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The ODYSSEY OUTCOMES trial, comprising over 47 000 patient-years of placebo-controlled observation, demonstrated important reductions in the risk of recurrent ischaemic cardiovascular events with the monoclonal antibody to proprotein convertase subtilisin/kexin type 9 alirocumab, as well as lower all-cause death. These benefits were observed in the context of substantial and persistent lowering of low-density lipoprotein cholesterol with alirocumab compared with that achieved with placebo. The safety profile of alirocumab was indistinguishable from matching placebo except for a ∼1.7% absolute increase in local injection site reactions. Further, the safety of alirocumab compared with placebo was evident in vulnerable groups identified before randomization, such as the elderly and those with diabetes mellitus, previous ischaemic stroke, or chronic kidney disease. The frequency of adverse events and laboratory-based abnormalities was generally similar to that in placebo-treated patients. Thus, alirocumab appears to be a safe and effective lipid-modifying treatment over a duration of at least 5 years.

Abstract We consider two explicit constructions of states in the orbifolds of a product of Minimal N = (2, 2) models which are based on twisting by spectral flow, mutual locality and operator algebra requirement. It is shown that these two constructions lead to the Berglund-Hubsh-Krawitz dual orbifold groups which define mirror pairs of isomorphic models. Then we generalize our construction for the orbifolds of Gepner models of superstring compactification and explicitly build IIA/IIB mirror map of the space of states of the superstrings using light-cone gauge.

Purpose of the study. To study the possibility of detecting freely circulating DNA of the H3F3A (K27M) gene in blood plasma and cerebrospinal fluid in the lumbar spine in children with diffuse midline gliomas (DMG) during a course of radiation therapy (RT).Materials and methods. Molecular genetic studies were carried out by digital PCR. 96 samples of lumbar cerebrospinal fluid and 288 samples of peripheral blood plasma from 96 pediatric patients were analyzed. The concentration of circulating tumor (ctDNA) mutant DNA and wild-type DNA of the H3F3A (K27M) gene was determined in the studied material against the background of a course of RT. Lumbar cerebrospinal fluid sampling was performed once at the beginning of therapy, blood sampling was performed three times: The 1st test before the start of RT, the 2nd against the background of a total dose 10–15 Gy, and the 3rd after the completion of the RT course. Patients are divided into the following groups: patients with stabilization of brain tumor growth during early magnetic resonance (MR) control 3 months after completion of the course of RT; patients with disease progression during the same follow-up period who underwent radiation or chemoradiotherapy.Results. When the disease stabilized after a RT course during treatment, the concentration level of both the mutant variant of ctDNA and wild-type ctDNA significantly decreased in the third blood fraction. The absence of changes or an increase in the concentration of mutant ctDNA and wild-type ctDNA of the H3F3A (K27M) gene by the end of the course of radiation therapy was typical for patients with disease progression in the form of the appearance of metastatic foci in the central nervous system or continued tumor growth. At the same time, the concentration of wild-type DNA of the H3F3A (K27M) gene in the group of patients with progression was higher both in the lumbar cerebrospinal fluid and in the first fraction of blood plasma.Connclusion. Determination of the concentration and dynamics of circulating tumor DNA of the mutant and wild-type of the H3F3A (K27M) gene in blood plasma and lumbar cerebrospinal fluid in children with diffuse median gliomas of the brain during radiation therapy is promising from the point of view of predicting the effectiveness of therapy.

Malignant gliomas make up 25 % of the central nervous system (CNS) tumors in adults and 8–15 % in children. About half of such gliomas have a median localization and are designated by the term "diffuse midline gliomas" (DMG). DMG in children are typically localized in the area of the pons; in 78 % of such cases a heterozygous somatic mutation H3K27M is present. The prognosis of H3K27M-mutant DSG is very unfavorable, with 2-year overall survival rate being less than 10 %. One of the ways of progression of gliomas leading to the death of patients is the spread of the tumor in the form of metastases. Malignant gliomas metastasize mainly into various structures of the CNS (according to autopsies – in about 20 % of patients with glioblastomas), the probability of their metastases to other organs (so-called extraneural metastases), according to some evaluations, is quite rare and doesn’t exceed 2 %. In our practice since 1993, which counts 1700 children with malignant gliomas, including 830 patients with DMG, we’ve observed only one patient with extraneural metastases. The article describes this case of a child who died of the progression of the DMG’s extraneural metastases, despite the fact that chemoradiotherapy had achieved its stabilization in the CNS. This patient with the initial lesion of the pons and cerebellum had massive metastasis to the lymph nodes: supraclavicular, mediastinal, retroperitoneal and inguinal ones, as well as to both pleural cavities, which occurred about one year after treatment of the progression, which had manifested in the form of continued growth of the primary tumor and its dissemination in the central nervous system. The article provides literature data on the frequency, clinical manifestations and possible treatment approaches for extraneural metastasis of brain gliomas. Extraneural metastases of those tumors occur most often to the bones, lymphatic system, lungs, abdominal organs, soft tissues. The effective treatment for extraneural metastases of gliomas has not been developed yet, which makes it urgent to solve this problem through multicenter studies.

The works in the field of radiation materials science of target materials of neutron sources based on the subcritical assemblies controlled by linear accelerators of electrons or protons, so-called accelerator driven systems (ADS), are reviewed. Now, electronuclear ADS systems are the prototype of safe nuclear reactors of the 5th generation. In connection with the physical start-up of the neutron source facility of the National Scientific Centre ‘Kharkiv Institute of Physics and Technology’ of the N.A.S. of Ukraine (NSC ‘KhIPT’ NASU), the target of which is fabricated from powdered tungsten covered with tantalum, the issues of preparation technology, construction, and physical and mechanical properties of W–Ta materials of targets in non-irradiated and irradiated states are considered. The nuclear-physical processes of radiation damage to the target during co-irradiation of it with both neutrons of a subcritical assembly and high-energy e- and γ-beams are analyzed. The target resources of ADS systems are estimated. As noted, the difficulty of predicting the ‘survivability’ of the W–Ta target also relates to the fact that, except for the works carried out at the NSC ‘KhIPT’ NASU in 70–90th of the last century, there are no experimental works in the world on the radiation damage of reactor materials by high-energy electrons with an energy of 100 MeV and above.

The term Solar Cell is commonly used for Photovoltaics that convert light into electrical energy. However, light can be harvested from various sources not limited to the Sun. This work considers the possibility of harvesting photons from different star types, including our closest neighbor star Proxima Centauri. The theoretical efficiency limits of single junction photovoltaic devices are calculated for different star types at a normalized light intensity corresponding to the AM0 spectrum intensity with AM0 = 1361 W/m2. An optimal bandgap of > 12 eV for the hottest O5V star type leads to 47% Shockley-Queisser photoconversion efficiency (SQ PCE), whereas a narrower optimal bandgap of 0.7 eV leads to 23% SQ PCE for the coldest red dwarf M0, M5.5Ve, and M8V type stars. Organic Photovoltaics (OPVs) are the most lightweight solar technology and have the potential to be employed in weight-restricted space applications, including foreseeable interstellar missions. With that in mind, the Suns G2V spectrum and Proxima Centauris M5.5Ve spectrum are considered in further detail in combination with two extreme bandgap OPV systems: one narrow bandgap system (PM2:COTIC-4F, Eg = 1.14 eV) and one wide bandgap system (PM6:o-IDTBR, Eg = 1.62 eV). Semi-empirically modeled JV-curves reveal that the absorption characteristics of the PM2:COTIC-4F blend match well with both the G2V and the M5.5Ve spectrum, yielding theoretical PCEs of 22.6% and 12.6%, respectively. In contrast, the PM6:o-IDTBR device shows a theoretical PCE of 18.2% under G2V illumination that drops sharply to 0.9% under M5.5Ve illumination.

Aim. To study the efficacy of the vitamin preparation Metovitan and multivitamin preparation Decamevit in preventing the development of oxidative stress in the development of oxidative stress in rat tissues and their survival under hypoxic hypoxia. Methods. Experiments were performed on Wistar rats, 160-220 g. A model of hypoxic hypoxia was induced by lifting the rats in a barocamp to a conditional altitude of 11 thousand meters above sea level (pressure 190 mm Hg). Tissue metabolite concentrations and enzyme activities were measured using conventional biochemical methods. Results. The results of the study showed that the positive effect of Metovitan, which contained methionine and vitamins E, B1, and B3, on many indicators, including the activity of antioxidant defense enzymes, was significantly higher than the effect of Decamevit, which contained the same components plus vitamins A, B2, B6, B9, B12, vitamin C, and the bioflavonoid rutin. The survival time of rats treated with Metovitan before the experiment was one and a half times longer than that of Decamevit. Conclusion. A preparation containing a limited amount of vitamins acting synergistically on narrow links of cellular metabolism was more effective in preventing oxidative stress than a conventional multivitamin preparation.

Abstract This study investigates the impact of proton irradiation on perovskite devices fabricated fully through vacuum deposition. Exposure to irradiation induces changes in both electrical and optical properties. The analysis reveals that the main factors influencing the observed performance changes in solar cells are a significant reduction in shunt resistance and a minor increase in series resistance, with minimal alterations in recombination dynamics. Remarkably, the devices maintain promising photodetector characteristics both before and after proton irradiation, particularly in a self-powered mode without a reverse bias. These findings provide valuable insights into the resilience of vacuum-deposited perovskite devices against ionizing radiation, highlighting their potential for applications in radiation-prone environments, such as the nuclear industry or space exploration.

The review provides an analysis of clinical studies and current clinical guidelines from the MEDLINE database on the PubMed platform regarding the treatment of choledocholithiasis. Choledocholithiasis occurs in almost 20 % of patients with gallstone disease and is characterized by frequent dangerous complications, in particular, bile duct obstruction, cholangitis, and biliary pancreatitis. Therefore, common bile duct exploration is an important component of surgical treatment for gallstone disease, but discussions about the optimal treatment for choledocholithiasis have been ongoing for many years. Currently, there is no generally accepted standard of treatment, and various methods and approaches to the staging and sequence of surgical interventions on the gallbladder and common bile duct are used. In recent years, the leading methods of choledocholithiasis treatment are minimally invasive endoscopic and/or laparoscopic interventions, which have almost completely replaced open surgeries. For common bile duct exploration and normalization of biliary excretion, endoscopic transpapillary (retrograde) access is used mostly, which is characterized by a high risk of post-procedural immediate and long-term complications. Endoscopic management of common bile duct stones requires an additional intervention — laparoscopic cholecystectomy, which is most often performed at the second stage or simultaneously with endoscopic intervention. The optimal staging and sequencing of interventions requires further research. A good alternative to endoscopic interventions on common bile duct is its laparoscopic exploration through the cystic duct or by choledochotomy (antegrade), which can be performed simultaneously with cholecystectomy. However, this technique has not yet been widely adopted, and immediate and long-term results are conflicting that require further research into the effectiveness and safety of the method. The effectiveness of surgical treatment for choledocholithiasis depends not only on the individual characteristics of a patient, including biliary anatomy, the form and severity of the disease, but also on the local experience and availability of appropriate equipment, which must be taken into account when planning treatment.

Introduction. The technological operation of soil tillage is an energy-intensive preparatory operation. The traction resistance of tillage units has a direct impact on this indicator. Aim of the Study. The study is aimed at searching optimal operating parameters for the field cultivator tool through determining the traction resistance created by this tool. Materials and Methods. The study was carried out in the field on an experimental facility using a full factorial experiment technique with a working model based on a three-level design. Results. Through the regression analysis of experimental data, there was obtained a mathematical model that allows determining the optimal operating parameters for the field cultivator tool when performing a technological operation of soil tillage. Discussion and Conclusion. While calculating, it was found that the lowest traction resistance PТ = 0,72 kN created by the tool is for the following values: tillage depth h = 4 cm, crumbling angle of the left-hand and right-hand flat-cutting wings f = 0° and the speed of the tillage unit v = 2,61 m/s. As the optimal operating parameters for a field cultivator tool, determined using the obtained mathematical model, it is recommended to use the crumbling angle of the left-hand and right-hand flat-cutting wings of the working body f = 0°, and the speed of the tillage unit v = 2,91 m/s. Taking into account the recommended optimal operating parameters of the tool, it is possible to calculate the value of the traction resistance index at different tillage depths. The traction resistance will change within the range of 0.79–1.81 kN, when the soil tillage depth changes from 4 to 12 cm. The resulting mathematical model of the traction resistance created by the tool will allow a more accurate approach to the issue of designing agricultural machines.

This work is devoted to calculating the rate of radiation damage production in a uranium target irradiated with high-energy electrons with an energy of 100 MeV. The Monte Carlo program MCNPX was used to perform a complete mathematical modeling of a complex of processes occurring in a uranium target when irradiated with high-energy electrons: the development of an electromagnetic shower, the production of photoneutrons, the transport of particles in the target and the creation of radiation damage in it. The analysis showed that fragments of U-238 photo-fission give the main input into the rate of damage production in a uranium target which reaches the value of 100 dpa/year. The expected service life of a uranium target under irradiation is 3 years of operation at full accelerator power.

Recently, flexible perovskite solar cells (FPSCs) fabricated using solution-processed printing techniques have garnered significant attention. However, challenges remain in achieving cost-effective, scalable manufacturing under ambient conditions and ensuring stable, efficient devices. This study focuses on fabricating printed FPSCs using the slot-die coating technique and examines the impact of SnO2 quantum dot (QD) and (6,6)-Phenyl C61 butyric acid methyl ester (PCBM) based electron transport layers (ETLs) on device performance and hysteresis. Experimentally results show that SnO2 QD-based devices exhibited favorable photovoltaic properties but significant hysteresis compared to PCBM-based devices. Numerical simulations have shown that the hysteresis effect in devices is influenced not only by the higher concentration of mobile ions in the perovskite layer of PCBM-based devices compared to SnO2 QD-based devices, but also by the more effective redistribution of these ions during forward and reverse J-V scans. The results provide insights into the behavior of printed FPSCs with different ETLs, contributing to the development of high-performance, hysteresis-free printed FPSCs.

У статті проаналізовано норми сімейного законодавства України щодо визначення місця проживання дитини у разі розірвання шлюбу. Метою дослідження є вивчення процесу прийняття рішень органами опіки та піклування, оцінка ефективності їх діяльності, що сприятиме забезпеченню найкращих інтересів дитини та рівних прав батьків. Окрему увагу приділено визначенню ролі органів опіки та піклування у цьому процесі. Встановлено, що їх участь можлива у двох формах: 1) вирішення органом опіки та піклування спору про визначення місця проживання дитини; 2) надання письмового висновку органу опіки та піклування при розгляді справ судом про визначення місця проживання дитини. Доведено, що роль органів опіки та піклування у визначенні місця проживання дитини є значною, оскільки вони залучаються у випадку відсутності консенсусу між батьками щодо проживання малолітньої дитини. Охарактеризовано процес прийняття рішення органами опіки та піклування. Виділено основні етапи у вирішенні питання про визначення місця проживання дитини за участі органів опіки та піклування: 1. Звернення до органів опіки та піклування батьків. 2. Проведення органами опіки та піклування бесіди з батьками та складання акту обстеження умов проживання дитини. 3. Прийняття рішення органами опіки та піклування відбувається на підставі аналізу умов та врахування думки дитини та формується у вигляді висновку. Важливими критеріями оцінки є ставлення батьків до виконання батьківських обов’язків, особиста прихильність дитини до кожного з батьків, стан здоров’я дитини та інші обставини, що мають істотне значення. Аналізуються основні засади, якими повинні керуватися органи опіки та піклування при визначенні місця проживання дитини, такі як забезпечення якнайкращих інтересів дитини та рівність прав батьків. Особлива увага приділяється проблемним аспектам, що виникають під час прийняття рішень органами опіки та піклування, до яких віднесено встановлення дійсного психоемоційного стану дитини психологом, забезпечення явки дитини до суду або органу опіки і піклування за постійним довоєнним місцем проживання.

In Gepner's pioneering work, the requirement that leads to a model having the desired N=1 Spacetime supersymmetry and E(8)×E(6) Gauge symmetry was the requirement that the spacetime symmetry is compatible with modular invariance. In this work we show that the requirement for the simultaneous fulfillment of mutual locality of the left-moving vertices of physical states with the space-time symmetry generators and of right-moving vertices with generators of E(8)×E(6)-gauge symmetry, which arises after some special reduction together with the requirement of mutual locality of complete (left-right) vertices of physical states among themselves leads to the same Gepner models.

Ukraine’s integration into the European Union (EU) is one of the most important areas of the State’s development, and therefore one of the conditions for rapprochement between Ukraine and the European Community, as well as a condition for accession to the EU, is the adaptation of Ukrainian domestic legislation to the EU acquis. The purpose of the study was to identify the peculiarities and problematic aspects of the implementation of EU law in national legislation. The research methods used were: historical, periodisation, formal legal and problem analysis methods. The study examined the peculiarities and problems of adaptation of Ukrainian legislation to EU law. The study found that the legislation is being adapted on the basis of the Association Agreement between Ukraine and the European Union, which includes the European Atomic Energy Community and its member states. The implementation process involves the transposition of EU norms into national legislation, while adaptation is the alignment of national law with EU legislation. The current legislation provides for three stages of adaptation of legislative norms, which aim to harmonize with EU law as much as possible. As implementation is a rule-making process, it involves a certain sequence of actions. In particular, it includes the establishment of the acquis communautaire, the creation of a list of legislative acts to be adopted and their preparation for adoption, monitoring of implementation and other sequential actions. In addition, the process of adaptation should be based on the principles of compliance with EU directives, the principle of voluntariness, clarity of terminology and completeness. Among the factors that are obstacles to implementation are the following: Russian aggression, institutional failure of state bodies, high level of corruption, numerous conflicts in legislation

This paper analyses the digitalization of museum marketing as an innovative tool for customer evaluation. The content analysis of digital tools created by the most visited museums in the world on social networks such as Facebook, Twitter and Instagram were carried out. To obtain statistical information about the pages of museums in social networks, the social media analytics and management tool Fanpage Karma was used. According to the selected indicators, Fanpage Karma filters the rating of the networks' current strongest content. The correlation between the number of museum visits and indicators showing the interaction of the museum with visitors using social networks, such as the number of fans, the page performance index, the number of posts per day, the growth rate of followers, post interactions, and the number of total reactions and comments, was evaluated. The aim of this paper is to analyse the impact of museum marketing digitalization processes on museum visits by tourists and, as a result, the economic development of the museum business. To monitor the digitalization strategy of the museum's marketing activities, a mixed approach based on qualitative and quantitative analysis was used. Multivariate analysis was carried out to determine the relationship between museum attendance and the interaction between museums and subscribers in social networks. It has been proven that the introduction of digital technologies in museum marketing can attract visitors and put the institution at the new informational level. The number of museum visits and the number of fans, the number of posts per day, interactions, and the number of reactions and comments are the same across all social networks. The paper allows us to know the potential audience of the museum and its needs and requests and to predict the interests of certain categories of museum visitors. The scientific novelty and originality of the research consists of the use of digital marketing tools for evaluating their influence on client behaviour. The results of the study may be useful for the development of monitoring systems and strategic management of marketing when evaluating the behaviour of consumers on the content of social networks at enterprises in various industries.

Background. Treatment for malignant brain gliomas includes surgery, radiation therapy, and chemotherapy with temozolomide. However, this complex treatment does not prevent tumor relapses and progression, which is caused by the activity of tumor cells and a high mutational burden. Researchers are experimenting with different intensity of focused ultrasound (FUS) in the treatment of glioblastoma (GBM). FUS has shown encouraging results in clinical studies.The aim of the study. This review presents brief information on the history of the development of the studied method, the results of its application in experiments and clinical trials, as well as the main possible directions for its implementation in neuro-oncology, in particular, for the treatment of glioblastomas, depending on parameters, including frequency, power, pulse duration and duty cycle.Methods. We carried out an analysis and interpretation of existing publications; for the search, we used the PubMed database and the keywords “focused ultrasound, glioma, HIFU, LIFU”, as well as Yandex and Google search engines and the same keywords in Russian.Results. Low-intensity FUS can be used to temporarily open the blood-brain barrier (BBB), which limits the diffusion of most macromolecules and therapeutic agents into the brain. High-intensity FUS can cause tumor ablation due to a hyperthermic effect, and also stimulate an immunological attack of tumor cells, activate sonosensitizers to exert a cytotoxic effect on tumor tissue, and can increase the sensitivity of tumors to radiation therapy. Histotripsy causes tumor ablation through acoustic cavitation.Conclusion. Focused ultrasound is a promising potential treatment for gliomas. Further study in the form of clinical trials should determine the optimal ultrasound parameters to achieve effective treatment for patients with malignant brain tumors.

It has been shown that Sn implantation with subsequent annealing in air leads to an increase in the electroluminescence (EL) intensity of SiO2/Si structure by two orders of magnitude. Intense violet EL with a maximum at 3.21 eV was observed at room temperature by the naked eye at forward bias. The observed emission was attributed to radiative recombination in SnO2 nanocrystals synthesized in SiO2 layers. The external quantum efficiency (EQE) increased with decreasing Sn concentration The maximum external quantum efficiency was found to be 0.7 % for the silica film Sn-implanted at the lowest fluence of 2.5 × 1016 cm−2. The non-radiative charge transport (shunt current) through the sample and mechanism of EL excitation are discussed. It has been concluded that the Poole–Frenkel mechanism, or tunneling between traps are the most likely mechanisms of charge transport to light-emitting centers.

Telecommuting came roaring to the forefront of the American workplace in the spring of 2020. While no more than 8% of work was done remotely in 2019, shutdowns and social-distancing policies introduced at the onset of the Covid-19 pandemic pushed more than 1 out of every 3 American workers to telecommute. To reflect this shift, the research team aimed to update the spatial modeling toolbox to allow remote employment and develop a quantitative framework capable of analyzing the full range of reallocations, both within and across cities, which may result from its increasing popularity. The researchers build a quantitative spatial model in which some workers can substitute on-site effort with work done from home. The team quantifies their framework to match the distribution of jobs and residents across 4,502 U.S. locations. A permanent increase in the attractiveness of telework results in a rich non-monotonic pattern of reallocations within and across cities. Workers who can telecommute experience welfare gains, and those who cannot suffer losses. Additionally, broader access to jobs reduces inequality across residential locations. The framework robustly predicts changes in residents and housing prices observed 2019—2021.View the NCST Project Webpage

Aim. To develop a method for early diagnosis of subcritical homeostasis disorders leading to sudden cardiac death (SCD). The basis is to improve the efficiency of predictive algorithms.Material and methods. This pilot, controlled, open-label, randomized, prospective clinical trial included 220 patients at risk of SCD and 150 patients without risk of SCD. Main and control groups was formed according to the global cardiovascular risk score. Based on the informative features proposed by specialized experts using multivariate statistics methods (discriminant analysis), two condition classes were formed. The conducted exploratory analysis confirmed the significance of diagnostic criteria in relation to SCD manifestation (manifestation of cardiac arrest — MCA), which is an integral assessment of a fatal complication. The development of decision rules was carried out on the basis of soft computing technology.Results. Taking into account the priority of clinical research, namely, the identification of subcritical stages of MCA, a classifier is proposed according to basic severity of patients — the severity of critical condition risk (SCCR). The discriminant function and intersection areas between MCA subclasses in the conditions of early SCD diagnosis determine the transition to soft computing technology. Membership functions for severe MCA are formed, followed by their iteration according to E. Shortliffe. The final decision rule, using a fuzzy classifier, differentiates the MCA into stages with different SCCR. In parallel with standard protocols for the management of severe somatic patients (chronic obstructive pulmonary disease, chronic kidney disease, hepatocellular failure), based on the proposed algorithm with an integral assessment of critical conditions, using the MCA decision rule in the main group in 30,5% of cases, subcritical stage was revealed, followed by targeted treatment and preventive support. In the first group, a subcritical condition was detected in 67 patients (30,5%); a critical condition without SCD — in 3 patients (1,4%). In all noted cases, early prevention of SCD was successfully carried out (these patients were transferred to a class with a lower SCD degree). Using conventional prognostic scores in this group, 46 patients (20,9%) were identified with a subcritical condition and 1 (0,4%) with a critical condition. In the control group, subcritical condition was determined in 35 patients (23,3%), of which 17 patients (11,3%) had a moderate risk of SCD. Using conventional prognostic scores, 23 patients (15,3%) with subcritical condition were identified.Conclusion. In the conditions of intensive care unit, general medicine departments, hemodialysis department, cardiac surgery, and organ transplantation department, an algorithm for early diagnosis and risk stratification of SCD with an integral assessment (MCA) should be used. The fuzzy classifier MCA according to SCCR makes it possible to carry out timely correction of treatment measures in addition to standard protocols.

Artificial intelligence is transforming many areas of activity, including completely transforming banks. Artificial intelligence offers solutions to improve the rationality of decisions, the speed and accuracy of information processing, the provision of ready–made solutions and the implementation of monitoring operations. This article examines the evolution of artificial intelligence in the banking sector. The key areas of AI use in the financial market are highlighted, such as scoring and underwriting, anti–fraud, investment portfolio management, robo–consulting, monitoring client requests and others.The subject of the research in the article is the system of relations arising during the transformation of the banking sector with the introduction of artificial intelligence.

This article examines the author's method for teaching professional art education through the utilization of polygonal and geometric shapes. It delves into the fundamental principles, tools, and techniques involved in working with such forms. Academic Drawing, a cornerstone discipline in painting education, is explored within the context of this method. Specifically, the article discusses the Method of Anatomical Polygonal-Pyramidal Structured Analysis and Geometrical-Plastic Modeling of Form, implemented within the professional art education curriculum at the Lugansk State Academy of Culture and Arts, Russia, under the Faculty of Fine and Applied Arts, Department of Easel Painting. To assess the method's effectiveness, a study employing the stratometric modeling method was conducted with five student study groups, comprising female students aged 18-25, all pursuing training in Stationary Painting. The study spanned various periods, revealing the method's capacity to expedite professional development and yield significant student achievements. The article concludes by underscoring the method's importance in nurturing spatial-artistic thinking, rooted in the identification of anatomical nodes influencing overall figure structure and internal plasticity. By connecting these nodes into a cohesive system, the method facilitates the expression of artistic constructive form. Through the transformation of triangles into volumetric geometric forms and their layered application, the method enables the creation of tonal gradations and overall figure volume. Moreover, it cultivates anatomical constructive thinking, enhances understanding of human structure, and fosters proficiency in applying mathematical principles to creative problem-solving.