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338 results on '"Parsons, Michael J"'

2. Objective assessment of stored blood quality by deep learning

Author

Doan, Minh, Sebastian, Joseph A., Caicedo, Juan C., Siegert, Stefanie, Roch, Aline, Turner, Tracey R., Mykhailova, Olga, Pinto, Ruben N., McQuin, Claire, Goodman, Allen, Parsons, Michael J., Wolkenhauer, Olaf, Hennig, Holger, Singh, Shantanu, Wilson, Anne, Acker, Jason P., Rees, Paul, Kolios, Michael C., and Carpenter, Anne E.

Published
2020

4. Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking

Author

Militi, Stefania, Maywood, Elizabeth S, Sandate, Colby R, Chesham, Johanna E, Barnard, Alun R, Parsons, Michael J, Vibert, Jennifer L, Joynson, Greg M, Partch, Carrie L, Hastings, Michael H, and Nolan, Patrick M

Subjects
Biochemistry and Cell Biology, Biological Sciences, Genetics, Sleep Research, Underpinning research, 1.1 Normal biological development and functioning, Amino Acid Sequence, Animals, Blotting, Western, COS Cells, Casein Kinase 1 epsilon, Chlorocebus aethiops, Circadian Clocks, Circadian Rhythm, Female, HEK293 Cells, Humans, Male, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Knockout, Models, Molecular, Molecular Sequence Data, Motor Activity, Mutation, Missense, Period Circadian Proteins, Protein Multimerization, Protein Structure, Tertiary, Sequence Homology, Amino Acid, Suprachiasmatic Nucleus, mouse mutant, behavior, protein stability, circadian period, genetic interaction
Abstract

The suprachiasmatic nucleus (SCN) defines 24 h of time via a transcriptional/posttranslational feedback loop in which transactivation of Per (period) and Cry (cryptochrome) genes by BMAL1-CLOCK complexes is suppressed by PER-CRY complexes. The molecular/structural basis of how circadian protein complexes function is poorly understood. We describe a novel N-ethyl-N-nitrosourea (ENU)-induced mutation, early doors (Edo), in the PER-ARNT-SIM (PAS) domain dimerization region of period 2 (PER2) (I324N) that accelerates the circadian clock of Per2(Edo/Edo) mice by 1.5 h. Structural and biophysical analyses revealed that Edo alters the packing of the highly conserved interdomain linker of the PER2 PAS core such that, although PER2(Edo) complexes with clock proteins, its vulnerability to degradation mediated by casein kinase 1ε (CSNK1E) is increased. The functional relevance of this mutation is revealed by the ultrashort (

Published
2016

6. A new model of inducible chronic hyperglycemia

Author

Tucker, Tori R., primary, Knitter, Courtney A., additional, Khoury, Deena M., additional, Eshghi, Sheida, additional, Tran, Sophia, additional, Sharrock, Abigail V., additional, Wiles, Travis J., additional, Ackerley, David F., additional, Mumm, Jeff S., additional, and Parsons, Michael J., additional

Published
2023
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12. The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis

Author

Parsons, Michael J., Brancaccio, Marco, Sethi, Siddharth, Maywood, Elizabeth S., Satija, Rahul, Edwards, Jessica K., Jagannath, Aarti, Couch, Yvonne, Finelli, Mattéa J., Smyllie, Nicola J., Esapa, Christopher, Butler, Rachel, Barnard, Alun R., Chesham, Johanna E., Saito, Shoko, Joynson, Greg, Wells, Sara, Foster, Russell G., Oliver, Peter L., Simon, Michelle M., Mallon, Ann-Marie, Hastings, Michael H., and Nolan, Patrick M.

Published
2015
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16. Generation of floxed alleles for cell-specific knockout in zebrafish

Author

Shin, Masahiro, primary, Nozaki, Takayuki, additional, Toles, Benjamin, additional, Kolb, Amy, additional, Luk, Kevin, additional, Isogai, Sumio, additional, Ishida, Kinji, additional, Hanasaka, Tomohito, additional, Parsons, Michael J., additional, Wolfe, Scot A., additional, and Lawson, Nathan D., additional

Published
2022
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19. The Notion of Competence and Competency as Educational Objectives.

Author

Parsons, Michael J.

Abstract

This article is an attempt to state an understanding of the notion of a competency as an educational objective. A competency is defined as the ability to use a concept or theory as a tool for some purpose. It is distinguished from the more general ability to judge which tool is best to use for a given purpose. A professional training program or other learning situation utilizing competencies that ignore the question of judgment is insufficient. One must be concerned with whether the use of certain tools (whose use is defined by a competency) will be wise or intelligent. There is a clear advantage in distinguishing between these two kinds of competency (the correct understanding of a tool, and the correct judgment of its value in any given situation) and in incorporating both kinds into curriculum development. (Author)

Published
1977

20. Gfap-positive radial glial cells are an essential progenitor population for later-born neurons and glia in the zebrafish spinal cord

Author

Johnson, Kimberly, Barragan, Jessica, Bashiruddin, Sarah, Smith, Cody J., Tyrrell, Chelsea, Parsons, Michael J., Doris, Rosemarie, Kucenas, Sarah, Downes, Gerald B., Velez, Carla M., Schneider, Caitlin, Sakai, Catalina, Pathak, Narendra, Anderson, Katrina, Stein, Rachael, Devoto, Stephen H., Mumm, Jeff S., and Barresi, Michael J. F.

Published
2016
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22. Art and Culture, Visual and Verbal Thinking: Where Are the Bridges?

Author

Parsons, Michael J.

Abstract

Discusses three types of distance in art education that should be bridged: (1) between studio art and art criticism/history; (2) between thinking in images and thinking in words; and (3) between art and culture in cognition. Recommends a curriculum to integrate studio work with criticism and teach art along with culture. (CFR)

Published
1994

25. Aesthetic Literacy: The Psychological Context.

Author

Parsons, Michael J.

Abstract

Discusses the psychological context of aesthetic literacy in relation to E. D. Hirsch's ideas on cultural literacy. Argues adults should not interpret artworks for children and notes the implications for curriculum planners. Provides examples of childrens' understanding of art works. Maintains that any curriculum is the interaction of content and student understanding, mediated by a teacher. (KM)

Published
1990

36. Attenuating the Epidermal Growth Factor Receptor–Extracellular Signal‐Regulated Kinase–Sex‐Determining Region Y‐Box 9 Axis Promotes Liver Progenitor Cell‐Mediated Liver Regeneration in Zebrafish

Author

So, Juhoon, primary, Kim, Minwook, additional, Lee, Seung‐Hoon, additional, Ko, Sungjin, additional, Lee, Daniel A., additional, Park, Hyewon, additional, Azuma, Mizuki, additional, Parsons, Michael J., additional, Prober, David, additional, and Shin, Donghun, additional

Published
2021
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39. Essential and overlapping roles for laminin alpha chains in notochord and blood vessel formation

Author

Pollard, Steven M., Parsons, Michael J., Kamei, Makoto, Kettleborough, Ross N.W., Thomas, Kevin A., Pham, Van N., Bae, Moon-Kyoung, Scott, Annabelle, Weinstein, Brant M., and Stemple, Derek L.

Subjects
Blood vessels -- Growth, Laminin -- Research, Notochord -- Growth, Zebra fish -- Research, Embryology, Experimental, Company growth, Biological sciences
Abstract

The contribution of laminin alpha chains in the development of the notochord and blood vessels in the embryos of zebra fish is studied.

Published
2006

49. Genetic variation in hippocampal microRNA expression differences in C57BL/6 J X DBA/2 J (BXD) recombinant inbred mouse strains

Author

Parsons Michael J, Grimm Christina, Paya-Cano Jose L, Fernandes Cathy, Liu Lin, Philip Vivek M, Chesler Elissa J, Nietfeld Wilfried, Lehrach Hans, and Schalkwyk Leonard C

Subjects
Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background miRNAs are short single-stranded non-coding RNAs involved in post-transcriptional gene regulation that play a major role in normal biological functions and diseases. Little is currently known about how expression of miRNAs is regulated. We surveyed variation in miRNA abundance in the hippocampus of mouse inbred strains, allowing us to take a genetic approach to the study of miRNA regulation, which is novel for miRNAs. The BXD recombinant inbred panel is a very well characterized genetic reference panel which allows quantitative trait locus (QTL) analysis of miRNA abundance and detection of correlates in a large store of brain and behavioural phenotypes. Results We found five suggestive trans QTLs for the regulation of miRNAs investigated. Further analysis of these QTLs revealed two genes, Tnik and Phf17, under the miR-212 regulatory QTLs, whose expression levels were significantly correlated with miR-212 expression. We found that miR-212 expression is correlated with cocaine-related behaviour, consistent with a reported role for this miRNA in the control of cocaine consumption. miR-31 is correlated with anxiety and alcohol related behaviours. KEGG pathway analysis of each miRNA’s expression correlates revealed enrichment of pathways including MAP kinase, cancer, long-term potentiation, axonal guidance and WNT signalling. Conclusions The BXD reference panel allowed us to establish genetic regulation and characterize biological function of specific miRNAs. QTL analysis enabled detection of genetic loci that regulate the expression of these miRNAs. eQTLs that regulate miRNA abundance are a new mechanism by which genetic variation influences brain and behaviour. Analysis of one of these QTLs revealed a gene, Tnik, which may regulate the expression of a miRNA, a molecular pathway and a behavioural phenotype. Evidence of genetic covariation of miR-212 abundance and cocaine related behaviours is strongly supported by previous functional studies, demonstrating the value of this approach for discovery of new functional roles and downstream processes regulated by miRNA.

Published
2012
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