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3. Effect of the Factor XIa Inhibitor Asundexian According to Baseline Infarct Pattern and on MRI Covert Infarct Outcomes

Author

Smith, Eric E., Shoamanesh, Ashkan, Xu, Lizhen, Heenan, Laura, Saad, Feryal, Colorado, Pablo, Chen, Chih-Hao, Lemmens, Robin, De Marchis, Gian Marco, Caso, Valeria, Masjuan, Jaime, Hirano, Teruyuki, Milanov, Ivan, Campbell, Bruce C.V., Mas, Jean-Louis, Connolly, Stuart J., Mundl, Hardi, Hart, Robert G., Bailey, P., Kleinig, T., Cordato, D., Choi, P., Garcia-Esperon, C., Chew, A., Cloud, G., Stanislaus, V., Krause, M., Priglinger, M., Grimley, R., Ghia, D., Sahathevan, R., Brown, H., Kwan, C., Devlin, M., Greisenegger, S., Bonelli-Nauer, S., Rath, J., Langer, A., Marko, M., Ferrari, J., Bernegger, A., Baumgartinger, M., Vigl, M., Krebs, S., Lang, W., Knoflach, M., Dejakum, B., Kiechl, S., Töll, T., Domig, L., Mutzenbach, J.S., Ganser, B., Hecker, C., Rösler, C., Bubel, N., Pikija, S., Zellner, T., Leitner, U., Berger, O., Surböck, B., Beirer, S., Staykov, D., Schrammel, D., Halilovic, A., Frattner, M., Barmherzigen, D., Lampl, C., Höfer, C., Nagl, S., Bocksrucker, C., Demeestere, J., Desfontaines, P., Ciobanu, C., De Pauw, A., Terwecoren, A., Hasenbroekx, M.C., Clement, F., De Klippel, N., Soors, P., Hermans, S., De Raedt, S., Vandervorst, F., Seynaeve, L., Fockaert, N., Smet, S., Rutgers, M., Del Gaudio, N., Paindeville, P., Staikov, I., Simeonova, A., Stoyanova, I., Cholakova, M., Mihnev, N., Petrova, T., Koralova, A., Dimov, D., Kuzev, Y., Danovska, M., Marinova, D., Marinova-Trifonova, D., Ovcharova, E., Mladenovski, I., Yanakieva, M., Stoev, P., Dimitrova, M., Todorova-Georgieva, S., Haralanov, L., Milkov, B., Solakov, D., Petkova, N., Ignatova-Valkova, V., Karabinov, V., Marinova, V., Miteva, Y., Andonova, V., Kasabova, D., Kostadinova, E., Shopova-Vrabcheva, Y., Gatev, D., Semova, D., Halil, E., Kaprelyan, A., Ivanov, B., Panov, G., Grudkova, M., Syuleyman, N., Kalpachki, R., Alexiev, F., Ivanova, I., Kancheva, K., Sakelarova, T., Maslarov, D., Drenska, D., Georgiev, V., Petrova, K., Petrova, N., Ivanova, I., Semerdjieva, N., Zhelyazkov, P., Spasova-Markova, S., Dong, X., Wang, D., Wang, S., Huang, W., Zhao, H., Wang, C., Jie, L., Xinyang, Y., Ping, Z., Dong, Q., Wang, Y., Fuling, Y., Yue, W., Liu, R., Yang, Y., Stetkarova, I., Mikulenka, P., Vasko, P., Peisker, T., Bar, M., Roubec, M., Mikulik, R., Cabukova, M., Vinklarek, J., Kovar, M., Pansky, M., Mencl, P., Skoda, O., Carek, M., Pernicka, M., Skodova, M., Geier, P., Cepkova, J., Drlik, J., Prax, T., Herzig, R., Krajickova, D., Vitkova, E., Haluskova, S., Vaclavik, D., Martinkova, J., Blejcharova, K., Tkacova, M., Pavlik, O., Nevšímalová, M., Rosol, J., Nevsimalova, M., Hruby, R., Iversen, H., Andersen, A.V., Rahimi, D., Christensen, H., Grundtvig, J., Hjort, N., Andersen, G., Sandal, B., Stilund, M., Modrau, B., Strade, A., Porobic, M., Andersen, S.D., Kruuse, C., Ölmestig, J., Kolmos, M., Parvez, A., Christensen, T., Stokholm, J., Jensen, H.B., Putaala, J., Strbian, D., Sibolt, G., Tiainen, M., Martinez-Majander, N., Curtze, S., Raty, S., Kraemer, Y., Roine, R., Aivo, J., Ruuskanen, J., Ylikotila, P., Roine, S., Hallikainen, M., Jakala, P., Kurl, S., Julkunen, V., Sibon, I., Olindo, S., Richard, S., Larrue, V., Gollion, C., Catala, H., Henon, H., Lucie, D.S., Nelly, D., Calvet, D., Malbranque, A., Mazé, B., Barbieux-Ghitu, C., Rosso, C., Samson, Y., Vannier, S., Moulin, T., Bonnet, L., Reiner, P., Buffon, F., Denier, C., Amri, K., Legris, N., Chassin, O., Selli, N., Mariana, S., Berrouschot, J., Stoll, A., Klunk, D., Keilitz, J., Neustadt, M., Zerrenner, S., Veltkamp, R., Hajjar, K., Heeger, A., Winezki, E., Apel, L., Pompsch, M., Mueller, P., Rappard, P., Auer, R., Ringleb, P.A., Berberich, A., Heyse, M., Mundiyanapurath, S., Reiff, T., Poli, S., Gomez-Exposito, A., Mengel, A., Tünnerhoff, J., Adeyemi, K., Poli, K., Kusch, V., Pelz, J., Michalski, D., Wartenberg, K., Althaus, K., Tavares, F., Mueller, S., Soda, H., Rascher, A., Hiermann, E., Weinhardt, R., Weissenborn, K., Leotescu, A., Grosse, G., Worthmann, H., Ernst, J., Gabriel, M., Schuppner, R., Schäfer, J.H., Charisse, D., Gruber, K., Kurka, N., Reitz, S.C., Pfeilschifter, W., Lee, J.I., Gliem, M., Moll, M., Steiner, T., Segura, L., Szegedi, N., Barandi, D., Uhrinakova, L., Czencz, M., Pasztor, M., Gyuker, N., Bartha, N.E., May, Z., Simony, Z., Szasz, G., Kakuk, I., Pető, N., Panczel, G.F., Olah, A., Racz, O., Balla, T., Horvath, B., Tuba, K., Czinderi, V., Klivenyi, P., Annus, A., Hertelendy, P., Szapary, L., Bosnyak, E., Kalmar, P., Karadi, Z., Cziba, L., Olah, L., Berki, A., Hudak, L., Kozák, M., Babel, S., Nemeth, L., Molnár, B., Simon, Z., Roveri, L., Cerri, F., Giacalone, G., Zini, A., Mauro, G., Asioli, G.M., Forlivesi, S., Arnone, G., Fiaccadori, A., Maria Fontana Francesca, E., Allegra, G., Mosconi, M.G., Longoni, M., Terlizzi, R., Paolucci, M., Tassi, R., Franci, B., Lucani, B., Domenichelli, C., Paoletti, D., Acampa, M., Zedde, M.L., Pezzella, F.R., Mangiardi, M., Galizia, P., Anticoli, S., Scalise, S., Lattanzi, S., Norata, D., Cannuccia, M., Cavallini, A., Federica, F., Denaro, M.F., Tosi, P., Sonoda, K., Kawajiri, M., Kusano, Y., Haraguchi, K., Kawano, H., Terasaki, T., Kaneko, C., Murase, S., Kumagai, M., Murai, N., Miyazaki, Y., Mori, T., Hatano, T., Kawanishi, M., Ochiai, J., Ishihara, S., Uehara, T., Yasaka, M., Nakagawa, H., Makino, M., Yonehara, T., Fukushima, Y., Hirotsune, N., Sakai, N., Yamasaki, M., Coutinho, J., Wouters, A., den Hertog, H., Zwartbol, R., Beumer, D., Kerklaan, J., Hilkens, P., Schreuder, T., Propper, D., Slowik, A., Wlodarczyk, E., Wrona, P., Pulyk, R., Lasek-Bal, A., Kosarz-Lanczek, K., Puz, P., Bilik, M., Magielska, A., Zamiela – Żółciak, A., Ochocinska, L., Bahdasaryan, S., Stępień, A., Dębiec, A., Joanna, K., Pawel, M., Jacek, S., Daniel, P., Marta, S., Rejdak, K., Wojczal, J., Luchowski, P., Fryze, W., Wisniewska, A., Krzyzanowska, M., Skowron, P., Wolosz, A., Galan, A., Grzymala, K., Krajewska, M., Nowak, R., Kłos, M., Cruz, V., Castro, P., Ferro, J., Canhão, P., Gouveia, R., Inácio, N., Rodrigues, M., Rachão, A., Ionel, C., Pereira, L., Viana-Baptista, M., Machado, C., Fernandes, C., Sargento, J., Inácio, N., Timchenko, L., Mironova, J., Zhadan, O., Torgashova, A., Bazhenova, O., Barashenkova, M., Kireeva, M., Romadina, N., Stepanova, I., Lenskaya, L., Lukinykh, L., Vorontsova, T., Agafina, A., Fedorova, A., Yashina, A., Alasheev, A., Smolkin, A., Prazdnichkova, E., Lutskovich, O., Gonysheva, Y., Mordvintseva, E., Nechaev, A., Martynova, E., Fedoraeva, N., Vishnyakova, T., Popov, D., Merzliakova, A., Margarita, K., Rechkalova, L., Ilyina, A., Kurenkova, N., Barbarash, O., Bazdyrev, E., Zvereva, T., Hromova, A., Morkvenas, A., Postnikova, E., Kovalenko, G., Taran, I., Pavlov, L., Ott, M., Chernitsova, N., Vodopyanova, N., Drozdova, E., Korebo, E., Lobanova, M., Lazareva, N., Snegova, N., Nikolaeva, O., Kolesnikov, Y., Kosheleva, Y., Krastev, G., Tomasova, K., Danis, M., Mako, M., Jankovicova, Z., Stevkova, Z., Kovacik, M., Kubikova, T., Jarosova, A., Serdahely, V., Cilingova, I., Pribulova, I., Sedlak, J., Slebodova, K., Paldaufova, M., Risnovsky, R., Berndtova, B., Urbanova, I., Junas, R., Karapetian, S., Gurcik, L., Vantrobova, A., Verbovsky, F., Vanacka, K., Ferenc, M., Galik, P., Bucakova, S., Ferencova, M., Kubalova, P., Boksanska, Z., Zacharova, E., Mahundi, E., Judita, H., Bachnak, M., Turcani, P., Kvasnicova Kamenska, A., Jurik, M., Vestenicka, V., Kycina, M., Sagatova, E., Dvorak, M., Hlubekova, A., Kucera, C., Gernath, L., Ferenc, M., Frimmelova, P., Slebodnikova, J., Aksteinerova, N., Horny, V., Gregova, Z., Segura, T., Romero, C., Ayo, O., Masjuan Vallejo, J., Cruz, A., De felipe, A, Matute, M.C., Garcia, S., Tembl Ferrairo, J., Vielba, I., Morales Caba, L., Molina, C., Garcia-Tornel García-Camba, Á., Requena Ruiz, M., Noelia, R., Rodriguez-Yañez, M., Rodriguez Castro, E., Lopez, I., Santamaria, M., Arias, S., Purroy García, F., Vázquez Justes, D., Mauri Capdevila, G., Vicente Pascual, M., Martí Fabregas, J., Camps Renom, P., Rodríguez Campello, A., Giralt, E., Krupinski, J., Molina, J., Trillo Senin, C. Ramos Martin, S., De La Fuente Sanz, E., Moniche, F., Manuel, M.R., Pardo, B., Martínez, I., Hernández Pérez, M., Arenillas Lara, J.F., De Lera, M., Egido, J.A., Gomez Escalonilla, C., Guillan, M., Martinez, J., Lindgren, A., Andsberg, G., Wictor, L., Leonidou, M., Stenman, M., Dalberg, N., Laska, A.C., Grünfeldt, A., Lundström, A., Nadzjafov, E., Rooth, E., Dalenbring, I., Sandén, P., Johansson, E., Thomas, G., Zietz, A.V., Rudin, S., Dittrich, T.D., Lilian, K., Kägi, G., Vehoff, J., Arnold, M., Scutelnic, A., Clénin, L., Beyeler, M., Madlaine, M., Maamari, B., Siepen, B., Vynckier, J., Tarnutzer, A., Bertschi, D., Luciani, M., Cereda, C., Maulucci, F., Bianco, G., Shairin, S., Pihan, H.A., Salmen, S., Quinn, T., McAlpine, C., Wright, F., Kalladka, D., Taylor, E., Sohaa, J., Brown, Z., Dawson, J., Cameron, A., Muir, S., Dima, S., Khan, U., Zhang, L., Warburton, E., Chatterjee, K., Nallasivan, A., Curran, D., Haider, S., Ghani, U., Kenton, A., Dallol, B., Mirza, M., Menezes, B., Davies, R., Robinson, T.G., Manning, L., Sztriha, L., Phinney, T., Sethi, P., Altafullah, I., Sharaf, A., Ostrander, M., Renati, S., Burgin, W.S., Olds, K., Delio, P., Malek, A., Dissin, J., Khatri, P., Flaherty, M., Demel, S., and Dofitas, S.

Published
2024
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7. Washback of Spanish University Entrance Examination on Chemistry Teaching in Upper Secondary Education

Author

de la Fuente Fernández, Almudena and Calvo Pascual, M. Araceli

Abstract

The washback effect is particularly relevant when it comes to high-stakes tests, such as university entrance exams. This article presents a research study performed with the aim of determining the current influence of these exams on the teaching of chemistry in upper secondary education. The study was based on a questionnaire distributed among chemistry teachers --447 participants-- from across Spain. The results show that the chemistry content taught in upper secondary education is closer to what is requested in university entrance exams than to what teachers themselves believe to be important for students to learn. For the aspects examined, significant differences between regions were observed; in fact, relevant changes in the curriculum taught and the teaching methodology were apparent in those regions that incorporated content in their tests which was distinct from the traditional approach. Based on the findings, some implications and suggestions are drawn for future university entrance exams.

Published
2022
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12. AB1474 NINTEDANIB IN AUTOIMMUNE DISEASE-RELATED INTERSTITIAL LUNG DISEASE: REAL-LIFE EFFECTIVENESS, SAFETY AND TOLERANCE IN A SPANISH MULTICENTER STUDY

Author

Pérez-García, P., primary, Retuerto-Guerrero, M., additional, Chuquimia, Y., additional, Sierra Herránz, L., additional, Loarce-Martos, J., additional, Atienza-Mateo, B., additional, Merino Argumánez, C., additional, Pavía Pascual, M., additional, Miguel Ibáñez, B., additional, Ordas Martínez, J., additional, Baenas González, P., additional, Sieiro Santos, C., additional, Moriano, C., additional, González, I., additional, Díez, C., additional, González Fernández, I., additional, Álvarez Castro, C., additional, Gutierrez, E., additional, and Diez Álvarez, E., additional

Published
2024
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13. AB1483 NINTEDANIB IN PROGRESSIVE PULMONARY FIBROSIS. COMPARING SUBGROUPS IN CLINICAL PRACTICE. EXPERIENCE OF PULMONOLOGISTS AND RHEUMATOLOGISTS

Author

Pérez-García, P., primary, Retuerto-Guerrero, M., additional, Chuquimia, Y., additional, Sierra Herránz, L., additional, Loarce-Martos, J., additional, Atienza-Mateo, B., additional, Merino Argumánez, C., additional, Pavía Pascual, M., additional, Miguel Ibáñez, B., additional, Ordas Martínez, J., additional, Baenas González, P., additional, Sieiro Santos, C., additional, Moriano, C., additional, González, I., additional, Díez, C., additional, González Fernández, I., additional, Álvarez Castro, C., additional, Gutierrez, E., additional, and Diez Álvarez, E., additional

Published
2024
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14. AB0224 USE OF JAK INHIBITORS IN REAL CLINICAL PRACTICE: SAFETY ANALYSIS IN A THIRD LEVEL HOSPITAL

Author

González, I., primary, González Fernández, I., additional, Baenas González, P., additional, Díez, C., additional, Retuerto-Guerrero, M., additional, Moriano, C., additional, Pérez-García, P., additional, Álvarez Castro, C., additional, Sieiro Santos, C., additional, Ordas Martínez, J., additional, Vallejo Pascual, M. E., additional, and Diez Álvarez, E., additional

Published
2024
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15. AB0797 DIAGNOSTIC PROTEIN BIOMARKERS IN SJÖGREN´S SYNDROME

Author

Fernandez Castro, M., primary, Merino Argumánez, C., additional, Santos Bórnez, M. J., additional, Navarro Palomo, P., additional, Pavía Pascual, M., additional, Machattou, M., additional, Navarro Joven, C., additional, Alonso de Francisco, M., additional, Sanz, J., additional, Campos, J., additional, Godoy, H., additional, Garcia-Magallon, B., additional, Barbadillo, C., additional, Isasi Zaragoza, C., additional, Rusinovich Lovgach, O., additional, Sánchez Fernández, M. C., additional, Liso Andrino, A., additional, Andréu Sánchez, J. L., additional, and Sánchez, A., additional

Published
2024
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17. Variables associated with mortality in patients with atrial fibrillation and ischaemic heart disease in Spain

Author

Minguez De La Guia, E, primary, Vallejo Calcerrada, N, additional, Corbi Pascual, M J, additional, Bonanad Lozano, C, additional, Cepas Guillen, P, additional, Cordero Fort, A, additional, Nunez Gil, I, additional, Thiscal Lopez, M, additional, Raposeiras Roubin, S, additional, Ferreiro Gutierrez, J L, additional, Moreno, E, additional, Diez Del Hoyo, F, additional, Ayesta, A, additional, Perez Rivera, J A, additional, and Diez Villanueva, P, additional

Published
2024
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19. Acute heart failure and acute coronary syndrome: not uncommon duo and dangerous

Author

Minguez De La Guia, E, primary, Lopez Vazquez, M, additional, Vallejo Calcerrada, N, additional, Pinar Abellan, A, additional, Cebrian Lopez, S, additional, Valentin Garcia, P M, additional, Salmeron Garcia, F M, additional, Corbi Pascual, M J, additional, Calero, S, additional, Ramirez Guijarro, C, additional, Urraca Espejel, C, additional, Cordoba Soriano, J M, additional, Diaz Lancha, S, additional, Ramos Martinez, R, additional, and Exposito Calamardo, L, additional

Published
2024
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21. What if youth is not enough? Acute coronary syndrome in young patients

Author

Lopez Vazquez, M, primary, Minguez De La Guia, E, additional, Vallejo Calcerrada, N, additional, Pinar Abellan, A, additional, Cebrian Lopez, S, additional, Valentin Garcia, P, additional, Salmeron Martinez, F, additional, Corbi Pascual, M, additional, Exposito Calamardo, L, additional, Ramos Martinez, R, additional, Cubells Pastor, M, additional, Prieto Lobato, A, additional, Portero Portaz, J, additional, Jimenez Mazuecos, J, additional, and Diaz Lancha, S, additional

Published
2024
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22. Characteristics, management and prognosis of patients with coronary artery disease undergoing coronary intervention and atrial fibrillation

Author

Minguez De La Guia, E, primary, Vallejo Calcerrada, N, additional, Moreno Monterde, E, additional, Esteve Claramunt, F, additional, Cordero Fort, A, additional, Nunez Gil, I, additional, Corbi Pascual, M J, additional, Lopez Lluva, M T, additional, Diez Del Hoyo, F, additional, Diez Villanueva, P, additional, Raposeiras Roubin, S, additional, Ayesta Lopez, A, additional, Goniz Magana, J, additional, Cepas Guillen, P L, additional, and Bonanad Lozano, C, additional

Published
2024
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24. Pediatric Takotsubo cardiomyopathy: a review and insights from a national multicentric registry

Author

Vazirani Ballesteros, R, primary, Rodriguez-Gonzalez, M, additional, Castellano-Martinez, A, additional, Andres, M, additional, Uribarri, A, additional, Corbi-Pascual, M, additional, Alfonso, F, additional, Blanco-Ponce, E, additional, Lluch-Requerey, C, additional, Fernandez-Cordon, C, additional, Almendro-Delia, M, additional, Vedia Cruz, O, additional, and Nunez-Gil, I, additional

Published
2024
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25. The mediating role of neuroimaging-derived biological brain age in the association between risk factors for dementia and cognitive decline in middle-aged and older individuals without cognitive impairment: a cohort study

Author

Cumplido-Mayoral, Irene, primary, Brugulat-Serrat, Anna, additional, Sánchez-Benavides, Gonzalo, additional, González-Escalante, Armand, additional, Anastasi, Federica, additional, Milà-Alomà, Marta, additional, López-Martos, David, additional, Akinci, Muge, additional, Falcón, Carles, additional, Shekari, Mahnaz, additional, Cacciaglia, Raffaele, additional, Arenaza-Urquijo, Eider M, additional, Minguillón, Carolina, additional, Fauria, Karine, additional, Molinuevo, José Luis, additional, Suárez-Calvet, Marc, additional, Grau-Rivera, Oriol, additional, Vilaplana, Verónica, additional, Gispert, Juan Domingo, additional, AQUITE AGUILAR, R, additional, BETETA GORRITI, A, additional, BRUGULAT SERRAT, A, additional, CACCIAGLIA, R E, additional, CANALS GISPERT, L, additional, CAÑAS MARTINEZ, A, additional, DEL CAMPO MILAN, M, additional, DEULOFEU GOMEZ, C, additional, DOMINGUEZ IGLESIAS, R, additional, EMILIO, M, additional, FAURIA, K M E, additional, FERNANDEZ, A, additional, FUENTES JULIAN, S D, additional, GENIUS SERRA, P, additional, GISPERT LOPEZ, J D, additional, GONZALEZ ESCALANTE, A, additional, GRAU RIVERA, O, additional, HERNANDEZ PENAS, L, additional, HUESA RODRÍGUEZ, G, additional, HUGUET NINOU, J, additional, IGLESIAS GAMEZ, L, additional, KNEZEVIC, I, additional, MARNE ALVAREZ, P, additional, MENCHON DIAZ, T, additional, MINGUILLON GIL, C, additional, PALACIOS, E, additional, PASCUAL, M, additional, PELKMANS, W, additional, POLO BALLESTER, A, additional, PRADAS MENDEZ, S, additional, RADOI, I A, additional, RODRIGUEZ FERNANDEZ, B, additional, ROS FREIXEDES, L, additional, SALA-VILA, A, additional, SANCHEZ BENAVIDES, G A, additional, SHEKARI, M, additional, SOLSONA HARSTER, L, additional, SOTERAS PRAT, A, additional, STANKEVICIUTE, L, additional, SUAREZ CALVET, M, additional, VILANOVA JARAMILLO, M, additional, and VILOR TEJEDOR, N, additional

Published
2024
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29. Estimating risk of endometrial malignancy and other intracavitary uterine pathology in women without abnormal uterine bleeding using IETA-1 multinomial regression model: validation study

Author

Heremans, R, Wynants, L, Valentin, L, Leone, F, Pascual, M, Fruscio, R, Testa, A, Buonomo, F, Guerriero, S, Epstein, E, Bourne, T, Timmerman, D, Van den Bosch, T, Leone, FPG, Pascual, MA, Testa, AC, Heremans, R, Wynants, L, Valentin, L, Leone, F, Pascual, M, Fruscio, R, Testa, A, Buonomo, F, Guerriero, S, Epstein, E, Bourne, T, Timmerman, D, Van den Bosch, T, Leone, FPG, Pascual, MA, and Testa, AC

Abstract

Objectives: To assess the ability of the International Endometrial Tumor Analysis (IETA)-1 polynomial regression model to estimate the risk of endometrial cancer (EC) and other intracavitary uterine pathology in women without abnormal uterine bleeding. Methods: This was a retrospective study, in which we validated the IETA-1 model on the IETA-3 study cohort (n = 1745). The IETA-3 study is a prospective observational multicenter study. It includes women without vaginal bleeding who underwent a standardized transvaginal ultrasound examination in one of seven ultrasound centers between January 2011 and December 2018. The ultrasonography was performed either as part of a routine gynecological examination, during follow-up of non-endometrial pathology, in the work-up before fertility treatment or before treatment for uterine prolapse or ovarian pathology. Ultrasonographic findings were described using IETA terminology and were compared with histology, or with results of clinical and ultrasound follow-up of at least 1 year if endometrial sampling was not performed. The IETA-1 model, which was created using data from patients with abnormal uterine bleeding, predicts four histological outcomes: (1) EC or endometrial intraepithelial neoplasia (EIN); (2) endometrial polyp or intracavitary myoma; (3) proliferative or secretory endometrium, endometritis, or endometrial hyperplasia without atypia; and (4) endometrial atrophy. The predictors in the model are age, body mass index and seven ultrasound variables (visibility of the endometrium, endometrial thickness, color score, cysts in the endometrium, non-uniform echogenicity of the endometrium, presence of a bright edge, presence of a single dominant vessel). We analyzed the discriminative ability of the model (area under the receiver-operating-characteristics curve (AUC); polytomous discrimination index (PDI)) and evaluated calibration of its risk estimates (observed/expected ratio). Results: The median age of the women in the

Published
2024

30. Luminescence of Nd3+-doped LaF3 glass-ceramics enhanced with Ag nanoparticles

Author

Ministerio de Ciencia e Innovación (España), Universidad del País Vasco, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Sedano, Mercedes, Gorni, Giulio, Mather, Glenn C., Durán, Alicia, Fernández, Joaquín, Balda, Rolindes, Pascual, M. Jesús, Ministerio de Ciencia e Innovación (España), Universidad del País Vasco, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Sedano, Mercedes, Gorni, Giulio, Mather, Glenn C., Durán, Alicia, Fernández, Joaquín, Balda, Rolindes, and Pascual, M. Jesús

Abstract

Nd3+-doped, LaF3-based, transparent oxyfluoride glass-ceramics (GCs) containing Ag nanoparticles (NPs) have been prepared by a melt-quenching method. Different Ag-containing precursors were employed, with AgNO3 as the most suitable for obtaining Ag NPs segregated in the glassy matrix. Transmission electron microscopy and X-ray absorption spectroscopy determined the presence of Ag0 NPs, with higher concentrations in glass-ceramics produced in an inert atmosphere (N2). The spectral features of emission and excitation spectra, in addition to the different lifetimes of the 4 F3/2 state in the co-doped samples with Ag NPs, demonstrate the incorporation of Nd3+ ions into the LaF3 nanocrystals. The relative contribution to the emission from Nd3+ in the nanocrystals depends on the Ag concentration and atmosphere. The glass-ceramic co-doped with 0.2 wt% Ag, thermally treated in N2, exhibits the highest contribution of emissions attributable to Nd3+ ions in the crystalline phase. The crystalline fraction is similar to that of a Ag-free sample synthesized under analogous conditions. This increase of the luminescence is likely attributable to the enhancement of the local electric field in the LaF3 nanocrystals due to the presence of Ag0 NPs.

Published
2024

32. Validation of ADNEX and IOTA two‐step strategy and estimation of risk of complications during follow‐up of adnexal masses in low‐risk population.

Author

Pascual, M. A., Vancraeynest, L., Timmerman, S., Ceusters, J., Ledger, A., Graupera, B., Rodriguez, I., Valero, B., Landolfo, C., Testa, A. C., Bourne, T., Timmerman, D., Valentin, L., Van Calster, B., and Froyman, W.

Subjects
*OVARIAN tumors, *CYST rupture, *PATTERN perception, *OVARIAN cancer, *ULTRASONIC imaging
Abstract

Objectives: To evaluate the ability of the Assessment of Different NEoplasias in the adneXa (ADNEX) model and the International Ovarian Tumour Analysis (IOTA) two‐step strategy to predict malignancy in adnexal masses detected in an outpatient low‐risk setting, and to estimate the risk of complications in masses with benign ultrasound morphology managed using clinical and ultrasound follow‐up. Methods: This single‐center study was performed at Hospital Universitari Dexeus, Barcelona, Spain, using interim data from the ongoing prospective observational IOTA Phase‐5 (IOTA5) study. The primary aim of the IOTA5 study is to describe the cumulative incidence of complications during follow‐up of adnexal masses classified as benign on ultrasound examination. Consecutive patients with an adnexal mass detected between June 2012 and September 2016 in a private center offering screening for gynecological cancer were included and followed up until February 2020. Tumors were classified as benign or malignant based on histology (if patients underwent surgery) or the outcome of clinical and ultrasound follow‐up at 12 (range, 10–14) months. Multiple imputation was used when outcomes were uncertain. The ability of the ADNEX model without CA125 and of the IOTA two‐step strategy to distinguish benign from malignant masses was evaluated retrospectively using the prospectively collected data. We assessed performance with regard to discrimination (area under the receiver‐operating‐characteristics curve (AUC)), calibration, classification (sensitivity and specificity) and clinical utility (Net Benefit). In the group of patients with a mass judged to be benign who were selected for conservative management, we evaluated the occurrence of spontaneous resolution or any mass complication during the first 5 years of follow‐up by assessing the cumulative incidence of malignancy, torsion, cyst rupture and minor mass complications (inflammation, infection or adhesions) and the time to occurrence of an event. Results: A total of 2654 patients were recruited to the study. After application of exclusion criteria, 2039 patients with a newly detected mass were included for the model validation. Of those, 1684 (83%) masses were benign, 49 (2%) masses were malignant and, for 306 (15%) masses, the outcome was uncertain and therefore imputed. The AUC was 0.95 (95% CI, 0.89–0.98) for ADNEX without CA125 and 0.94 (95% CI, 0.88–0.97) for the two‐step strategy. Calibration performance could not be meaningfully interpreted because the small number of malignancies resulted in very wide confidence intervals. The two‐step strategy had better clinical utility than did the ADNEX model at malignancy risk thresholds < 3%. There were 1472 (72%) patients whose mass was judged to be benign based on pattern recognition by an experienced ultrasound examiner and were managed with clinical and ultrasound follow‐up. In this group, the 5‐year cumulative incidence was 66% (95% CI, 63–69%) for spontaneous resolution of the mass, 0% (95% CI, 0–0.2%) for torsion, 0.1% (95% CI, < 0.1–0.4%) for cyst rupture, 0.2% (95% CI, 0.1–0.6%) for a borderline tumor and 0.2% (95% CI, 0.1–0.6%) for invasive malignancy. Conclusions: The ADNEX model and IOTA two‐step strategy performed well to distinguish benign from malignant adnexal masses detected in a low‐risk population. Conservative management is safe for masses with a benign ultrasound appearance in this population. © 2024 International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Co-occurrence of the cephalosporinase cepA and carbapenemase cfiA genes in a Bacteroides fragilis division II strain, an unexpected finding.

Author

Valdezate, S, Medina-Pascual, M J, Villalón, P, Garrido, N, Monzón, S, Cuesta, I, and Cobo, F

Subjects
*BACTEROIDES fragilis, *NUCLEIC acid hybridization, *BIOLOGICAL classification, *BETA lactamases, *WHOLE genome sequencing, *P-glycoprotein
Abstract

Background Bacteroides fragilis , an anaerobic gut bacterium and opportunistic pathogen, comprises two genetically divergent groups (or divisions) at the species level. Differences exist both in the core and accessory genomes and the beta-lactamase genes, with the cephalosporinase gene cep A represented only in division I and the carbapenemase gene cfi A only in division II. Methods Multidrug resistance in a clinical B. fragilis strain was examined by whole-genome sequencing. Results Strain CNM20200260 carried the antimicrobial resistance genes cep A, cfi A2, ant (6'), erm (F), mef (En2), est (T), tet (Q) and cat (A), along with 82-Phe mutation in gyr A (together with 47 amino acid changes in gyr A/B and par C/parE). bex A/B and other efflux pump genes were also observed. None of the detected insertion sequences was located upstream of cfi A2. The genome-based taxonomy coefficients (average nucleotide identity, DNA–DNA hybridization similarity and difference in genomic G + C%) with respect to genomes of the strains of B. fragilis division II and the novel species Bacteroides hominis (both cfi A-positive) met the criteria for CNM20200260 to belong to either species (>95%, >70% and <1%, respectively). No such similarity was seen with type strain NCTC 9343 or the representative genome FDAARGOS 1225 of B. fragilis (division I, cfi A-negative). Strain CNM20200260 harboured four out of nine Kyoto Encyclopedia of Genes and Genomes orthologues defined for division I and one of two defined for division II. Conclusions This is the first description of the co-occurrence of cep A and cfi A in a Bacteroides strain, confirming the complexity of the taxonomy of this species. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Software-Defined Silicon Photonics based Metro Node for Spatial and Wavelength Superchannel Switching

Author

Vujicic, Vidak, Anthur, Aravind P., Gazman, Alexander, Browning, Colm, Pascual, M. Deseada Gutierrez, Zhu, Ziyi, Bergman, Keren, and Barry, Liam P.

Subjects
Computer Science - Networking and Internet Architecture
Abstract

Due to the growing popularity of optical superchannels and software defined networking, reconfigurable optical add-drop multiplexer (ROADM) architectures for superchannel switching have recently attracted significant attention. ROADMs based on micro electro-mechanical system (MEMS) and liquid crystal-on-silicon (LCoS) technologies are predominantly used. Motivated by requirements for low power, high-speed, small area footprint and compact switching solutions, we propose and demonstrate spatial and wavelength flexible superchannel switching using monolithically integrated silicon photonics (SiP) micro-ring resonators (MRR). We demonstrate the MRRs capabilities and potential to be used as a fundamental building block in ROADMs. Unicast and multicast switching operation of an entire superchannel is demonstrated after transmission over 50 km of standard single mode fiber. The performance of each sub-channel from the 120 Gb/s QPSK Nyquist superchannel is analyzed and degradation in error vector magnitude performance was observed for outer sub-channels due to the 3-dB bandwidth of the MRRs, which is comparable with the superchannel bandwidth. However, all sub-channels for all switching cases (unicast, multicast and bi-directional operation) exhibit performance far below the 7% FEC limit. The switching time of the SiP MRR chip is such that high capacity superchannel interconnects between users can be setup and reconfigured on the microsecond timescale.

Published
2016

39. The Latin American Giant Observatory: a successful collaboration in Latin America based on Cosmic Rays and computer science domains

Author

Asorey, H., Mayo-García, R., Núñez, L. A., Rodríguez-Pascual, M., Montero, A. J. Rubio, Suarez-Durán, M., and Torres-Niño, L. A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Computer Science - Distributed, Parallel, and Cluster Computing
Abstract

In this work the strategy of the Latin American Giant Observatory (LAGO) to build a Latin American collaboration is presented. Installing Cosmic Rays detectors settled all around the Continent, from Mexico to the Antarctica, this collaboration is forming a community that embraces both high energy physicist and computer scientists. This is so because the data that are measured must be analytical processed and due to the fact that \textit{a priori} and \textit{a posteriori} simulations representing the effects of the radiation must be performed. To perform the calculi, customized codes have been implemented by the collaboration. With regard to the huge amount of data emerging from this network of sensors and from the computational simulations performed in a diversity of computing architectures and e-infrastructures, an effort is being carried out to catalog and preserve a vast amount of data produced by the water-Cherenkov Detector network and the complete LAGO simulation workflow that characterize each site. Metadata, Permanent Identifiers and the facilities from the LAGO Data Repository are described in this work jointly with the simulation codes used. These initiatives allow researchers to produce and find data and to directly use them in a code running by means of a Science Gateway that provides access to different clusters, Grid and Cloud infrastructures worldwide., Comment: to be published in Proccedings of the 16th IEEE/ACM International Symposium on Cluster, Cloud, and Grid Computing

Published
2016
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40. The Latin American Giant Observatory: Contributions to the 34th International Cosmic Ray Conference (ICRC 2015)

Author

The LAGO Collaboration, Alvarez, W., Alvarez, C., Araujo, C., Areso, O., Arnaldi, H., Asorey, H., Audelo, M., Barros, H., Bertou, X., Bonnett, M., Calderon, R., Calderon, M., Campos-Fauth, A., Carramiñana, A., Carrasco, E., Carrera, E., Cazar, D., Cifuentes, E., Cogollo, D., Conde, R., Cotzomi, J., Dasso, S., De Castro, A., De La Torre, J., De León, R., Estupiñan, A., Galindo, A., Garcia, L., Berisso, M. Gómez, González, M., Guevara, W., Gulisano, A. M., Hernández, H., Jaimes, A., López, J., Mantilla, C., Martín, R., Martínez-Mendez, A., Martínez, O., Martins, E., Masías-Meza, J. J., Mayo-García, R., Melo, T., Mendoza, J., Miranda, P., Montes, E., Morales, E., Morales, I., Moreno, E., Murrugarra, C., Nina, C., Núñez, L. A., Núñez-Castiñeyra, A., Otiniano, L., Peña-Rodríguez, J., Perenguez, J., Pérez, H., Perez, Y., Perez, G., Pinilla-Velandia, S., Ponce, E., Quishpe, R., Quispe, F., Ramelli, M., Reyes, K., Rivera, H., Rodriguez, J., Rodríguez-Pascual, M., Romero, M., Rubio-Montero, A. J., Salazar, H., Salinas, J., Sarmiento-Cano, C., Sidelnik, I., Haro, M. Sofo, Suárez-Durán, M., Subieta, M., Tello, J., Ticona, R., Torres, I., Torres-Niño, L., Truyenque, J., Valencia-Otero, M., Vargas, S., Vásquez, N., Villasenor, L., Zamalloa, M., and Zavala, L.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The Latin American Giant Observatory (LAGO) is an extended cosmic ray observatory composed by a network of water-Cherenkov detectors spanning over different sites located at significantly different altitudes (from sea level up to more than $5000$\,m a.s.l.) and latitudes across Latin America, covering a huge range of geomagnetic rigidity cut-offs and atmospheric absorption/reaction levels. This detection network is designed to measure the temporal evolution of the radiation flux at ground level with extreme detail. The LAGO project is mainly oriented to perform basic research in three branches: high energy phenomena, space weather and atmospheric radiation at ground level. LAGO is built and operated by the LAGO Collaboration, a non-centralized collaborative union of more than 30 institutions from ten countries. These are the contributions of the LAGO Collaboration to the 34th International Cosmic Ray Conference, 30 July - 6 August 2015, The Hague, The Netherlands, Comment: 9 proceedings, the 34th International Cosmic Ray Conference, 30 July - 6 August 2015, The Hague, The Netherlands; in PoS(ICRC2015)

Published
2016

44. Estimating risk of endometrial malignancy and other intracavitary uterine pathology in women without abnormal uterine bleeding using IETA‐1 multinomial regression model: validation study.

Author

Heremans, R., Wynants, L., Valentin, L., Leone, F. P. G., Pascual, M. A., Fruscio, R., Testa, A. C., Buonomo, F., Guerriero, S., Epstein, E., Bourne, T., Timmerman, D., and Van den Bosch, T.

Subjects
UTERINE hemorrhage, REGRESSION analysis, MODEL validation, PATHOLOGY, TRANSVAGINAL ultrasonography, UTERUS
Abstract

Objectives: To assess the ability of the International Endometrial Tumor Analysis (IETA)‐1 polynomial regression model to estimate the risk of endometrial cancer (EC) and other intracavitary uterine pathology in women without abnormal uterine bleeding. Methods: This was a retrospective study, in which we validated the IETA‐1 model on the IETA‐3 study cohort (n = 1745). The IETA‐3 study is a prospective observational multicenter study. It includes women without vaginal bleeding who underwent a standardized transvaginal ultrasound examination in one of seven ultrasound centers between January 2011 and December 2018. The ultrasonography was performed either as part of a routine gynecological examination, during follow‐up of non‐endometrial pathology, in the work‐up before fertility treatment or before treatment for uterine prolapse or ovarian pathology. Ultrasonographic findings were described using IETA terminology and were compared with histology, or with results of clinical and ultrasound follow‐up of at least 1 year if endometrial sampling was not performed. The IETA‐1 model, which was created using data from patients with abnormal uterine bleeding, predicts four histological outcomes: (1) EC or endometrial intraepithelial neoplasia (EIN); (2) endometrial polyp or intracavitary myoma; (3) proliferative or secretory endometrium, endometritis, or endometrial hyperplasia without atypia; and (4) endometrial atrophy. The predictors in the model are age, body mass index and seven ultrasound variables (visibility of the endometrium, endometrial thickness, color score, cysts in the endometrium, non‐uniform echogenicity of the endometrium, presence of a bright edge, presence of a single dominant vessel). We analyzed the discriminative ability of the model (area under the receiver‐operating‐characteristics curve (AUC); polytomous discrimination index (PDI)) and evaluated calibration of its risk estimates (observed/expected ratio). Results: The median age of the women in the IETA‐3 cohort was 51 (range, 20–85) years and 51% (887/1745) of the women were postmenopausal. Histology showed EC or EIN in 29 (2%) women, endometrial polyps or intracavitary myomas in 1094 (63%), proliferative or secretory endometrium, endometritis, or hyperplasia without atypia in 144 (8%) and endometrial atrophy in 265 (15%) women. The endometrial sample had insufficient material in five (0.3%) cases. In 208 (12%) women who did not undergo endometrial sampling but were followed up for at least 1 year without clinical or ultrasound signs of endometrial malignancy, the outcome was classified as benign. The IETA‐1 model had an AUC of 0.81 (95% CI, 0.73–0.89, n = 1745) for discrimination between malignant (EC or EIN) and benign endometrium, and the observed/expected ratio for EC or EIN was 0.51 (95% CI, 0.32–0.82). The model was able to categorize the four histological outcomes with considerable accuracy: the PDI of the model was 0.68 (95% CI, 0.62–0.73) (n = 1532). The IETA‐1 model discriminated very well between endometrial atrophy and all other intracavitary uterine conditions, with an AUC of 0.96 (95% CI, 0.95–0.98). Including only patients in whom the endometrium was measurable (n = 1689), the model's AUC was 0.83 (95% CI, 0.75–0.91), compared with 0.62 (95% CI, 0.52–0.73) when using endometrial thickness alone to predict malignancy (difference in AUC, 0.21; 95% CI, 0.08–0.32). In postmenopausal women with measurable endometrial thickness (n = 848), the IETA‐1 model gave an AUC of 0.81 (95% CI, 0.71–0.91), while endometrial thickness alone gave an AUC of 0.70 (95% CI, 0.60–0.81) (difference in AUC, 0.11; 95% CI, 0.01–0.20). Conclusion: The IETA‐1 model discriminates well between benign and malignant conditions in the uterine cavity in patients without abnormal bleeding, but it overestimates the risk of malignancy. It also discriminates well between the four histological outcome categories. © 2023 International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]

Published
2024
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45. The effect of transcutaneous electrical stimulation of the submental area on the cardiorespiratory response in normal and awake subjects

Author

Alsharifi, A, Kaltsakas, G, Pengo, M, Parati, G, Serna-Pascual, M, Rafferty, G, Steier, J, Alsharifi A., Kaltsakas G., Pengo M., Parati G., Serna-Pascual M., Rafferty G., Steier J., Alsharifi, A, Kaltsakas, G, Pengo, M, Parati, G, Serna-Pascual, M, Rafferty, G, Steier, J, Alsharifi A., Kaltsakas G., Pengo M., Parati G., Serna-Pascual M., Rafferty G., and Steier J.

Abstract

Background: Electrical stimulation has recently been introduced to treat patients with Obstructive sleep apnoea There are, however, few data on the effects of transcutaneous submental electrical stimulation (TES) on the cardiovascular system. We studied the effect of TES on cardiorespiratory variables in healthy volunteers during head-down-tilt (HDT) induced baroreceptor loading. Method: Cardiorespiratory parameters (blood pressure, heart rate, respiratory rate, tidal volume, airflow/minute ventilation, oxygen saturation, and end-tidal CO2/O2 concentration) were recorded seated, supine, and during head-down-tilt (50) under normoxic, hypercapnic (FiCO2 5%) and poikilocapnic hypoxic (FiO2 12%) conditions. Blood pressure (BP) was measured non-invasively and continuously (Finapres). Gas conditions were applied in random order. All participants were studied twice on different days, once without and once with TES. Results: We studied 13 healthy subjects (age 29 (12) years, six female, body mass index (BMI) 23.23 (1.6) kg·m−2). A three-way ANOVA indicated that BP decreased significantly with TES (systolic: p = 4.93E-06, diastolic: p = 3.48E-09, mean: p = 3.88E-08). Change in gas condition (systolic: p = 0.0402, diastolic: p = 0.0033, mean: p = 0.0034) and different postures (systolic: 8.49E-08, diastolic: p = 6.91E-04, mean: p = 5.47E-05) similarly impacted on BP control. When tested for interaction, there were no significant associations between the three different factors electrical stimulation, gas condition, or posture, except for an effect on minute ventilation (gas condition/posture p = 0.0369). Conclusion: Transcutaneous electrical stimulation has a substantial impact on the blood pressure. Similarly, postural changes and variations in inspired gas impact on blood pressure control. Finally, there was an interaction between posture and inspired gases that affects minute ventilation. These observations have implications on our understanding of integrated cardiorespira

Published
2023

46. Facile, fast and green synthesis of a highly porous calcium-syringate bioMOF with intriguing triple bioactivity

Author

Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina (España), Instituto de Salud Carlos III, Consejo Superior de Investigaciones Científicas (España), Rosado, Albert [0000-0003-3222-9566], Vallcorba, Oriol [0000-0001-6499-7688], García, Luis V. 0000-0002-4179-2556], Aguilar, María Rosa [0000-0001-7395-5754], López Periago, Ana M. [0000-0002-3777-3205], Domingo Pascual, M. Concepción [0000-0002-6976-8283], Ayllón, José A. [0000-0001-7965-7424], Ramírez-Jiménez, Rosa Ana [0000-0001-7563-2553], Rosado, Albert, Vallcorba, Oriol, Vázquez Lasa, Blanca, García, Luis V., Ramírez-Jiménez, Rosa Ana, Aguilar, María Rosa, López Periago, Ana M., Domingo Pascual, M. Concepción, Ayllón, José A., Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina (España), Instituto de Salud Carlos III, Consejo Superior de Investigaciones Científicas (España), Rosado, Albert [0000-0003-3222-9566], Vallcorba, Oriol [0000-0001-6499-7688], García, Luis V. 0000-0002-4179-2556], Aguilar, María Rosa [0000-0001-7395-5754], López Periago, Ana M. [0000-0002-3777-3205], Domingo Pascual, M. Concepción [0000-0002-6976-8283], Ayllón, José A. [0000-0001-7965-7424], Ramírez-Jiménez, Rosa Ana [0000-0001-7563-2553], Rosado, Albert, Vallcorba, Oriol, Vázquez Lasa, Blanca, García, Luis V., Ramírez-Jiménez, Rosa Ana, Aguilar, María Rosa, López Periago, Ana M., Domingo Pascual, M. Concepción, and Ayllón, José A.

Abstract

A facile, fast and green strategy based on ethanol is utilized to prepare a new bioMOF, namely, CaSyr-1, with particular characteristics of full biocompatibility given by using just calcium and syringic acid, the latter being a phenolic natural product found in fruits and vegetables, permanent porosity with an outstanding surface area >1000 m2 g−1, and a micropore diameter of 1.4 nm close to mesopore values. Collectively, these data establish CaSyr-1 as one of the most porous bioMOFs reported to date, with high molecular adsorption capacity. The CaSyr-1 adsorptive behavior is revised here through the reversible adsorption of CO2 and the encapsulation of bioactive ingredients in the structure. Remarkably, CaSyr-1 enables the development of triple therapeutic entities, involving bioactive Ca2+, syringic acid and an impregnated drug.

Published
2023

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