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12 results on '"Parsell, Dawn M."'

1. Increased human complement pathway regulatory protein gene dose is associated with increased endothelial expression and prolonged survival during ex‐vivo perfusion of GTKO pig lungs with human blood

Author

Chaban, Ryan, primary, McGrath, Gannon, additional, Habibabady, Zahra, additional, Rosales, Ivy, additional, Burdorf, Lars, additional, Ayares, David L., additional, Rybak, Elana, additional, Zhang, Tianshu, additional, Harris, Donald G., additional, Dahi, Siamak, additional, Ali, Franchesca, additional, Parsell, Dawn M., additional, Braileanu, Gheorghe, additional, Cheng, Xiangfei, additional, Sievert, Evelyn, additional, Phelps, Carol, additional, Azimzadeh, Agnes M., additional, and Pierson, Richard N., additional

Published
2023
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2. Maternal transfer of IgA and IgG SARS-CoV-2 specific antibodies transplacentally and via breast milk feeding

Author

Sajadi, Mohammad M., primary, Shokatpour, Narjes, additional, Purcell, Madeleine, additional, Tehrani, Zahra Rikhtegaran, additional, Lankford, Allison, additional, Bathula, Allison, additional, Campbell, James D., additional, Hammershaimb, Elizabeth Adrianne, additional, Deatrick, Kristopher B., additional, Bor, Casey, additional, Parsell, Dawn M., additional, Dugan, Colleen, additional, Levine, Andrea R., additional, Ramelli, Sabrina C., additional, Chertow, Daniel S., additional, Herr, Daniel L., additional, Saharia, Kapil K., additional, Lewis, George K., additional, and Grazioli, Alison, additional

Published
2023
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4. hEPCR.hTBM.hCD47.hHO‐1 with donor clodronate and DDAVP treatment improves perfusion and function of GalTKO.hCD46 porcine livers perfused with human blood

Author

Cimeno, Arielle, primary, Kuravi, Kasinath, additional, Sorrells, Lori, additional, Dandro, Amy, additional, Sendil, Selin, additional, Burdorf, Lars, additional, Parsell, Dawn M., additional, Eyestone, Will, additional, Phelps, Carol, additional, Ayares, David, additional, Azimzadeh, Agnes M., additional, Pierson, Richard N., additional, Barth, Rolf N., additional, and LaMattina, John C., additional

Published
2022
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5. Maternal transfer of IgA and IgG SARS-CoV-2 specific antibodies transplacentally and via breastfeeding

Author

Sajadi, Mohammad M., primary, Shokatpour, Narjes, additional, Bathula, Allison, additional, Tehrani, Zahra, additional, Lankford, Allison, additional, Purcell, Madeleine, additional, Campbell, James D., additional, Hammershaimb, Elizabeth Adrianne Duque, additional, Deatrick, Kristopher B., additional, Bor, Casey, additional, Parsell, Dawn M., additional, Dugan, Colleen, additional, Levine, Andrea, additional, Ramelli, Sabrina C., additional, Chertow, Daniel, additional, Herr, Daniel L., additional, Lewis, George K., additional, and Grazioli, Alison, additional

Published
2021
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6. Thromboxane and histamine mediate PVR elevation during xenogeneic pig lung perfusion with human blood

Author

Burdorf, Lars, primary, Harris, Donald, additional, Dahi, Siamak, additional, Laird, Christopher, additional, Zhang, Tianshu, additional, Ali, Franchesca, additional, Shah, Aakash, additional, Thompson, Mercedes, additional, Braileanu, Gheorghe, additional, Cheng, Xiangfei, additional, Sievert, Evelyn, additional, Schwartz, Evan, additional, Sendil, Selin, additional, Parsell, Dawn M., additional, Redding, Emily, additional, Phelps, Carol J., additional, Ayares, David L., additional, Azimzadeh, Agnes M., additional, and Pierson, Richard N., additional

Published
2018
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7. N-glycolylneuraminic acid knockout reduces erythrocyte sequestration and thromboxane elaboration in an ex vivo pig-to-human xenoperfusion model

Author

Cimeno, Arielle, primary, Hassanein, Wessam, additional, French, Beth M., additional, Powell, Jessica M., additional, Burdorf, Lars, additional, Goloubeva, Olga, additional, Cheng, Xiangfei, additional, Parsell, Dawn M., additional, Ramsoondar, Jagdeece, additional, Kuravi, Kasinath, additional, Vaught, Todd, additional, Uluer, Mehmet C., additional, Redding, Emily, additional, O'Neill, Natalie, additional, Laird, Christopher, additional, Hershfeld, Alena, additional, Tatarov, Ivan, additional, Thomas, Kathryn, additional, Ayares, David, additional, Azimzadeh, Agnes M., additional, Pierson, Richard N., additional, Barth, Rolf N., additional, and LaMattina, John C., additional

Published
2017
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12. Thromboxane and histamine mediate PVR elevation during xenogeneic pig lung perfusion with human blood.

Author

Burdorf, Lars, Harris, Donald, Dahi, Siamak, Laird, Christopher, Zhang, Tianshu, Ali, Franchesca, Shah, Aakash, Thompson, Mercedes, Braileanu, Gheorghe, Cheng, Xiangfei, Sievert, Evelyn, Schwartz, Evan, Sendil, Selin, Parsell, Dawn M., Redding, Emily, Phelps, Carol J., Ayares, David L., Azimzadeh, Agnes M., and Pierson, Richard N.

Subjects
HISTAMINE, VASCULAR resistance, HISTAMINE receptors, PERFUSION, BLOOD platelet activation
Abstract

Background: Elevated pulmonary vascular resistance (PVR), platelet adhesion, coagulation activation, and inflammation are prominent features of xenolung rejection. Here, we evaluate the role of thromboxane and histamine on PVR, and their contribution to other lung xenograft injury mechanisms. Methods: GalTKO.hCD46 single pig lungs were perfused ex vivo with fresh heparinized human blood: lungs were either treated with 1‐Benzylimidazole (1‐BIA) combined with histamine receptor blocker famotidine (n = 4) or diphenhydramine (n = 6), 1‐BIA alone (n = 6) or were left untreated (n = 9). Results: Six of the nine control experiments (GalTKO.hCD46 untreated), "survived" until elective termination at 4 hours. Without treatment, initial PVR elevation within the first 30 minutes resolved partially over the following hour, and increased progressively during the final 2 hours of perfusion. In contrast, 1‐BIA, alone or in addition to either antihistamine treatment, was associated with low stable PVR. Combined treatments significantly lowered the airway pressure when compared to untreated reference. Although platelet and neutrophil sequestration and coagulation cascade activation were not consistently altered by any intervention, increased terminal wet/dry weight ratio in untreated lungs was significantly blunted by combined treatments. Conclusion: Combined thromboxane and histamine pathway blockade prevents PVR elevation and significantly inhibits loss of vascular barrier function when GalTKO.hCD46 lungs are perfused with human blood. Platelet activation and platelet and neutrophil sequestration persist in all groups despite efficient complement regulation, and appear to occur independent of thromboxane and histamine antagonism. Our work identifies thromboxane and histamine as key mediators of xenolung injury and defines those pathways as therapeutic targets to achieve successful xenolung transplantation. [ABSTRACT FROM AUTHOR]

Published
2019
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