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8 results on '"Parodi, E. L."'

1. Interdialytic weight gain is not associated with symptoms of depression or apathy in patients on chronic hemodialysis

Author

Bossola, Maurizio, Angioletti, Laura, Di Stasio, Enrico, Monteburini, T., Santarelli, S., Parodi, E. L., Balconi, Michela, Bossola M. (ORCID:0000-0003-1627-0235), Angioletti L. (ORCID:0000-0002-3027-2272), Di Stasio E. (ORCID:0000-0003-1047-4261), Balconi M. (ORCID:0000-0002-8634-1951), Bossola, Maurizio, Angioletti, Laura, Di Stasio, Enrico, Monteburini, T., Santarelli, S., Parodi, E. L., Balconi, Michela, Bossola M. (ORCID:0000-0003-1627-0235), Angioletti L. (ORCID:0000-0002-3027-2272), Di Stasio E. (ORCID:0000-0003-1047-4261), and Balconi M. (ORCID:0000-0002-8634-1951)

Abstract

Purpose: Little is known about the relationships between apathy, depressive symptoms and interdialytic weight gain (IDWG) in patients on chronic hemodialysis. Aim of the present study is to investigate the association between IDWG and symptoms of depression and apathy in hemodialysis patients. Methods: A total of 139 chronic patients of the HD units between January 2020 and December 2021 were included in the present cross-sectional study. IDWG was calculated as the difference between the pre-HD weight and the weight registered after the previous session; the average of the sessions in a month was registered. Apathy Evaluation Scale (AES) was adopted to evaluate apathy. Depression was assessed by Beck Depression Inventory (BDI). Results: Ninety-three patients had IDWG% ≤ 4 and 46 had an IDWG% > 4. Correlation between IDWG% and BDI as well that between IDWG% and AES were not statistically significant. Median BDI and mean AES did not differ significantly between the groups. In addition, 104 patients had a BDI < 16 and 35 had a BDI ≥ 6. Seventy-five patients had an AES score ≤ 35 and 63 had a AES score > 35. The IDWG (kg) and the IDWG% did not differ significantly between the two groups. Conclusion: IDWG is not associated with symptoms of depression or apathy in hemodialysis patients. Thus, these results may question if the use of behavioral intervention aimed at improving motivation is warranted in the hemodialysis population to reduce the IDWG.

Published
2023

3. Fatigue and apathy in patients on chronic hemodialysis

Author

Bossola, Maurizio, Di Stasio, Enrico, Monteburini, T., Santarelli, S., Cenerelli, S., Manes, M., Parodi, E. L., Angioletti, Laura, Balconi, Michela, Bossola M. (ORCID:0000-0003-1627-0235), Di Stasio E. (ORCID:0000-0003-1047-4261), Angioletti L. (ORCID:0000-0002-3027-2272), Balconi M. (ORCID:0000-0002-8634-1951), Bossola, Maurizio, Di Stasio, Enrico, Monteburini, T., Santarelli, S., Cenerelli, S., Manes, M., Parodi, E. L., Angioletti, Laura, Balconi, Michela, Bossola M. (ORCID:0000-0003-1627-0235), Di Stasio E. (ORCID:0000-0003-1047-4261), Angioletti L. (ORCID:0000-0002-3027-2272), and Balconi M. (ORCID:0000-0002-8634-1951)

Abstract

Introduction: This study explores the link between fatigue and apathy in patients on chronic hemodialysis (HD). Methods: One hundred thirty-nine chronic HD patients underwent the assessment of fatigue, apathy, depression, and their functional status, with the fatigue severity scale (FSS), the Apathy Evaluation Scale (AES), the beck depression inventory (BDI), the activity of daily living (ADL), and instrumental activity of daily living (IADL). Results: Patients with high FSS had a significantly lower ADL and IADL score, higher BDI, Charlson Comorbidity Index, and AES score, and lower serum levels of creatinine, compared to low FSS patients. FSS was highly correlated with the AES, as well as with the BDI and the AES correlates with the BDI. At multiple regression analyses, only apathy and IADL were independent predictor variables of fatigue in HD population. Conclusion: Future longitudinal studies could determine if apathy is a causative factor for fatigue manifestation and development in HD patients.

Published
2022

5. DIABETES

Author

Dave, S. D., primary, Vanikar, A. V., additional, Trivedi, H. L., additional, Bertram, A., additional, Shushakova, N., additional, Park, J. K., additional, Kirsch, T., additional, Agustian, P. A., additional, Menne, J., additional, Hermann, H., additional, Gellai, R., additional, Hodrea, J., additional, Lenart, L., additional, Koszegi, S., additional, Ver, A., additional, Banki, N. F., additional, Wagner, L., additional, Fulop, N., additional, Molnar, A., additional, Vannay, A., additional, Szabo, A. J., additional, Fekete, A., additional, Silva, K. A. S., additional, Santos, R. A., additional, Arlotti, M. R., additional, Jorge, L., additional, Luiz, R. S., additional, Rampaso, R. R., additional, Cunha, T. S., additional, Schor, N., additional, Parodi, E. L., additional, Ansaldo, F., additional, Veziano, E., additional, Villaggio, B., additional, Mij, M., additional, Gianiorio, F., additional, Viazzi, F., additional, Verzola, D., additional, Garibotto, G., additional, Ritz, E., additional, Ruilope, L. M., additional, Chatzikyrkou, C., additional, Viberti, G., additional, and Haller, H., additional

Published
2014
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6. Transplantation - clinical II

Author

Riegersperger, M., primary, Plischke, M., additional, Steiner-Boker, S., additional, Seidinger, D., additional, Winkelmayer, W., additional, Sunder-Plassmann, G., additional, Vlahovic, P., additional, Cvetkovic, T., additional, Djordjevic, V., additional, Velickovic-Radovanovic, R., additional, Stefanovic, N., additional, Ignjatovic, A., additional, Sladojevic, N., additional, Cademartori, V., additional, Massarino, F., additional, Parodi, E. L., additional, Russo, R., additional, Sofia, A., additional, Fontana, I., additional, Viviani, G. L., additional, Garibotto, G., additional, Mai, M., additional, Mai, W., additional, Taner, B., additional, Wadei, H., additional, Prendergast, M., additional, Gonwa, T., additional, Martin, J., additional, Aurore, S., additional, Aline, C. S., additional, Nicolas, M., additional, Manolie, M., additional, Catherine, S., additional, Eric, A., additional, Christophe, M., additional, Brakemeier, S., additional, Liefeldt, L., additional, Glander, P., additional, Waiser, J., additional, Lachmann, N., additional, Schonemann, C., additional, Zukunft, B., additional, Illigens, P., additional, Schmidt, D., additional, Wu, K., additional, Rudolph, B., additional, Neumayer, H.-H., additional, Budde, K., additional, Pallardo Mateu, L., additional, Gavela Martinez, E., additional, Sancho Calabuig, A., additional, Crespo Albiach, J., additional, Beltran Catalan, S., additional, Kanter Berga, J., additional, Kimura, T., additional, Yagisawa, T., additional, Ishikawa, N., additional, Sakuma, Y., additional, Hujiwara, T., additional, Nukui, A., additional, Yashi, M., additional, Duraes, J., additional, Malheiro, J., additional, Fonseca, I., additional, Rocha, A., additional, Martins, L. S., additional, Almeida, M., additional, Dias, L., additional, Castro-Henriques, A., additional, Cabrita, A., additional, Volpe, A., additional, Quaglia, M., additional, Menegotto, A., additional, Fenoglio, R., additional, Izzo, C., additional, Airoldi, A., additional, Terrone, C., additional, Stratta, P., additional, Ahmed, B., additional, Mireille, K., additional, Nilufer, B., additional, Annick, M., additional, Karl Martin, W., additional, Anh-Dung, H., additional, Dimitri, M., additional, Philippe, M., additional, Judith, R., additional, Daniel, A., additional, Lan, Y., additional, Heine, C., additional, Capone, V., additional, Grace, B., additional, Clayton, P., additional, Cass, A., additional, Mcdonald, S., additional, Fujiwara, T., additional, Iwabuchi, T., additional, Muraishi, O., additional, Torregrosa, V., additional, Barros, X., additional, Martinez de Osaba, M. J., additional, Paschoalin, R., additional, Campistol, J. M., additional, Hassan, R., additional, El-Hefnawy, A., additional, Soliman, S., additional, Shokeir, A., additional, Cobanoglu Kudu, A., additional, Gungor, O., additional, Kircelli, F., additional, Altinel, E., additional, Asci, G., additional, Ozbek, S. S., additional, Toz, H., additional, Ok, E., additional, Sandrini, S., additional, Setti, G., additional, Valerio, F., additional, Possenti, S., additional, Torrisi, I., additional, Polanco, N., additional, Garcia-Puente, L., additional, Gonzalez Monte, E., additional, Morales, E., additional, Gutierrez, E., additional, Bengoa, I., additional, Hernandez, A., additional, Caballero, J., additional, Morales, J. M., additional, Andres, A., additional, Sgarlato, V., additional, Comai, G., additional, La Manna, G., additional, Moretti, I., additional, Grandinetti, V., additional, Martelli, D., additional, Scolari, M. P., additional, Stefoni, S., additional, Valentini, C., additional, Persici, E., additional, Cappuccilli, M. L., additional, Liviano D'arcangelo, G., additional, Fabbrizio, B., additional, Carretta, E., additional, Mosconi, G., additional, Feliciangeli, G., additional, Grigioni, F. W., additional, Apicella, L., additional, Guida, B., additional, Vitale, S., additional, Garofalo, G., additional, Russo, L., additional, Maresca, I., additional, Rossano, R., additional, Memoli, B., additional, Carrano, R., additional, Federico, S., additional, Sabbatini, M., additional, Carta, P., additional, Zanazzi, M., additional, DI Maria, L., additional, Caroti, L., additional, Miejshtri, A., additional, Tsalouchos, A., additional, Bertoni, E., additional, Sezer, S., additional, Erkmen Uyar, M., additional, Colak, T., additional, Bal, Z., additional, Tutal, E., additional, Kalaci, G., additional, Ozdemir Acar, F. N., additional, Jacquelinet, C., additional, Bayat, S., additional, Pernin, V., additional, Portales, P., additional, Szwarc, I., additional, Garrigue, V., additional, Vetromile, F., additional, Delmas, S., additional, Eliaou, J. F., additional, Mourad, G., additional, Huber, L., additional, Slowinski, T., additional, Naik, M., additional, Nakai, K., additional, Fujii, H., additional, Kono, K., additional, Goto, S., additional, Ishimura, T., additional, Takeda, M., additional, Fujisawa, M., additional, Nishi, S., additional, Pereira Paschoalin, R., additional, Torregrosa, J. V., additional, Barros Freiria, X., additional, Duran Rebolledo, C. E., additional, Sanchez Escuredo, A., additional, Sole, M., additional, Youssouf, S., additional, Tabbasm, F., additional, Bell, R., additional, Al-Jayyousi, R., additional, Warwick, G., additional, Grall, A., additional, Treguer, L., additional, Essig, M., additional, Lecaque, C., additional, Noel, N., additional, Buchler, M., additional, Bertrand, D., additional, Rivalan, J., additional, Braun, L., additional, Villemain, F., additional, Hurault de Ligny, B., additional, Totet, A., additional, Pestourie, N., additional, Toubas, D., additional, Nevez, G., additional, Le Meur, Y., additional, Nour el Houda, B., additional, Mustapha, H., additional, Wafaa, F., additional, Inass, L., additional, Rambabova Bushljetikj, I., additional, Masin-Spasovska, J., additional, Spasovski, G., additional, Popov, Z., additional, Sikole, A., additional, Ivanovski, N., additional, Raimundo, M., additional, Guerra, J., additional, Teixeira, C., additional, Santana, A., additional, Silva, S., additional, Mil Homens, C., additional, Gomes Da Costa, A., additional, Loredo, D., additional, Cleres, M., additional, Gondolesi, G., additional, Gutierrez, L. M., additional, Fortunato, R. M., additional, Descalzi, V., additional, and Raffaele, P., additional

Published
2012
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7. Ten-Year Efficacy and Safety of Once-Daily Tacrolimus in Kidney Transplant: A Prospective Cohort Study.

Author

Parodi EL, La Porta E, Russo R, Marsano L, Bellino D, Paoletti E, Massarino F, Sofia A, Garibotto G, Esposito P, Murugavel A, Cappadona F, Fontana I, Viazzi F, and Picciotto D

Subjects
Cohort Studies, Drug Administration Schedule, Female, Graft Survival drug effects, Humans, Male, Middle Aged, Prospective Studies, Graft Rejection prevention & control, Immunosuppression Therapy methods, Immunosuppressive Agents administration & dosage, Kidney Transplantation, Tacrolimus administration & dosage
Abstract

Tacrolimus is a cornerstone in the immunosuppressive therapy of kidney transplantation. The once-daily formulation of tacrolimus has been shown to improve adherence of patients without affecting short-term efficacy. However, long-term proof of once-daily tacrolimus efficacy and safety is still lacking. From January 2009 to November 2013, 170 clinically stable kidney transplant patients were offered to change from the ongoing twice-daily tacrolimus (TDT) formulation to a once-daily tacrolimus (ODT) regimen. Kidney transplant recipients agreeing to the change to be treated with an ODT regimen (n = 105, estimated glomerular filtration rate [eGFR] 57.1 ± 1.6 mL/min/1.73 m 2 ) and patients continuing on a TDT formulation (n = 65, eGFR 52.0 ± 2.2 mL/min/1.73 m 2 ) were prospectively followed (median follow-up time 10.4 and 12.6 years in the ODT and TDT groups, respectively, P = not significant). At the end of the follow-up, patients in both groups experienced similar eGFR (50.4 ± 2.2 vs 48.0 ± 2.7 mL/min/1.73 m 2 in the ODT and TDT groups, respectively, P = not significant). No differences were observed in biopsy-proven acute rejection, overall graft survival, doubling of serum creatinine, and new onset of proteinuria. The 2 groups also had a comparable rate of death, sepsis, and neoplasia. In conclusion, ODT appears safe and effective in stable kidney graft recipients even 10 years after transplantation. These findings support the use of ODT as a primary tacrolimus formulation in patients with kidney transplantation., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Published
2020
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8. Effects of peritoneal dialysis on protein metabolism.

Author

Garibotto G, Sofia A, Saffioti S, Bonanni A, Mannucci I, Parodi EL, Cademartori V, and Verzola D

Subjects
Amino Acids metabolism, Dietary Supplements, Humans, Protein-Energy Malnutrition diet therapy, Kidney Failure, Chronic metabolism, Kidney Failure, Chronic therapy, Peritoneal Dialysis, Protein-Energy Malnutrition metabolism, Proteins metabolism
Abstract

Protein-energy wasting is relatively common in renal patients treated with haemodialysis or peritoneal dialysis (PD) and is associated with worse outcome. In this article, we review the current state of our knowledge regarding the effects of PD on protein metabolism and the possible interactions between PD-induced changes in protein turnover and the uraemia-induced alterations in protein metabolism. Available evidence shows that PD induces a new state in muscle protein dynamics, which is characterized by decreased turnover rates and a reduced efficiency of protein turnover, a condition which may be harmful in stress conditions, when nutrient intake is diminished or during superimposed catabolic illnesses. There is a need to develop more effective treatments to enhance the nutritional status of PD patients. New approaches include the use of amino acid/keto acids-containing supplements combined with physical exercise, incremental doses of intraperitoneal amino acids, vitamin D and myostatin antagonism for malnourished patients refractory to standard nutritional therapy., (Copyright © 2012 Elsevier B.V. All rights reserved.)

Published
2013
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