Search

Your search keyword '"Parrini, Donatella"' showing total 17 results
Start Over Author "Parrini, Donatella"
17 results on '"Parrini, Donatella"'

5. Body mass index and body composition in adolescents treated with gonadotropin-releasing hormone analogue triptorelin depot for central precocious puberty: data at near final height

Author

Chiocca, E, Dati, E, Baroncelli, G, Mora, S, Parrini, D, Erba, P, Bertelloni, S, Chiocca, Elena, Dati, Eleonora, Baroncelli, Giampiero I, Mora, Stefano, Parrini, Donatella, Erba, Paola, Bertelloni, Silvano, Chiocca, E, Dati, E, Baroncelli, G, Mora, S, Parrini, D, Erba, P, Bertelloni, S, Chiocca, Elena, Dati, Eleonora, Baroncelli, Giampiero I, Mora, Stefano, Parrini, Donatella, Erba, Paola, and Bertelloni, Silvano

Abstract

Background/Aim: In children with central precocious puberty (CPP), gonadotropin-releasing hormone (GnRH) analogue treatment has been associated with an increase in body mass index (BMI). We evaluated BMI and body composition in adolescents treated with GnRH analogue at their near final height to assess the long-term effects of therapy on these parameters. Patients and Methods: We studied 20 patients (14.8 ± 1.6 years; 17 females) previously treated with triptorelin depot for CPP (3.75 mg/28 days) from 8.1 ± 0.8 to 11.5 ± 0.8 years. 23 healthy adolescents with normal onset of puberty (14.7 ± 2.1 years, 19 females) were the controls. BMI and body composition (dual-energy x-ray absorptiometry) were assessed. Results: Patients reached their near adult height (-0.5 ± 1.1 standard deviation score (SDS)); the girls were menstruating and the majority (15/17) had regular cycles, the boys showed normal testicular function. BMI was unchanged from the start of GnRH analogue therapy (0.4 ± 1.0 SDS) to near adult height (0.2 ± 1.0 SDS, p = NS vs. 0). Total fat mass (TFM) was significantly increased (16,144 ± 8,065 g; controls 10,712.1 ± 4,120.4 g, p < 0.02); glucose homeostasis and lipid profile corresponded to reference ranges. Conclusions: GnRH analogue therapy did not show long-term detrimental effects on BMI, but it may increase TFM, suggesting that body composition should be monitored till adulthood.

Published
2009

11. Treatment of Hirsutism

Author

Fruzzetti, Franca, primary, Bersi, Chiara, additional, Parrini, Donatella, additional, Ricci, Cabiria, additional, and Genazzani, Andrea Riccardo, additional

Published
1999
Full Text
View/download PDF

14. Effect of Epimestrol on Gonadotropin and Prolactin Plasma Levels and Response to Luteinizing Hormone-Releasing Hormone/Thyrotropin-Releasing Hormone in Secondary Amenorrhea and Oligomenorrhea

Author

Genazzani, Andrea R., Facchinetti, Fabio, De Leo, Vicenzo, Picciolini, Enrico, Franchi, Franco, Parrini, Donatella, and Kicovic, Petar M.

Abstract

The effects of epimestrol (5mg every 6hours for 5days) on basal levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (Prl), estradiol, progesterone, and dehydroepiandrosterone sulfate, and on the response to LH-releasing hormone (LH-RH) and thyrotropin-releasing hormone (TRH) stimulation, were studied in 18 cases of secondary amenorrhea and oligomenorrhea of hypothalamic-pituitary origin, in three cases of anorexia nervosa, in two cases of long-lasting progestin-induced amenorrhea, and in one case of precocious menopause. The results in the first 18 patients indicate that epimestrol treatment induces a significant increase in LH and Prl levels after 24hours, while the FSH increase becomes significant only after 4days of therapy. Twelve hours after discontinuation of treatment, all three hormone levels decreased significantly to values similar to the basal levels, while the pituitary response to LH-RH indicated a much more marked LH secretion than before treatment. A second test, performed 36hours after the last drug administration, again showed a significantly higher LH response than that found under basal conditions. No significant variations were observed in the FSH response to LH-RH, nor in the Prl response to TRH.

Published
1978
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results