was þ0.18 ± 0.34 mm/ year and þ0.36 ± 0.54 mm/year at the Valsalva and tubular level, respectively. Determinants of the progression of AA size were smaller AA diameter (P < 0.01) but not baseline AS severity or valve anatomy (all P > 0.05). Only four patients presented an AA progression ≥ 2 mm/year. Correlations between TTE and CT scan were excellent (all r >0.74) and similar results were obtained using CT. During follow-up, two BAV patients underwent a combined AA surgery; no surgery was primarily performed for AA aneurysm and no dissection was observed. Conclusion In this prospective cohort of AS patients determinants of AA diameters were age, sex, BSA, and valve anatomy but not AS severity. AA progression rates were low and not influenced by AS severity or valve anatomy. [ABSTRACT FROM AUTHOR]

Published
2018
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29. Multimodal assessment of the aortic annulus diameter: implications for transcatheter aortic valve implantation

Author

Messika-Zeitoun, David, Serfaty, Jean-Michel, Brochet, Eric, Ducrocq, Gregory, Lepage, Laurent, Detaint, Delphine, Hyafil, Fabien, Himbert, Dominique, Pasi, Nicoletta, Laissy, Jean-Pierre, Iung, Bernard, Vahanian, Alec, Messika-Zeitoun, David, Service de cardiologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Hémostase, bio-ingénierie et remodelage cardiovasculaires (LBPC), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut Galilée-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de radiologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Diderot - Paris 7 (UPD7)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Galilée

Subjects
transthoracic echocardiography, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, transesophageal echocardiography, aortic stenosis, multislice computed tomography, human activities, transcatheter aortic valve implantation, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Abstract

International audience; OBJECTIVES: We sought to compare 3 methods of measurements of the aortic annulus, transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), and multislice computed tomography (MSCT), and to evaluate their potential clinical impact on transcatheter aortic valve implantation (TAVI) strategy. BACKGROUND: Exact measurement of the aortic annulus is critical for a patient's selection and successful implantation. METHODS: Annulus diameter was measured using TTE, TEE, and MSCT in 45 consecutive patients with severe aortic stenosis referred for TAVI. The TAVI strategy (decision to implant and choice of the prosthesis' size) was based on manufacturer's recommendations (Edwards-Sapien prosthesis, Edwards Lifesciences, Inc., Irvine, California). RESULTS: Correlations between methods were good but the difference between MSCT and TTE (1.22 +/- 1.3 mm) or TEE (1.52 +/- 1.1 mm) was larger than the difference between TTE and TEE (0.6 +/- 0.8 mm; p = 0.03 and p < 0.0001, respectively). Regarding TAVI strategy, agreement between TTE and TEE overall was good (kappa = 0.68), but TAVI strategy would have been different in 8 patients (17%). Agreement between MSCT and TTE or TEE was only modest (kappa = 0.28 and 0.27), and a decision based on MSCT measurements would have modified the TAVI strategy in a large number of patients (40% to 42%). Implantation, performed in 34 patients (76%) based on TEE measurements, was successful in all but 1 patient with grade 3/4 regurgitation. CONCLUSIONS: In patients referred for TAVI, measurements of the aortic annulus using TTE, TEE, and MSCT were close but not identical, and the method used has important potential clinical implications on TAVI strategy. In the absence of a gold standard, a strategy based on TEE measurements provided good clinical results.

Published
2010
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31. Vascular complications of transfemoral aortic valve implantation with the Edwards SAPIEN™ prosthesis: incidence and impact on outcome

Author

Ducrocq, Gregory, primary, Francis, Fady, additional, Serfaty, Jean-Michel, additional, Himbert, Dominique, additional, Maury, Jean-Michel, additional, Pasi, Nicoletta, additional, Marouene, Sami, additional, Provenchère, Sophie, additional, Iung, Bernard, additional, Castier, Yves, additional, Lesèche, Guy, additional, and Vahanian, Alec, additional

Published
2010
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32. Cardiac diffusion-weighted MR imaging in recent, subacute and chronic myocardial infarction: a pilot study.

Author

Laissy, Jean-Pierre, Gaxotte, Virginia, Pasi, Nicoletta, BenDriss, Ahmed, Feldman, Laurent, Steg, P. Gabriel, and Serfaty, Jean-Michel

Subjects
CARDIAC magnetic resonance imaging
Abstract

An abstract of the paper "Cardiac Diffusion-Weighted MR Imaging in Recent, Subacute and Chronic Myocardial Infarction: A Pilot Study," by Jean-Pierre Laissy and colleagues is presented.

Published
2011
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33. Ascending aorta dilatation rates in patients with tricuspid and bicuspid aortic stenosis: the COFRASA/GENERAC study.

Author

Kerneis C, Pasi N, Arangalage D, Nguyen V, Mathieu T, Verdonk C, Codogno I, Ou P, Duval X, Tubiana S, Cimadevilla C, Vahanian A, and Messika-Zeitoun D

Subjects
Age Factors, Aged, Aged, 80 and over, Aorta diagnostic imaging, Aortic Valve Stenosis epidemiology, Aortic Valve Stenosis pathology, Cohort Studies, Disease Progression, Female, Humans, Male, Mitral Valve diagnostic imaging, Mitral Valve pathology, Prognosis, Prospective Studies, Risk Assessment, Sensitivity and Specificity, Sex Factors, Tricuspid Valve diagnostic imaging, Tricuspid Valve pathology, Aorta pathology, Aortic Valve Stenosis diagnostic imaging, Asymptomatic Diseases epidemiology, Echocardiography methods, Tomography, X-Ray Computed methods
Abstract

Background: Ascending aorta (AA) dilatation is common in aortic valve stenosis (AS) but data regarding AA progression, its determinants and impact of valve anatomy [bicuspid (BAV), or tricuspid (TAV)] are scarce., Methods and Results: Asymptomatic AS patients enrolled in a prospective cohort (COFRASA/GENERAC) with at least 2 years of follow-up were considered in the present analysis. A transthoracic echocardiography (TTE) and a computed tomography (CT) scan were performed at inclusion and yearly thereafter. We enrolled 195 patients [mean gradient 22 ± 11 mmHg, 42 BAV patients (22%)]. Mean aorta diameters assessed using TTE were 35 ± 4 and 36 ± 5 mm at the sinuses of Valsalva and tubular level, respectively. Ascending aorta diameter was >40 mm in 29% of patients (24% in TAV vs. 52% in BAV, P < 0.01). Determinants of AA diameters were age, sex, BSA, and BAV, but not AS severity. After a mean follow-up of 3.8 ± 1.5years, AA enlargement rate assessed using TTE was +0.18 ± 0.34 mm/year and +0.36 ± 0.54 mm/year at the Valsalva and tubular level, respectively. Determinants of the progression of AA size were smaller AA diameter (P < 0.01) but not baseline AS severity or valve anatomy (all P > 0.05). Only four patients presented an AA progression ≥2 mm/year. Correlations between TTE and CT scan were excellent (all r >0.74) and similar results were obtained using CT. During follow-up, two BAV patients underwent a combined AA surgery; no surgery was primarily performed for AA aneurysm and no dissection was observed., Conclusion: In this prospective cohort of AS patients determinants of AA diameters were age, sex, BSA, and valve anatomy but not AS severity. AA progression rates were low and not influenced by AS severity or valve anatomy.

Published
2018
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