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370 results on '"Parkhouse, R. M. E."'

3. Two Surface Antigen Targets for Immunotoxin-Mediated Elimination of Normal and Neoplastic Murine B Cells

Author

Parkhouse, R. M. E., Santos-Argumedo, L., Teixeiral, C., Henry, R. V., Wawrzynczak, E., Capron, A., editor, Compans, R. W., editor, Cooper, M., editor, Koprowski, H., editor, McConnell, I., editor, Melchers, F., editor, Oldstone, M., editor, Olsnes, S., editor, Potter, M., editor, Saedler, H., editor, Vogt, P. K., editor, Wagner, H., editor, Wilson, I., editor, Potter, Michael, editor, and Melchers, Fritz, editor

Published
1992
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32. Antigens of Taeniid Cestodes in Protection, Diagnosis and Escape

Author

Harrison, L. J. S., Parkhouse, R. M. E., Clarke, A., editor, Compans, R. W., editor, Cooper, M., editor, Eisen, H., editor, Goebel, W., editor, Koprowski, H., editor, Melchers, F., editor, Oldstone, M., editor, Rott, R., editor, Vogt, P. K., editor, Wagner, H., editor, Wilson, I., editor, and Parkhouse, R. M. E., editor

Published
1985
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33. Nematode Antigens

Author

Almond, N. M., Parkhouse, R. M. E., Clarke, A., editor, Compans, R. W., editor, Cooper, M., editor, Eisen, H., editor, Goebel, W., editor, Koprowski, H., editor, Melchers, F., editor, Oldstone, M., editor, Rott, R., editor, Vogt, P. K., editor, Wagner, H., editor, Wilson, I., editor, and Parkhouse, R. M. E., editor

Published
1985
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47. A B lymphocyte surface molecule mediating activation and protection from apoptosis via calcium channels

Author

Leopoldo Santos-Argumedo, Teixeira, C., Preece, G., Kirkham, P. A., and Parkhouse, R. M. E.

Subjects
Immunology, Immunology and Allergy
Abstract

A rat mAb (NIM-R5) was prepared against a 42-kD B cell activation Ag (p42). The expression of p42 is increased upon activation. NIM-R5 induces an increase of intracellular Ca2+, due to influx from the exterior milieu via calcium channels. This stimulation does not prejudice further stimulation with anti-Ig, and thus p42 constitutes an activation signal independent of membrane Ig. The antibody induces increased expression of class II molecules on resting B lymphocytes and prepares the cells for "spreading" when interacted with immobilized anti-class II antibody. The antibody alone is weakly mitogenic and comitogenic with IL-4 on resting B cells. Of particular interest, NIM-R5 induces proliferation and rescue from apoptosis in B cells activated in vitro. In conclusion, NIM-R5 induces an Ig-independent activation and proliferation of resting and activated B cells. This antibody does not recognize other known B cell activation Ag such as CD23, CD40, or CD72. We therefore propose that the p42 Ag is a glycoprotein with an important role in the regulation of B lymphocyte activation and survival.

Published
1993
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