Search

Your search keyword '"Parviainen, Suvi"' showing total 122 results
Start Over Author "Parviainen, Suvi"
122 results on '"Parviainen, Suvi"'

3. Data from Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus

Author

Diaconu, Iulia, primary, Cerullo, Vincenzo, primary, Hirvinen, Mari L.M., primary, Escutenaire, Sophie, primary, Ugolini, Matteo, primary, Pesonen, Saila K., primary, Bramante, Simona, primary, Parviainen, Suvi, primary, Kanerva, Anna, primary, Loskog, Angelica S.I., primary, Eliopoulos, Aristides G., primary, Pesonen, Sari, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

4. Supplementary Figure 6 from Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus

Author

Diaconu, Iulia, primary, Cerullo, Vincenzo, primary, Hirvinen, Mari L.M., primary, Escutenaire, Sophie, primary, Ugolini, Matteo, primary, Pesonen, Saila K., primary, Bramante, Simona, primary, Parviainen, Suvi, primary, Kanerva, Anna, primary, Loskog, Angelica S.I., primary, Eliopoulos, Aristides G., primary, Pesonen, Sari, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

5. Supplementary Figure 5 from Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus

Author

Diaconu, Iulia, primary, Cerullo, Vincenzo, primary, Hirvinen, Mari L.M., primary, Escutenaire, Sophie, primary, Ugolini, Matteo, primary, Pesonen, Saila K., primary, Bramante, Simona, primary, Parviainen, Suvi, primary, Kanerva, Anna, primary, Loskog, Angelica S.I., primary, Eliopoulos, Aristides G., primary, Pesonen, Sari, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

6. Supplementary Figure 2 from Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus

Author

Diaconu, Iulia, primary, Cerullo, Vincenzo, primary, Hirvinen, Mari L.M., primary, Escutenaire, Sophie, primary, Ugolini, Matteo, primary, Pesonen, Saila K., primary, Bramante, Simona, primary, Parviainen, Suvi, primary, Kanerva, Anna, primary, Loskog, Angelica S.I., primary, Eliopoulos, Aristides G., primary, Pesonen, Sari, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

7. Supplementary Figure 1 from Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus

Author

Diaconu, Iulia, primary, Cerullo, Vincenzo, primary, Hirvinen, Mari L.M., primary, Escutenaire, Sophie, primary, Ugolini, Matteo, primary, Pesonen, Saila K., primary, Bramante, Simona, primary, Parviainen, Suvi, primary, Kanerva, Anna, primary, Loskog, Angelica S.I., primary, Eliopoulos, Aristides G., primary, Pesonen, Sari, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

8. Supplementary Figure 3 from Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus

Author

Diaconu, Iulia, primary, Cerullo, Vincenzo, primary, Hirvinen, Mari L.M., primary, Escutenaire, Sophie, primary, Ugolini, Matteo, primary, Pesonen, Saila K., primary, Bramante, Simona, primary, Parviainen, Suvi, primary, Kanerva, Anna, primary, Loskog, Angelica S.I., primary, Eliopoulos, Aristides G., primary, Pesonen, Sari, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

9. Supplementary Methods from Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus

Author

Diaconu, Iulia, primary, Cerullo, Vincenzo, primary, Hirvinen, Mari L.M., primary, Escutenaire, Sophie, primary, Ugolini, Matteo, primary, Pesonen, Saila K., primary, Bramante, Simona, primary, Parviainen, Suvi, primary, Kanerva, Anna, primary, Loskog, Angelica S.I., primary, Eliopoulos, Aristides G., primary, Pesonen, Sari, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

10. Supplementary Figure 4 from Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus

Author

Diaconu, Iulia, primary, Cerullo, Vincenzo, primary, Hirvinen, Mari L.M., primary, Escutenaire, Sophie, primary, Ugolini, Matteo, primary, Pesonen, Saila K., primary, Bramante, Simona, primary, Parviainen, Suvi, primary, Kanerva, Anna, primary, Loskog, Angelica S.I., primary, Eliopoulos, Aristides G., primary, Pesonen, Sari, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

16. Human adipocyte differentiation and composition of disease-relevant lipids are regulated by miR-221-3p

Author

Ahonen, Maria A., primary, Asghar, Muhammad Yasir, additional, Parviainen, Suvi J., additional, Liebisch, Gerhard, additional, Höring, Marcus, additional, Leidenius, Marjut, additional, Fischer-Posovszky, Pamela, additional, Wabitsch, Martin, additional, Mikkola, Tomi S., additional, Törnquist, Kid, additional, Savolainen-Peltonen, Hanna, additional, Haridas, P.A. Nidhina, additional, and Olkkonen, Vesa M., additional

Published
2020
Full Text
View/download PDF

18. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Author

Ager, Casey, Reilley, Matthew, Nicholas, Courtney, Bartkowiak, Todd, Jaiswal, Ashvin, Curran, Michael, Albershardt, Tina C., Bajaj, Anshika, Archer, Jacob F., Reeves, Rebecca S., Ngo, Lisa Y., Berglund, Peter, ter Meulen, Jan, Denis, Caroline, Ghadially, Hormas, Arnoux, Thomas, Chanuc, Fabien, Fuseri, Nicolas, Wilkinson, Robert W., Wagtmann, Nicolai, Morel, Yannis, Andre, Pascale, Atkins, Michael B., Carlino, Matteo S., Ribas, Antoni, Thompson, John A., Choueiri, Toni K., Hodi, F. Stephen, Hwu, Wen-Jen, McDermott, David F., Atkinson, Victoria, Cebon, Jonathan S., Fitzharris, Bernie, Jameson, Michael B., McNeil, Catriona, Hill, Andrew G., Mangin, Eric, Ahamadi, Malidi, van Vugt, Marianne, van Zutphen, Mariëlle, Ibrahim, Nageatte, Long, Georgina V., Gartrell, Robyn, Blake, Zoe, Simoes, Ines, Fu, Yichun, Saito, Takuro, Qian, Yingzhi, Lu, Yan, Saenger, Yvonne M., Budhu, Sadna, De Henau, Olivier, Zappasodi, Roberta, Schlunegger, Kyle, Freimark, Bruce, Hutchins, Jeff, Barker, Christopher A., Wolchok, Jedd D., Merghoub, Taha, Burova, Elena, Allbritton, Omaira, Hong, Peter, Dai, Jie, Pei, Jerry, Liu, Matt, Kantrowitz, Joel, Lai, Venus, Poueymirou, William, MacDonald, Douglas, Ioffe, Ella, Mohrs, Markus, Olson, William, Thurston, Gavin, Capasso, Cristian, Frascaro, Federica, Carpi, Sara, Tähtinen, Siri, Feola, Sara, Fusciello, Manlio, Peltonen, Karita, Martins, Beatriz, Sjöberg, Madeleine, Pesonen, Sari, Ranki, Tuuli, Kyruk, Lukasz, Ylösmäki, Erkko, Cerullo, Vincenzo, Cerignoli, Fabio, Xi, Biao, Guenther, Garret, Yu, Naichen, Muir, Lincoln, Zhao, Leyna, Abassi, Yama, Cervera-Carrascón, Víctor, Siurala, Mikko, Santos, João, Havunen, Riikka, Parviainen, Suvi, Hemminki, Akseli, Dalgleish, Angus, Mudan, Satvinder, DeBenedette, Mark, Plachco, Ana, Gamble, Alicia, Grogan, Elizabeth W., Krisko, John, Tcherepanova, Irina, Nicolette, Charles, Dhupkar, Pooja, Yu, Ling, Kleinerman, Eugenie S., Gordon, Nancy, Grenga, Italia, Lepone, Lauren, Gameiro, Sofia, Knudson, Karin M., Fantini, Massimo, Tsang, Kwong, Hodge, James, Donahue, Renee, Schlom, Jeffrey, Evans, Elizabeth, Bussler, Holm, Mallow, Crystal, Reilly, Christine, Torno, Sebold, Scrivens, Maria, Foster, Cathie, Howell, Alan, Balch, Leslie, Knapp, Alyssa, Leonard, John E., Paris, Mark, Fisher, Terry, Hu-Lieskovan, Siwen, Smith, Ernest, Zauderer, Maurice, Fogler, William, Franklin, Marilyn, Thayer, Matt, Saims, Dan, Magnani, John L., Gong, Jian, Gray, Michael, Fromm, George, de Silva, Suresh, Giffin, Louise, Xu, Xin, Rose, Jason, Schreiber, Taylor H., Gameiro, Sofia R., Clavijo, Paul E., Allen, Clint T., Hodge, James W., Tsang, Kwong Y., Grogan, Jane, Manieri, Nicholas, Chiang, Eugene, Caplazi, Patrick, Yadav, Mahesh, Hagner, Patrick, Chiu, Hsiling, Waldman, Michelle, Klippel, Anke, Thakurta, Anjan, Pourdehnad, Michael, Gandhi, Anita, Henrich, Ian, Quick, Laura, Young, Rob, Chou, Margaret, Hotson, Andrew, Willingham, Stephen, Ho, Po, Choy, Carmen, Laport, Ginna, McCaffery, Ian, Miller, Richard, Tipton, Kimberly A., Wong, Kenneth R., Singson, Victoria, Wong, Chihunt, Chan, Chanty, Huang, Yuanhiu, Liu, Shouchun, Richardson, Jennifer H., Kavanaugh, W. Michael, West, James, Irving, Bryan A., Jaini, Ritika, Loya, Matthew, Eng, Charis, Johnson, Melissa L., Adjei, Alex A., Opyrchal, Mateusz, Ramalingam, Suresh, Janne, Pasi A., Dominguez, George, Gabrilovich, Dmitry, de Leon, Laura, Hasapidis, Jeannette, Diede, Scott J., Ordentlich, Peter, Cruickshank, Scott, Meyers, Michael L., Hellmann, Matthew D., Kalinski, Pawel, Zureikat, Amer, Edwards, Robert, Muthuswamy, Ravi, Obermajer, Nataša, Urban, Julie, Butterfield, Lisa H., Gooding, William, Zeh, Herbert, Bartlett, David, Zubkova, Olga, Agapova, Larissa, Kapralova, Marina, Krasovskaia, Liudmila, Ovsepyan, Armen, Lykov, Maxim, Eremeev, Artem, Bokovanov, Vladimir, Grigoryeva, Olga, Karpov, Andrey, Ruchko, Sergey, Shuster, Alexandr, Khalil, Danny N., Campesato, Luis Felipe, Li, Yanyun, Lazorchak, Adam S., Patterson, Troy D., Ding, Yueyun, Sasikumar, Pottayil, Sudarshan, Naremaddepalli, Gowda, Nagaraj, Ramachandra, Raghuveer, Samiulla, Dodheri, Giri, Sanjeev, Eswarappa, Rajesh, Ramachandra, Murali, Tuck, David, Wyant, Timothy, Leshem, Jasmin, Liu, Xiu-fen, Bera, Tapan, Terabe, Masaki, Bossenmaier, Birgit, Niederfellner, Gerhard, Reiter, Yoram, Pastan, Ira, Xia, Leiming, Xia, Yang, Hu, Yangyang, Wang, Yi, Bao, Yangyi, Dai, Fu, Huang, Shiang, Hurt, Elaine, Hollingsworth, Robert E., Lum, Lawrence G., Chang, Alfred E., Wicha, Max S., Li, Qiao, Mace, Thomas, Makhijani, Neil, Talbert, Erin, Young, Gregory, Guttridge, Denis, Conwell, Darwin, Lesinski, Gregory B., Gonzales, Rodney JM Macedo, Huffman, Austin P., Wang, Ximi K., Reshef, Ran, MacKinnon, Andy, Chen, Jason, Gross, Matt, Marguier, Gisele, Shwonek, Peter, Sotirovska, Natalija, Steggerda, Susanne, Parlati, Francesco, Makkouk, Amani, Bennett, Mark K., Emberley, Ethan, Huang, Tony, Li, Weiqun, Neou, Silinda, Pan, Alison, Zhang, Jing, Zhang, Winter, Marshall, Netonia, Marron, Thomas U., Agudo, Judith, Brown, Brian, Brody, Joshua, McQuinn, Christopher, Farren, Matthew, Komar, Hannah, Shakya, Reena, Ludwug, Thomas, Morillon, Y. Maurice, Hammond, Scott A., Greiner, John W., Nath, Pulak R., Schwartz, Anthony L., Maric, Dragan, Roberts, David D., Naing, Aung, Papadopoulos, Kyriakos P., Autio, Karen A., Wong, Deborah J., Patel, Manish, Falchook, Gerald, Pant, Shubham, Ott, Patrick A., Whiteside, Melinda, Patnaik, Amita, Mumm, John, Janku, Filip, Chan, Ivan, Bauer, Todd, Colen, Rivka, VanVlasselaer, Peter, Brown, Gail L., Tannir, Nizar M., Oft, Martin, Infante, Jeffrey, Lipson, Evan, Gopal, Ajay, Neelapu, Sattva S., Armand, Philippe, Spurgeon, Stephen, Leonard, John P., Sanborn, Rachel E., Melero, Ignacio, Gajewski, Thomas F., Maurer, Matthew, Perna, Serena, Gutierrez, Andres A., Clynes, Raphael, Mitra, Priyam, Suryawanshi, Satyendra, Gladstone, Douglas, Callahan, Margaret K., Crooks, James, Brown, Sheila, Gauthier, Audrey, de Boisferon, Marc Hillairet, MacDonald, Andrew, Brunet, Laura Rosa, Rothwell, William T., Bell, Peter, Wilson, James M., Sato-Kaneko, Fumi, Yao, Shiyin, Zhang, Shannon S., Carson, Dennis A., Guiducci, Cristina, Coffman, Robert L., Kitaura, Kazutaka, Matsutani, Takaji, Suzuki, Ryuji, Hayashi, Tomoko, Cohen, Ezra E. W., Schaer, David, Li, Yanxia, Dobkin, Julie, Amatulli, Michael, Hall, Gerald, Doman, Thompson, Manro, Jason, Dorsey, Frank Charles, Sams, Lillian, Holmgaard, Rikke, Persaud, Krishnadatt, Ludwig, Dale, Surguladze, David, Kauh, John S., Novosiadly, Ruslan, Kalos, Michael, Driscoll, Kyla, Pandha, Hardev, Ralph, Christy, Harrington, Kevin, Curti, Brendan, Akerley, Wallace, Gupta, Sumati, Melcher, Alan, Mansfield, David, Kaufman, David R., Schmidt, Emmett, Grose, Mark, Davies, Bronwyn, Karpathy, Roberta, Shafren, Darren, Shamalov, Katerina, Cohen, Cyrille, Sharma, Naveen, Allison, James, Shekarian, Tala, Valsesia-Wittmann, Sandrine, Caux, Christophe, Marabelle, Aurelien, Slomovitz, Brian M., Moore, Kathleen M., Youssoufian, Hagop, Posner, Marshall, Tewary, Poonam, Brooks, Alan D., Xu, Ya-Ming, Wijeratne, Kithsiri, Gunatilaka, Leslie A. A., Sayers, Thomas J., Vasilakos, John P., Alston, Tesha, Dovedi, Simon, Elvecrog, James, Grigsby, Iwen, Herbst, Ronald, Johnson, Karen, Moeckly, Craig, Mullins, Stefanie, Siebenaler, Kristen, SternJohn, Julius, Tilahun, Ashenafi, Tomai, Mark A., Vogel, Katharina, Vietsch, Eveline E., Wellstein, Anton, Wythes, Martin, Crosignani, Stefano, Tumang, Joseph, Alekar, Shilpa, Bingham, Patrick, Cauwenberghs, Sandra, Chaplin, Jenny, Dalvie, Deepak, Denies, Sofie, De Maeseneire, Coraline, Feng, JunLi, Frederix, Kim, Greasley, Samantha, Guo, Jie, Hardwick, James, Kaiser, Stephen, Jessen, Katti, Kindt, Erick, Letellier, Marie-Claire, Li, Wenlin, Maegley, Karen, Marillier, Reece, Miller, Nichol, Murray, Brion, Pirson, Romain, Preillon, Julie, Rabolli, Virginie, Ray, Chad, Ryan, Kevin, Scales, Stephanie, Srirangam, Jay, Solowiej, Jim, Stewart, Al, Streiner, Nicole, Torti, Vince, Tsaparikos, Konstantinos, Zheng, Xianxian, Driessens, Gregory, Gomes, Bruno, Kraus, Manfred, Xu, Chunxiao, Zhang, Yanping, Kradjian, Giorgio, Qin, Guozhong, Qi, Jin, Xu, Xiaomei, Marelli, Bo, Yu, Huakui, Guzman, Wilson, Tighe, Rober, Salazar, Rachel, Lo, Kin-Ming, English, Jessie, Radvanyi, Laszlo, Lan, Yan, Postow, Michael, Senbabaoglu, Yasin, Gasmi, Billel, Zhong, Hong, Liu, Cailian, Hirschhorhn-Cymerman, Daniel, Zha, Yuanyuan, Malnassy, Gregory, Fulton, Noreen, Park, Jae-Hyun, Stock, Wendy, Nakamura, Yusuke, Liu, Hongtao, Ju, Xiaoming, Kosoff, Rachelle, Ramos, Kimberly, Coder, Brandon, Petit, Robert, Princiotta, Michael, Perry, Kyle, Zou, Jun, Arina, Ainhoa, Fernandez, Christian, Zheng, Wenxin, Beckett, Michael A., Mauceri, Helena J., Fu, Yang-Xin, Weichselbaum, Ralph R., Lewis, Whitney, Han, Yanyan, Wu, Yeting, Yang, Chou, Huang, Jing, Wu, Dongyun, Li, Jin, Liang, Xiaoling, Zhou, Xiangjun, Hou, Jinlin, Hassan, Raffit, Jahan, Thierry, Antonia, Scott J., Kindler, Hedy L., Alley, Evan W., Honarmand, Somayeh, Liu, Weiqun, Leong, Meredith L., Whiting, Chan C., Nair, Nitya, Enstrom, Amanda, Lemmens, Edward E., Tsujikawa, Takahiro, Kumar, Sushil, Coussens, Lisa M., Murphy, Aimee L., Brockstedt, Dirk G., Koch, Sven D., Sebastian, Martin, Weiss, Christian, Früh, Martin, Pless, Miklos, Cathomas, Richard, Hilbe, Wolfgang, Pall, Georg, Wehler, Thomas, Alt, Jürgen, Bischoff, Helge, Geissler, Michael, Griesinger, Frank, Kollmeier, Jens, Papachristofilou, Alexandros, Doener, Fatma, Fotin-Mleczek, Mariola, Hipp, Madeleine, Hong, Henoch S., Kallen, Karl-Josef, Klinkhardt, Ute, Stosnach, Claudia, Scheel, Birgit, Schroeder, Andreas, Seibel, Tobias, Gnad-Vogt, Ulrike, Zippelius, Alfred, Park, Ha-Ram, Ahn, Yong-Oon, Kim, Tae Min, Kim, Soyeon, Kim, Seulki, Lee, Yu Soo, Keam, Bhumsuk, Kim, Dong-Wan, Heo, Dae Seog, Pilon-Thomas, Shari, Weber, Amy, Morse, Jennifer, Kodumudi, Krithika, Liu, Hao, Mullinax, John, Sarnaik, Amod A., Pike, Luke, Bang, Andrew, Balboni, Tracy, Taylor, Allison, Spektor, Alexander, Wilhite, Tyler, Krishnan, Monica, Cagney, Daniel, Alexander, Brian, Aizer, Ayal, Buchbinder, Elizabeth, Awad, Mark, Ghandi, Leena, Schoenfeld, Jonathan, Lessey-Morillon, Elizabeth, Ridnour, Lisa, Segal, Neil H., Sharma, Manish, Le, Dung T., Ferris, Robert L., Zelenetz, Andrew D., Levy, Ronald, Lossos, Izidore S., Jacobson, Caron, Ramchandren, Radhakrishnan, Godwin, John, Colevas, A. Dimitrios, Meier, Roland, Krishnan, Suba, Gu, Xuemin, Neely, Jaclyn, Timmerman, John, Vanpouille-Box, Claire I., Formenti, Silvia C., Demaria, Sandra, Wennerberg, Erik, Mediero, Aranzazu, Cronstein, Bruce N., Gustafson, Michael P., DiCostanzo, AriCeli, Wheatley, Courtney, Kim, Chul-Ho, Bornschlegl, Svetlana, Gastineau, Dennis A., Johnson, Bruce D., Dietz, Allan B., MacDonald, Cameron, Bucsek, Mark, Qiao, Guanxi, Hylander, Bonnie, Repasky, Elizabeth, Turbitt, William J., Xu, Yitong, Mastro, Andrea, Rogers, Connie J., Withers, Sita, Wang, Ziming, Khuat, Lam T., Dunai, Cordelia, Blazar, Bruce R., Longo, Dan, Rebhun, Robert, Grossenbacher, Steven K., Monjazeb, Arta, Murphy, William J., Rowlinson, Scott, Agnello, Giulia, Alters, Susan, Lowe, David, Scharping, Nicole, Menk, Ashley V., Whetstone, Ryan, Zeng, Xue, Delgoffe, Greg M., Santos, Patricia M., Shi, Jian, Delgoffe, Greg, Nagasaka, Misako, Sukari, Ammar, Byrne-Steele, Miranda, Pan, Wenjing, Hou, Xiaohong, Brown, Brittany, Eisenhower, Mary, Han, Jian, Collins, Natalie, Manguso, Robert, Pope, Hans, Shrestha, Yashaswi, Boehm, Jesse, Haining, W. Nicholas, Cron, Kyle R., Sivan, Ayelet, Aquino-Michaels, Keston, Orecchioni, Marco, Bedognetti, Davide, Hendrickx, Wouter, Fuoco, Claudia, Spada, Filomena, Sgarrella, Francesco, Cesareni, Gianni, Marincola, Francesco, Kostarelos, Kostas, Bianco, Alberto, Delogu, Lucia, Roelands, Jessica, Boughorbel, Sabri, Decock, Julie, Presnell, Scott, Wang, Ena, Marincola, Franco M., Kuppen, Peter, Ceccarelli, Michele, Rinchai, Darawan, Chaussabel, Damien, Miller, Lance, Nguyen, Andrew, Sanborn, J. Zachary, Vaske, Charles, Rabizadeh, Shahrooz, Niazi, Kayvan, Benz, Steven, Patel, Shashank, Restifo, Nicholas, White, James, Angiuoli, Sam, Sausen, Mark, Jones, Sian, Sevdali, Maria, Simmons, John, Velculescu, Victor, Diaz, Luis, Zhang, Theresa, Sims, Jennifer S., Barton, Sunjay M., Kadenhe-Chiweshe, Angela, Dela Cruz, Filemon, Turk, Andrew T., Mazzeo, Christopher F., Kung, Andrew L., Bruce, Jeffrey N., Yamashiro, Darrell J., Connolly, Eileen P., Baird, Jason, Crittenden, Marka, Friedman, David, Xiao, Hong, Leidner, Rom, Bell, Bryan, Young, Kristina, Gough, Michael, Bian, Zhen, Kidder, Koby, Liu, Yuan, Curran, Emily, Chen, Xiufen, Corrales, Leticia P., Kline, Justin, Aguilar, Ethan G., Guerriero, Jennifer, Sotayo, Alaba, Ponichtera, Holly, Pourzia, Alexandra, Schad, Sara, Carrasco, Ruben, Lazo, Suzan, Bronson, Roderick, Letai, Anthony, Kornbluth, Richard S., Gupta, Sachin, Termini, James, Guirado, Elizabeth, Stone, Geoffrey W., Meyer, Christina, Helming, Laura, Wilson, Nicholas, Hofmeister, Robert, Neubert, Natalie J., Tillé, Laure, Barras, David, Soneson, Charlotte, Baumgaertner, Petra, Rimoldi, Donata, Gfeller, David, Delorenzi, Mauro, Fuertes Marraco, Silvia A., Speiser, Daniel E., Abraham, Tara S., Xiang, Bo, Magee, Michael S., Waldman, Scott A., Snook, Adam E., Blogowski, Wojciech, Zuba-Surma, Ewa, Budkowska, Marta, Salata, Daria, Dolegowska, Barbara, Starzynska, Teresa, Chan, Leo, Somanchi, Srinivas, McCulley, Kelsey, Lee, Dean, Buettner, Nico, Shi, Feng, Myers, Paisley T., Curbishley, Stuart, Penny, Sarah A., Steadman, Lora, Millar, David, Speers, Ellen, Ruth, Nicola, Wong, Gabriel, Thimme, Robert, Adams, David, Cobbold, Mark, Thomas, Remy, Al-Muftah, Mariam, Wong, Michael KK, Morse, Michael, Clark, Joseph I., Kaufman, Howard L., Daniels, Gregory A., Hua, Hong, Rao, Tharak, Dutcher, Janice P., Kang, Kai, Saunthararajah, Yogen, Velcheti, Vamsidhar, Kumar, Vikas, Anwar, Firoz, Verma, Amita, Chheda, Zinal, Kohanbash, Gary, Sidney, John, Okada, Kaori, Shrivastav, Shruti, Carrera, Diego A., Liu, Shuming, Jahan, Naznin, Mueller, Sabine, Pollack, Ian F., Carcaboso, Angel M., Sette, Alessandro, Hou, Yafei, Okada, Hideho, Field, Jessica J., Zeng, Weiping, Shih, Vincent FS, Law, Che-Leung, Senter, Peter D., Gardai, Shyra J., Okeley, Nicole M., Abelin, Jennifer G., Saeed, Abu Z., Malaker, Stacy A., Shabanowitz, Jeffrey, Ward, Stephen T., Hunt, Donald F., Profusek, Pam, Wood, Laura, Shepard, Dale, Grivas, Petros, Kapp, Kerstin, Volz, Barbara, Oswald, Detlef, Wittig, Burghardt, Schmidt, Manuel, Sefrin, Julian P., Hillringhaus, Lars, Lifke, Valeria, Lifke, Alexander, Skaletskaya, Anna, Ponte, Jose, Chittenden, Thomas, Setiady, Yulius, Sivado, Eva, Thomas, Vincent, El Alaoui, Meddy, Papot, Sébastien, Dumontet, Charles, Dyson, Mike, McCafferty, John, El Alaoui, Said, Bommareddy, Praveen K., Zloza, Andrew, Kohlhapp, Frederick, Silk, Ann W., Jhawar, Sachin, Paneque, Tomas, Newman, Jenna, Beltran, Pedro, Cao, Felicia, Hong, Bang-Xing, Rodriguez-Cruz, Tania, Song, Xiao-Tong, Gottschalk, Stephen, Calderon, Hugo, Illingworth, Sam, Brown, Alice, Fisher, Kerry, Seymour, Len, Champion, Brian, Eriksson, Emma, Wenthe, Jessica, Hellström, Ann-Charlotte, Paul-Wetterberg, Gabriella, Loskog, Angelica, Milenova, Ioanna, Ståhle, Magnus, Jarblad-Leja, Justyna, Ullenhag, Gustav, Dimberg, Anna, Moreno, Rafael, Alemany, Ramon, Goyal, Sharad, Silk, Ann, Mehnert, Janice, Gabrail, Nashat, Bryan, Jennifer, Medina, Daniel, Mitchell, Leah, Yagiz, Kader, Lopez, Fernando, Mendoza, Daniel, Munday, Anthony, Gruber, Harry, Jolly, Douglas, Fuhrmann, Steven, Radoja, Sasa, Tan, Wei, Pourchet, Aldo, Frey, Alan, Mohr, Ian, Mulvey, Matthew, Andtbacka, Robert H. I., Ross, Merrick, Agarwala, Sanjiv, Grossmann, Kenneth, Taylor, Matthew, Vetto, John, Neves, Rogerio, Daud, Adil, Khong, Hung, Meek, Stephanie M., Ungerleider, Richard, Welden, Scott, Tanaka, Maki, Williams, Matthew, Hallmeyer, Sigrun, Fox, Bernard, Feng, Zipei, Paustian, Christopher, Bifulco, Carlo, Zafar, Sadia, Hemminki, Otto, Bramante, Simona, Vassilev, Lotta, Wang, Hongjie, Lieber, Andre, Hemmi, Silvio, de Gruijl, Tanja, Kanerva, Anna, Ansari, Tameem, Sundararaman, Srividya, Roen, Diana, Lehmann, Paul, Bloom, Anja C., Bender, Lewis H., Walters, Ian B., Berzofsky, Jay A., Chapelin, Fanny, Ahrens, Eric T., DeFalco, Jeff, Harbell, Michael, Manning-Bog, Amy, Scholz, Alexander, Zhang, Danhui, Baia, Gilson, Tan, Yann Chong, Sokolove, Jeremy, Kim, Dongkyoon, Williamson, Kevin, Chen, Xiaomu, Colrain, Jillian, Santo, Gregg Espiritu, Nguyen, Ngan, Volkmuth, Wayne, Greenberg, Norman, Robinson, William, Emerling, Daniel, Drake, Charles G., Petrylak, Daniel P., Antonarakis, Emmanuel S., Kibel, Adam S., Chang, Nancy N., Vu, Tuyen, Campogan, Dwayne, Haynes, Heather, Trager, James B., Sheikh, Nadeem A., Quinn, David I., Kirk, Peter, Addepalli, Murali, Chang, Thomas, Zhang, Ping, Konakova, Marina, Hagihara, Katsunobu, Pai, Steven, VanderVeen, Laurie, Obalapur, Palakshi, Kuo, Peiwen, Quach, Phi, Fong, Lawrence, Charych, Deborah H., Zalevsky, Jonathan, Langowski, John L., Kirksey, Yolanda, Nutakki, Ravi, Kolarkar, Shalini, Pena, Rhoneil, Hoch, Ute, Doberstein, Stephen K., Cha, John, Mallon, Zach, Perez, Myra, McDaniel, Amanda, Anand, Snjezana, Uecker, Darrin, Nuccitelli, Richard, Wieckowski, Eva, Muthuswamy, Ravikumar, Ravindranathan, Roshni, Renrick, Ariana N., Thounaojam, Menaka, Thomas, Portia, Pellom, Samuel, Shanker, Anil, Dudimah, Duafalia, Brooks, Alan, Su, Yu-Lin, Adamus, Tomasz, Zhang, Qifang, Nechaev, Sergey, Kortylewski, Marcin, Wei, Spencer, Anderson, Clark, Tang, Chad, Schoenhals, Jonathan, Tsouko, Efrosini, Heymach, John, de Groot, Patricia, Chang, Joe, Hess, Kenneth R., Diab, Adi, Sharma, Padmanee, Hong, David, Welsh, James, Parsons, Andrea J., Leleux, Jardin, Ascarateil, Stephane, Koziol, Marie Eve, Bai, Dina, Dai, Peihong, Wang, Weiyi, Yang, Ning, Shuman, Stewart, Deng, Liang, Dillon, Patrick, Petroni, Gina, Brenin, David, Bullock, Kim, Olson, Walter, Smolkin, Mark E., Smith, Kelly, Nail, Carmel, Slingluff, Craig L., Sharma, Meenu, Fa’ak, Faisal, Janssen, Louise, Khong, Hiep, Xiao, Zhilan, Hailemichael, Yared, Singh, Manisha, Vianden, Christina, Overwijk, Willem W., Facciabene, Andrea, Stefano, Pierini, Chongyung, Fang, Rafail, Stavros, Nielsen, Michael, Vanderslice, Peter, Woodside, Darren G., Market, Robert V., Biediger, Ronald J., Marathi, Upendra K., Hollevoet, Kevin, Geukens, Nick, Declerck, Paul, Joly, Nathalie, McIntosh, Laura, Paramithiotis, Eustache, Rizell, Magnus, Sternby, Malin, Andersson, Bengt, Karlsson-Parra, Alex, Kuai, Rui, Ochyl, Lukasz, Schwendeman, Anna, Moon, James, Deng, Weiwen, Hudson, Thomas E., Hanson, Bill, Rae, Chris S., Burrill, Joel, Skoble, Justin, Katibah, George, deVries, Michele, Lauer, Peter, Dubensky, Thomas W., Chen, Xin, Zhou, Li, Ren, Xiubao, Aggarwal, Charu, Mangrolia, Drishty, Cohen, Roger, Weinstein, Gregory, Morrow, Matthew, Bauml, Joshua, Kraynyak, Kim, Boyer, Jean, Yan, Jian, Lee, Jessica, Humeau, Laurent, Oyola, Sandra, Duff, Susan, Weiner, David, Yang, Zane, Bagarazzi, Mark, McNeel, Douglas G., Eickhoff, Jens, Jeraj, Robert, Staab, Mary Jane, Straus, Jane, Rekoske, Brian, Liu, Glenn, Melssen, Marit, Grosh, William, Varhegyi, Nikole, Galeassi, Nadejda, Deacon, Donna H., Gaughan, Elizabeth, Ghisoli, Maurizio, Barve, Minal, Mennel, Robert, Wallraven, Gladice, Manning, Luisa, Senzer, Neil, Nemunaitis, John, Ogasawara, Masahiro, Ota, Shuichi, Peace, Kaitlin M., Hale, Diane F., Vreeland, Timothy J., Jackson, Doreen O., Berry, John S., Trappey, Alfred F., Herbert, Garth S., Clifton, Guy T., Hardin, Mark O., Toms, Anne, Qiao, Na, Litton, Jennifer, Peoples, George E., Mittendorf, Elizabeth A., Ghamsari, Lila, Flano, Emilio, Jacques, Judy, Liu, Biao, Havel, Jonathan, Makarov, Vladimir, Chan, Timothy A., Flechtner, Jessica B., Facciponte, John, Ugel, Stefano, De Sanctis, Francesco, Coukos, George, Paris, Sébastien, Pottier, Agnes, Levy, Laurent, Lu, Bo, Cappuccini, Federica, Pollock, Emily, Bryant, Richard, Hamdy, Freddie, Hill, Adrian, Redchenko, Irina, Sultan, Hussein, Kumai, Takumi, Fesenkova, Valentyna, Celis, Esteban, Fernando, Ingrid, Palena, Claudia, David, Justin M., Gabitzsch, Elizabeth, Jones, Frank, Gulley, James L., Herranz, Mireia Uribe, Wada, Hiroshi, Shimizu, Atsushi, Osada, Toshihiro, Fukaya, Satoshi, Sasaki, Eiji, Abolhalaj, Milad, Askmyr, David, Lundberg, Kristina, Albrekt, Ann-Sofie, Greiff, Lennart, Lindstedt, Malin, Flies, Dallas B., Higuchi, Tomoe, Ornatowski, Wojciech, Harris, Jaryse, Adams, Sarah F., Aguilera, Todd, Rafat, Marjan, Castellini, Laura, Shehade, Hussein, Kariolis, Mihalis, Jang, Dadi, vonEbyen, Rie, Graves, Edward, Ellies, Lesley, Rankin, Erinn, Koong, Albert, Giaccia, Amato, Ajina, Reham, Wang, Shangzi, Smith, Jill, Pierobon, Mariaelena, Jablonski, Sandra, Petricoin, Emanuel, Weiner, Louis M., Sherry, Lorcan, Waller, John, Anderson, Mark, Bigley, Alison, Bernatchez, Chantale, Haymaker, Cara, Kluger, Harriet, Tetzlaff, Michael, Jackson, Natalie, Gergel, Ivan, Tagliaferri, Mary, Hwu, Patrick, Snzol, Mario, Hurwitz, Michael, Barberi, Theresa, Martin, Allison, Suresh, Rahul, Barakat, David, Harris-Bookman, Sarah, Drake, Charles, Friedman, Alan, Berkey, Sara, Downs-Canner, Stephanie, Edwards, Robert P., Curiel, Tyler, Odunsi, Kunle, Bruno, Tullia C., Moore, Brandon, Squalls, Olivia, Ebner, Peggy, Waugh, Katherine, Mitchell, John, Franklin, Wilbur, Merrick, Daniel, McCarter, Martin, Palmer, Brent, Kern, Jeffrey, Vignali, Dario, Slansky, Jill, Chan, Anissa S. H., Qiu, Xiaohong, Fraser, Kathryn, Jonas, Adria, Ottoson, Nadine, Gordon, Keith, Kangas, Takashi O., Leonardo, Steven, Ertelt, Kathleen, Walsh, Richard, Uhlik, Mark, Graff, Jeremy, Bose, Nandita, Gupta, Ravi, Mandloi, Nitin, Paul, Kiran, Patil, Ashwini, Sathian, Rekha, Mohan, Aparna, Manoharan, Malini, Chaudhuri, Amitabha, Chen, Yu, Lin, Jing, Ye, Yun-bin, Xu, Chun-wei, Chen, Gang, Guo, Zeng-qing, Komarov, Andrey, Chenchik, Alex, Makhanov, Michael, Frangou, Costa, Zheng, Yi, Coltharp, Carla, Unfricht, Darryn, Dilworth, Ryan, Fridman, Leticia, Liu, Linying, Rajopadhye, Milind, Miller, Peter, Concha-Benavente, Fernando, Bauman, Julie, Trivedi, Sumita, Srivastava, Raghvendra, Ohr, James, Heron, Dwight, Duvvuri, Uma, Kim, Seungwon, Torrey, Heather, Mera, Toshi, Okubo, Yoshiaki, Vanamee, Eva, Foster, Rosemary, Faustman, Denise, Stack, Edward, Izaki, Daisuke, Beck, Kristen, Jia, Dan Tong, Armenta, Paul, White-Stern, Ashley, Marks, Douglas, Taback, Bret, Horst, Basil, Glickman, Laura Hix, Kanne, David B., Gauthier, Kelsey S., Desbien, Anthony L., Francica, Brian, Leong, Justin L., Sung, Leonard, Metchette, Ken, Kasibhatla, Shailaja, Pferdekamper, Anne Marie, Zheng, Lianxing, Cho, Charles, Feng, Yan, McKenna, Jeffery M., Tallarico, John, Bender, Steven, Ndubaku, Chudi, McWhirter, Sarah M., Gugel, Elena Gonzalez, Bell, Charles J. M., Munk, Adiel, Muniz, Luciana, Bhardwaj, Nina, Zhao, Fei, Evans, Kathy, Xiao, Christine, Holtzhausen, Alisha, Hanks, Brent A., Scholler, Nathalie, Yin, Catherine, Van der Meijs, Pien, Prantner, Andrew M., Krejsa, Cecile M., Smith, Leia, Johnson, Brian, Branstetter, Daniel, Stein, Paul L., Jaen, Juan C., Tan, Joanne BL, Chen, Ada, Park, Timothy, Powers, Jay P., Sexton, Holly, Xu, Guifen, Young, Steve W., Schindler, Ulrike, Deng, Wentao, Klinke, David John, Komar, Hannah M., Serpa, Gregory, Elnaggar, Omar, Hart, Philip, Schmidt, Carl, Dillhoff, Mary, Jin, Ming, Ostrowski, Michael C., Koti, Madhuri, Au, Katrina, Peterson, Nichole, Truesdell, Peter, Reid-Schachter, Gillian, Graham, Charles, Craig, Andrew, Francis, Julie-Ann, Kotlan, Beatrix, Balatoni, Timea, Farkas, Emil, Toth, Laszlo, Ujhelyi, Mihaly, Savolt, Akos, Doleschall, Zoltan, Horvath, Szabolcs, Eles, Klara, Olasz, Judit, Csuka, Orsolya, Kasler, Miklos, Liszkay, Gabriella, Barnea, Eytan, Blakely, Collin, Flynn, Patrick, Goodman, Reid, Bueno, Raphael, Sugarbaker, David, Jablons, David, Broaddus, V. Courtney, West, Brian, Kunk, Paul R., Obeid, Joseph M., Winters, Kevin, Pramoonjago, Patcharin, Stelow, Edward B., Bauer, Todd W., Rahma, Osama E., Lamble, Adam, Kosaka, Yoko, Huang, Fei, Saser, Kate A., Adams, Homer, Tognon, Christina E., Laderas, Ted, McWeeney, Shannon, Loriaux, Marc, Tyner, Jeffery W., Druker, Brian J., Lind, Evan F., Liu, Zhuqing, Lu, Shanhong, Kane, Lawrence P., Shayan, Gulidanna, Femel, Julia, Lane, Ryan, Booth, Jamie, Lund, Amanda W., Rodriguez, Anthony, Engelhard, Victor H., Metelli, Alessandra, Wu, Bill X., Fugle, Caroline W., Saleh, Rachidi, Sun, Shaoli, Wu, Jennifer, Liu, Bei, Li, Zihai, Morris, Zachary S., Guy, Emily I., Heinze, Clinton, Kler, Jasdeep, Gressett, Monica M., Werner, Lauryn R., Gillies, Stephen D., Korman, Alan J., Loibner, Hans, Hank, Jacquelyn A., Rakhmilevich, Alexander L., Harari, Paul M., Sondel, Paul M., Huelsmann, Erica, Broucek, Joseph, Brech, Dorothee, Straub, Tobias, Irmler, Martin, Beckers, Johannes, Buettner, Florian, Schaeffeler, Elke, Schwab, Matthias, Noessner, Elfriede, Wolfreys, Alison, Da Costa, Andre, Silva, John, Crosby, Andrea, Staelens, Ludovicus, Craggs, Graham, Cauvin, Annick, Mason, Sean, Paterson, Alison M., Lake, Andrew C., Armet, Caroline M., O’Connor, Rachel W., Hill, Jonathan A., Normant, Emmanuel, Adam, Ammar, Biniszkiewicz, Detlev M., Chappel, Scott C., Palombella, Vito J., Holland, Pamela M., Becker, Annette, Leleti, Manmohan R., Newcomb, Eric, Tan, Joanne B. L., Rapisuwon, Suthee, Radfar, Arash, Gardner, Kellie, Gibney, Geoffrey, Atkins, Michael, Rennier, Keith R., Crowder, Robert, Wang, Ping, Pachynski, Russell K., Carrero, Rosa M. Santana, Rivas, Sarai, Beceren-Braun, Figen, Anthony, Scott, Schluns, Kimberly S., Sawant, Deepali, Chikina, Maria, Yano, Hiroshi, Workman, Creg, Salerno, Elise, Mauldin, Ileana, Deacon, Donna, Shea, Sofia, Pinczewski, Joel, Gajewski, Thomas, Spranger, Stefani, Horton, Brendan, Suzuki, Akiko, Leland, Pamela, Joshi, Bharat H., Puri, Raj K., Sweis, Randy F., Bao, Riyue, Luke, Jason, Theodoraki, Marie-Nicole, Mogundo, Frances-Mary, Won, Haejung, Moreira, Dayson, Gao, Chan, Zhao, Xingli, Duttagupta, Priyanka, Jones, Jeremy, D’Apuzzo, Massimo, and Pal, Sumanta

Subjects
Meeting Abstracts
Published
2016

19. Intravenously usable fully serotype 3 oncolytic adenovirus coding for CD40L as an enabler of dendritic cell therapy

Author

Zafar, Sadia, primary, Parviainen, Suvi, additional, Siurala, Mikko, additional, Hemminki, Otto, additional, Havunen, Riikka, additional, Tähtinen, Siri, additional, Bramante, Simona, additional, Vassilev, Lotta, additional, Wang, Hongjie, additional, Lieber, Andre, additional, Hemmi, Silvio, additional, de Gruijl, Tanja, additional, Kanerva, Anna, additional, and Hemminki, Akseli, additional

Published
2017
Full Text
View/download PDF

20. Developing genetically engineered oncolytic viruses for cancer gene therapy

Author

Parviainen, Suvi, University of Helsinki, Faculty of Medicine, Haartman Institute, Medicum, Helsingin yliopisto, lääketieteellinen tiedekunta, kliinisteoreettinen laitos, Helsingfors universitet, medicinska fakulteten, Haartman institutet, Essand, Magnus, and Hemminki, Akseli

Subjects
biolääketiede
Abstract

It has been estimated that up to half of people living in industrial societies will get cancer. Almost all cancer deaths are caused by metastatic disease and only few metastatic solid tumors can be cured with available therapies. Therefore, novel therapeutic modalities are needed. Genetically engineered oncolytic viruses such as adenoviruses and vaccinia viruses are a promising therapeutic approach given their capacity to specifically replicate in and kill tumor cells as well as to reach distant metastasis. Oncolytic viruses have demonstrated good safety, tolerability and promising signs of anti-tumor efficacy in several clinical trials, but the efficacy of the therapy needs improvement to reach its full clinical potential. Adenoviruses are one of the most studied vectors in oncolytic virotherapy. Two major obstacles limiting the efficacy have been insufficient transduction of the tumor cells and the recognition of the virus by the immune system, which rapidly clears the virus from systemic circulation, hampering the overall efficacy. This study shows that novel capsid modifications can increase the transduction efficacy and oncolytic potency of the virus, and that embedding oncolytic virus in a silica implant might help to circumvent the problem of clearance by prompting only modest immune responses against the virus. Recently, arming oncolytic viruses with immunomodulatory molecules has been a major focus in virotherapy. Immunotherapy means inducing the patient´s immune system to recognize and attack the tumor and has been recently linked with oncolytic virotherapy, as the replication of the virus in the tumor can be immunogenic per se and also release cancer epitopes available for antigen-presenting cells. Host immune responses have been shown to be a key player in oncolytic virotherapy as the balance between anti-viral and anti-tumoral immunity determines the efficacy of the therapy. Oncolytic vaccinia virus possesses unique immunogenicity and mechanisms of action that are distinct from other treatment modalities, and its self-perpetuating nature provides an ideal platform for therapeutic transgenic insertion. Therefore we engineered novel oncolytic vaccinia viruses with granulocyte-macrophage colony-stimulating factor (GMCSF) or CD40-ligand and studied their ability to increase the therapeutical outcome and anti-tumor immune responses in preclinical animal models. In the final part of the thesis the life cycle of oncolytic vaccinia virus was studied in more detail as we were able to show that the life cycle was compromised in a feline squamous cell carcinoma cell line. This finding might be important for a deeper understanding of the vaccinia virus-host cell interactions. Syöpäsairaudet ovat vakava maailmanlaajuinen ongelma, johon sairastuu elämänsä aikana arviolta joka toinen mies ja joka kolmas nainen. Vaikka syövän diagnostiikka, ennaltaehkäisy ja nykyiset hoitomuodot ovat parantuneet huomattavasti, erityisesti eräpesäkkeitä muodostavissa syöpäsairauksissa on ennuste usein huono ja parantavaa hoitoa ei ole. Tämän väitöskirjatutkimuksen tavoitteena oli kehittää onkolyyttisiin vaccinia- ja adenoviruksiin perustuvia syöpähoitoja. Viruksia on usein muokattu siten, että ne kopioituvat ensisijaisesti syöpäsoluissa rikkoen syöpäsoluja oman elinkiertonsa päätteeksi. Väitöskirjatyössäni tutkittiin mahdollisuuksia muokata viruksen syöpäsoluun tarttuvaa reseptoria eri tavoin, ja muokkausten huomattiinkin tehostavan viruksen siirtymistä syöpäsolun sisälle huomattavasti. Tutkimme myös mahdollisuutta annostella virus osana elimistössä hajoavaa silika-implanttia, jonka huomattiinkin vapauttavan virusta verenkiertoon hitaammin ja vähentävän siten myös neutralisoivien vasta-aineiden muodostumista. Immunologisten tekijöiden on osoitettu olevat tärkeitä onkolyyttisten virusten tehokkuuden määräytymisessä. Viruksen lisääntyminen kasvaimissa voimistaa immuunivastetta lisäämällä sytokiinien tuotantoa ja vapauttamalla kasvimen antigeenejä immuunijärjestelmän tunnistettavaksi. Viruksia voidaan käyttää vektoreina kuljettaen hoidon kannalta oleellisia geenejä soluihin, joten niiden varustaminen terapeuttisilla siirtogeeneillä saattaa parantaa viruksen kasvaimelle haitallista vaikutusta, säilyttäen kuitenkin turvallisuutensa syöpäkudokseen rajoitetun lisääntymisensä myötä. Väitöskirjatyössäni tutkittiin mahdollisuutta muokata viruksia tuottamaan kahta erilaista immuunijärjestelmää aktivoivaa proteiinia; granulosyytti-makrofagikasvutekijää (GMCSF) sekä CD40-ligandia. Hoitojen toimivuutta testattiin ensin syöpäsoluissa in vitro ja hyviksi havaitut mallit testattiin eläinkokeiden avulla käyttämällä eläinmalleina hiiriä ja hamstereita. Eläinkokeiden tavoitteena oli tutkia miten hoidot toimivat elävässä elimistössä: miten eläimen immuunijärjestelmä vaikuttaa hoitojen tehoon, miten verenkiertoon annostellut hoidot kulkeutuvat elimistössä, miten hoidot tehoavat ja onko niillä sivuvaikutuksia. Sekä GMCSF sekä CD40l aseistetun onkolyyttisen virukens huomatiin herättävän immuunivasteen syöpäsoluissa ja johtavan kasvainten pienenemiseen. Väitöskirjatyön tulokset tuovat kliinisesti merkittävää tietoa teholtaan parannettujen onkolyyttisten virusten kehitystyöhön.

Published
2015

23. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Author

Ager, Casey, primary, Reilley, Matthew, additional, Nicholas, Courtney, additional, Bartkowiak, Todd, additional, Jaiswal, Ashvin, additional, Curran, Michael, additional, Albershardt, Tina C., additional, Bajaj, Anshika, additional, Archer, Jacob F., additional, Reeves, Rebecca S., additional, Ngo, Lisa Y., additional, Berglund, Peter, additional, ter Meulen, Jan, additional, Denis, Caroline, additional, Ghadially, Hormas, additional, Arnoux, Thomas, additional, Chanuc, Fabien, additional, Fuseri, Nicolas, additional, Wilkinson, Robert W., additional, Wagtmann, Nicolai, additional, Morel, Yannis, additional, Andre, Pascale, additional, Atkins, Michael B., additional, Carlino, Matteo S., additional, Ribas, Antoni, additional, Thompson, John A., additional, Choueiri, Toni K., additional, Hodi, F. Stephen, additional, Hwu, Wen-Jen, additional, McDermott, David F., additional, Atkinson, Victoria, additional, Cebon, Jonathan S., additional, Fitzharris, Bernie, additional, Jameson, Michael B., additional, McNeil, Catriona, additional, Hill, Andrew G., additional, Mangin, Eric, additional, Ahamadi, Malidi, additional, van Vugt, Marianne, additional, van Zutphen, Mariëlle, additional, Ibrahim, Nageatte, additional, Long, Georgina V., additional, Gartrell, Robyn, additional, Blake, Zoe, additional, Simoes, Ines, additional, Fu, Yichun, additional, Saito, Takuro, additional, Qian, Yingzhi, additional, Lu, Yan, additional, Saenger, Yvonne M., additional, Budhu, Sadna, additional, De Henau, Olivier, additional, Zappasodi, Roberta, additional, Schlunegger, Kyle, additional, Freimark, Bruce, additional, Hutchins, Jeff, additional, Barker, Christopher A., additional, Wolchok, Jedd D., additional, Merghoub, Taha, additional, Burova, Elena, additional, Allbritton, Omaira, additional, Hong, Peter, additional, Dai, Jie, additional, Pei, Jerry, additional, Liu, Matt, additional, Kantrowitz, Joel, additional, Lai, Venus, additional, Poueymirou, William, additional, MacDonald, Douglas, additional, Ioffe, Ella, additional, Mohrs, Markus, additional, Olson, William, additional, Thurston, Gavin, additional, Capasso, Cristian, additional, Frascaro, Federica, additional, Carpi, Sara, additional, Tähtinen, Siri, additional, Feola, Sara, additional, Fusciello, Manlio, additional, Peltonen, Karita, additional, Martins, Beatriz, additional, Sjöberg, Madeleine, additional, Pesonen, Sari, additional, Ranki, Tuuli, additional, Kyruk, Lukasz, additional, Ylösmäki, Erkko, additional, Cerullo, Vincenzo, additional, Cerignoli, Fabio, additional, Xi, Biao, additional, Guenther, Garret, additional, Yu, Naichen, additional, Muir, Lincoln, additional, Zhao, Leyna, additional, Abassi, Yama, additional, Cervera-Carrascón, Víctor, additional, Siurala, Mikko, additional, Santos, João, additional, Havunen, Riikka, additional, Parviainen, Suvi, additional, Hemminki, Akseli, additional, Dalgleish, Angus, additional, Mudan, Satvinder, additional, DeBenedette, Mark, additional, Plachco, Ana, additional, Gamble, Alicia, additional, Grogan, Elizabeth W., additional, Krisko, John, additional, Tcherepanova, Irina, additional, Nicolette, Charles, additional, Dhupkar, Pooja, additional, Yu, Ling, additional, Kleinerman, Eugenie S., additional, Gordon, Nancy, additional, Grenga, Italia, additional, Lepone, Lauren, additional, Gameiro, Sofia, additional, Knudson, Karin M., additional, Fantini, Massimo, additional, Tsang, Kwong, additional, Hodge, James, additional, Donahue, Renee, additional, Schlom, Jeffrey, additional, Evans, Elizabeth, additional, Bussler, Holm, additional, Mallow, Crystal, additional, Reilly, Christine, additional, Torno, Sebold, additional, Scrivens, Maria, additional, Foster, Cathie, additional, Howell, Alan, additional, Balch, Leslie, additional, Knapp, Alyssa, additional, Leonard, John E., additional, Paris, Mark, additional, Fisher, Terry, additional, Hu-Lieskovan, Siwen, additional, Smith, Ernest, additional, Zauderer, Maurice, additional, Fogler, William, additional, Franklin, Marilyn, additional, Thayer, Matt, additional, Saims, Dan, additional, Magnani, John L., additional, Gong, Jian, additional, Gray, Michael, additional, Fromm, George, additional, de Silva, Suresh, additional, Giffin, Louise, additional, Xu, Xin, additional, Rose, Jason, additional, Schreiber, Taylor H., additional, Gameiro, Sofia R., additional, Clavijo, Paul E., additional, Allen, Clint T., additional, Hodge, James W., additional, Tsang, Kwong Y., additional, Grogan, Jane, additional, Manieri, Nicholas, additional, Chiang, Eugene, additional, Caplazi, Patrick, additional, Yadav, Mahesh, additional, Hagner, Patrick, additional, Chiu, Hsiling, additional, Waldman, Michelle, additional, Klippel, Anke, additional, Thakurta, Anjan, additional, Pourdehnad, Michael, additional, Gandhi, Anita, additional, Henrich, Ian, additional, Quick, Laura, additional, Young, Rob, additional, Chou, Margaret, additional, Hotson, Andrew, additional, Willingham, Stephen, additional, Ho, Po, additional, Choy, Carmen, additional, Laport, Ginna, additional, McCaffery, Ian, additional, Miller, Richard, additional, Tipton, Kimberly A., additional, Wong, Kenneth R., additional, Singson, Victoria, additional, Wong, Chihunt, additional, Chan, Chanty, additional, Huang, Yuanhiu, additional, Liu, Shouchun, additional, Richardson, Jennifer H., additional, Kavanaugh, W. Michael, additional, West, James, additional, Irving, Bryan A., additional, Jaini, Ritika, additional, Loya, Matthew, additional, Eng, Charis, additional, Johnson, Melissa L., additional, Adjei, Alex A., additional, Opyrchal, Mateusz, additional, Ramalingam, Suresh, additional, Janne, Pasi A., additional, Dominguez, George, additional, Gabrilovich, Dmitry, additional, de Leon, Laura, additional, Hasapidis, Jeannette, additional, Diede, Scott J., additional, Ordentlich, Peter, additional, Cruickshank, Scott, additional, Meyers, Michael L., additional, Hellmann, Matthew D., additional, Kalinski, Pawel, additional, Zureikat, Amer, additional, Edwards, Robert, additional, Muthuswamy, Ravi, additional, Obermajer, Nataša, additional, Urban, Julie, additional, Butterfield, Lisa H., additional, Gooding, William, additional, Zeh, Herbert, additional, Bartlett, David, additional, Zubkova, Olga, additional, Agapova, Larissa, additional, Kapralova, Marina, additional, Krasovskaia, Liudmila, additional, Ovsepyan, Armen, additional, Lykov, Maxim, additional, Eremeev, Artem, additional, Bokovanov, Vladimir, additional, Grigoryeva, Olga, additional, Karpov, Andrey, additional, Ruchko, Sergey, additional, Shuster, Alexandr, additional, Khalil, Danny N., additional, Campesato, Luis Felipe, additional, Li, Yanyun, additional, Lazorchak, Adam S., additional, Patterson, Troy D., additional, Ding, Yueyun, additional, Sasikumar, Pottayil, additional, Sudarshan, Naremaddepalli, additional, Gowda, Nagaraj, additional, Ramachandra, Raghuveer, additional, Samiulla, Dodheri, additional, Giri, Sanjeev, additional, Eswarappa, Rajesh, additional, Ramachandra, Murali, additional, Tuck, David, additional, Wyant, Timothy, additional, Leshem, Jasmin, additional, Liu, Xiu-fen, additional, Bera, Tapan, additional, Terabe, Masaki, additional, Bossenmaier, Birgit, additional, Niederfellner, Gerhard, additional, Reiter, Yoram, additional, Pastan, Ira, additional, Xia, Leiming, additional, Xia, Yang, additional, Hu, Yangyang, additional, Wang, Yi, additional, Bao, Yangyi, additional, Dai, Fu, additional, Huang, Shiang, additional, Hurt, Elaine, additional, Hollingsworth, Robert E., additional, Lum, Lawrence G., additional, Chang, Alfred E., additional, Wicha, Max S., additional, Li, Qiao, additional, Mace, Thomas, additional, Makhijani, Neil, additional, Talbert, Erin, additional, Young, Gregory, additional, Guttridge, Denis, additional, Conwell, Darwin, additional, Lesinski, Gregory B., additional, Gonzales, Rodney JM Macedo, additional, Huffman, Austin P., additional, Wang, Ximi K., additional, Reshef, Ran, additional, MacKinnon, Andy, additional, Chen, Jason, additional, Gross, Matt, additional, Marguier, Gisele, additional, Shwonek, Peter, additional, Sotirovska, Natalija, additional, Steggerda, Susanne, additional, Parlati, Francesco, additional, Makkouk, Amani, additional, Bennett, Mark K., additional, Emberley, Ethan, additional, Huang, Tony, additional, Li, Weiqun, additional, Neou, Silinda, additional, Pan, Alison, additional, Zhang, Jing, additional, Zhang, Winter, additional, Marshall, Netonia, additional, Marron, Thomas U., additional, Agudo, Judith, additional, Brown, Brian, additional, Brody, Joshua, additional, McQuinn, Christopher, additional, Farren, Matthew, additional, Komar, Hannah, additional, Shakya, Reena, additional, Ludwug, Thomas, additional, Morillon, Y. Maurice, additional, Hammond, Scott A., additional, Greiner, John W., additional, Nath, Pulak R., additional, Schwartz, Anthony L., additional, Maric, Dragan, additional, Roberts, David D., additional, Naing, Aung, additional, Papadopoulos, Kyriakos P., additional, Autio, Karen A., additional, Wong, Deborah J., additional, Patel, Manish, additional, Falchook, Gerald, additional, Pant, Shubham, additional, Ott, Patrick A., additional, Whiteside, Melinda, additional, Patnaik, Amita, additional, Mumm, John, additional, Janku, Filip, additional, Chan, Ivan, additional, Bauer, Todd, additional, Colen, Rivka, additional, VanVlasselaer, Peter, additional, Brown, Gail L., additional, Tannir, Nizar M., additional, Oft, Martin, additional, Infante, Jeffrey, additional, Lipson, Evan, additional, Gopal, Ajay, additional, Neelapu, Sattva S., additional, Armand, Philippe, additional, Spurgeon, Stephen, additional, Leonard, John P., additional, Sanborn, Rachel E., additional, Melero, Ignacio, additional, Gajewski, Thomas F., additional, Maurer, Matthew, additional, Perna, Serena, additional, Gutierrez, Andres A., additional, Clynes, Raphael, additional, Mitra, Priyam, additional, Suryawanshi, Satyendra, additional, Gladstone, Douglas, additional, Callahan, Margaret K., additional, Crooks, James, additional, Brown, Sheila, additional, Gauthier, Audrey, additional, de Boisferon, Marc Hillairet, additional, MacDonald, Andrew, additional, Brunet, Laura Rosa, additional, Rothwell, William T., additional, Bell, Peter, additional, Wilson, James M., additional, Sato-Kaneko, Fumi, additional, Yao, Shiyin, additional, Zhang, Shannon S., additional, Carson, Dennis A., additional, Guiducci, Cristina, additional, Coffman, Robert L., additional, Kitaura, Kazutaka, additional, Matsutani, Takaji, additional, Suzuki, Ryuji, additional, Hayashi, Tomoko, additional, Cohen, Ezra E. W., additional, Schaer, David, additional, Li, Yanxia, additional, Dobkin, Julie, additional, Amatulli, Michael, additional, Hall, Gerald, additional, Doman, Thompson, additional, Manro, Jason, additional, Dorsey, Frank Charles, additional, Sams, Lillian, additional, Holmgaard, Rikke, additional, Persaud, Krishnadatt, additional, Ludwig, Dale, additional, Surguladze, David, additional, Kauh, John S., additional, Novosiadly, Ruslan, additional, Kalos, Michael, additional, Driscoll, Kyla, additional, Pandha, Hardev, additional, Ralph, Christy, additional, Harrington, Kevin, additional, Curti, Brendan, additional, Akerley, Wallace, additional, Gupta, Sumati, additional, Melcher, Alan, additional, Mansfield, David, additional, Kaufman, David R., additional, Schmidt, Emmett, additional, Grose, Mark, additional, Davies, Bronwyn, additional, Karpathy, Roberta, additional, Shafren, Darren, additional, Shamalov, Katerina, additional, Cohen, Cyrille, additional, Sharma, Naveen, additional, Allison, James, additional, Shekarian, Tala, additional, Valsesia-Wittmann, Sandrine, additional, Caux, Christophe, additional, Marabelle, Aurelien, additional, Slomovitz, Brian M., additional, Moore, Kathleen M., additional, Youssoufian, Hagop, additional, Posner, Marshall, additional, Tewary, Poonam, additional, Brooks, Alan D., additional, Xu, Ya-Ming, additional, Wijeratne, Kithsiri, additional, Gunatilaka, Leslie A. A., additional, Sayers, Thomas J., additional, Vasilakos, John P., additional, Alston, Tesha, additional, Dovedi, Simon, additional, Elvecrog, James, additional, Grigsby, Iwen, additional, Herbst, Ronald, additional, Johnson, Karen, additional, Moeckly, Craig, additional, Mullins, Stefanie, additional, Siebenaler, Kristen, additional, SternJohn, Julius, additional, Tilahun, Ashenafi, additional, Tomai, Mark A., additional, Vogel, Katharina, additional, Vietsch, Eveline E., additional, Wellstein, Anton, additional, Wythes, Martin, additional, Crosignani, Stefano, additional, Tumang, Joseph, additional, Alekar, Shilpa, additional, Bingham, Patrick, additional, Cauwenberghs, Sandra, additional, Chaplin, Jenny, additional, Dalvie, Deepak, additional, Denies, Sofie, additional, De Maeseneire, Coraline, additional, Feng, JunLi, additional, Frederix, Kim, additional, Greasley, Samantha, additional, Guo, Jie, additional, Hardwick, James, additional, Kaiser, Stephen, additional, Jessen, Katti, additional, Kindt, Erick, additional, Letellier, Marie-Claire, additional, Li, Wenlin, additional, Maegley, Karen, additional, Marillier, Reece, additional, Miller, Nichol, additional, Murray, Brion, additional, Pirson, Romain, additional, Preillon, Julie, additional, Rabolli, Virginie, additional, Ray, Chad, additional, Ryan, Kevin, additional, Scales, Stephanie, additional, Srirangam, Jay, additional, Solowiej, Jim, additional, Stewart, Al, additional, Streiner, Nicole, additional, Torti, Vince, additional, Tsaparikos, Konstantinos, additional, Zheng, Xianxian, additional, Driessens, Gregory, additional, Gomes, Bruno, additional, Kraus, Manfred, additional, Xu, Chunxiao, additional, Zhang, Yanping, additional, Kradjian, Giorgio, additional, Qin, Guozhong, additional, Qi, Jin, additional, Xu, Xiaomei, additional, Marelli, Bo, additional, Yu, Huakui, additional, Guzman, Wilson, additional, Tighe, Rober, additional, Salazar, Rachel, additional, Lo, Kin-Ming, additional, English, Jessie, additional, Radvanyi, Laszlo, additional, Lan, Yan, additional, Postow, Michael, additional, Senbabaoglu, Yasin, additional, Gasmi, Billel, additional, Zhong, Hong, additional, Liu, Cailian, additional, Hirschhorhn-Cymerman, Daniel, additional, Zha, Yuanyuan, additional, Malnassy, Gregory, additional, Fulton, Noreen, additional, Park, Jae-Hyun, additional, Stock, Wendy, additional, Nakamura, Yusuke, additional, Liu, Hongtao, additional, Ju, Xiaoming, additional, Kosoff, Rachelle, additional, Ramos, Kimberly, additional, Coder, Brandon, additional, Petit, Robert, additional, Princiotta, Michael, additional, Perry, Kyle, additional, Zou, Jun, additional, Arina, Ainhoa, additional, Fernandez, Christian, additional, Zheng, Wenxin, additional, Beckett, Michael A., additional, Mauceri, Helena J., additional, Fu, Yang-Xin, additional, Weichselbaum, Ralph R., additional, Lewis, Whitney, additional, Han, Yanyan, additional, Wu, Yeting, additional, Yang, Chou, additional, Huang, Jing, additional, Wu, Dongyun, additional, Li, Jin, additional, Liang, Xiaoling, additional, Zhou, Xiangjun, additional, Hou, Jinlin, additional, Hassan, Raffit, additional, Jahan, Thierry, additional, Antonia, Scott J., additional, Kindler, Hedy L., additional, Alley, Evan W., additional, Honarmand, Somayeh, additional, Liu, Weiqun, additional, Leong, Meredith L., additional, Whiting, Chan C., additional, Nair, Nitya, additional, Enstrom, Amanda, additional, Lemmens, Edward E., additional, Tsujikawa, Takahiro, additional, Kumar, Sushil, additional, Coussens, Lisa M., additional, Murphy, Aimee L., additional, Brockstedt, Dirk G., additional, Koch, Sven D., additional, Sebastian, Martin, additional, Weiss, Christian, additional, Früh, Martin, additional, Pless, Miklos, additional, Cathomas, Richard, additional, Hilbe, Wolfgang, additional, Pall, Georg, additional, Wehler, Thomas, additional, Alt, Jürgen, additional, Bischoff, Helge, additional, Geissler, Michael, additional, Griesinger, Frank, additional, Kollmeier, Jens, additional, Papachristofilou, Alexandros, additional, Doener, Fatma, additional, Fotin-Mleczek, Mariola, additional, Hipp, Madeleine, additional, Hong, Henoch S., additional, Kallen, Karl-Josef, additional, Klinkhardt, Ute, additional, Stosnach, Claudia, additional, Scheel, Birgit, additional, Schroeder, Andreas, additional, Seibel, Tobias, additional, Gnad-Vogt, Ulrike, additional, Zippelius, Alfred, additional, Park, Ha-Ram, additional, Ahn, Yong-Oon, additional, Kim, Tae Min, additional, Kim, Soyeon, additional, Kim, Seulki, additional, Lee, Yu Soo, additional, Keam, Bhumsuk, additional, Kim, Dong-Wan, additional, Heo, Dae Seog, additional, Pilon-Thomas, Shari, additional, Weber, Amy, additional, Morse, Jennifer, additional, Kodumudi, Krithika, additional, Liu, Hao, additional, Mullinax, John, additional, Sarnaik, Amod A., additional, Pike, Luke, additional, Bang, Andrew, additional, Balboni, Tracy, additional, Taylor, Allison, additional, Spektor, Alexander, additional, Wilhite, Tyler, additional, Krishnan, Monica, additional, Cagney, Daniel, additional, Alexander, Brian, additional, Aizer, Ayal, additional, Buchbinder, Elizabeth, additional, Awad, Mark, additional, Ghandi, Leena, additional, Schoenfeld, Jonathan, additional, Lessey-Morillon, Elizabeth, additional, Ridnour, Lisa, additional, Segal, Neil H., additional, Sharma, Manish, additional, Le, Dung T., additional, Ferris, Robert L., additional, Zelenetz, Andrew D., additional, Levy, Ronald, additional, Lossos, Izidore S., additional, Jacobson, Caron, additional, Ramchandren, Radhakrishnan, additional, Godwin, John, additional, Colevas, A. Dimitrios, additional, Meier, Roland, additional, Krishnan, Suba, additional, Gu, Xuemin, additional, Neely, Jaclyn, additional, Timmerman, John, additional, Vanpouille-Box, Claire I., additional, Formenti, Silvia C., additional, Demaria, Sandra, additional, Wennerberg, Erik, additional, Mediero, Aranzazu, additional, Cronstein, Bruce N., additional, Gustafson, Michael P., additional, DiCostanzo, AriCeli, additional, Wheatley, Courtney, additional, Kim, Chul-Ho, additional, Bornschlegl, Svetlana, additional, Gastineau, Dennis A., additional, Johnson, Bruce D., additional, Dietz, Allan B., additional, MacDonald, Cameron, additional, Bucsek, Mark, additional, Qiao, Guanxi, additional, Hylander, Bonnie, additional, Repasky, Elizabeth, additional, Turbitt, William J., additional, Xu, Yitong, additional, Mastro, Andrea, additional, Rogers, Connie J., additional, Withers, Sita, additional, Wang, Ziming, additional, Khuat, Lam T., additional, Dunai, Cordelia, additional, Blazar, Bruce R., additional, Longo, Dan, additional, Rebhun, Robert, additional, Grossenbacher, Steven K., additional, Monjazeb, Arta, additional, Murphy, William J., additional, Rowlinson, Scott, additional, Agnello, Giulia, additional, Alters, Susan, additional, Lowe, David, additional, Scharping, Nicole, additional, Menk, Ashley V., additional, Whetstone, Ryan, additional, Zeng, Xue, additional, Delgoffe, Greg M., additional, Santos, Patricia M., additional, Shi, Jian, additional, Delgoffe, Greg, additional, Nagasaka, Misako, additional, Sukari, Ammar, additional, Byrne-Steele, Miranda, additional, Pan, Wenjing, additional, Hou, Xiaohong, additional, Brown, Brittany, additional, Eisenhower, Mary, additional, Han, Jian, additional, Collins, Natalie, additional, Manguso, Robert, additional, Pope, Hans, additional, Shrestha, Yashaswi, additional, Boehm, Jesse, additional, Haining, W. Nicholas, additional, Cron, Kyle R., additional, Sivan, Ayelet, additional, Aquino-Michaels, Keston, additional, Orecchioni, Marco, additional, Bedognetti, Davide, additional, Hendrickx, Wouter, additional, Fuoco, Claudia, additional, Spada, Filomena, additional, Sgarrella, Francesco, additional, Cesareni, Gianni, additional, Marincola, Francesco, additional, Kostarelos, Kostas, additional, Bianco, Alberto, additional, Delogu, Lucia, additional, Roelands, Jessica, additional, Boughorbel, Sabri, additional, Decock, Julie, additional, Presnell, Scott, additional, Wang, Ena, additional, Marincola, Franco M., additional, Kuppen, Peter, additional, Ceccarelli, Michele, additional, Rinchai, Darawan, additional, Chaussabel, Damien, additional, Miller, Lance, additional, Nguyen, Andrew, additional, Sanborn, J. Zachary, additional, Vaske, Charles, additional, Rabizadeh, Shahrooz, additional, Niazi, Kayvan, additional, Benz, Steven, additional, Patel, Shashank, additional, Restifo, Nicholas, additional, White, James, additional, Angiuoli, Sam, additional, Sausen, Mark, additional, Jones, Sian, additional, Sevdali, Maria, additional, Simmons, John, additional, Velculescu, Victor, additional, Diaz, Luis, additional, Zhang, Theresa, additional, Sims, Jennifer S., additional, Barton, Sunjay M., additional, Kadenhe-Chiweshe, Angela, additional, Dela Cruz, Filemon, additional, Turk, Andrew T., additional, Mazzeo, Christopher F., additional, Kung, Andrew L., additional, Bruce, Jeffrey N., additional, Yamashiro, Darrell J., additional, Connolly, Eileen P., additional, Baird, Jason, additional, Crittenden, Marka, additional, Friedman, David, additional, Xiao, Hong, additional, Leidner, Rom, additional, Bell, Bryan, additional, Young, Kristina, additional, Gough, Michael, additional, Bian, Zhen, additional, Kidder, Koby, additional, Liu, Yuan, additional, Curran, Emily, additional, Chen, Xiufen, additional, Corrales, Leticia P., additional, Kline, Justin, additional, Aguilar, Ethan G., additional, Guerriero, Jennifer, additional, Sotayo, Alaba, additional, Ponichtera, Holly, additional, Pourzia, Alexandra, additional, Schad, Sara, additional, Carrasco, Ruben, additional, Lazo, Suzan, additional, Bronson, Roderick, additional, Letai, Anthony, additional, Kornbluth, Richard S., additional, Gupta, Sachin, additional, Termini, James, additional, Guirado, Elizabeth, additional, Stone, Geoffrey W., additional, Meyer, Christina, additional, Helming, Laura, additional, Wilson, Nicholas, additional, Hofmeister, Robert, additional, Neubert, Natalie J., additional, Tillé, Laure, additional, Barras, David, additional, Soneson, Charlotte, additional, Baumgaertner, Petra, additional, Rimoldi, Donata, additional, Gfeller, David, additional, Delorenzi, Mauro, additional, Fuertes Marraco, Silvia A., additional, Speiser, Daniel E., additional, Abraham, Tara S., additional, Xiang, Bo, additional, Magee, Michael S., additional, Waldman, Scott A., additional, Snook, Adam E., additional, Blogowski, Wojciech, additional, Zuba-Surma, Ewa, additional, Budkowska, Marta, additional, Salata, Daria, additional, Dolegowska, Barbara, additional, Starzynska, Teresa, additional, Chan, Leo, additional, Somanchi, Srinivas, additional, McCulley, Kelsey, additional, Lee, Dean, additional, Buettner, Nico, additional, Shi, Feng, additional, Myers, Paisley T., additional, Curbishley, Stuart, additional, Penny, Sarah A., additional, Steadman, Lora, additional, Millar, David, additional, Speers, Ellen, additional, Ruth, Nicola, additional, Wong, Gabriel, additional, Thimme, Robert, additional, Adams, David, additional, Cobbold, Mark, additional, Thomas, Remy, additional, Al-Muftah, Mariam, additional, Wong, Michael KK, additional, Morse, Michael, additional, Clark, Joseph I., additional, Kaufman, Howard L., additional, Daniels, Gregory A., additional, Hua, Hong, additional, Rao, Tharak, additional, Dutcher, Janice P., additional, Kang, Kai, additional, Saunthararajah, Yogen, additional, Velcheti, Vamsidhar, additional, Kumar, Vikas, additional, Anwar, Firoz, additional, Verma, Amita, additional, Chheda, Zinal, additional, Kohanbash, Gary, additional, Sidney, John, additional, Okada, Kaori, additional, Shrivastav, Shruti, additional, Carrera, Diego A., additional, Liu, Shuming, additional, Jahan, Naznin, additional, Mueller, Sabine, additional, Pollack, Ian F., additional, Carcaboso, Angel M., additional, Sette, Alessandro, additional, Hou, Yafei, additional, Okada, Hideho, additional, Field, Jessica J., additional, Zeng, Weiping, additional, Shih, Vincent FS, additional, Law, Che-Leung, additional, Senter, Peter D., additional, Gardai, Shyra J., additional, Okeley, Nicole M., additional, Abelin, Jennifer G., additional, Saeed, Abu Z., additional, Malaker, Stacy A., additional, Shabanowitz, Jeffrey, additional, Ward, Stephen T., additional, Hunt, Donald F., additional, Profusek, Pam, additional, Wood, Laura, additional, Shepard, Dale, additional, Grivas, Petros, additional, Kapp, Kerstin, additional, Volz, Barbara, additional, Oswald, Detlef, additional, Wittig, Burghardt, additional, Schmidt, Manuel, additional, Sefrin, Julian P., additional, Hillringhaus, Lars, additional, Lifke, Valeria, additional, Lifke, Alexander, additional, Skaletskaya, Anna, additional, Ponte, Jose, additional, Chittenden, Thomas, additional, Setiady, Yulius, additional, Sivado, Eva, additional, Thomas, Vincent, additional, El Alaoui, Meddy, additional, Papot, Sébastien, additional, Dumontet, Charles, additional, Dyson, Mike, additional, McCafferty, John, additional, El Alaoui, Said, additional, Bommareddy, Praveen K., additional, Zloza, Andrew, additional, Kohlhapp, Frederick, additional, Silk, Ann W., additional, Jhawar, Sachin, additional, Paneque, Tomas, additional, Newman, Jenna, additional, Beltran, Pedro, additional, Cao, Felicia, additional, Hong, Bang-Xing, additional, Rodriguez-Cruz, Tania, additional, Song, Xiao-Tong, additional, Gottschalk, Stephen, additional, Calderon, Hugo, additional, Illingworth, Sam, additional, Brown, Alice, additional, Fisher, Kerry, additional, Seymour, Len, additional, Champion, Brian, additional, Eriksson, Emma, additional, Wenthe, Jessica, additional, Hellström, Ann-Charlotte, additional, Paul-Wetterberg, Gabriella, additional, Loskog, Angelica, additional, Milenova, Ioanna, additional, Ståhle, Magnus, additional, Jarblad-Leja, Justyna, additional, Ullenhag, Gustav, additional, Dimberg, Anna, additional, Moreno, Rafael, additional, Alemany, Ramon, additional, Goyal, Sharad, additional, Silk, Ann, additional, Mehnert, Janice, additional, Gabrail, Nashat, additional, Bryan, Jennifer, additional, Medina, Daniel, additional, Mitchell, Leah, additional, Yagiz, Kader, additional, Lopez, Fernando, additional, Mendoza, Daniel, additional, Munday, Anthony, additional, Gruber, Harry, additional, Jolly, Douglas, additional, Fuhrmann, Steven, additional, Radoja, Sasa, additional, Tan, Wei, additional, Pourchet, Aldo, additional, Frey, Alan, additional, Mohr, Ian, additional, Mulvey, Matthew, additional, Andtbacka, Robert H. I., additional, Ross, Merrick, additional, Agarwala, Sanjiv, additional, Grossmann, Kenneth, additional, Taylor, Matthew, additional, Vetto, John, additional, Neves, Rogerio, additional, Daud, Adil, additional, Khong, Hung, additional, Meek, Stephanie M., additional, Ungerleider, Richard, additional, Welden, Scott, additional, Tanaka, Maki, additional, Williams, Matthew, additional, Hallmeyer, Sigrun, additional, Fox, Bernard, additional, Feng, Zipei, additional, Paustian, Christopher, additional, Bifulco, Carlo, additional, Zafar, Sadia, additional, Hemminki, Otto, additional, Bramante, Simona, additional, Vassilev, Lotta, additional, Wang, Hongjie, additional, Lieber, Andre, additional, Hemmi, Silvio, additional, de Gruijl, Tanja, additional, Kanerva, Anna, additional, Ansari, Tameem, additional, Sundararaman, Srividya, additional, Roen, Diana, additional, Lehmann, Paul, additional, Bloom, Anja C., additional, Bender, Lewis H., additional, Walters, Ian B., additional, Berzofsky, Jay A., additional, Chapelin, Fanny, additional, Ahrens, Eric T., additional, DeFalco, Jeff, additional, Harbell, Michael, additional, Manning-Bog, Amy, additional, Scholz, Alexander, additional, Zhang, Danhui, additional, Baia, Gilson, additional, Tan, Yann Chong, additional, Sokolove, Jeremy, additional, Kim, Dongkyoon, additional, Williamson, Kevin, additional, Chen, Xiaomu, additional, Colrain, Jillian, additional, Santo, Gregg Espiritu, additional, Nguyen, Ngan, additional, Volkmuth, Wayne, additional, Greenberg, Norman, additional, Robinson, William, additional, Emerling, Daniel, additional, Drake, Charles G., additional, Petrylak, Daniel P., additional, Antonarakis, Emmanuel S., additional, Kibel, Adam S., additional, Chang, Nancy N., additional, Vu, Tuyen, additional, Campogan, Dwayne, additional, Haynes, Heather, additional, Trager, James B., additional, Sheikh, Nadeem A., additional, Quinn, David I., additional, Kirk, Peter, additional, Addepalli, Murali, additional, Chang, Thomas, additional, Zhang, Ping, additional, Konakova, Marina, additional, Hagihara, Katsunobu, additional, Pai, Steven, additional, VanderVeen, Laurie, additional, Obalapur, Palakshi, additional, Kuo, Peiwen, additional, Quach, Phi, additional, Fong, Lawrence, additional, Charych, Deborah H., additional, Zalevsky, Jonathan, additional, Langowski, John L., additional, Kirksey, Yolanda, additional, Nutakki, Ravi, additional, Kolarkar, Shalini, additional, Pena, Rhoneil, additional, Hoch, Ute, additional, Doberstein, Stephen K., additional, Cha, John, additional, Mallon, Zach, additional, Perez, Myra, additional, McDaniel, Amanda, additional, Anand, Snjezana, additional, Uecker, Darrin, additional, Nuccitelli, Richard, additional, Wieckowski, Eva, additional, Muthuswamy, Ravikumar, additional, Ravindranathan, Roshni, additional, Renrick, Ariana N., additional, Thounaojam, Menaka, additional, Thomas, Portia, additional, Pellom, Samuel, additional, Shanker, Anil, additional, Dudimah, Duafalia, additional, Brooks, Alan, additional, Su, Yu-Lin, additional, Adamus, Tomasz, additional, Zhang, Qifang, additional, Nechaev, Sergey, additional, Kortylewski, Marcin, additional, Wei, Spencer, additional, Anderson, Clark, additional, Tang, Chad, additional, Schoenhals, Jonathan, additional, Tsouko, Efrosini, additional, Heymach, John, additional, de Groot, Patricia, additional, Chang, Joe, additional, Hess, Kenneth R., additional, Diab, Adi, additional, Sharma, Padmanee, additional, Hong, David, additional, Welsh, James, additional, Parsons, Andrea J., additional, Leleux, Jardin, additional, Ascarateil, Stephane, additional, Koziol, Marie Eve, additional, Bai, Dina, additional, Dai, Peihong, additional, Wang, Weiyi, additional, Yang, Ning, additional, Shuman, Stewart, additional, Deng, Liang, additional, Dillon, Patrick, additional, Petroni, Gina, additional, Brenin, David, additional, Bullock, Kim, additional, Olson, Walter, additional, Smolkin, Mark E., additional, Smith, Kelly, additional, Nail, Carmel, additional, Slingluff, Craig L., additional, Sharma, Meenu, additional, Fa’ak, Faisal, additional, Janssen, Louise, additional, Khong, Hiep, additional, Xiao, Zhilan, additional, Hailemichael, Yared, additional, Singh, Manisha, additional, Vianden, Christina, additional, Overwijk, Willem W., additional, Facciabene, Andrea, additional, Stefano, Pierini, additional, Chongyung, Fang, additional, Rafail, Stavros, additional, Nielsen, Michael, additional, Vanderslice, Peter, additional, Woodside, Darren G., additional, Market, Robert V., additional, Biediger, Ronald J., additional, Marathi, Upendra K., additional, Hollevoet, Kevin, additional, Geukens, Nick, additional, Declerck, Paul, additional, Joly, Nathalie, additional, McIntosh, Laura, additional, Paramithiotis, Eustache, additional, Rizell, Magnus, additional, Sternby, Malin, additional, Andersson, Bengt, additional, Karlsson-Parra, Alex, additional, Kuai, Rui, additional, Ochyl, Lukasz, additional, Schwendeman, Anna, additional, Moon, James, additional, Deng, Weiwen, additional, Hudson, Thomas E., additional, Hanson, Bill, additional, Rae, Chris S., additional, Burrill, Joel, additional, Skoble, Justin, additional, Katibah, George, additional, deVries, Michele, additional, Lauer, Peter, additional, Dubensky, Thomas W., additional, Chen, Xin, additional, Zhou, Li, additional, Ren, Xiubao, additional, Aggarwal, Charu, additional, Mangrolia, Drishty, additional, Cohen, Roger, additional, Weinstein, Gregory, additional, Morrow, Matthew, additional, Bauml, Joshua, additional, Kraynyak, Kim, additional, Boyer, Jean, additional, Yan, Jian, additional, Lee, Jessica, additional, Humeau, Laurent, additional, Oyola, Sandra, additional, Duff, Susan, additional, Weiner, David, additional, Yang, Zane, additional, Bagarazzi, Mark, additional, McNeel, Douglas G., additional, Eickhoff, Jens, additional, Jeraj, Robert, additional, Staab, Mary Jane, additional, Straus, Jane, additional, Rekoske, Brian, additional, Liu, Glenn, additional, Melssen, Marit, additional, Grosh, William, additional, Varhegyi, Nikole, additional, Galeassi, Nadejda, additional, Deacon, Donna H., additional, Gaughan, Elizabeth, additional, Ghisoli, Maurizio, additional, Barve, Minal, additional, Mennel, Robert, additional, Wallraven, Gladice, additional, Manning, Luisa, additional, Senzer, Neil, additional, Nemunaitis, John, additional, Ogasawara, Masahiro, additional, Ota, Shuichi, additional, Peace, Kaitlin M., additional, Hale, Diane F., additional, Vreeland, Timothy J., additional, Jackson, Doreen O., additional, Berry, John S., additional, Trappey, Alfred F., additional, Herbert, Garth S., additional, Clifton, Guy T., additional, Hardin, Mark O., additional, Toms, Anne, additional, Qiao, Na, additional, Litton, Jennifer, additional, Peoples, George E., additional, Mittendorf, Elizabeth A., additional, Ghamsari, Lila, additional, Flano, Emilio, additional, Jacques, Judy, additional, Liu, Biao, additional, Havel, Jonathan, additional, Makarov, Vladimir, additional, Chan, Timothy A., additional, Flechtner, Jessica B., additional, Facciponte, John, additional, Ugel, Stefano, additional, De Sanctis, Francesco, additional, Coukos, George, additional, Paris, Sébastien, additional, Pottier, Agnes, additional, Levy, Laurent, additional, Lu, Bo, additional, Cappuccini, Federica, additional, Pollock, Emily, additional, Bryant, Richard, additional, Hamdy, Freddie, additional, Hill, Adrian, additional, Redchenko, Irina, additional, Sultan, Hussein, additional, Kumai, Takumi, additional, Fesenkova, Valentyna, additional, Celis, Esteban, additional, Fernando, Ingrid, additional, Palena, Claudia, additional, David, Justin M., additional, Gabitzsch, Elizabeth, additional, Jones, Frank, additional, Gulley, James L., additional, Herranz, Mireia Uribe, additional, Wada, Hiroshi, additional, Shimizu, Atsushi, additional, Osada, Toshihiro, additional, Fukaya, Satoshi, additional, Sasaki, Eiji, additional, Abolhalaj, Milad, additional, Askmyr, David, additional, Lundberg, Kristina, additional, Albrekt, Ann-Sofie, additional, Greiff, Lennart, additional, Lindstedt, Malin, additional, Flies, Dallas B., additional, Higuchi, Tomoe, additional, Ornatowski, Wojciech, additional, Harris, Jaryse, additional, Adams, Sarah F., additional, Aguilera, Todd, additional, Rafat, Marjan, additional, Castellini, Laura, additional, Shehade, Hussein, additional, Kariolis, Mihalis, additional, Jang, Dadi, additional, vonEbyen, Rie, additional, Graves, Edward, additional, Ellies, Lesley, additional, Rankin, Erinn, additional, Koong, Albert, additional, Giaccia, Amato, additional, Ajina, Reham, additional, Wang, Shangzi, additional, Smith, Jill, additional, Pierobon, Mariaelena, additional, Jablonski, Sandra, additional, Petricoin, Emanuel, additional, Weiner, Louis M., additional, Sherry, Lorcan, additional, Waller, John, additional, Anderson, Mark, additional, Bigley, Alison, additional, Bernatchez, Chantale, additional, Haymaker, Cara, additional, Kluger, Harriet, additional, Tetzlaff, Michael, additional, Jackson, Natalie, additional, Gergel, Ivan, additional, Tagliaferri, Mary, additional, Hwu, Patrick, additional, Snzol, Mario, additional, Hurwitz, Michael, additional, Barberi, Theresa, additional, Martin, Allison, additional, Suresh, Rahul, additional, Barakat, David, additional, Harris-Bookman, Sarah, additional, Drake, Charles, additional, Friedman, Alan, additional, Berkey, Sara, additional, Downs-Canner, Stephanie, additional, Edwards, Robert P., additional, Curiel, Tyler, additional, Odunsi, Kunle, additional, Bruno, Tullia C., additional, Moore, Brandon, additional, Squalls, Olivia, additional, Ebner, Peggy, additional, Waugh, Katherine, additional, Mitchell, John, additional, Franklin, Wilbur, additional, Merrick, Daniel, additional, McCarter, Martin, additional, Palmer, Brent, additional, Kern, Jeffrey, additional, Vignali, Dario, additional, Slansky, Jill, additional, Chan, Anissa S. H., additional, Qiu, Xiaohong, additional, Fraser, Kathryn, additional, Jonas, Adria, additional, Ottoson, Nadine, additional, Gordon, Keith, additional, Kangas, Takashi O., additional, Leonardo, Steven, additional, Ertelt, Kathleen, additional, Walsh, Richard, additional, Uhlik, Mark, additional, Graff, Jeremy, additional, Bose, Nandita, additional, Gupta, Ravi, additional, Mandloi, Nitin, additional, Paul, Kiran, additional, Patil, Ashwini, additional, Sathian, Rekha, additional, Mohan, Aparna, additional, Manoharan, Malini, additional, Chaudhuri, Amitabha, additional, Chen, Yu, additional, Lin, Jing, additional, Ye, Yun-bin, additional, Xu, Chun-wei, additional, Chen, Gang, additional, Guo, Zeng-qing, additional, Komarov, Andrey, additional, Chenchik, Alex, additional, Makhanov, Michael, additional, Frangou, Costa, additional, Zheng, Yi, additional, Coltharp, Carla, additional, Unfricht, Darryn, additional, Dilworth, Ryan, additional, Fridman, Leticia, additional, Liu, Linying, additional, Rajopadhye, Milind, additional, Miller, Peter, additional, Concha-Benavente, Fernando, additional, Bauman, Julie, additional, Trivedi, Sumita, additional, Srivastava, Raghvendra, additional, Ohr, James, additional, Heron, Dwight, additional, Duvvuri, Uma, additional, Kim, Seungwon, additional, Torrey, Heather, additional, Mera, Toshi, additional, Okubo, Yoshiaki, additional, Vanamee, Eva, additional, Foster, Rosemary, additional, Faustman, Denise, additional, Stack, Edward, additional, Izaki, Daisuke, additional, Beck, Kristen, additional, Jia, Dan Tong, additional, Armenta, Paul, additional, White-Stern, Ashley, additional, Marks, Douglas, additional, Taback, Bret, additional, Horst, Basil, additional, Glickman, Laura Hix, additional, Kanne, David B., additional, Gauthier, Kelsey S., additional, Desbien, Anthony L., additional, Francica, Brian, additional, Leong, Justin L., additional, Sung, Leonard, additional, Metchette, Ken, additional, Kasibhatla, Shailaja, additional, Pferdekamper, Anne Marie, additional, Zheng, Lianxing, additional, Cho, Charles, additional, Feng, Yan, additional, McKenna, Jeffery M., additional, Tallarico, John, additional, Bender, Steven, additional, Ndubaku, Chudi, additional, McWhirter, Sarah M., additional, Gugel, Elena Gonzalez, additional, Bell, Charles J. M., additional, Munk, Adiel, additional, Muniz, Luciana, additional, Bhardwaj, Nina, additional, Zhao, Fei, additional, Evans, Kathy, additional, Xiao, Christine, additional, Holtzhausen, Alisha, additional, Hanks, Brent A., additional, Scholler, Nathalie, additional, Yin, Catherine, additional, Van der Meijs, Pien, additional, Prantner, Andrew M., additional, Krejsa, Cecile M., additional, Smith, Leia, additional, Johnson, Brian, additional, Branstetter, Daniel, additional, Stein, Paul L., additional, Jaen, Juan C., additional, Tan, Joanne BL, additional, Chen, Ada, additional, Park, Timothy, additional, Powers, Jay P., additional, Sexton, Holly, additional, Xu, Guifen, additional, Young, Steve W., additional, Schindler, Ulrike, additional, Deng, Wentao, additional, Klinke, David John, additional, Komar, Hannah M., additional, Serpa, Gregory, additional, Elnaggar, Omar, additional, Hart, Philip, additional, Schmidt, Carl, additional, Dillhoff, Mary, additional, Jin, Ming, additional, Ostrowski, Michael C., additional, Koti, Madhuri, additional, Au, Katrina, additional, Peterson, Nichole, additional, Truesdell, Peter, additional, Reid-Schachter, Gillian, additional, Graham, Charles, additional, Craig, Andrew, additional, Francis, Julie-Ann, additional, Kotlan, Beatrix, additional, Balatoni, Timea, additional, Farkas, Emil, additional, Toth, Laszlo, additional, Ujhelyi, Mihaly, additional, Savolt, Akos, additional, Doleschall, Zoltan, additional, Horvath, Szabolcs, additional, Eles, Klara, additional, Olasz, Judit, additional, Csuka, Orsolya, additional, Kasler, Miklos, additional, Liszkay, Gabriella, additional, Barnea, Eytan, additional, Blakely, Collin, additional, Flynn, Patrick, additional, Goodman, Reid, additional, Bueno, Raphael, additional, Sugarbaker, David, additional, Jablons, David, additional, Broaddus, V. Courtney, additional, West, Brian, additional, Kunk, Paul R., additional, Obeid, Joseph M., additional, Winters, Kevin, additional, Pramoonjago, Patcharin, additional, Stelow, Edward B., additional, Bauer, Todd W., additional, Rahma, Osama E., additional, Lamble, Adam, additional, Kosaka, Yoko, additional, Huang, Fei, additional, Saser, Kate A., additional, Adams, Homer, additional, Tognon, Christina E., additional, Laderas, Ted, additional, McWeeney, Shannon, additional, Loriaux, Marc, additional, Tyner, Jeffery W., additional, Druker, Brian J., additional, Lind, Evan F., additional, Liu, Zhuqing, additional, Lu, Shanhong, additional, Kane, Lawrence P., additional, Shayan, Gulidanna, additional, Femel, Julia, additional, Lane, Ryan, additional, Booth, Jamie, additional, Lund, Amanda W., additional, Rodriguez, Anthony, additional, Engelhard, Victor H., additional, Metelli, Alessandra, additional, Wu, Bill X., additional, Fugle, Caroline W., additional, Saleh, Rachidi, additional, Sun, Shaoli, additional, Wu, Jennifer, additional, Liu, Bei, additional, Li, Zihai, additional, Morris, Zachary S., additional, Guy, Emily I., additional, Heinze, Clinton, additional, Kler, Jasdeep, additional, Gressett, Monica M., additional, Werner, Lauryn R., additional, Gillies, Stephen D., additional, Korman, Alan J., additional, Loibner, Hans, additional, Hank, Jacquelyn A., additional, Rakhmilevich, Alexander L., additional, Harari, Paul M., additional, Sondel, Paul M., additional, Huelsmann, Erica, additional, Broucek, Joseph, additional, Brech, Dorothee, additional, Straub, Tobias, additional, Irmler, Martin, additional, Beckers, Johannes, additional, Buettner, Florian, additional, Schaeffeler, Elke, additional, Schwab, Matthias, additional, Noessner, Elfriede, additional, Wolfreys, Alison, additional, Da Costa, Andre, additional, Silva, John, additional, Crosby, Andrea, additional, Staelens, Ludovicus, additional, Craggs, Graham, additional, Cauvin, Annick, additional, Mason, Sean, additional, Paterson, Alison M., additional, Lake, Andrew C., additional, Armet, Caroline M., additional, O’Connor, Rachel W., additional, Hill, Jonathan A., additional, Normant, Emmanuel, additional, Adam, Ammar, additional, Biniszkiewicz, Detlev M., additional, Chappel, Scott C., additional, Palombella, Vito J., additional, Holland, Pamela M., additional, Becker, Annette, additional, Leleti, Manmohan R., additional, Newcomb, Eric, additional, Tan, Joanne B. L., additional, Rapisuwon, Suthee, additional, Radfar, Arash, additional, Gardner, Kellie, additional, Gibney, Geoffrey, additional, Atkins, Michael, additional, Rennier, Keith R., additional, Crowder, Robert, additional, Wang, Ping, additional, Pachynski, Russell K., additional, Carrero, Rosa M. Santana, additional, Rivas, Sarai, additional, Beceren-Braun, Figen, additional, Anthony, Scott, additional, Schluns, Kimberly S., additional, Sawant, Deepali, additional, Chikina, Maria, additional, Yano, Hiroshi, additional, Workman, Creg, additional, Salerno, Elise, additional, Mauldin, Ileana, additional, Deacon, Donna, additional, Shea, Sofia, additional, Pinczewski, Joel, additional, Gajewski, Thomas, additional, Spranger, Stefani, additional, Horton, Brendan, additional, Suzuki, Akiko, additional, Leland, Pamela, additional, Joshi, Bharat H., additional, Puri, Raj K., additional, Sweis, Randy F., additional, Bao, Riyue, additional, Luke, Jason, additional, Theodoraki, Marie-Nicole, additional, Mogundo, Frances-Mary, additional, Won, Haejung, additional, Moreira, Dayson, additional, Gao, Chan, additional, Zhao, Xingli, additional, Duttagupta, Priyanka, additional, Jones, Jeremy, additional, D’Apuzzo, Massimo, additional, and Pal, Sumanta, additional

Published
2016
Full Text
View/download PDF

24. Corrigendum to “Adenoviral Delivery of Tumor Necrosis Factor-α and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma”

Author

Siurala, Mikko, primary, Havunen, Riikka, additional, Saha, Dipongkor, additional, Lumen, Dave, additional, Airaksinen, Anu J., additional, Tähtinen, Siri, additional, Cervera-Carrascon, Víctor, additional, Bramante, Simona, additional, Parviainen, Suvi, additional, Vähä-Koskela, Markus, additional, Kanerva, Anna, additional, and Hemminki, Akseli, additional

Published
2016
Full Text
View/download PDF

25. Abstract B063: Oncolytic adenoviruses armed with tumor necrosis factor alpha and interleukin-2 enable successful adoptive T cell therapy of solid tumors

Author

Siurala, Mikko, primary, Havunen, Riikka, additional, Santos, João, additional, Tähtinen, Siri, additional, Saha, Dipongkor, additional, Vähä-Koskela, Markus, additional, Behr, Michael, additional, Nettelbeck, Dirk M., additional, Ehrhardt, Anja, additional, Parviainen, Suvi, additional, and Hemminki, Akseli, additional

Published
2016
Full Text
View/download PDF

33. Favorable Alteration of Tumor Microenvironment by Immunomodulatory Cytokines for Efficient T-Cell Therapy in Solid Tumors

Author

University of Helsinki, Clinicum, University of Helsinki, Haartman Institute, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Tahtinen, Siri, Kaikkonen, Saija, Merisalo-Soikkeli, Maiju, Gronberg-Vaha-Koskela, Susanna, Kanerva, Anna, Parviainen, Suvi, Vaha-Koskela, Markus, Hemminki, Akseli, University of Helsinki, Clinicum, University of Helsinki, Haartman Institute, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Tahtinen, Siri, Kaikkonen, Saija, Merisalo-Soikkeli, Maiju, Gronberg-Vaha-Koskela, Susanna, Kanerva, Anna, Parviainen, Suvi, Vaha-Koskela, Markus, and Hemminki, Akseli

Abstract

Unfavorable ratios between the number and activation status of effector and suppressor immune cells infiltrating the tumor contribute to resistance of solid tumors to T-cell based therapies. Here, we studied the capacity of FDA and EMA approved recombinant cytokines to manipulate this balance in favor of efficient anti-tumor responses in B16. OVA melanoma bearing C57BL/6 mice. Intratumoral administration of IFN-alpha 2, IFN-gamma, TNF-alpha, and IL-2 significantly enhanced the anti-tumor effect of ovalbumin-specific CD8+ T-cell (OT-I) therapy, whereas GM-CSF increased tumor growth in association with an increase in immunosuppressive cell populations. None of the cytokines augmented tumor trafficking of OT-I cells significantly, but injections of IFN-alpha 2, IFN-gamma and IL-2 increased intratumoral cytokine secretion and recruitment of endogenous immune cells capable of stimulating T-cells, such as natural killer and maturated CD11c+ antigen-presenting cells. Moreover, IFN-alpha 2 and IL-2 increased the levels of activated tumor-infiltrating CD8+ T-cells concomitant with reduction in the CD8+ T-cell expression of anergy markers CTLA-4 and PD-1. In conclusion, intratumoral administration of IFN-alpha 2, IFN-gamma and IL-2 can lead to immune sensitization of the established tumor, whereas GM-CSF may contribute to tumor-associated immunosuppression. The results described here provide rationale for including local administration of immunostimulatory cytokines into T-cell therapy regimens. One appealing embodiment of this would be vectored delivery which could be advantageous over direct injection of recombinant molecules with regard to efficacy, cost, persistence and convenience.

Published
2015

34. Incomplete but Infectious Vaccinia Virions Are Produced in the Absence of Oncolysis in Feline SCCF1 Cells

Author

University of Helsinki, Haartman Institute, University of Helsinki, Department of Equine and Small Animal Medicine, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Research Programs Unit, University of Helsinki, Faculty of Pharmacy, University of Helsinki, Medicum, Parviainen, Suvi, Autio, Karoliina, Vähä-Koskela, Markus, Guse, Kilian, Pesonen, Sari, Rosol, Thomas J., Zhao, Fang, Hemminki, Akseli, University of Helsinki, Haartman Institute, University of Helsinki, Department of Equine and Small Animal Medicine, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Research Programs Unit, University of Helsinki, Faculty of Pharmacy, University of Helsinki, Medicum, Parviainen, Suvi, Autio, Karoliina, Vähä-Koskela, Markus, Guse, Kilian, Pesonen, Sari, Rosol, Thomas J., Zhao, Fang, and Hemminki, Akseli

Abstract

Vaccinia virus is a large, enveloped virus of the poxvirus family. It has broad tropism and typically virus replication culminates in accumulation and lytic release of intracellular mature virus (IMV), the most abundant form of infectious virus, as well as release by budding of extracellular enveloped virus (EEV). Vaccinia viruses have been modified to replicate selectively in cancer cells and clinically tested as oncolytic agents. During preclinical screening of relevant cancer targets for a recombinant Western Reserve strain deleted for both copies of the thymidine kinase and vaccinia growth factor genes, we noticed that confluent monolayers of SCCF1 cat squamous carcinoma cells were not destroyed even after prolonged infection. Interestingly, although SCCF1 cells were not killed, they continuously secreted virus into the cell culture supernatant. To investigate this finding further, we performed detailed studies by electron microscopy. Both intracellular and secreted virions showed morphological abnormalities on ultrastructural inspection, suggesting compromised maturation and morphogenesis of vaccinia virus in SCCF1 cells. Our data suggest that SCCF1 cells produce a morphologically abnormal virus which is nevertheless infective, providing new information on the virus-host cell interactions and intracellular biology of vaccinia virus.

Published
2015

35. Developing genetically engineered oncolytic viruses for cancer gene therapy

Author

Helsingin yliopisto, lääketieteellinen tiedekunta, kliinisteoreettinen laitos, Helsingfors universitet, medicinska fakulteten, Haartman institutet, University of Helsinki, Faculty of Medicine, Haartman Institute, Medicum, Parviainen, Suvi, Helsingin yliopisto, lääketieteellinen tiedekunta, kliinisteoreettinen laitos, Helsingfors universitet, medicinska fakulteten, Haartman institutet, University of Helsinki, Faculty of Medicine, Haartman Institute, Medicum, and Parviainen, Suvi

Abstract

It has been estimated that up to half of people living in industrial societies will get cancer. Almost all cancer deaths are caused by metastatic disease and only few metastatic solid tumors can be cured with available therapies. Therefore, novel therapeutic modalities are needed. Genetically engineered oncolytic viruses such as adenoviruses and vaccinia viruses are a promising therapeutic approach given their capacity to specifically replicate in and kill tumor cells as well as to reach distant metastasis. Oncolytic viruses have demonstrated good safety, tolerability and promising signs of anti-tumor efficacy in several clinical trials, but the efficacy of the therapy needs improvement to reach its full clinical potential. Adenoviruses are one of the most studied vectors in oncolytic virotherapy. Two major obstacles limiting the efficacy have been insufficient transduction of the tumor cells and the recognition of the virus by the immune system, which rapidly clears the virus from systemic circulation, hampering the overall efficacy. This study shows that novel capsid modifications can increase the transduction efficacy and oncolytic potency of the virus, and that embedding oncolytic virus in a silica implant might help to circumvent the problem of clearance by prompting only modest immune responses against the virus. Recently, arming oncolytic viruses with immunomodulatory molecules has been a major focus in virotherapy. Immunotherapy means inducing the patient´s immune system to recognize and attack the tumor and has been recently linked with oncolytic virotherapy, as the replication of the virus in the tumor can be immunogenic per se and also release cancer epitopes available for antigen-presenting cells. Host immune responses have been shown to be a key player in oncolytic virotherapy as the balance between anti-viral and anti-tumoral immunity determines the efficacy of the therapy. Oncolytic vaccinia virus possesses unique immunogenicity and mechanisms of acti, Syöpäsairaudet ovat vakava maailmanlaajuinen ongelma, johon sairastuu elämänsä aikana arviolta joka toinen mies ja joka kolmas nainen. Vaikka syövän diagnostiikka, ennaltaehkäisy ja nykyiset hoitomuodot ovat parantuneet huomattavasti, erityisesti eräpesäkkeitä muodostavissa syöpäsairauksissa on ennuste usein huono ja parantavaa hoitoa ei ole. Tämän väitöskirjatutkimuksen tavoitteena oli kehittää onkolyyttisiin vaccinia- ja adenoviruksiin perustuvia syöpähoitoja. Viruksia on usein muokattu siten, että ne kopioituvat ensisijaisesti syöpäsoluissa rikkoen syöpäsoluja oman elinkiertonsa päätteeksi. Väitöskirjatyössäni tutkittiin mahdollisuuksia muokata viruksen syöpäsoluun tarttuvaa reseptoria eri tavoin, ja muokkausten huomattiinkin tehostavan viruksen siirtymistä syöpäsolun sisälle huomattavasti. Tutkimme myös mahdollisuutta annostella virus osana elimistössä hajoavaa silika-implanttia, jonka huomattiinkin vapauttavan virusta verenkiertoon hitaammin ja vähentävän siten myös neutralisoivien vasta-aineiden muodostumista. Immunologisten tekijöiden on osoitettu olevat tärkeitä onkolyyttisten virusten tehokkuuden määräytymisessä. Viruksen lisääntyminen kasvaimissa voimistaa immuunivastetta lisäämällä sytokiinien tuotantoa ja vapauttamalla kasvimen antigeenejä immuunijärjestelmän tunnistettavaksi. Viruksia voidaan käyttää vektoreina kuljettaen hoidon kannalta oleellisia geenejä soluihin, joten niiden varustaminen terapeuttisilla siirtogeeneillä saattaa parantaa viruksen kasvaimelle haitallista vaikutusta, säilyttäen kuitenkin turvallisuutensa syöpäkudokseen rajoitetun lisääntymisensä myötä. Väitöskirjatyössäni tutkittiin mahdollisuutta muokata viruksia tuottamaan kahta erilaista immuunijärjestelmää aktivoivaa proteiinia; granulosyytti-makrofagikasvutekijää (GMCSF) sekä CD40-ligandia. Hoitojen toimivuutta testattiin ensin syöpäsoluissa in vitro ja hyviksi havaitut mallit testattiin eläinkokeiden avulla käyttämällä eläinmalleina hiiriä ja hamstereita. Eläinkokeiden tavoitteena

Published
2015

41. Immunological data from cancer patients treated with Ad5/3-E2F-Δ24-GMCSF suggests utility for tumor immunotherapy

Author

Hemminki, Otto, primary, Parviainen, Suvi, additional, Juhila, Juuso, additional, Turkki, Riku, additional, Linder, Nina, additional, Lundin, Johan, additional, Kankainen, Matti, additional, Ristimäki, Ari, additional, Koski, Anniina, additional, Liikanen, Ilkka, additional, Oksanen, Minna, additional, Nettelbeck, Dirk M., additional, Kairemo, Kalevi, additional, Partanen, Kaarina, additional, Joensuu, Timo, additional, Kanerva, Anna, additional, and Hemminki, Akseli, additional

Published
2015
Full Text
View/download PDF

45. Oncolytic adenovirus and doxorubicin-based chemotherapy results in synergistic antitumor activity against soft-tissue sarcoma

Author

Siurala, Mikko, primary, Bramante, Simona, additional, Vassilev, Lotta, additional, Hirvinen, Mari, additional, Parviainen, Suvi, additional, Tähtinen, Siri, additional, Guse, Kilian, additional, Cerullo, Vincenzo, additional, Kanerva, Anna, additional, Kipar, Anja, additional, Vähä-Koskela, Markus, additional, and Hemminki, Akseli, additional

Published
2014
Full Text
View/download PDF

46. Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus

Author

Diaconu, Iulia, Cerullo, Vincenzo, Hirvinen, Mari L M, Escutenaire, Sophie, Ugolini, Matteo, Pesonen, Saila K, Bramante, Simona, Parviainen, Suvi, Kanerva, Anna, Loskog, Angelica S I, Eliopoulos, Aristides G, Pesonen, Sari, Hemminki, Akseli, Diaconu, Iulia, Cerullo, Vincenzo, Hirvinen, Mari L M, Escutenaire, Sophie, Ugolini, Matteo, Pesonen, Saila K, Bramante, Simona, Parviainen, Suvi, Kanerva, Anna, Loskog, Angelica S I, Eliopoulos, Aristides G, Pesonen, Sari, and Hemminki, Akseli

Abstract

Oncolytic adenovirus is an attractive platform for immunotherapy because virus replication is highly immunogenic and not subject to tolerance. Although oncolysis releases tumor epitopes and provides costimulatory danger signals, arming the virus with immunostimulatory molecules can further improve efficacy. CD40 ligand (CD40L, CD154) induces apoptosis of tumor cells and triggers several immune mechanisms, including a T-helper type 1 (TH1) response, which leads to activation of cytotoxic T cells and reduction of immunosuppression. In this study, we constructed a novel oncolytic adenovirus, Ad5/3-hTERT-E1A-hCD40L, which features a chimeric Ad5/3 capsid for enhanced tumor transduction, a human telomerase reverse transcriptase (hTERT) promoter for tumor selectivity, and human CD40L for increased efficacy. Ad5/3-hTERT-E1A-hCD40L significantly inhibited tumor growth in vivo via oncolytic and apoptotic effects, and (Ad5/3-hTERT-E1A-hCD40L)–mediated oncolysis resulted in enhanced calreticulin exposure and HMGB1 and ATP release, which were suggestive of immunogenicity. In two syngeneic mouse models, murine CD40L induced recruitment and activation of antigen-presenting cells, leading to increased interleukin-12 production in splenocytes. This effect was associated with induction of the TH1 cytokines IFN-γ, RANTES, and TNF-α. Tumors treated with Ad5/3-CMV-mCD40L also displayed an enhanced presence of macrophages and cytotoxic CD8+ T cells but not B cells. Together, our findings show that adenoviruses coding for CD40L mediate multiple antitumor effects including oncolysis, apoptosis, induction of T-cell responses, and upregulation of TH1 cytokines.

Published
2012
Full Text
View/download PDF

47. Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus

Author

Diaconu, Iulia, primary, Cerullo, Vincenzo, additional, Hirvinen, Mari L.M., additional, Escutenaire, Sophie, additional, Ugolini, Matteo, additional, Pesonen, Saila K., additional, Bramante, Simona, additional, Parviainen, Suvi, additional, Kanerva, Anna, additional, Loskog, Angelica S.I., additional, Eliopoulos, Aristides G., additional, Pesonen, Sari, additional, and Hemminki, Akseli, additional

Published
2012
Full Text
View/download PDF

48. Effects of capsid‐modified oncolytic adenoviruses and their combinations with gemcitabine or silica gel on pancreatic cancer

Author

Kangasniemi, Lotta, primary, Parviainen, Suvi, additional, Pisto, Tommi, additional, Koskinen, Mika, additional, Jokinen, Mika, additional, Kiviluoto, Tuula, additional, Cerullo, Vincenzo, additional, Jalonen, Harry, additional, Koski, Anniina, additional, Kangasniemi, Anna, additional, Kanerva, Anna, additional, Pesonen, Sari, additional, and Hemminki, Akseli, additional

Published
2011
Full Text
View/download PDF

50. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one: National Harbor, MD, USA. 9-13 November 2016

Author

Lundqvist, Andreas, van Hoef, Vincent, Zhang, Xiaonan, Wennerberg, Erik, Lorent, Julie, Witt, Kristina, Sanz, Laia Masvidal, Liang, Shuo, Murray, Shannon, Larsson, Ola, Kiessling, Rolf, Mao, Yumeng, Sidhom, John-William, Bessell, Catherine A., Havel, Jonathan, Schneck, Jonathan, Chan, Timothy A., Sachsenmeier, Eliot, Woods, David, Berglund, Anders, Ramakrishnan, Rupal, Sodre, Andressa, Weber, Jeffrey, Zappasodi, Roberta, Li, Yanyun, Qi, Jingjing, Wong, Philip, Sirard, Cynthia, Postow, Michael, Newman, Walter, Koon, Henry, Velcheti, Vamsidhar, Callahan, Margaret K., Wolchok, Jedd D., Merghoub, Taha, Lum, Lawrence G., Choi, Minsig, Thakur, Archana, Deol, Abhinav, Dyson, Gregory, Shields, Anthony, Haymaker, Cara, Uemura, Marc, Murthy, Ravi, James, Marihella, Wang, Daqing, Brevard, Julie, Monaghan, Catherine, Swann, Suzanne, Geib, James, Cornfeld, Mark, Chunduru, Srinivas, Agrawal, Sudhir, Yee, Cassian, Wargo, Jennifer, Patel, Sapna P., Amaria, Rodabe, Tawbi, Hussein, Glitza, Isabella, Woodman, Scott, Hwu, Wen-Jen, Davies, Michael A., Hwu, Patrick, Overwijk, Willem W., Bernatchez, Chantale, Diab, Adi, Massarelli, Erminia, Segal, Neil H., Ribrag, Vincent, Melero, Ignacio, Gangadhar, Tara C., Urba, Walter, Schadendorf, Dirk, Ferris, Robert L., Houot, Roch, Morschhauser, Franck, Logan, Theodore, Luke, Jason J., Sharfman, William, Barlesi, Fabrice, Ott, Patrick A., Mansi, Laura, Kummar, Shivaani, Salles, Gilles, Carpio, Cecilia, Meier, Roland, Krishnan, Suba, McDonald, Dan, Maurer, Matthew, Gu, Xuemin, Neely, Jaclyn, Suryawanshi, Satyendra, Levy, Ronald, Khushalani, Nikhil, Wu, Jennifer, Zhang, Jinyu, Basher, Fahmin, Rubinstein, Mark, Bucsek, Mark, Qiao, Guanxi, MacDonald, Cameron, Hylander, Bonnie, Repasky, Elizabeth, Chatterjee, Shilpak, Daenthanasanmak, Anusara, Chakraborty, Paramita, Toth, Kyle, Meek, Megan, Garrett-Mayer, Elizabeth, Nishimura, Michael, Paulos, Chrystal, Beeson, Craig, Yu, Xuezhong, Mehrotra, Shikhar, Zhao, Fei, Evans, Kathy, Xiao, Christine, Holtzhausen, Alisha, Hanks, Brent A., Scharping, Nicole, Menk, Ashley V., Moreci, Rebecca, Whetstone, Ryan, Dadey, Rebekah, Watkins, Simon, Ferris, Robert, Delgoffe, Greg M., Peled, Jonathan, Devlin, Sean, Staffas, Anna, Lumish, Melissa, Rodriguez, Kori Porosnicu, Ahr, Katya, Perales, Miguel, Giralt, Sergio, Taur, Ying, Pamer, Eric, van den Brink, Marcel R. M., Jenq, Robert, Annels, Nicola, Pandha, Hardev, Simpson, Guy, Mostafid, Hugh, Harrington, Kevin, Melcher, Alan, Grose, Mark, Davies, Bronwyn, Au, Gough, Karpathy, Roberta, Shafren, Darren, Ricca, Jacob, Zamarin, Dmitriy, Batista, Luciana, Marliot, Florence, Vasaturo, Angela, Carpentier, Sabrina, Poggionovo, Cécile, Frayssinet, Véronique, Fieschi, Jacques, Van den Eynde, Marc, Pagès, Franck, Galon, Jérôme, Hermitte, Fabienne, Smith, Sean G., Nguyen, Khue, Ravindranathan, Sruthi, Koppolu, Bhanu, Zaharoff, David, Schvartsman, Gustavo, Bassett, Roland, McQuade, Jennifer L., Haydu, Lauren E., Kline, Douglas, Chen, Xiufen, Fosco, Dominick, Kline, Justin, Overacre, Abigail, Chikina, Maria, Brunazzi, Erin, Shayan, Gulidanna, Horne, William, Kolls, Jay, Bruno, Tullia C., Workman, Creg, Vignali, Dario, Adusumilli, Prasad S., Ansa-Addo, Ephraim A, Li, Zihai, Gerry, Andrew, Sanderson, Joseph P., Howe, Karen, Docta, Roslin, Gao, Qian, Bagg, Eleanor A. L., Tribble, Nicholas, Maroto, Miguel, Betts, Gareth, Bath, Natalie, Melchiori, Luca, Lowther, Daniel E., Ramachandran, Indu, Kari, Gabor, Basu, Samik, Binder-Scholl, Gwendolyn, Chagin, Karen, Pandite, Lini, Holdich, Tom, Amado, Rafael, Zhang, Hua, Glod, John, Bernstein, Donna, Jakobsen, Bent, Mackall, Crystal, Wong, Ryan, Silk, Jonathan D., Adams, Katherine, Hamilton, Garth, Bennett, Alan D., Brett, Sara, Jing, Junping, Quattrini, Adriano, Saini, Manoj, Wiedermann, Guy, Brewer, Joanna, Duong, MyLinh, Lu, An, Chang, Peter, Mahendravada, Aruna, Shinners, Nicholas, Slawin, Kevin, Spencer, David M., Foster, Aaron E., Bayle, J. Henri, Bergamaschi, Cristina, Ng, Sinnie Sin Man, Nagy, Bethany, Jensen, Shawn, Hu, Xintao, Alicea, Candido, Fox, Bernard, Felber, Barbara, Pavlakis, George, Chacon, Jessica, Yamamoto, Tori, Garrabrant, Thomas, Cortina, Luis, Powell, Daniel J., Donia, Marco, Kjeldsen, Julie Westerlin, Andersen, Rikke, Westergaard, Marie Christine Wulff, Bianchi, Valentina, Legut, Mateusz, Attaf, Meriem, Dolton, Garry, Szomolay, Barbara, Ott, Sascha, Lyngaa, Rikke, Hadrup, Sine Reker, Sewell, Andrew Kelvin, Svane, Inge Marie, Fan, Aaron, Kumai, Takumi, Celis, Esteban, Frank, Ian, Stramer, Amanda, Blaskovich, Michelle A., Wardell, Seth, Fardis, Maria, Bender, James, Lotze, Michael T., Goff, Stephanie L., Zacharakis, Nikolaos, Assadipour, Yasmine, Prickett, Todd D., Gartner, Jared J., Somerville, Robert, Black, Mary, Xu, Hui, Chinnasamy, Harshini, Kriley, Isaac, Lu, Lily, Wunderlich, John, Robbins, Paul F., Rosenberg, Steven, Feldman, Steven A., Trebska-McGowan, Kasia, Malekzadeh, Parisa, Payabyab, Eden, Sherry, Richard, Gokuldass, Aishwarya, Kopits, Charlene, Rabinovich, Brian, Green, Daniel S., Kamenyeva, Olena, Zoon, Kathryn C., Annunziata, Christina M., Hammill, Joanne, Helsen, Christopher, Aarts, Craig, Bramson, Jonathan, Harada, Yui, Yonemitsu, Yoshikazu, Mwawasi, Kenneth, Denisova, Galina, Giri, Rajanish, Jin, Benjamin, Campbell, Tracy, Draper, Lindsey M., Stevanovic, Sanja, Yu, Zhiya, Weissbrich, Bianca, Restifo, Nicholas P., Trimble, Cornelia L., Hinrichs, Christian S., Tsang, Kwong, Fantini, Massimo, Hodge, James W., Fujii, Rika, Fernando, Ingrid, Jochems, Caroline, Heery, Christopher, Gulley, James, Soon-Shiong, Patrick, Schlom, Jeffrey, Jing, Weiqing, Gershan, Jill, Blitzer, Grace, Weber, James, McOlash, Laura, Johnson, Bryon D., Kiany, Simin, Gangxiong, Huang, Kleinerman, Eugenie S., Klichinsky, Michael, Ruella, Marco, Shestova, Olga, Kenderian, Saad, Kim, Miriam, Scholler, John, June, Carl H., Gill, Saar, Moogk, Duane, Zhong, Shi, Liadi, Ivan, Rittase, William, Fang, Victoria, Dougherty, Janna, Perez-Garcia, Arianne, Osman, Iman, Zhu, Cheng, Varadarajan, Navin, Frey, Alan, Krogsgaard, Michelle, Landi, Daniel, Fousek, Kristen, Mukherjee, Malini, Shree, Ankita, Joseph, Sujith, Bielamowicz, Kevin, Byrd, Tiara, Ahmed, Nabil, Hegde, Meenakshi, Lee, Sylvia, Byrd, David, Thompson, John, Bhatia, Shailender, Tykodi, Scott, Delismon, Judy, Chu, Liz, Abdul-Alim, Siddiq, Ohanian, Arpy, DeVito, Anna Marie, Riddell, Stanley, Margolin, Kim, Magalhaes, Isabelle, Mattsson, Jonas, Uhlin, Michael, Nemoto, Satoshi, Villarroel, Patricio Pérez, Nakagawa, Ryosuke, Mule, James J., Mailloux, Adam W., Mata, Melinda, Nguyen, Phuong, Gerken, Claudia, DeRenzo, Christopher, Gottschalk, Stephen, Mathieu, Mélissa, Pelletier, Sandy, Stagg, John, Turcotte, Simon, Minutolo, Nicholas, Sharma, Prannda, Tsourkas, Andrew, Mockel-Tenbrinck, Nadine, Mauer, Daniela, Drechsel, Katharina, Barth, Carola, Freese, Katharina, Kolrep, Ulrike, Schult, Silke, Assenmacher, Mario, Kaiser, Andrew, Mullinax, John, Hall, MacLean, Le, Julie, Kodumudi, Krithika, Royster, Erica, Richards, Allison, Gonzalez, Ricardo, Sarnaik, Amod, Pilon-Thomas, Shari, Nielsen, Morten, Krarup-Hansen, Anders, Hovgaard, Dorrit, Petersen, Michael Mørk, Loya, Anand Chainsukh, Junker, Niels, Rivas, Charlotte, Parihar, Robin, Rooney, Cliona M., Qin, Haiying, Nguyen, Sang, Su, Paul, Burk, Chad, Duncan, Brynn, Kim, Bong-Hyun, Kohler, M. Eric, Fry, Terry, Rao, Arjun A., Teyssier, Noam, Pfeil, Jacob, Sgourakis, Nikolaos, Salama, Sofie, Haussler, David, Richman, Sarah A., Nunez-Cruz, Selene, Gershenson, Zack, Mourelatos, Zissimos, Barrett, David, Grupp, Stephan, Milone, Michael, Rodriguez-Garcia, Alba, Robinson, Matthew K., Adams, Gregory P., Santos, João, Havunen, Riikka, Siurala, Mikko, Cervera-Carrascón, Víctor, Parviainen, Suvi, Antilla, Marjukka, Hemminki, Akseli, Sethuraman, Jyothi, Santiago, Laurelis, Chen, Jie Qing, Dai, Zhimin, Sha, Huizi, Su, Shu, Ding, Naiqing, Liu, Baorui, Pasetto, Anna, Helman, Sarah R., Rosenberg, Steven A., Burgess, Melissa, Zhang, Hui, Lee, Tien, Klingemann, Hans, Nghiem, Paul, Kirkwood, John M., Rossi, John M., Sherman, Marika, Xue, Allen, Shen, Yueh-wei, Navale, Lynn, Kochenderfer, James N., Bot, Adrian, Veerapathran, Anandaraman, Wiener, Doris, Waller, Edmund K., Li, Jian-Ming, Petersen, Christopher, Blazar, Bruce R., Li, Jingxia, Giver, Cynthia R., Wang, Ziming, Grossenbacher, Steven K., Sturgill, Ian, Canter, Robert J., Murphy, William J., Zhang, Congcong, Burger, Michael C., Jennewein, Lukas, Waldmann, Anja, Mittelbronn, Michel, Tonn, Torsten, Steinbach, Joachim P., Wels, Winfried S., Williams, Jason B., Zha, Yuanyuan, Gajewski, Thomas F., Williams, LaTerrica C., Krenciute, Giedre, Kalra, Mamta, Louis, Chrystal, Xin, Gang, Schauder, David, Jiang, Aimin, Joshi, Nikhil, Cui, Weiguo, Zeng, Xue, Zhao, Zeguo, Hamieh, Mohamad, Eyquem, Justin, Gunset, Gertrude, Bander, Neil, Sadelain, Michel, Askmyr, David, Abolhalaj, Milad, Lundberg, Kristina, Greiff, Lennart, Lindstedt, Malin, Angell, Helen K., Kim, Kyoung-Mee, Kim, Seung-Tae, Kim, Sung, Sharpe, Alan D., Ogden, Julia, Davenport, Anna, Hodgson, Darren R., Barrett, Carl, Lee, Jeeyun, Kilgour, Elaine, Hanson, Jodi, Caspell, Richard, Karulin, Alexey, Lehmann, Paul, Ansari, Tameem, Schiller, Annemarie, Sundararaman, Srividya, Roen, Diana, Ayers, Mark, Levitan, Diane, Arreaza, Gladys, Liu, Fang, Mogg, Robin, Bang, Yung-Jue, O’Neil, Bert, Cristescu, Razvan, Friedlander, Philip, Wassman, Karl, Kyi, Chrisann, Oh, William, Bhardwaj, Nina, Bornschlegl, Svetlana, Gustafson, Michael P., Gastineau, Dennis A., Parney, Ian F., Dietz, Allan B., Carvajal-Hausdorf, Daniel, Mani, Nikita, Schalper, Kurt, Rimm, David, Chang, Serena, Kurland, John, Ahlers, Christoph Matthias, Jure-Kunkel, Maria, Cohen, Lewis, Maecker, Holden, Kohrt, Holbrook, Chen, Shuming, Crabill, George, Pritchard, Theresa, McMiller, Tracee, Pardoll, Drew, Pan, Fan, Topalian, Suzanne, Danaher, Patrick, Warren, Sarah, Dennis, Lucas, White, Andrew M., D’Amico, Leonard, Geller, Melissa, Disis, Mary L., Beechem, Joseph, Odunsi, Kunle, Fling, Steven, Derakhshandeh, Roshanak, Webb, Tonya J., Dubois, Sigrid, Conlon, Kevin, Bryant, Bonita, Hsu, Jennifer, Beltran, Nancy, Müller, Jürgen, Waldmann, Thomas, Duhen, Rebekka, Duhen, Thomas, Thompson, Lucas, Montler, Ryan, Weinberg, Andrew, Kates, Max, Early, Brandon, Yusko, Erik, Schreiber, Taylor H., Bivalacqua, Trinity J., Lunceford, Jared, Nebozhyn, Michael, Murphy, Erin, Loboda, Andrey, Kaufman, David R., Albright, Andrew, Cheng, Jonathan, Kang, S. Peter, Shankaran, Veena, Piha-Paul, Sarina A., Yearley, Jennifer, Seiwert, Tanguy, Ribas, Antoni, McClanahan, Terrill K., Sher, Xinwei, Liu, Xiao Qiao, Joe, Andrew, Plimack, Elizabeth, Forrest-Hay, Alex, Guyre, Cheryl A., Narumiya, Kohei, Delcommenne, Marc, Hirsch, Heather A., Deshpande, Amit, Reeves, Jason, Shu, Jenny, Zi, Tong, Michaelson, Jennifer, Law, Debbie, Trehu, Elizabeth, Sathyanaryanan, Sriram, Hodkinson, Brendan P., Hutnick, Natalie A., Schaffer, Michael E., Gormley, Michael, Hulett, Tyler, Ballesteros-Merino, Carmen, Dubay, Christopher, Afentoulis, Michael, Reddy, Ashok, David, Larry, Jayant, Kumar, Agrawal, Swati, Agrawal, Rajendra, Jeyakumar, Ghayathri, Kim, Seongho, Kim, Heejin, Silski, Cynthia, Suisham, Stacey, Heath, Elisabeth, Vaishampayan, Ulka, Vandeven, Natalie, Viller, Natasja Nielsen, O’Connor, Alison, Chen, Hui, Bossen, Bolette, Sievers, Eric, Uger, Robert, Johnson, Lisa, Kao, Hsiang-Fong, Hsiao, Chin-Fu, Lai, Shu-Chuan, Wang, Chun-Wei, Ko, Jenq-Yuh, Lou, Pei-Jen, Lee, Tsai-Jan, Liu, Tsang-Wu, Hong, Ruey-Long, Kearney, Staci J., Black, Joshua C., Landis, Benjamin J., Koegler, Sally, Hirsch, Brooke, Gianani, Roberto, Kim, Jeffrey, He, Ming-Xiao, Zhang, Bingqing, Su, Nan, Luo, Yuling, Ma, Xiao-Jun, Park, Emily, Kim, Dae Won, Copploa, Domenico, Kothari, Nishi, doo Chang, Young, Kim, Richard, Kim, Namyong, Lye, Melvin, Wan, Ee, Knaus, Hanna A., Berglund, Sofia, Hackl, Hubert, Karp, Judith E., Gojo, Ivana, Luznik, Leo, Hong, Henoch S., Koch, Sven D., Scheel, Birgit, Gnad-Vogt, Ulrike, Kallen, Karl-Josef, Wiegand, Volker, Backert, Linus, Kohlbacher, Oliver, Hoerr, Ingmar, Fotin-Mleczek, Mariola, Billingsley, James M., Koguchi, Yoshinobu, Conrad, Valerie, Miller, William, Gonzalez, Iliana, Poplonski, Tomasz, Meeuwsen, Tanisha, Howells-Ferreira, Ana, Rattray, Rogan, Campbell, Mary, Bifulco, Carlo, Bahjat, Keith, Curti, Brendan, Vetsika, E-K, Kallergi, G., Aggouraki, Despoina, Lyristi, Z., Katsarlinos, P., Koinis, Filippos, Georgoulias, V., Kotsakis, Athanasios, Martin, Nathan T., Aeffner, Famke, Cerkovnik, Logan, Pratte, Luke, Kim, Rebecca, Krueger, Joseph, Martínez-Usatorre, Amaia, Jandus, Camilla, Donda, Alena, Carretero-Iglesia, Laura, Speiser, Daniel E., Zehn, Dietmar, Rufer, Nathalie, Romero, Pedro, Panda, Anshuman, Mehnert, Janice, Hirshfield, Kim M., Riedlinger, Greg, Damare, Sherri, Saunders, Tracie, Sokol, Levi, Stein, Mark, Poplin, Elizabeth, Rodriguez-Rodriguez, Lorna, Silk, Ann, Chan, Nancy, Frankel, Melissa, Kane, Michael, Malhotra, Jyoti, Aisner, Joseph, Kaufman, Howard L., Ali, Siraj, Ross, Jeffrey, White, Eileen, Bhanot, Gyan, Ganesan, Shridar, Monette, Anne, Bergeron, Derek, Amor, Amira Ben, Meunier, Liliane, Caron, Christine, Morou, Antigoni, Kaufmann, Daniel, Liberman, Moishe, Jurisica, Igor, Mes-Masson, Anne-Marie, Hamzaoui, Kamel, Lapointe, Rejean, Mongan, Ann, Ku, Yuan-Chieh, Tom, Warren, Sun, Yongming, Pankov, Alex, Looney, Tim, Au-Young, Janice, Hyland, Fiona, Conroy, Jeff, Morrison, Carl, Glenn, Sean, Burgher, Blake, Ji, He, Gardner, Mark, Omilian, Angela R., Bshara, Wiam, Angela, Omilian, Obeid, Joseph M., Erdag, Gulsun, Smolkin, Mark E., Deacon, Donna H., Patterson, James W., Chen, Lieping, Bullock, Timothy N., Slingluff, Craig L., Loffredo, John T., Vuyyuru, Raja, Beyer, Sophie, Spires, Vanessa M., Fox, Maxine, Ehrmann, Jon M., Taylor, Katrina A., Korman, Alan J., Graziano, Robert F., Page, David, Sanchez, Katherine, Martel, Maritza, De Macedo, Mariana Petaccia, Qin, Yong, Reuben, Alex, Spencer, Christine, Guindani, Michele, Racolta, Adriana, Kelly, Brian, Jones, Tobin, Polaske, Nathan, Theiss, Noah, Robida, Mark, Meridew, Jeffrey, Habensus, Iva, Zhang, Liping, Pestic-Dragovich, Lidija, Tang, Lei, Sullivan, Ryan J., Olencki, Thomas, Hutson, Thomas, Roder, Joanna, Blackmon, Shauna, Roder, Heinrich, Stewart, John, Amin, Asim, Ernstoff, Marc S., Clark, Joseph I., Atkins, Michael B., Sosman, Jeffrey, McDermott, David F., Kluger, Harriet, Halaban, Ruth, Snzol, Mario, Asmellash, Senait, Steingrimsson, Arni, Wang, Chichung, Roman, Kristin, Clement, Amanda, Downing, Sean, Hoyt, Clifford, Harder, Nathalie, Schmidt, Guenter, Schoenmeyer, Ralf, Brieu, Nicolas, Yigitsoy, Mehmet, Madonna, Gabriele, Botti, Gerardo, Grimaldi, Antonio, Ascierto, Paolo A., Huss, Ralf, Athelogou, Maria, Hessel, Harald, Buchner, Alexander, Stief, Christian, Binnig, Gerd, Kirchner, Thomas, Sellappan, Shankar, Thyparambil, Sheeno, Schwartz, Sarit, Cecchi, Fabiola, Nguyen, Andrew, Vaske, Charles, Hembrough, Todd, Spacek, Jan, Vocka, Michal, Zavadova, Eva, Skalova, Helena, Dundr, Pavel, Petruzelka, Lubos, Francis, Nicole, Tilman, Rau T., Hartmann, Arndt, Netikova, Irena, Stump, Julia, Tufman, Amanda, Berger, Frank, Neuberger, Michael, Hatz, Rudolf, Lindner, Michael, Sanborn, Rachel E., Handy, John, Huber, Rudolf M., Winter, Hauke, Reu, Simone, Sun, Cheng, Xiao, Weihua, Tian, Zhigang, Arora, Kshitij, Desai, Niyati, Kulkarni, Anupriya, Rajurkar, Mihir, Rivera, Miguel, Deshpande, Vikram, Ting, David, Tsai, Katy, Nosrati, Adi, Goldinger, Simone, Hamid, Omid, Algazi, Alain, Tumeh, Paul, Hwang, Jimmy, Liu, Jacqueline, Chen, Lawrence, Dummer, Reinhard, Rosenblum, Michael, Daud, Adil, Tsao, Tsu-Shuen, Ashworth-Sharpe, Julia, Johnson, Donald, Bhaumik, Srabani, Bieniarz, Christopher, Couto, Joseph, Farrell, Michael, Ghaffari, Mahsa, Hubbard, Antony, Kosmeder, Jerome, Lee, Cleo, Marner, Erin, Uribe, Diana, Zhang, Hongjun, Zhang, Jian, Zhang, Wenjun, Zhu, Yifei, Morrison, Larry, Tsujikawa, Takahiro, Borkar, Rohan N., Azimi, Vahid, Kumar, Sushil, Thibault, Guillaume, Mori, Motomi, El Rassi, Edward, Clayburgh, Daniel R., Kulesz-Martin, Molly F., Flint, Paul W., Coussens, Lisa M., Villabona, Lisa, Masucci, Giuseppe V., Geiss, Gary, Birditt, Brian, Mei, Qian, Huang, Alan, Eagan, Maribeth A., Ignacio, Eduardo, Elliott, Nathan, Dunaway, Dwayne, Jung, Jaemyeong, Merritt, Chris, Sprague, Isaac, Webster, Philippa, Liang, Yan, Wenthe, Jessica, Enblad, Gunilla, Karlsson, Hannah, Essand, Magnus, Savoldo, Barbara, Dotti, Gianpietro, Höglund, Martin, Brenner, Malcolm K., Hagberg, Hans, Loskog, Angelica, Bernett, Matthew J., Moore, Gregory L., Hedvat, Michael, Bonzon, Christine, Chu, Seung, Rashid, Rumana, Avery, Kendra N., Muchhal, Umesh, Desjarlais, John, Kraman, Matthew, Kmiecik, Katarzyna, Allen, Natalie, Faroudi, Mustapha, Zimarino, Carlo, Wydro, Mateusz, Doody, Jacqueline, Srinivasa, Sreesha P., Govindappa, Nagaraja, Reddy, Praveen, Dubey, Aparajita, Periyasamy, Sankar, Adekandi, Madhukara, Dey, Chaitali, Joy, Mary, van Loo, Pieter Fokko, Veninga, Henrike, Shamsili, Setareh, Throsby, Mark, Dolstra, Harry, Bakker, Lex, Alva, Ajjai, Gschwendt, Juergen, Loriot, Yohann, Bellmunt, Joaquim, Feng, Dai, Poehlein, Christian, Powles, Thomas, Antonarakis, Emmanuel S., Drake, Charles G., Wu, Haiyan, De Bono, Johann, Bannerji, Rajat, Byrd, John, Gregory, Gareth, Opat, Stephen, Shortt, Jake, Yee, Andrew J., Raje, Noopur, Thompson, Seth, Balakumaran, Arun, Kumar, Shaji, Rini, Brian I., Choueiri, Toni K., Mariani, Mariangela, Albiges, Laurence, Haanen, John B., Larkin, James, Schmidinger, Manuela, Magazzù, Domenico, di Pietro, Alessandra, Motzer, Robert J., Borch, Troels Holz, Kongsted, Per, Pedersen, Magnus, Met, Özcan, Boudadi, Karim, Wang, Hao, Vasselli, James, Baughman, Jan E., Wigginton, Jon, Abdallah, Rehab, Ross, Ashley, Park, Jiwon, Grossenbacher, Steven, Luna, Jesus I., Withers, Sita, Culp, William, Chen, Mingyi, Monjazeb, Arta, Kent, Michael S., Chandran, Smita, Danforth, David, Yang, James, Klebanoff, Christopher, Goff, Stephanie, Paria, Biman, Sabesan, Arvind, Srivastava, Abhishek, Kammula, Udai, Richards, Jon, Faries, Mark, Andtbacka, Robert H. I., Diaz, Luis A., Le, Dung T., Yoshino, Takayuki, André, Thierry, Bendell, Johanna, Koshiji, Minori, Zhang, Yayan, Kang, S Peter, Lam, Bao, Jäger, Dirk, Bauer, Todd M., Wang, Judy S., Lee, Jean K., Manji, Gulam A., Kudchadkar, Ragini, Kauh, John S., Tang, Shande, Laing, Naomi, Falchook, Gerald, Garon, Edward B., Halmos, Balazs, Rina, Hui, Leighl, Natasha, Lee, Sung Sook, Walsh, William, Dragnev, Konstanin, Piperdi, Bilal, Rodriguez, Luis Paz-Ares, Shinwari, Nabeegha, Wei, Ziewn, Maas, Mary L, Deeds, Michael, Armstrong, Adam, Peterson, Tim, Steinmetz, Sue, Herzog, Thomas, Backes, Floor J., Copeland, Larry, Del Pilar Estevez Diz, Maria, Hare, Thomas W., Huh, Warner, Kim, Byoung-Gie, Moore, Kathleen M., Oaknin, Ana, Small, William, Tewari, Krishnansu S., Monk, Bradley J., Kamat, Ashish M., Nam, Kijoeng, De Santis, Maria, Dreicer, Robert, Hahn, Noah M., Perini, Rodolfo, Siefker-Radtke, Arlene, Sonpavde, Guru, de Wit, Ronald, Witjes, J. Alfred, Keefe, Stephen, Bajorin, Dean, Armand, Philippe, Kuruvilla, John, Moskowitz, Craig, Hamadani, Mehdi, Zinzani, Pier Luigi, Chlosta, Sabine, Bartlett, Nancy, Sabado, Rachel, Saenger, Yvonne, William, Loging, Donovan, Michael Joseph, Sacris, Erlinda, Mandeli, John, Salazar, Andres M., Powderly, John, Brody, Joshua, Nemunaitis, John, Emens, Leisha, Patnaik, Amita, McCaffery, Ian, Miller, Richard, Laport, Ginna, Coveler, Andrew L., Smith, David C., Grilley-Olson, Juneko E., Goel, Sanjay, Gardai, Shyra J., Law, Che-Leung, Means, Gary, Manley, Thomas, Marrone, Kristen A., Rosner, Gary, Anagnostou, Valsamo, Riemer, Joanne, Wakefield, Jessica, Zanhow, Cynthia, Baylin, Stephen, Gitlitz, Barbara, Brahmer, Julie, Signoretti, Sabina, Li, Wenting, Schloss, Charles, Michot, Jean-Marie, Ding, Wei, Christian, Beth, Marinello, Patricia, Shipp, Margaret, Najjar, Yana G., Lin, Butterfield, Lisa H., Tarhini, Ahmad A., Davar, Diwakar, Zarour, Hassane, Rush, Elizabeth, Sander, Cindy, Fu, Siqing, Bauer, Todd, Molineaux, Chris, Bennett, Mark K., Orford, Keith W., Papadopoulos, Kyriakos P., Padda, Sukhmani K., Shah, Sumit A., Colevas, A Dimitrios, Narayanan, Sujata, Fisher, George A., Supan, Dana, Wakelee, Heather A., Aoki, Rhonda, Pegram, Mark D., Villalobos, Victor M., Liu, Jie, Takimoto, Chris H., Chao, Mark, Volkmer, Jens-Peter, Majeti, Ravindra, Weissman, Irving L., Sikic, Branimir I., Yu, Wendy, Conlin, Alison, Ruzich, Janet, Lewis, Stacy, Acheson, Anupama, Kemmer, Kathleen, Perlewitz, Kelly, Moxon, Nicole M., Mellinger, Staci, McArthur, Heather, Juhler-Nøttrup, Trine, Desai, Jayesh, Markman, Ben, Sandhu, Shahneen, Gan, Hui, Friedlander, Michael L., Tran, Ben, Meniawy, Tarek, Lundy, Joanne, Colyer, Duncan, Ameratunga, Malaka, Norris, Christie, Yang, Jason, Li, Kang, Wang, Lai, Luo, Lusong, Qin, Zhen, Mu, Song, Tan, Xuemei, Song, James, Millward, Michael, Katz, Matthew H. G., Bauer, Todd W., Varadhachary, Gauri R., Acquavella, Nicolas, Merchant, Nipun, Petroni, Gina, Rahma, Osama E., Chen, Mei, Song, Yang, Puhlmann, Markus, Khattri, Arun, Brisson, Ryan, Harvey, Christopher, Shah, Jatin, Mateos, Maria Victoria, Matsumoto, Morio, Blacklock, Hilary, Rocafiguera, Albert Oriol, Goldschmidt, Hartmut, Iida, Shinsuke, Yehuda, Dina Ben, Ocio, Enrique, Rodríguez-Otero, Paula, Jagannath, Sundar, Lonial, Sagar, Kher, Uma, San-Miguel, Jesus, de Oliveira, Moacyr Ribeiro, Yimer, Habte, Rifkin, Robert, Schjesvold, Fredrik, Ghori, Razi, Spreafico, Anna, Lee, Victor, Ngan, Roger K. C., To, Ka Fai, Ahn, Myung Ju, Ng, Quan Sing, Lin, Jin-Ching, Swaby, Ramona F., Gause, Christine, Saraf, Sanatan, Chan, Anthony T. C., Lam, Elaine, Tannir, Nizar M., Meric-Bernstam, Funda, Gross, Matt, MacKinnon, Andy, Whiting, Sam, Voss, Martin, Yu, Evan Y., Albertini, Mark R., Ranheim, Erik A., Hank, Jacquelyn A., Zuleger, Cindy, McFarland, Thomas, Collins, Jennifer, Clements, Erin, Weber, Sharon, Weigel, Tracey, Neuman, Heather, Hartig, Greg, Mahvi, David, Henry, MaryBeth, Gan, Jacek, Yang, Richard, Carmichael, Lakeesha, Kim, KyungMann, Gillies, Stephen D., Sondel, Paul M., Subbiah, Vivek, Noffsinger, Lori, Hendricks, Kyle, Bosch, Marnix, Lee, Jay M., Lee, Mi-Heon, Goldman, Jonathan W., Baratelli, Felicita E., Schaue, Dorthe, Wang, Gerald, Rosen, Frances, Yanagawa, Jane, Walser, Tonya C., Lin, Ying Q., Adams, Sharon, Marincola, Franco M., Tumeh, Paul C., Abtin, Fereidoun, Suh, Robert, Reckamp, Karen, Wallace, William D., Zeng, Gang, Elashoff, David A., Sharma, Sherven, Dubinett, Steven M., Pavlick, Anna C., Gastman, Brian, Hanks, Brent, Keler, Tibor, Davis, Tom, Vitale, Laura A., Sharon, Elad, Morishima, Chihiro, Cheever, Martin, Heery, Christopher R., Kim, Joseph W., Lamping, Elizabeth, Marte, Jennifer, McMahon, Sheri, Cordes, Lisa, Fakhrejahani, Farhad, Madan, Ravi, Salazar, Rachel, Zhang, Maggie, Helwig, Christoph, Gulley, James L, Li, Roger, Amrhein, John, Cohen, Zvi, Champagne, Monique, Kamat, Ashish, Aznar, M. Angela, Labiano, Sara, Diaz-Lagares, Angel, Esteller, Manel, Sandoval, Juan, Barbee, Susannah D., Bellovin, David I., Timmer, John C., Wondyfraw, Nebiyu, Johnson, Susan, Park, Johanna, Chen, Amanda, Mkrtichyan, Mikayel, Razai, Amir S., Jones, Kyle S., Hata, Chelsie Y., Gonzalez, Denise, Deveraux, Quinn, Eckelman, Brendan P., Borges, Luis, Bhardwaj, Rukmini, Puri, Raj K., Suzuki, Akiko, Leland, Pamela, Joshi, Bharat H., Bartkowiak, Todd, Jaiswal, Ashvin, Ager, Casey, Ai, Midan, Budhani, Pratha, Chin, Renee, Hong, David, Curran, Michael, Hastings, William D., Pinzon-Ortiz, Maria, Murakami, Masato, Dobson, Jason R., Quinn, David, Wagner, Joel P., Rong, Xianhui, Shaw, Pamela, Dammassa, Ernesta, Guan, Wei, Dranoff, Glenn, Cao, Alexander, Fulton, Ross B., Leonardo, Steven, Fraser, Kathryn, Kangas, Takashi O., Ottoson, Nadine, Bose, Nandita, Huhn, Richard D., Graff, Jeremy, Lowe, Jamie, Gorden, Keith, Uhlik, Mark, O’Neill, Thomas, Widger, Jenifer, Crocker, Andrea, He, Li-Zhen, Weidlick, Jeffrey, Sundarapandiyan, Karuna, Ramakrishna, Venky, Storey, James, Thomas, Lawrence J., Goldstein, Joel, Marsh, Henry C., Grailer, Jamison, Gilden, Julia, Stecha, Pete, Garvin, Denise, Hartnett, Jim, Fan, Frank, Cong, Mei, Cheng, Zhi-jie Jey, Hinner, Marlon J., Aiba, Rachida-Siham Bel, Schlosser, Corinna, Jaquin, Thomas, Allersdorfer, Andrea, Berger, Sven, Wiedenmann, Alexander, Matschiner, Gabriele, Schüler, Julia, Moebius, Ulrich, Rothe, Christine, Shane, Olwill A., Horton, Brendan, Spranger, Stefani, Moreira, Dayson, Adamus, Tomasz, Zhao, Xingli, Swiderski, Piotr, Pal, Sumanta, Kortylewski, Marcin, Kosmides, Alyssa, Necochea, Kevin, Mahoney, Kathleen M., Shukla, Sachet A., Patsoukis, Nikolaos, Chaudhri, Apoorvi, Pham, Hung, Hua, Ping, Bu, Xia, Zhu, Baogong, Hacohen, Nir, Wu, Catherine J., Fritsch, Edward, Boussiotis, Vassiliki A., Freeman, Gordon J., Moran, Amy E., Polesso, Fanny, Lukaesko, Lisa, Rådestad, Emelie, Egevad, Lars, Sundberg, Berit, Henningsohn, Lars, Levitsky, Victor, Rafelson, William, Reagan, John L., Fast, Loren, Sasikumar, Pottayil, Sudarshan, Naremaddepalli, Ramachandra, Raghuveer, Gowda, Nagesh, Samiulla, Dodheri, Chandrasekhar, Talapaneni, Adurthi, Sreenivas, Mani, Jiju, Nair, Rashmi, Dhudashia, Amit, Gowda, Nagaraj, Ramachandra, Murali, Sankin, Alexander, Gartrell, Benjamin, Cumberbatch, Kerwin, Huang, Hongying, Stern, Joshua, Schoenberg, Mark, Zang, Xingxing, Swanson, Ryan, Kornacker, Michael, Evans, Lawrence, Rickel, Erika, Wolfson, Martin, Valsesia-Wittmann, Sandrine, Shekarian, Tala, Simard, François, Nailo, Rodrigo, Dutour, Aurélie, Jallas, Anne-Catherine, Caux, Christophe, and Marabelle, Aurélien

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results