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The ODYSSEY OUTCOMES trial, comprising over 47 000 patient-years of placebo-controlled observation, demonstrated important reductions in the risk of recurrent ischaemic cardiovascular events with the monoclonal antibody to proprotein convertase subtilisin/kexin type 9 alirocumab, as well as lower all-cause death. These benefits were observed in the context of substantial and persistent lowering of low-density lipoprotein cholesterol with alirocumab compared with that achieved with placebo. The safety profile of alirocumab was indistinguishable from matching placebo except for a ∼1.7% absolute increase in local injection site reactions. Further, the safety of alirocumab compared with placebo was evident in vulnerable groups identified before randomization, such as the elderly and those with diabetes mellitus, previous ischaemic stroke, or chronic kidney disease. The frequency of adverse events and laboratory-based abnormalities was generally similar to that in placebo-treated patients. Thus, alirocumab appears to be a safe and effective lipid-modifying treatment over a duration of at least 5 years.

Abstract This study investigates the impact of proton irradiation on perovskite devices fabricated fully through vacuum deposition. Exposure to irradiation induces changes in both electrical and optical properties. The analysis reveals that the main factors influencing the observed performance changes in solar cells are a significant reduction in shunt resistance and a minor increase in series resistance, with minimal alterations in recombination dynamics. Remarkably, the devices maintain promising photodetector characteristics both before and after proton irradiation, particularly in a self-powered mode without a reverse bias. These findings provide valuable insights into the resilience of vacuum-deposited perovskite devices against ionizing radiation, highlighting their potential for applications in radiation-prone environments, such as the nuclear industry or space exploration.

The term Solar Cell is commonly used for Photovoltaics that convert light into electrical energy. However, light can be harvested from various sources not limited to the Sun. This work considers the possibility of harvesting photons from different star types, including our closest neighbor star Proxima Centauri. The theoretical efficiency limits of single junction photovoltaic devices are calculated for different star types at a normalized light intensity corresponding to the AM0 spectrum intensity with AM0 = 1361 W/m2. An optimal bandgap of > 12 eV for the hottest O5V star type leads to 47% Shockley-Queisser photoconversion efficiency (SQ PCE), whereas a narrower optimal bandgap of 0.7 eV leads to 23% SQ PCE for the coldest red dwarf M0, M5.5Ve, and M8V type stars. Organic Photovoltaics (OPVs) are the most lightweight solar technology and have the potential to be employed in weight-restricted space applications, including foreseeable interstellar missions. With that in mind, the Suns G2V spectrum and Proxima Centauris M5.5Ve spectrum are considered in further detail in combination with two extreme bandgap OPV systems: one narrow bandgap system (PM2:COTIC-4F, Eg = 1.14 eV) and one wide bandgap system (PM6:o-IDTBR, Eg = 1.62 eV). Semi-empirically modeled JV-curves reveal that the absorption characteristics of the PM2:COTIC-4F blend match well with both the G2V and the M5.5Ve spectrum, yielding theoretical PCEs of 22.6% and 12.6%, respectively. In contrast, the PM6:o-IDTBR device shows a theoretical PCE of 18.2% under G2V illumination that drops sharply to 0.9% under M5.5Ve illumination.

Introduction. The technological operation of soil tillage is an energy-intensive preparatory operation. The traction resistance of tillage units has a direct impact on this indicator. Aim of the Study. The study is aimed at searching optimal operating parameters for the field cultivator tool through determining the traction resistance created by this tool. Materials and Methods. The study was carried out in the field on an experimental facility using a full factorial experiment technique with a working model based on a three-level design. Results. Through the regression analysis of experimental data, there was obtained a mathematical model that allows determining the optimal operating parameters for the field cultivator tool when performing a technological operation of soil tillage. Discussion and Conclusion. While calculating, it was found that the lowest traction resistance PТ = 0,72 kN created by the tool is for the following values: tillage depth h = 4 cm, crumbling angle of the left-hand and right-hand flat-cutting wings f = 0° and the speed of the tillage unit v = 2,61 m/s. As the optimal operating parameters for a field cultivator tool, determined using the obtained mathematical model, it is recommended to use the crumbling angle of the left-hand and right-hand flat-cutting wings of the working body f = 0°, and the speed of the tillage unit v = 2,91 m/s. Taking into account the recommended optimal operating parameters of the tool, it is possible to calculate the value of the traction resistance index at different tillage depths. The traction resistance will change within the range of 0.79–1.81 kN, when the soil tillage depth changes from 4 to 12 cm. The resulting mathematical model of the traction resistance created by the tool will allow a more accurate approach to the issue of designing agricultural machines.

This work is devoted to calculating the rate of radiation damage production in a uranium target irradiated with high-energy electrons with an energy of 100 MeV. The Monte Carlo program MCNPX was used to perform a complete mathematical modeling of a complex of processes occurring in a uranium target when irradiated with high-energy electrons: the development of an electromagnetic shower, the production of photoneutrons, the transport of particles in the target and the creation of radiation damage in it. The analysis showed that fragments of U-238 photo-fission give the main input into the rate of damage production in a uranium target which reaches the value of 100 dpa/year. The expected service life of a uranium target under irradiation is 3 years of operation at full accelerator power.

In Gepner's pioneering work, the requirement that leads to a model having the desired N=1 Spacetime supersymmetry and E(8)×E(6) Gauge symmetry was the requirement that the spacetime symmetry is compatible with modular invariance. In this work we show that the requirement for the simultaneous fulfillment of mutual locality of the left-moving vertices of physical states with the space-time symmetry generators and of right-moving vertices with generators of E(8)×E(6)-gauge symmetry, which arises after some special reduction together with the requirement of mutual locality of complete (left-right) vertices of physical states among themselves leads to the same Gepner models.

Telecommuting came roaring to the forefront of the American workplace in the spring of 2020. While no more than 8% of work was done remotely in 2019, shutdowns and social-distancing policies introduced at the onset of the Covid-19 pandemic pushed more than 1 out of every 3 American workers to telecommute. To reflect this shift, the research team aimed to update the spatial modeling toolbox to allow remote employment and develop a quantitative framework capable of analyzing the full range of reallocations, both within and across cities, which may result from its increasing popularity. The researchers build a quantitative spatial model in which some workers can substitute on-site effort with work done from home. The team quantifies their framework to match the distribution of jobs and residents across 4,502 U.S. locations. A permanent increase in the attractiveness of telework results in a rich non-monotonic pattern of reallocations within and across cities. Workers who can telecommute experience welfare gains, and those who cannot suffer losses. Additionally, broader access to jobs reduces inequality across residential locations. The framework robustly predicts changes in residents and housing prices observed 2019—2021.View the NCST Project Webpage

Ukraine’s integration into the European Union (EU) is one of the most important areas of the State’s development, and therefore one of the conditions for rapprochement between Ukraine and the European Community, as well as a condition for accession to the EU, is the adaptation of Ukrainian domestic legislation to the EU acquis. The purpose of the study was to identify the peculiarities and problematic aspects of the implementation of EU law in national legislation. The research methods used were: historical, periodisation, formal legal and problem analysis methods. The study examined the peculiarities and problems of adaptation of Ukrainian legislation to EU law. The study found that the legislation is being adapted on the basis of the Association Agreement between Ukraine and the European Union, which includes the European Atomic Energy Community and its member states. The implementation process involves the transposition of EU norms into national legislation, while adaptation is the alignment of national law with EU legislation. The current legislation provides for three stages of adaptation of legislative norms, which aim to harmonize with EU law as much as possible. As implementation is a rule-making process, it involves a certain sequence of actions. In particular, it includes the establishment of the acquis communautaire, the creation of a list of legislative acts to be adopted and their preparation for adoption, monitoring of implementation and other sequential actions. In addition, the process of adaptation should be based on the principles of compliance with EU directives, the principle of voluntariness, clarity of terminology and completeness. Among the factors that are obstacles to implementation are the following: Russian aggression, institutional failure of state bodies, high level of corruption, numerous conflicts in legislation

This paper analyses the digitalization of museum marketing as an innovative tool for customer evaluation. The content analysis of digital tools created by the most visited museums in the world on social networks such as Facebook, Twitter and Instagram were carried out. To obtain statistical information about the pages of museums in social networks, the social media analytics and management tool Fanpage Karma was used. According to the selected indicators, Fanpage Karma filters the rating of the networks' current strongest content. The correlation between the number of museum visits and indicators showing the interaction of the museum with visitors using social networks, such as the number of fans, the page performance index, the number of posts per day, the growth rate of followers, post interactions, and the number of total reactions and comments, was evaluated. The aim of this paper is to analyse the impact of museum marketing digitalization processes on museum visits by tourists and, as a result, the economic development of the museum business. To monitor the digitalization strategy of the museum's marketing activities, a mixed approach based on qualitative and quantitative analysis was used. Multivariate analysis was carried out to determine the relationship between museum attendance and the interaction between museums and subscribers in social networks. It has been proven that the introduction of digital technologies in museum marketing can attract visitors and put the institution at the new informational level. The number of museum visits and the number of fans, the number of posts per day, interactions, and the number of reactions and comments are the same across all social networks. The paper allows us to know the potential audience of the museum and its needs and requests and to predict the interests of certain categories of museum visitors. The scientific novelty and originality of the research consists of the use of digital marketing tools for evaluating their influence on client behaviour. The results of the study may be useful for the development of monitoring systems and strategic management of marketing when evaluating the behaviour of consumers on the content of social networks at enterprises in various industries.

Background. Treatment for malignant brain gliomas includes surgery, radiation therapy, and chemotherapy with temozolomide. However, this complex treatment does not prevent tumor relapses and progression, which is caused by the activity of tumor cells and a high mutational burden. Researchers are experimenting with different intensity of focused ultrasound (FUS) in the treatment of glioblastoma (GBM). FUS has shown encouraging results in clinical studies.The aim of the study. This review presents brief information on the history of the development of the studied method, the results of its application in experiments and clinical trials, as well as the main possible directions for its implementation in neuro-oncology, in particular, for the treatment of glioblastomas, depending on parameters, including frequency, power, pulse duration and duty cycle.Methods. We carried out an analysis and interpretation of existing publications; for the search, we used the PubMed database and the keywords “focused ultrasound, glioma, HIFU, LIFU”, as well as Yandex and Google search engines and the same keywords in Russian.Results. Low-intensity FUS can be used to temporarily open the blood-brain barrier (BBB), which limits the diffusion of most macromolecules and therapeutic agents into the brain. High-intensity FUS can cause tumor ablation due to a hyperthermic effect, and also stimulate an immunological attack of tumor cells, activate sonosensitizers to exert a cytotoxic effect on tumor tissue, and can increase the sensitivity of tumors to radiation therapy. Histotripsy causes tumor ablation through acoustic cavitation.Conclusion. Focused ultrasound is a promising potential treatment for gliomas. Further study in the form of clinical trials should determine the optimal ultrasound parameters to achieve effective treatment for patients with malignant brain tumors.

Enterprises develop and interact with the global environment. Their activities are influenced by various factors, and timely identification of the degree of their influence allows forecasting business development and reasonably choosing development strategies. The work is based on the hypothesis that in the global environment, under the influence of internal and external factors, tools can be developed for enterprise assessment and business strategy formation. The puprose of the paper is to develop a toolkit for evaluating an enterprise in a global environment for choosing a development strategy. In the article, the authors conduct a study of the influence of factors of the global environment on the development of the enterprise, propose a model with the help of which it is expedient to forecast the metastate of the enterprise and put forward proposals for choosing an effective development strategy. A structural and logical model for ensuring the stable development of business systems has been proposed. In the process of research, the authors developed a system of indicators that form an integral index that characterizes the effectiveness of the development of business systems. The basis of the integral indicator of the metastate of the development of business systems is a set of indicators for assessing the development and changes in the state of business systems in a dynamic global environment. The economic and mathematical model of estimating the metastate of business systems is considered as a reflection and formalization of the main, essential parameters of business systems development (production, technological and property, personnel, social, financial, material and supply, marketing, foreign trade. The integral metastate index of business systems systematically reflects the effectiveness of the Kharkiv machine-building business systems and allows determining strategies for their development. The selected machine-building enterprises have been grouped by the following types of development strategies: a rapid growth strategy aimed at ensuring the development of enterprises, offensive positions; a strategy of moderate growth and stabilization, characterized by stable parameters of business systems development, adequacy of resources for development, aimed at saving resources and costs, market expansion and development, product upgrades, innovative development; a strategy of curtailment, reduction, which is characterized by negative development trends due to lower profits, reduced assets, reorientation of consumers to other products or markets. As a result of the research, a methodological approach to the assessment of trends in the development of business systems has been developed, which will allow obtaining additional advantages in the global environment. Determination of benefits becomes a basic characteristic for monitoring information provision regarding the organization of enterprise activities in a global environment. The paper makes a contribution to the research of the methodology for assessing the development of enterprises that can be applied to other enterprises, not only to the Kharkiv area. In the event of a change in the influence of global environmental factors, the degree of influence should be specified. The work offers an opportunity to develop further research from the point of view of strategic management, the concept of six sigma, and production optimization.

The notion “grant project” is elaborated on, with investigating the types of state support to grant activities in Ukraine. It is argued that the number of grant programs in Ukraine has been constantly increasing. This type of targeted financing can be received as part of national initiatives and from private companies or international organizations. It is substantiated that the importance of grants in the war and postwar time will be rising, which is quite logical given the increasing scopes and complexity of problems in economic and social sphere. Grants offer a good way of facing these problems: the competitive approach allows for selecting the best, the most promising and productive entrepreneurs capable to achieve the goals in an efficient manner. The number of potential donors and funds allocated for them continue growing. It should be noted that grants are a conventional and widespread practice of funding in EU. It means that businesses have to carefully consider this potential channel of funding. The following programs for support of Ukrainian business were implemented in IV quarter 2023: micro-grants for creating one’s own business; grants to operate a processing factory; funds to operate a greenhouse facility; grants for a startup; grants for veterans and their family members. The peculiarity of each of the above programs are analyzed. The program eRobota (eWork) launched 1 July, 2022 and aimed at stimulation of entrepreneurial activities and job creation proved to be a most ambitious one: its total funding in 2023 amounted to 1,800,000,000 UAH. The principal requirements to grant recipients are highlighted: absence of business activities on the temporarily occupied territories and in the Russian Federation, not being a sanctioned entity, absence of bankruptcy procedures and debts to the state. The overwhelming majority of recipients got micro-grants that were invested in acquisitions of equipment required for business operation. The most demanded sectors where grant recipients operate are wholesale and retail trade, repair of automobile vehicles, temporary accommodation and meals, manufacturing industry, medical and social aid.