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21 results on '"Pascual, Antonia"'

1. Haploidentical versus Cord Blood Transplantation in Pediatric AML. A Retrospective Outcome Analysis on Behalf of the Pediatric Subcommittee of GETH (Grupo Español de Trasplante Hematopoyético)

Author

Sisinni, Luisa, Monserrate, Gerardo Xavier Aguilar, Hurtado, José María Pérez, Panesso, Melissa, Molina, Blanca, Fuentes, Carolina, Fuster, José Luís, Verdu-Amoros, Jaime, Regueiro, Alexandra, Palomo, Pilar, Beléndez, Cristina, Pascual, Antonia, Badell, Isabel, Mozo, Yasmina, Bueno, David, Pérez-Martínez, Antonio, Fernández, José María, Vicent, Marta González, and de Heredia, Cristina Díaz

Published
2024
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2. Treosulfan-Based Conditioning Regimen In Pediatric Hematopoietic Stem Cell Transplantation: A Retrospective Analysis on Behalf of the Spanish Group for Hematopoietic Transplantation and Cellular Therapy (GETH-TC)

Author

Galán, Victor, Beléndez, Cristina, Echecopar, Carlos, Estival, Pablo, Sissini, Luisa, Olivas, Raquel, Bueno, David, Molina, Blanca, Fuentes, Carolina, Regueiro, Alexandra, Benítez, Isabel, Plaza, Mercedes, Margarit, Adriana, Rifón, José, Pascual, Antonia, Palomo, Pilar, Urtasun, Andrea, Fuster, José Luis, Díaz de Heredia, Cristina, Fernández Navarro, José María, González-Vicent, Marta, Ruz, Beatriz, and Pérez-Martínez, Antonio

Published
2023
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4. Trasplante de progenitores hematopoyéticos con intensidad reducida en enfermedades genéticas. Experiencia del grupo GETMON (Grupo Español de Trasplante de Médula Ósea en Niños)

Author

López-Granados, Lucía, Torrent, Montserrat, Sastre, Ana, Gonzalez-Vicent, Marta, Díaz de Heredia, Cristina, Argilés, Bienvenida, Pascual, Antonia, Pérez-Hurtado, José M., Sisinni, Luisa, Diaz, Miguel Ángel, Elorza, Izaskun, Dasí, M. Angeles, and Badell, Isabel

Published
2018
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5. Haploidentical vs. HLA-matched donor hematopoietic stem-cell transplantation for pediatric patients with acute lymphoblastic leukemia in second remission: A collaborative retrospective study of the Spanish Group for Bone Marrow Transplantation in Children (GETMON/GETH) and the Spanish Childhood Relapsed ALL Board (ReALLNet)

Author

Moreno, Celia, primary, Ramos-Elbal, Eduardo, additional, Velasco, Pablo, additional, Aguilar, Yurena, additional, Gonzáález Martínez, Berta, additional, Fuentes, Carolina, additional, Molinos, Águeda, additional, Guerra-García, Pilar, additional, Palomo, Pilar, additional, Verdu, Jaime, additional, Adán Pedroso, Rosa María, additional, Vagace, José Manuel, additional, López-Duarte, Mónica, additional, Regueiro, Alexandra, additional, Tasso, María, additional, Dapena, José Luis, additional, Salinas, José Antonio, additional, Navarro, Samuel, additional, Bautista, Francisco, additional, Lassaletta, Álvaro, additional, Lendínez, Francisco, additional, Rives, Susana, additional, Pascual, Antonia, additional, Rodríguez, Antonia, additional, Pérez-Hurtado, José María, additional, Fernández, José María, additional, Pérez-Martínez, Antonio, additional, González-Vicent, Marta, additional, Díaz de Heredia, Cristina, additional, and Fuster, José Luis, additional

Published
2023
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6. Haploidentical hematopoietic stem cell transplantation in pediatric and adolescent patients: A study of the Spanish hematopoietic stem cell transplantation group (GETH)

Author

Ochoa-Fernández, Bárbara, primary, Galán-Gómez, Víctor, additional, Mestre, Carmen, additional, González-Vicent, Marta, additional, Pascual, Antonia, additional, Alonso, Laura, additional, Regueiro, Alexandra, additional, Plaza, Mercedes, additional, Pérez Hurtado, José María, additional, Benito, Ana, additional, Fuster, José Luis, additional, Bueno, David, additional, Mozo, Yasmina, additional, Vicario, José Luis, additional, Balas, Antonio, additional, Sisinni, Luisa, additional, Díaz de Heredia, Cristina, additional, and Pérez-Martínez, Antonio, additional

Published
2022
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7. Mesenchymal Stromal Cells for Treating Steroid-Resistant Acute and Chronic Graft Versus Host Disease: A Multicenter Compassionate Use Experience

Author

Macías-Sánchez, María del Mar [0000-0002-4291-5116], Sánchez-Pernaute, Rosario [0000-0003-1144-9025], Macías-Sánchez, María del Mar, Morata-Tarifa, Cynthia, Cuende, Natividad, Cardesa-Gil, Ana, Cuesta-Casas, María Ángeles, Pascual, M. Jesús, Pascual, Antonia, Martín-Calvo, Carmen, Jurado, Manuel, Pérez-Simón, José A., Espigado, Ildefonso, Garzón López, Sebastián, Carmona Sánchez, Gloria, Mata, Rosario, Sánchez-Pernaute, Rosario, Macías-Sánchez, María del Mar [0000-0002-4291-5116], Sánchez-Pernaute, Rosario [0000-0003-1144-9025], Macías-Sánchez, María del Mar, Morata-Tarifa, Cynthia, Cuende, Natividad, Cardesa-Gil, Ana, Cuesta-Casas, María Ángeles, Pascual, M. Jesús, Pascual, Antonia, Martín-Calvo, Carmen, Jurado, Manuel, Pérez-Simón, José A., Espigado, Ildefonso, Garzón López, Sebastián, Carmona Sánchez, Gloria, Mata, Rosario, and Sánchez-Pernaute, Rosario

Abstract

Graft versus host disease (GVHD) is a severe complication after allogenic hematopoietic cell transplantation (HSCT). Several clinical trials have reported the use of mesenchymal stromal cells (MSCs) for the treatment of GVHD. In March 2008, the Andalusian Health Care System launched a compassionate use program to treat steroid-resistant GVHD with MSC. Clinical-grade MSC were obtained under GMP conditions. MSC therapy was administered intravenously in four separate doses of 1 × 106 cells/kg. Sixty-two patients, 45 males (7 children) and 17 females (2 children), received the treatment. Patients had a median age of 39 years (range: 7-66) at the time of the allogenic HSCT. The overall response was achieved in 58.7% of patients with acute (a)GVHD. Two years' survival for aGVHD responders was 51.85%. The overall response for patients with chronic (c)GVHD was 65.50% and the 2-year survival rate for responders was 70%. Age at the time of HSCT was the only predictor found to be inversely correlated with survival in aGVHD. Regarding safety, four adverse events were reported, all recovered without sequelae. Thus, analysis of this compassionate use experience shows MSC to be an effective and safe therapeutic option for treating refractory GVHD, resulting in a significant proportion of patients responding to the therapy.

Published
2022

8. Mesenchymal Stromal Cells for Treating Steroid-Resistant Acute and Chronic Graft Versus Host Disease: A Multicenter Compassionate Use Experience

Author

Macías-Sánchez, María del Mar, primary, Morata-Tarifa, Cynthia, additional, Cuende, Natividad, additional, Cardesa-Gil, Ana, additional, Cuesta-Casas, María Ángeles, additional, Pascual-Cascon, María Jesús, additional, Pascual, Antonia, additional, Martín-Calvo, Carmen, additional, Jurado, Manuel, additional, Perez-Simón, José Antonio, additional, Espigado, Ildefonso, additional, Garzón López, Sebastián, additional, Carmona Sánchez, Gloria, additional, Mata-Alcázar-Caballero, Rosario, additional, and Sánchez-Pernaute, Rosario, additional

Published
2022
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9. Measurable Residual Disease Assessed by Flow-Cytometry Is a Stable Prognostic Factor for Pediatric T-Cell Acute Lymphoblastic Leukemia in Consecutive SEHOP Protocols Whereas the Impact of Oncogenetics Depends on Treatment

Author

Vega-García, Nerea, primary, Perez-Jaume, Sara, additional, Esperanza-Cebollada, Elena, additional, Vicente-Garcés, Clara, additional, Torrebadell, Montserrat, additional, Jiménez-Velasco, Antonio, additional, Ortega, Margarita, additional, Llop, Marta, additional, Abad, Lorea, additional, Vagace, José Manuel, additional, Minguela, Alfredo, additional, Pratcorona, Marta, additional, Sánchez-Garcia, Joaquín, additional, García-Calderón, Clara B., additional, Gómez-Casares, María Teresa, additional, Martín-Clavero, Estela, additional, Escudero, Adela, additional, Riñón Martinez-Gallo, Marta, additional, Muñoz, Luz, additional, Velasco, María Rosario, additional, García-Morin, Marina, additional, Català, Albert, additional, Pascual, Antonia, additional, Velasco, Pablo, additional, Fernández, José Mª., additional, Lassaletta, Alvaro, additional, Fuster, José Luis, additional, Badell, Isabel, additional, Molinos-Quintana, Águeda, additional, Molinés, Antonio, additional, Guerra-García, Pilar, additional, Pérez-Martínez, Antonio, additional, García-Abós, Miriam, additional, Robles Ortiz, Reyes, additional, Pisa, Sandra, additional, Adán, Rosa, additional, Díaz de Heredia, Cristina, additional, Dapena, José Luis, additional, Rives, Susana, additional, Ramírez-Orellana, Manuel, additional, and Camós, Mireia, additional

Published
2021
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10. Haploidentical transplantation in pediatric non‐malignant diseases: A retrospective analysis on behalf of the Spanish Group for Hematopoietic Transplantation (GETH)

Author

Torres Canizales, Juan, primary, Ferreras, Cristina, additional, Pascual, Antonia, additional, Alonso, Laura, additional, Regueiro, Alexandra, additional, Plaza, Mercedes, additional, Pérez Hurtado, José María, additional, Benito, Ana, additional, Couselo, José M., additional, Fuster, José L., additional, Díaz‐Almirón, Mariana, additional, Bueno, David, additional, Mozo, Yasmina, additional, Gómez López, Alicia, additional, Vicario, José L., additional, Balas, Antonio, additional, Sisinni, Luisa, additional, Díaz de Heredia, Cristina, additional, and Pérez‐Martínez, Antonio, additional

Published
2020
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11. A phase II clinical trial of infusing haploidentical K562-mb-IL15-41BBL activated and expanded Natural Killer cells as consolidation therapy for pediatric acute myeloblastic leukemia

Author

a, Lara Maria G mez Garc, primary, Escudero, Adela, additional, Maestre, Carmen, additional, Soler, Jos Luis Fuster, additional, Pascual, Antonia, additional, Valero, Jos Manuel Vagace, additional, Vela, Mar a, additional, Ruz, Beatriz, additional, Zapata, Alfonso Navarro, additional, ndez, Luc a Fern, additional, ndez, Adri n Fern, additional, Leivas, Alejandra, additional, pez, Joaqu n Mart nez L, additional, Ferreras, Cristina, additional, Paz, Raquel De, additional, Blanquer, Miguel Blanquer, additional, n, V ctor Gal, additional, lez, Berta Gonz, additional, Corral, Dolores, additional, Sisinni, Luisa, additional, Mirones, Isabel, additional, Balas, Antonio, additional, Vicario, Jos Luis, additional, Valle, Paula, additional, Borobia, Alberto M, additional, and nez, Antonio P rez Mart, additional

Published
2020
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12. Haploidentical transplantation in pediatric non-malignant diseases: A retrospective analysis on behalf of the Spanish Group for Hematopoietic Transplantation (GETH)

Author

canizales, juan torres, primary, Ferreras, Cristina, additional, Pascual, Antonia, additional, Alonso, Laura, additional, Regueiro, Alexandra, additional, Plaza, Mercedes, additional, HURTADO, JOSE MARIA PEREZ, additional, Benito, Ana, additional, Couselo, Jose, additional, Soler, Jos Luis Fuster, additional, Blanquer, Miguel Blanquer, additional, n, Mariana Diaz Almir, additional, Bueno, David, additional, Mozo, Yasmina, additional, mez, Alicia G, additional, Vicario, Jos Luis, additional, Balas, Antonio, additional, Sisinni, Luisa, additional, Heredia, Cristina D az de, additional, and nez, Antonio P rez Mart, additional

Published
2020
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13. Haploidentical transplantation in high‐risk pediatric leukemia: A retrospective comparative analysis on behalf of the Spanish working Group for bone marrow transplantation in children (GETMON) and the Spanish Grupo for hematopoietic transplantation (GETH)

Author

Pérez‐Martínez, Antonio, primary, Ferreras, Cristina, additional, Pascual, Antonia, additional, Gonzalez‐Vicent, Marta, additional, Alonso, Laura, additional, Badell, Isabel, additional, Fernández Navarro, José María, additional, Regueiro, Alexandra, additional, Plaza, Mercedes, additional, Pérez Hurtado, Jose María, additional, Benito, Ana, additional, Beléndez, Cristina, additional, Couselo, José Miguel, additional, Fuster, José Luis, additional, Díaz‐Almirón, Mariana, additional, Bueno, David, additional, Mozo, Yasmina, additional, Marsal, Julia, additional, Gómez López, Alicia, additional, Sisinni, Luisa, additional, Heredia, Cristina Díaz, additional, and Díaz, Miguel Ángel, additional

Published
2019
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15. Haploidentical transplantation in pediatric non‐malignant diseases: A retrospective analysis on behalf of the Spanish Group for Hematopoietic Transplantation (GETH).

Author

Torres Canizales, Juan, Ferreras, Cristina, Pascual, Antonia, Alonso, Laura, Regueiro, Alexandra, Plaza, Mercedes, Pérez Hurtado, José María, Benito, Ana, Couselo, José M., Fuster, José L., Díaz‐Almirón, Mariana, Bueno, David, Mozo, Yasmina, Gómez López, Alicia, Vicario, José L., Balas, Antonio, Sisinni, Luisa, Díaz de Heredia, Cristina, and Pérez‐Martínez, Antonio

Subjects
STEM cell transplantation, HEMATOPOIETIC stem cell transplantation, GRAFT versus host disease, APLASTIC anemia, CHILD patients
Abstract

Objective: Describe the GETH haploidentical stem cell transplantation (haplo‐HSCT) activity in non‐malignant disease (NMDs). Methods: We retrospectively analyzed data from children with NMDs who underwent haplo‐HSCT. Results: From January 2001 to December 2016, 26 pediatric patients underwent 31 haplo‐HSCT through ex vivo T cell‐depleted (TCD) graft platforms or post‐transplantation cyclophosphamide (PT‐Cy) at 7 Spanish centers. Five cases employed unmanipulated PT‐Cy haplo‐HSCT, 16 employed highly purified CD34+ cells, and 10 employed ex vivo TCD grafts manipulated either with CD3+CD19+ depletion, TCRαβ+CD19+ selection or naive CD45RA+ T‐cell depletion. Peripheral blood stem cells were the sole source for patients following TCD haplo‐HSCT, and bone marrow was the source for one PT‐Cy haplo‐HSCT. The most common indications for transplantation were primary immunodeficiency disorders (PIDs), severe aplastic anemia, osteopetrosis, and thalassemia. The 1‐year cumulative incidence of graft failure was 27.4%. The 1‐year III‐IV acute graft‐versus‐host disease (GvHD) and 1‐year chronic GvHD rates were 34.6% and 16.7%, respectively. The 2‐year overall survival was 44.9% for PIDs, and the 2‐year graft‐versus‐host disease‐free and relapse‐free survival rate was 37.6% for the other NMDs. The transplantation‐related mortality at day 100 was 30.8%. Conclusion: Although these results are discouraging, improvements will come if procedures are centralized in centers of expertise. [ABSTRACT FROM AUTHOR]

Published
2021
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16. Trasplante de progenitores hematopoyéticos con intensidad reducida en enfermedades genéticas. Experiencia del grupo GETMON (Grupo Español de Trasplante de Médula Ósea en Niños)

Author

López-Granados, Lucía, Torrent, Montserrat, Sastre, Ana, Gonzalez-Vicent, Marta, Díaz de Heredia, Cristina, Argilés, Bienvenida, Pascual, Antonia, Pérez-Hurtado, José M., Sisinni, Luisa, Diaz, Miguel Ángel, Elorza, Izaskun, Dasí, M. Angeles, and Badell, Isabel

Abstract

El trasplante de progenitores hematopoyéticos (TPH) consiste en implantar elementos celulares capaces de generar un sistema hematopoyético nuevo y sano. El régimen de intensidad reducida (RIR) consiste en un tratamiento predominantemente inmunosupresor, para facilitar un implante progresivo con menor morbilidad. Este tipo de acondicionamiento puede también provocar mielosupresión, aunque potencialmente reversible en el tiempo.

Published
2024
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17. Haploidentical transplantation in high‐risk pediatric leukemia: A retrospective comparative analysis on behalf of the Spanish working Group for bone marrow transplantation in children (GETMON) and the Spanish Grupo for hematopoietic transplantation (GETH)

Author

Pérez‐Martínez, Antonio, Ferreras, Cristina, Pascual, Antonia, Gonzalez‐Vicent, Marta, Alonso, Laura, Badell, Isabel, Fernández Navarro, José María, Regueiro, Alexandra, Plaza, Mercedes, Pérez Hurtado, Jose María, Benito, Ana, Beléndez, Cristina, Couselo, José Miguel, Fuster, José Luis, Díaz‐Almirón, Mariana, Bueno, David, Mozo, Yasmina, Marsal, Julia, Gómez López, Alicia, and Sisinni, Luisa

Published
2020
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18. Autoimmune hemolytic anemia (AIHA) following allogeneic hematopoietic stem cell transplantation (HSCT): A retrospective analysis and a proposal of treatment on behalf of the Grupo Español De Trasplante de Medula Osea en Niños (GETMON) and the Grupo Español de Trasplante Hematopoyetico (GETH)

Author

González-Vicent, Marta, primary, Sanz, Jaime, additional, Fuster, José Luis, additional, Cid, Joan, additional, de Heredia, Cristina Díaz, additional, Morillo, Daniel, additional, Fernández, José María, additional, Pascual, Antonia, additional, Badell, Isabel, additional, Serrano, David, additional, Fox, Laura, additional, de la Serna, Javier, additional, Benito, Ana, additional, Couselo, José Miguel, additional, Molina, Blanca, additional, Díaz, Miguel Ángel, additional, and Sanz, Miguel Ángel, additional

Published
2018
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20. [Opportunistic screening for peripheral arterial disease in middle-aged hypertensive patients attended in a primary health center].

Author

Rosell Malchirant MI, Cantallops Borràs MA, Fóthy JF, Fe Pascual A, Picornell Yanes C, and Mendez Guillaumet JM

Subjects
Age Factors, Aged, Ankle Brachial Index, Cross-Sectional Studies, Female, Humans, Intermittent Claudication etiology, Male, Middle Aged, Peripheral Arterial Disease complications, Primary Health Care, Sample Size, Sex Factors, Hypertension complications, Intermittent Claudication diagnosis, Peripheral Arterial Disease diagnosis
Published
2018
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21. Pattern of expression of CXCR4 and adhesion molecules by human CD34+ cells from different sources: role in homing efficiency in NOD/SCID mice.

Author

Herrera C, Sanchez J, Torres A, Pascual A, Rueda A, and Alvarez MA

Subjects
Animals, Antigens, CD34, Blood Cells metabolism, Bone Marrow Cells metabolism, Cell Adhesion Molecules biosynthesis, Cells, Cultured metabolism, Hematopoietic Stem Cell Transplantation, Humans, Mice, Mice, Inbred NOD, Mice, SCID, Receptors, CXCR4 biosynthesis, Selection, Genetic, Specific Pathogen-Free Organisms, Spleen cytology, Transplantation, Heterologous, Cell Adhesion Molecules physiology, Chemotaxis, Leukocyte physiology, Hematopoietic Stem Cells metabolism, Receptors, CXCR4 physiology
Abstract

Background and Objectives: The role of adhesion molecules (AM) and CXCR4 in the homing of CD34+ cells to NOD/SCID marrow and spleen is not completely elucidated. In this work, we study the differences in the expression of CXCR4 and AM by human CD34+ cells from different sources and their impact on homing ability in NOD/SCID mice., Design and Methods: We used flow cytometry to analyze the expression of CXCR4 and AM ( CD49d, CD49e, CD11a, CD58, CD54, CD31, CD62L, CD43 and CD44) on fresh CD34+ cells from bone marrow (BM), mobilized peripheral blood (MPB), positively selected CD34+ cells (PS) and after expansion cultures with two cytokine combinations. Secondly, we studied the homing efficiency of CD34+ cells from each source in 75 irradiated NOD/SCID mice, and finally the pattern of expression of CXCR4 and AMs by retrieved human CD34+ cells that had efficiently homed., Results: The homing efficiency of PS CD34+ cells was significantly lower than that of BM and MPB CD34+ cells. Our results reveal that changes in the expression of CXCR4 and AM are induced by mobilization, PS and in vitro expansion. However none of these changes has definitive impact on the homing efficiency. Human CD34+ cells found in the marrow and spleen of NOD/SCID mice have the same adhesive profile as the injected cells: CXCR4, CD62L and CD11a mainly negative, and CD49d+, indicating that homing is not restricted to positive cells., Interpretation and Conclusions: We conclude that changes induced in CXCR4 and AM expression after mobilization, selection and expansion of human CD34+ cells do not cause significant differences in the homing efficiency of these cells. The lower homing efficiency of PS CD34 cells could be explained by the absence of accessory cells.

Published
2004

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