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6. Single cell atlas of human gastric muscle immune cells and macrophage-driven changes in idiopathic gastroparesis

Author

Chikkamenahalli, Lakshmikanth L., Jessen, Erik, Bernard, Cheryl E., Ip, W.K. Eddie, Breen-Lyles, Margaret, Cipriani, Gianluca, Pullapantula, Suraj R., Li, Ying, AlAsfoor, Shefaa, Wilson, Laura, Koch, Kenneth L., Kuo, Braden, Shulman, Robert J., Chumpitazi, Bruno P., McKenzie, Travis J., Kellogg, Todd A., Tonascia, James, Hamilton, Frank A., Sarosiek, Irene, McCallum, Richard, Parkman, Henry P., Pasricha, Pankaj J., Abell, Thomas L., Farrugia, Gianrico, Dasari, Surendra, and Grover, Madhusudan

Published
2024
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7. Endoscopic Pyloric Therapies for Gastroparesis

Author

Brewer Gutierrez, Olaya I., Khashab, Mouen A., Parkman, Henry P., Nguyen, Ninh T., editor, Clarke, John O., editor, Lipham, John C., editor, Chang, Kenneth J., editor, Schnoll-Sussman, Felice, editor, Bell, Reginald C.W., editor, and Kahrilas, Peter J., editor

Published
2023
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13. Progress in Gastroparesis - A Narrative Review of the Work of the Gastroparesis Clinical Research Consortium

Author

Pasricha, Pankaj J., Grover, Madhusudan, Yates, Katherine P., Abell, Thomas L., Koch, Kenneth L., McCallum, Richard W., Sarosiek, Irene, Bernard, Cheryl E., Kuo, Braden, Bulat, Robert, Shulman, Robert J., Chumpitazi, Bruno P., Tonascia, James, Miriel, Laura A., Wilson, Laura A., Van Natta, Mark L., Mitchell, Emily, Hamilton, Frank, Farrugia, Gianrico, and Parkman, Henry P.

Published
2022
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19. Comparative evaluation of single versus double leg raise maneuver in high‐resolution esophageal manometry.

Author

Rim, Daniel S. and Parkman, Henry P.

Subjects
*HIATAL hernia, *INTRA-abdominal pressure, *GASTROESOPHAGEAL reflux, *FUNDOPLICATION
Abstract

Background: The straight leg raise (SLR) maneuver, often performed during esophageal manometry, requires patients to lift their leg(s) to augment intraabdominal pressure (IAP). Diverse techniques have been applied for SLR. This study aimed to evaluate and compare the effects of SLR between single and double leg raises. Methods: During esophageal manometry, patients were asked to raise one leg, followed by elevating both legs. The efficacy of SLR for (1) detecting hiatal hernia, (2) increasing IAP, and (3) predicting gastroesophageal reflux disease (GERD) with intraesophageal pressure (IEP) was assessed. The value of change in impedance to indicate reflux during SLR in predicting esophageal acid exposure was investigated. Key Results: The leg raise procedures were performed in 86 patients undergoing high‐resolution esophageal manometry. Both the single and double leg raises exhibited a higher hiatal hernia detection rate compared to the landmark (p = 0.008 and 0.005, respectively). Double leg raise was more effective in raising IAP by >50% compared to single leg raise (100% vs. 65.1%, p < 0.001), increasing yield by 53.6%. The change in IAP showed a positive correlation with the change in IEP during double leg raise (r = 0.31; p = 0.004), higher than that for single leg raise (r = 0.23; p = 0.03). Lower intraesophageal impedance during SLR was associated with AET > 6% with double leg raise (1.5 kΩ vs. 2.5 kΩ, p = 0.04). Conclusions & Inferences: Our study demonstrates the efficacy of both single and double leg raise maneuvers during HREMI in increasing hiatal hernia detection and possible value in predicting GERD. The double leg raise resulted in a higher rate of effective increase in IAP, potentially enabling more patients to undergo effective SLR during HREMI. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Abdominal Pain and Chronic Opiate Use in Patients with Gastroparesis.

Author

Ifrah, Abraham, Ebeid, John, and Parkman, Henry P.

Subjects
PEARSON correlation (Statistics), CHRONIC pain, ACADEMIC medical centers, T-test (Statistics), EHLERS-Danlos syndrome, GASTROINTESTINAL motility, ABDOMINAL pain, QUESTIONNAIRES, HOSPITAL care, TREATMENT effectiveness, DESCRIPTIVE statistics, HOSPITAL emergency services, SURVEYS, OPIOID analgesics, ANALYSIS of variance, PAIN management, CONFIDENCE intervals, GASTROPARESIS
Abstract

Introduction: Although opiate narcotics may worsen gastroparesis(GP), patients can take these for abdominal pain (AP) or other chronic pain syndromes. This study aims to evaluate medications patients with gastroparesis use for AP and compare patients who use opiate analgesics for AP to those using opiate analgesics for non-abdominal pain. Methods: Patients at a tertiary academic center gastroenterology clinic completed the Patient Assessment of Gastrointestinal Disorders–Symptom Severity Index (PAGI-SYM) and Quality of Life Short-Form 8 (QOL SF-8) surveys between 10/2021 and 03/2023. Patients recorded gastroparesis treatments, pain treatments and indication, and any hospitalizations/emergency department (ED) visits within 3 months of a clinic visit. Results: A total of 53 patients were enrolled: 72% reported having AP. Patients were using the following medications for AP: 25% heating pad, ice or hot showers, 20.8% acetaminophen, 14.6% hyoscyamine, 13% opiate use, 13% marijuana use, 10.4% dicyclomine, 8.3% Nonsteroidal anti-inflammatory drugs (NSAIDs), 4% benzodiazepine, and 2.1% gabapentin. The reported reasons for using opiates were 58% AP, 16.6% chronic back pain, 16.6% Reflex Sympathetic Dystrophy (RSD) and fibromyalgia, and 8.3% osteoarthritis. All opiate users reported daily scheduled use. AP severity scores (4.1 vs. 2.8; p = 0.041), morphine equivalent usage (77 ± 44 vs. 32 ± 28; p = 0.037), and the number of ER visits (1.0 vs. 0 over 3 months) were higher in patients using opiates for AP than those using opiates for non-abdominal pain. Conclusions: In this series, 72% of patients with gastroparesis had abdominal pain, and 13% of patients were taking opiates. Patients who used opiate analgesics for abdominal pain had a higher average abdominal pain severity score and used a higher amount of opiate analgesia than patients using opiates for musculoskeletal pain. Abdominal pain in patients with gastroparesis can be harder to control with opiate analgesia compared to non-abdominal pain, supporting the concept of avoiding chronic opiate usage for abdominal pain in gastroparesis. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Abdominal pain in gastroparesis

Author

Oladunjoye, Olubunmi, primary, Jehangir, Asad, additional, Oladunjoye, Adeolu, additional, Qureshi, Anam, additional, Malik, Zubair, additional, and Parkman, Henry P., additional

Published
2022
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25. Contributors

Author

Alamam, Dalyah, primary, de Almeida, Amanda Spring, additional, Altun, Gulbin Tore, additional, Arslantas, Reyhan, additional, Aşcı, Ramazan, additional, Bagatin, D., additional, Bagatin, T., additional, Bahamondes, Luis, additional, Bansal, Sonia, additional, Baria, Ariel, additional, Batur (Furkan), Ali, additional, Bayar, Kılıçhan, additional, Bolat, Mustafa Suat, additional, Branco, Luiz Guilherme S., additional, Brandt, R.B., additional, Burch, Robert (Trey) H., additional, Büyükalpelli, Recep, additional, Cantón-Habas, Vanesa, additional, Canturk, Mehmet, additional, Carrera-González, María del Pilar, additional, Chandrika, U.G., additional, Chen, Mengmeng, additional, Cinar, Önder, additional, Cindryani, Marilaeta, additional, Cole, Arron M., additional, Courel-Ibáñez, Javier, additional, Cruz-Montecinos, Carlos, additional, Davydov, Dmitry M., additional, Deutsch, J., additional, Devlin, John W., additional, Díaz de Terán, Javier, additional, Dincer, Pelin Corman, additional, Estévez-López, Fernando, additional, Failo, Alessandro, additional, Fallahi, Hamid Reza, additional, Francesco, Deni, additional, Fronczek, R., additional, Gil-Martínez, Alfonso, additional, Haan, J., additional, Haddad, Jorge, additional, Heredia-Rizo, Alberto Marcos, additional, Hirose, Munetaka, additional, Ismail, Che Aishah Nazariah, additional, Isomura, E., additional, Jaya, A.A. Gde Putra Semara, additional, Jehangir, Asad, additional, Karunarathna, Ureshani, additional, Kaur, Hardeep, additional, Keyhan, Seied Omid, additional, Kim, Matthew, additional, Kljajić, Z., additional, Koç, Meltem, additional, Kokki, Hannu, additional, Kokki, Merja, additional, Komatsu, Jun, additional, Lemaire, Antoine, additional, Liu, Nancy, additional, Long, Idris, additional, Lopes, Bettega Costa, additional, Luigi, Beretta, additional, Madeleine, Pascal, additional, Maestre-Cascales, Cristina, additional, de Magalhaes, Thais F., additional, Mahajan, Gaurav, additional, Malaguarnera, Michele, additional, Malić, M., additional, Malik, Zubair, additional, Margatho, Deborah, additional, Marilena, Marmiere, additional, Martínez-Martos, José Manuel, additional, Medeiros, Liciane Fernandes, additional, Miletich, Derek M., additional, Mullet, Etienne, additional, Mullins, Lynita, additional, Nascimento, Glauce Crivelaro, additional, Nemrava, J., additional, Ng, Kelsey, additional, Nishijo, Hisao, additional, Núñez-Cortés, Rodrigo, additional, Oladunjoye, Adeolu, additional, Oladunjoye, Olubunmi, additional, Ono, Taketoshi, additional, Paladini, Antonella, additional, Pangarkar, Sanjog, additional, Parkman, Henry P., additional, Pérez-Alenda, Sofía, additional, Phillips, C. Ryan, additional, Pommer, Paula Pino, additional, Prada-Arias, Marcos, additional, Pullen, Sara, additional, Qureshi, Anam, additional, Ramirez-Éxposito, María Jesús, additional, Rekatsina, Martina, additional, Renato, Meani, additional, Rich-Ruiz, Manuel, additional, Sabzian, Roya, additional, Sakai, Shigekazu, additional, Šakić, K., additional, Šakić, L., additional, Saltelli, Giorgia, additional, Santos, Bruna Maitan, additional, Šarec Ivelj, M., additional, Sclafani, Anthony P., additional, Senapathi, Tjokorda Gde Agung, additional, ShangGuan, Wangning, additional, Shomorony, Andre, additional, Sorum, Paul Clay, additional, Sriganesh, Kamath, additional, Stefano, Turi, additional, Stein, Dirson João, additional, Szeto, Grace P.Y., additional, Szumita, Paul M., additional, Takamoto, Kouichi, additional, Tapia, Claudio, additional, Terwindt, G.M., additional, Torres, Iraci L.S., additional, Trevisan, Gabriela, additional, Tuna, Turgay, additional, Urakawa, Susumu, additional, Varrassi, Giustino, additional, Veal, Felicity, additional, Wonders, Quinn, additional, and Zandian, Dana, additional

Published
2022
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45. List of Contributors

Author

Abell, Thomas, primary, Ahuja, Nitin K., additional, Ali, M. Showkat, additional, Banerjee, Sreerup, additional, Bashashati, Mohammad, additional, Becker, Laren, additional, Bridges, Meagan, additional, Bulat, Robert, additional, Camilleri, Michael, additional, Cangemi, David J., additional, Carbone, Florencia, additional, Chikkamenahalli, Lakshmikanth L., additional, Clarke, John O., additional, Davis, Brian R., additional, DeGrazia-DiTucci, Maryangela, additional, Diaz, Jesus, additional, Douglas, Yellowlees, additional, Elmasry, Mohamed, additional, Febo-Rodriguez, Liz, additional, Fletcher, Reid, additional, Fox, Mark, additional, Friedman, Marvin I., additional, Gajendran, Mahesh, additional, Gajula, Prianka, additional, Gonzalez, Zorisadday, additional, Grover, Madhusudan, additional, Hajiyeva, Gulara, additional, Harris, Ciel, additional, Hasler, William L., additional, Haston, Carissa, additional, Horowitz, Michael, additional, Itzoe, MariaLisa, additional, Jaradeh, Safwan, additional, Jones, Karen L., additional, Kalloo, Anthony N., additional, King, Joyce E., additional, Koch, Kenneth L., additional, Kuo, Braden, additional, Lacy, Brian E., additional, Lee, Allen, additional, Lee, Linda A., additional, Lee, Ta-ya, additional, Lombardi, Marissa, additional, Marciani, Luca, additional, Maurer, Alan H., additional, McCallum, Richard, additional, McCallum, Richard W., additional, Moshiree, Baha, additional, Ngamruengphong, Saowanee, additional, Parker, Helen, additional, Parkman, Henry P., additional, Quigley, Eamonn M.M., additional, Rayner, Christopher K., additional, Revicki, Dennis, additional, Rooker, Ceciel, additional, Sarosiek, Irene, additional, Schey, Ron, additional, Schol, Jolien, additional, Shulman, Robert J., additional, Simons, Malorie, additional, Sinn, Dong In, additional, Smith, Samantha, additional, Smith, Terence K., additional, Snape, William J., additional, Spear, Estelle T., additional, Swanström, Lee L., additional, Tack, Jan, additional, Tansel, Aylin, additional, Treisman, Glenn J., additional, VanHouten, Melissa Adams, additional, Vélez, Christopher David, additional, and Wo, John M., additional

Published
2021
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48. Ethnic, Racial, and Sex Differences in Etiology, Symptoms, Treatment, and Symptom Outcomes of Patients With Gastroparesis

Author

Parkman, Henry P., Yamada, Goro, Van Natta, Mark L., Yates, Katherine, Hasler, William L., Sarosiek, Irene, Grover, Madhusudan, Schey, Ron, Abell, Thomas L., Koch, Kenneth L., Kuo, Braden, Clarke, John, Farrugia, Gianrico, Nguyen, Linda, Snape, William J., Miriel, Laura, Tonascia, James, Hamilton, Frank, Pasricha, Pankaj J., and McCallum, Richard W.

Published
2019
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49. Opioid Use and Potency Are Associated With Clinical Features, Quality of Life, and Use of Resources in Patients With Gastroparesis

Author

Pasricha, Pankaj Jay, Clarke, John, Kim, Yale, Nguyen, Linda, Ullah, Nighat, Snape, William, DeVole, Nata, Greene, Mary, Lee, Candice, Ponsetto, Courtney, Shetler, Katerina, Parkman, Henry P., Kantor, Steven, Lytes, Vanessa, Palit, Amiya, Simmons, Kellie, McCallum, Richard W., Hejazi, Reza, Roeser, Kathy, Sarosiek, Irene, Vasquez, Denise, Vega, Natalia, Abell, Thomas, Beatty, Karen, Hatter, Lisa, Howard, Ronna, Nowotny, Lindsay, Tang, Shou, Amin, Om S., Henry, Olivia, Kedar, Archana, McNair, Valerie, Pruett, Susanne, Smith, Margaret, Spree, Danielle, Hasler, William, Castle, Michelle, Coleski, Radoslav, Wootten, Sophanara, Koch, Kenneth, Baxter, Lynn, Brown, Anya, Culler, Samantha, Hooker, Judy, Stuart, Paula, Farrugia, Gianrico, Grover, Madhusudan, Bernard, Cheryl, Calles-Escandon, Jorge, Serrano, Jose, Hamilton, Frank, James, Steven, Torrance, Rebecca, Van Raaphorst, Rebekah, Tonascia, James, Belt, Patricia, Hallinan, Erin Corless, Colvin, Ryan, Donithan, Michele, Green, Mika, Isaacson, Milana, Kim, Wana, Lee, Linda, May, Patrick, Miriel, Laura, Sternberg, Alice, Van Natta, Mark, Vaughn, Ivana, Wilson, Laura, Yates, Katherine, Hasler, William L., Wilson, Laura A., Nguyen, Linda A., Snape, William J., Abell, Thomas L., Koch, Kenneth L., Pasricha, Pankaj J., Lee, Linda A., and Hamilton, Frank A.

Published
2019
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