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548 results on '"Parsons, J T"'

1. Modular Domains of Focal Adhesion-Associated Proteins

Author

Taylor, J. M., Richardson, A., Parsons, J. T., Compans, R. W., editor, Cooper, M., editor, Hogle, J. H., editor, Ito, Y., editor, Koprowski, H., editor, Melchers, F., editor, Oldstone, M., editor, Olsnes, S., editor, Potter, M., editor, Saedler, H., editor, Vogt, P. K., editor, Wagner, H., editor, and Pawson, Anthony J., editor

Published
1998
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2. Regional Lymph Node Irradiation

Author

Parsons, J. T., Million, R. R., Mendenhall, W. M., Herfarth, Ch., editor, Senn, H.-J., editor, Baum, M., editor, Diehl, V., editor, Gutzwiller, F., editor, Rajewsky, M. F., editor, Wannenmacher, M., editor, Pape, H.-D., editor, Ganzer, U., editor, and Schmitt, G., editor

Published
1994
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23. Zur Stickstoffbestimmung in Düngemitteln

Author

Mach, F., Sindlinger, F., Lucas, R., Hirschberger, W., Jacob, K. D., Geldard, W. J., Davisson, B. S., Parsons, J. T., Gunning-Forster, Rousseaux, E., Kellogg, J. W., Fleury, P., Levaltier, H., Rudolph, W., Lepper, W., Kleemann, A., and Justini-Mueller, E.

Published
1931
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24. Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK

Author

Cobb, B S, Schaller, M D, Leu, T H, and Parsons, J T

Subjects
Binding Sites, animal structures, Recombinant Fusion Proteins, Proto-Oncogene Proteins pp60(c-src), Chick Embryo, Cell Biology, Protein-Tyrosine Kinases, Proto-Oncogene Proteins c-fyn, Transformation, Genetic, Focal Adhesion Kinase 1, Focal Adhesion Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Cell Adhesion, Animals, Phosphorylation, Cell Adhesion Molecules, Molecular Biology, Cells, Cultured, Research Article, Signal Transduction
Abstract

Changes in cellular growth and dramatic alterations in cell morphology and adhesion are common features of cells transformed by oncogenic protein tyrosine kinases, such as pp60src and other members of the Src family. In this report, we present evidence for the stable association of two Src family kinases (pp60src and pp59fyn) with tyrosine-phosphorylated forms of a focal adhesion-associated protein tyrosine kinase, pp125FAK. In Src-transformed chicken embryo cells, most of the pp125FAK was stably complexed with activated pp60src (e.g., pp60(527F). The stable association of pp125FAK with pp60(527F) in vivo required the structural integrity of the Src SH2 domain. The association of pp60(527F) and pp125FAK could be reconstituted in vitro by incubation of normal cell extracts with glutathione S-transferase fusion proteins containing SH2 or SH3/SH2 domains of pp60src. Furthermore, the association of isolated SH2 or SH3/SH2 domains with in vitro 32P-labeled pp125FAK protected the major site of pp125FAK autophosphorylation from digestion with a tyrosine phosphatase, indicating that the autophosphorylation site of pp125FAK participates in binding with Src. Immunoprecipitation of Src family kinases from extracts of normal chicken embryo cells revealed stable complexes of pp59fyn and tyrosine-phosphorylated pp125FAK. These data provide evidence for a direct interaction between two cytoplasmic nonreceptor protein tyrosine kinases and suggest that Src may contribute to changes in pp125FAK regulation in transformed cells. Furthermore, pp125FAK may directly participate in the targeting of pp59fyn or possibly other Src family kinases to focal adhesions in normal cells.

Published
1994
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25. FRNK Expression Promotes Smooth Muscle Cell Maturation During Vascular Development and After Vascular Injury

Author

Sayers, R. L., Rojas, M., Parsons, J. T., Taylor, J. M., Mack, C. P., Hayasaka, H., and Sundberg-Smith, L. J.

Subjects
cardiovascular system, musculoskeletal system
Abstract

Smooth muscle cell (SMC) differentiation is a dynamic process that must be tightly regulated for proper vascular development and to control the onset of vascular disease. Our lab previously reported that a specific focal adhesion kinase (FAK) inhibitor termed FRNK (FAK Related Non-Kinase) is selectively expressed in large arterioles when SMC are transitioning from a synthetic to contractile phenotype and that FRNK inhibits FAK-dependent SMC proliferation and migration. Herein, we sought to determine whether FRNK expression modulates SMC phenotypes in vivo.

Published
2008
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27. SRChing for the substrates of Src

Author

Reynolds, A B, primary, Kanner, S B, additional, Bouton, A H, additional, Schaller, M D, additional, Weed, S A, additional, Flynn, D C, additional, and Parsons, J T, additional

Published
2013
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30. Design, ancillary testing, analysis and fabrication data for the advanced composite stabilizer for Boeing 737 aircraft. Volume 1: Technical summary

Author

Aniversario, R. B, Harvey, S. T, Mccarty, J. E, Parsons, J. T, Peterson, D. C, Pritchett, L. D, Wilson, D. R, and Wogulis, E. R

Subjects
Composite Materials
Abstract

The horizontal stabilizer of the 737 transport was redesigned. Five shipsets were fabricated using composite materials. Weight reduction greater than the 20% goal was achieved. Parts and assemblies were readily produced on production-type tooling. Quality assurance methods were demonstrated. Repair methods were developed and demonstrated. Strength and stiffness analytical methods were substantiated by comparison with test results. Cost data was accumulated in a semiproduction environment. FAA certification was obtained.

Published
1983

31. Full-scale testing, production and cost analysis data for the advanced composite stabilizer for Boeing 737 aircraft. Volume 1: Technical summary

Author

Aniversario, R. B, Harvey, S. T, Mccarty, J. E, Parsons, J. T, Peterson, D. C, Pritchett, L. D, Wilson, D. R, and Wogulis, E. R

Subjects
Composite Materials
Abstract

The full scale ground test, ground vibration test, and flight tests conducted to demonstrate a composite structure stabilizer for the Boeing 737 aircraft and obtain FAA certification are described. Detail tools, assembly tools, and overall production are discussed. Cost analyses aspects covered include production costs, composite material usage factors, and cost comparisons.

Published
1983

32. Design, ancillary testing, analysis and fabrication data for the advanced composite stabilizer for Boeing 737 aircraft, volume 2

Author

Aniversario, R. B, Harvey, S. T, Mccarty, J. E, Parsons, J. T, Peterson, D. C, Pritchett, L. D, Wilson, D. R, and Wogulis, E. R

Subjects
Composite Materials
Abstract

Results of tests conducted to demonstrate that composite structures save weight, possess long term durability, and can be fabricated at costs competitive with conventional metal structures are presented with focus on the use of graphite-epoxy in the design of a stabilizer for the Boeing 737 aircraft. Component definition, materials evaluation, material design properties, and structural elements tests are discussed. Fabrication development, as well as structural repair and inspection are also examined.

Published
1982

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