1. Neurophysiological investigations in a case of primary paroxysmal hemicrania-tic syndrome.
- Author
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Maestrini I, Viganò A, Di Stefano G, Toscano M, and Di Piero V
- Subjects
- Humans, Middle Aged, Male, Paroxysmal Hemicrania physiopathology, Paroxysmal Hemicrania diagnosis, Paroxysmal Hemicrania drug therapy, Trigeminal Neuralgia physiopathology, Trigeminal Neuralgia diagnosis
- Abstract
Background: The association between paroxysmal hemicrania (PH) and trigeminal neuralgia-the so-called PH-tic syndrome-has rarely been described. However, a correct diagnosis is crucial since both disorders require specific treatments. Little is known about pathophysiological mechanisms, and, to date, there are no electrophysiological studies in patients with PH-tic syndrome., Case: We describe the case of a 52-year-old man with a PH-tic syndrome successfully treated with an association of carbamazepine (1200 mg/day) and indomethacin (150 mg/die). Patient underwent trigeminal reflex testing, including blink and masseter inhibitory reflex, and laser-evoked potential (LEP) recording after supraorbital region stimulation in the affected and unaffected side. Both neurophysiological investigations resulted normal; LEPs failed to detect any latency asymmetry between both sides., Conclusions: Neurophysiological findings demonstrate for the first time the integrity of somatosensory system in a primary PH-tic syndrome case. Central pathophysiological mechanisms and hypothalamic dysregulation may contribute to the development of this rare syndrome., (© 2024. Fondazione Società Italiana di Neurologia.)
- Published
- 2024
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