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Engagement with theories and theoretical frameworks in the planning and conduct of research about library instruction, in conjunction with the existing evidence base, can help researchers develop coherent conceptual models to justify the research approach and importance of the research produced. This column describes some of the limitations of common evaluation approaches that lack explicit theoretical framing and provides definitions of concepts that allow practitioners and researchers alike to explore and understand the complexities of educational encounters. Using an illustrative study with a theoretical framework applying sociomaterialism and related theories, this article presents arguments for in-depth explorations of informatics education through qualitative research. [ABSTRACT FROM AUTHOR]

Background: Doctor of pharmacy educational accreditation standards state student pharmacists should be able to evaluate the scientific literature as well as critically analyze and apply information in answering drug information questions. Student pharmacists often struggle with identifying and using appropriate resources to answer medication-related questions. To ensure educational needs were met, a college of pharmacy hired a health sciences librarian to support the faculty and students. Case Presentation: The health sciences librarian collaborated with faculty and students throughout the doctor of pharmacy curriculum to identify and address any gaps related to appropriate drug resource utilization. Adding instruction time to the new student pharmacist orientation, coursework throughout the first year of the pharmacy program, and a two-semester evidence-based seminar course provided opportunities for the health sciences librarian to work with student pharmacists in the areas of library resource access, instruction on drug information resources, and evaluation of drug information found on the internet. Conclusion: The deliberate inclusion of a health sciences librarian into the doctor of pharmacy curriculum can benefit faculty and students. Opportunities for collaboration are available throughout the curriculum, such as providing instruction for database utilization and supporting the research activities of both faculty and student pharmacists. [ABSTRACT FROM AUTHOR]

The goal of this commentary is to provide recent pharmacy school graduates and student pharmacists completing APPEs the essential background for correct vancomycin therapeutic drug monitoring (TDM) in the inpatient setting. [ABSTRACT FROM AUTHOR]

A consensus surveillance protocol is lacking for non-cirrhotic patients with hypervascular liver lesions presumed to represent hepatocellular adenomas. Patients with hypervascular liver lesions <5 cm not meeting criteria for focal nodular hyperplasia or hepatocellular carcinoma underwent surveillance with contrast-enhanced magnetic resonance imaging (MRI) 6, 12, and 24 months after baseline imaging. If lesions remained stable or decreased in size, then surveillance imaging was discontinued. Between 2011 and 2014, 116 patients with hypervascular liver lesions were evaluated. Seventy-nine patients were eligible for the surveillance protocol. Median follow-up was 24 months (range, 1-144 months). One patient (1 %) continued oral contraceptive pill (OCP) use and presented with hemorrhage requiring embolization 5 months after initial diagnosis. Ten patients (13 %) underwent elective embolization or surgical resection for size ≥5 cm. The remaining 68 patients (86 %) continued surveillance without hemorrhage or malignant transformation. Risk factors for requiring intervention during the surveillance period included younger age, larger lesion size, and estrogen use (all p < 0.05). Patients with hepatocellular adenomas <5 cm can safely be observed after discontinuing OCP with serial imaging 6, 12, and 24 months after diagnosis. If lesions remain stable or decrease in size, then longer-term surveillance is unlikely to identify patients at risk for complications. [ABSTRACT FROM AUTHOR]

Objective: Online training for systematic review methodology is an attractive option due to flexibility and limited availability of in-person instruction. Librarians often direct new reviewers to these online resources, so they should be knowledgeable about the variety of available resources. The objective for this project was to conduct an environmental scan of online systematic review training resources and evaluate those identified resources. Methods: The authors systematically searched for electronic learning resources pertaining to systematic review methods. After screening for inclusion, we collected data about characteristics of training resources and assigned scores in the domains of (1) content, (2) design, (3) interactivity, and (4) usability by applying a previously published evaluation rubric for online instruction modules. We described the characteristics and scores for each training resource and compared performance across the domains. Results: Twenty training resources were evaluated. Average overall score of online instructional resources was 61%. Online courses (n=7) averaged 73%, web modules (n=5) 64%, and videos (n=8) 48%. The top 5 highest scoring resources were in course or web module format, featured high interactivity, and required a longer (>5hrs) time commitment from users. Conclusion: This study revealed that resources include appropriate content but are less likely to adhere to principles of online training design and interactivity. Awareness of these resources will allow librarians to make informed recommendations for training based on patrons' needs. Future online systematic review training resources should use established best practices for e-learning to provide high-quality resources, regardless of format or user time commitment. [ABSTRACT FROM AUTHOR]

Objective: LGBTQ+ health research guides can strengthen the LGBTQ+ community through connecting people to quality health services and information, and previous studies have recommended that health sciences libraries create and maintain these guides. Little evidence exists, though, on how these guides are used and how well they meet the needs of LGBTQ+ users. Using retrospective data retrieved from multiple LGBTQ+ health research guides, we examined the categories of LGBTQ+ health information most used, as well as how often guides were accessed. Based on these results, we hope to find patterns which can lead to best practices for libraries. Methods: Five North American academic health sciences libraries contributed select usage data from their LGBTQ+ health research guides, covering a three-year period (July 2018-June 2021). Data was analyzed in two ways. Firstly, the 20 most-clicked resources from each guide were categorized through open coding, to assess if certain information resource categories were more popular among guide users, allowing for inference of user needs. A time-series analysis was also conducted for two sites, using the Classical Seasonal Decomposition by Moving Averages method, to provide deeper insights into the data. Results: Open coding data showed consumer health information resources were used more often than other health resource categories. Resources from more locally based organizations and those with provider and services information were heavily used, indicating that users may be looking for information connecting to local health services and providers. The time series analysis allowed the potential positive effect of guide promotion to be showcased in ways that would not have been clear from the raw data. Conclusion: This study shows that people are accessing LGBTQ+ consumer health information through academic library research guides, with a preference for local information. Guide usage appears to be positively driven by outreach within one's institution and to the greater community. Locating external partners may increase guide impact and provide important links to local resources and services. [ABSTRACT FROM AUTHOR]

Our objectives was to create an initiative to change the culture of a small community to improve quality of life as it relates to health for the residents through the use of health-related educational sessions, a coordinated fitness and nutrition program, and the construction of community fitness trails. We compared the use of a health-focused community driven program to the status quo in seeking opportunities to improve perception and understanding of one's health and overall quality of life for participants. Among the various techniques identified to improve a community's health outcomes, dissemination of information through the use of educational sessions empowered citizens to take control of their health status, and ultimately, their quality of life. This came with zero negative impacts for those providing the education, as well as those participating in the sessions. Although the application of these methods depends on local resources, leadership, and partnerships, programs similar to those presented here can help to improve quality of life for citizens in communities across the country facing the challenges secondary to a sedentary lifestyle. [ABSTRACT FROM AUTHOR]

BACKGROUND: Employment has been recognized as an important goal for improving the quality of life of adults with intellectual disabilities (ID). Governments at both the federal and state level have invested billions of dollars to encourage better outcomes for adults with ID as they transition out of high school and into the labor force. OBJECTIVE: Given these important efforts, this study documented the employment situation of working-aged adults with intellectual disabilities across the country. METHODS: Respondents included a nationally representative random sample of 1,017 parents/guardians of adult children (21 years of age or older) with an intellectual disability surveyed by Gallup. These parents/guardians were selected from approximately 341,000 households screened by Gallup. This methodology allowed for the inclusion of a sample of adults with ID who had never been in the labor force or even sought employment. RESULTS: The results indicate a troublingly low employment rate for adults with ID and a puzzlingly low number who are even in the labor force. CONCLUSIONS: The employment outlook for adults with ID will continue to be bleak until new ways are found to meaningfully incorporate this population into the labor force. [ABSTRACT FROM AUTHOR]

Abstract: Tamaki Estuary is an arm of the Hauraki Gulf situated on the eastern side of central Auckland. Over the last 100 years, Tamaki catchment has evolved from a nearly rural landscape to an urbanised and industrialised area. Pollen, 14C and glass shards analyses, were carried out on three cores collected along the estuary with the aim to reconstruct the estuary's history over the last ∼8000 years and trace natural and anthropogenic effects recorded in the sediments. Glass shard analysis was used to establish key tephra time markers such as the peralkaline eruption of Mayor Island, ∼6000 years BP. During the pre-Polynesian period (since at least 8000 years BP), regional vegetation was podocarp/hardwood forest dominated by Dacrydium cupressinun, Prumnopits taxifolia, and Metrosideros. Major Polynesian settler impact (commencing ∼700 yr BP) was associated with forest clearance as indicated by a sharp decline in forest pollen types. This coincided with an increase in bracken (Pteridium esculentum) spores and grass pollen. Continuing landscape disturbance during European settlement (commencing after 1840 AD) was accompanied by the distinctive appearance of exotic pollen taxa such as Pinus. [Copyright &y& Elsevier]

The article discusses the dimensions of inclusion and social integration, by Gary N. Siperstein and Robin C. Parker.

The authors surveyed a national random sample of 5,837 middle school students on their attitudes toward the inclusion of peers with intellectual disabilities (ID). The national sample provided results that were accurate, with a margin of error of ± 1.4%. Findings indicated that youth (a) have limited contact with students with ID in their classrooms and school; (b) perceive students with ID as moderately impaired rather than mildly impaired; (c) believe that students with ID can participate in nonacademic classes, but not in academic classes; (d) view inclusion as having both positive and negative effects; and (e) do not want to interact socially with a peer with ID, particularly outside school. Structural equation modeling showed that youths' perceptions of the competence of students with ID significantly influence their willingness to interact with these students and their support of inclusion. [ABSTRACT FROM AUTHOR]

A human case of culture-negative bacterial endocarditis is presented where conventional methods failed to determine a microbial aetiology. DNA sequencing performed directly on autopsy heart valve tissue revealed Streptococcus agalactiae (group B streptococcus). To our knowledge, this is the first report of DNA sequence-based detection of this organism directly from a heart valve. [ABSTRACT FROM AUTHOR]

• Knowledge of trauma quality improvement (QI) initiatives at community hospitals is limited. • This review summarizes the available evidence based on the type of QI interventions and outcomes studied (patient, process, provider, costs). • Provider education predominates as the mode of quality improvement intervention with demonstrated effects on process but not patient outcomes. • Initiatives using additional resources (skilled providers) and formal structures (trauma service) demonstrate improved patient outcomes. • Future research should focus on combining patient outcome data across community sites to identify interventions that improve patient outcomes. Due to complex geography and resource constraints, trauma patients are often initially transported to community or rural facilities rather than a larger Level I or II trauma center. The objective of this scoping review was to synthesize evidence on interventions that improved the quality of trauma care and/or reduced healthcare costs at non-Level I or II facilities. A scoping review was performed to identify studies implementing a Quality Improvement (QI) initiative at a non-major trauma center (i.e., non-Level I or II trauma center [or equivalent]). We searched 3 electronic databases (MEDLINE, Embase, CINAHL) and the grey literature (relevant networks, organizations/associations). Methodological quality was evaluated using NIH and JBI study quality assessment tools. Studies were included if they evaluated the effect of implementing a trauma care QI initiative on one or more of the following: 1) trauma outcomes (mortality, morbidity); 2) system outcomes (e.g., length of stay [LOS], transfer times, provider factors); 3) provider knowledge or perception; or 4) healthcare costs. Pediatric trauma, pre-hospital and tele-trauma specific studies were excluded. Of 1046 data sources screened, 36 were included for full review (29 journal articles, 7 abstracts/posters without full text). Educational initiatives including the Rural Trauma Team Development Course and the Advanced Trauma Life Support course were the most common QI interventions investigated. Study outcomes included process metrics such as transfer time to tertiary care and hospital LOS, along with measures of provider perception and knowledge. Improvement in mortality was reported in a single study evaluating the impact of establishing a dedicated trauma service at a community hospital. Our review captured a broad spectrum of trauma QI projects implemented at non-major trauma centers. Educational interventions did result in process outcome improvements and high rates of self-reported improvements in trauma care. Given the heterogeneous capabilities of community and rural hospitals, there is no panacea for trauma QI at these facilities. Future research should focus on patient outcomes like mortality and morbidity, and locally relevant initiatives. [ABSTRACT FROM AUTHOR]

Objectives: To assess the effects of percutaneous nephrolithotomy (PCNL) vs retrograde intrarenal surgery (RIRS) for the treatment of renal stones in adults. Methods: We performed a comprehensive search of the Cochrane Library, MEDLINE, Embase, three other databases, trials registries, other sources of the grey literature, and conference proceedings up to 23 March 2023. We applied no restrictions on publication language or status. Screening, data extraction, risk‐of‐bias assessment, and certainty of evidence (CoE) rating using the Grading of Recommendations Assessment, Development and Evaluations (GRADE) approach were done in duplicate by two independent reviewers. This co‐publication focuses on the primary outcomes of this review only. Results: We included 42 trials that met the inclusion criteria. Stone‐free rate (SFR): PCNL may improve SFRs (risk ratio [RR] 1.13, 95% confidence interval [CI] 1.08–1.18; I2 = 71%; 39 studies, 4088 participants; low CoE). Major complications: PCNL probably has little to no effect on major complications (RR 0.86, 95% CI 0.59–1.25; I2 = 15%; 34 studies, 3649; participants; moderate CoE) compared to RIRS. Need for secondary interventions: PCNL may reduce the need for secondary interventions (RR 0.31, 95% CI 0.17–0.55; I2 = 61%; 21 studies, 2005 participants; low CoE) compared to RIRS. Conclusion: Despite shortcomings in most studies that lowered our certainty in the estimates of effect to mostly very low or low, we found that PCNL may improve SFRs and reduce the need for secondary interventions while not impacting major complications. Ureteric stricture rates may be similar compared to RIRS. We expect the findings of this review to be helpful for shared decision‐making about management choices for individuals with renal stones. [ABSTRACT FROM AUTHOR]

Background: Since the advent of antiretrovirals, people with HIV are living longer and have improved quality of life. However, 30–60% of these individuals experience cognitive impairment. Fortunately, physical activity has emerged as a management strategy for cognitive impairment. Purpose: To map the evidence on physical activity and cognition in HIV. Methods: We searched five databases using terms related to physical activity and HIV. Two authors independently reviewed titles and abstracts for studies that addressed physical activity/exercise and cognition in people with HIV. Authors reviewed full texts to identify articles that met our inclusion criteria. One author extracted the data, then we collated the results and summarized the characteristics of included studies. Results: Sixteen studies from high-income countries were included; eight were interventional (five randomized controlled trials and three pre-post single group observational studies) and eight were non-interventional studies. The interventional studies included aerobic, resistive, and Tai Chi exercise for 8 weeks to 12 months in duration. Two of eight interventional studies found exercise to benefit self-reported cognition. All eight non-interventional studies showed a positive relationship between physical activity and cognitive function. Conclusions: Results of this study suggest that physical activity may preserve or improve cognition in people living with HIV. Physical activity may play a role in preserving or improving cognition in the human immunodeficiency virus population. Exercise should be prescribed for people with human immunodeficiency virus based on the stage of infection. Rehabilitation professionals should follow current exercise guidelines when prescribing exercise for people living with human immunodeficiency virus. [ABSTRACT FROM AUTHOR]

Major depressive, bipolar, or psychotic disorders are preceded by earlier manifestations in behaviours and experiences. We present a synthesis of evidence on associations between person-level antecedents (behaviour, performance, psychopathology) in childhood, adolescence, or early adulthood and later onsets of major depressive disorder, bipolar disorder, or psychotic disorder based on prospective studies published up to September 16, 2022. We screened 11,342 records, identified 460 eligible publications, and extracted 570 risk ratios quantifying the relationships between 52 antecedents and onsets in 198 unique samples with prospective follow-up of 122,766 individuals from a mean age of 12.4 to a mean age of 24.8 for 1522,426 person years of follow-up. We completed meta-analyses of 12 antecedents with adequate data. Psychotic symptoms, depressive symptoms, anxiety, disruptive behaviors, affective lability, and sleep problems were transdiagnostic antecedents associated with onsets of depressive, bipolar, and psychotic disorders. Attention-deficit/hyperactivity and hypomanic symptoms specifically predicted bipolar disorder. While transdiagnostic and diagnosis-specific antecedents inform targeted prevention and help understand pathogenic mechanisms, extensive gaps in evidence indicate potential for improving early risk identification. • Multiple experiences and behaviours in childhood/adolescence are robustly associated with later onsets of depressive, bipolar, and psychotic disorders. • Anxiety and sleep problems are transdiagnostic antecedents associated with increased risk of major depressive, bipolar, and psychotic disorders. • Subthreshold hypomanic and attention-deficit/hyperactivity symptoms are specifically associated with increased risk of bipolar disorder. • Filling in the gaps in antecedent-outcome relationships has strong potential to improve early identification of risk and targeted prevention. [ABSTRACT FROM AUTHOR]

Purpose: We performed a systematic review and meta-analysis of the literature to evaluate the efficacy of the routine use of tranexamic acid (TXA) during percutaneous nephrolithotomy (PCNL). Methods: This systematic review was conducted following the updated reporting guidelines from PRISMA 2020. Results: In total, 275 titles and abstracts were reviewed, of which 20 were screened to be eligible for full text review. Of these 20 articles, 11 were selected for inclusion after full article evaluations. Seven of these 11 studies were seen as having a low risk of bias with a Jadad score of ≥3. These studies were included for data extraction. Once data were extracted, 964 patients were included. The primary outcome, blood transfusion rate, showed significant reduction with a ratio for transfusion rate of 0.34 [95% confidence interval (CI) (0.19 to 0.61), z = 3.61, p = 0.0003]. Mean hemoglobin (Hgb) drop and operative time were both shown to be reduced with the use of TXA. The mean difference for Hgb drop was −0.86 [95% CI (−1.26 to −0.46), z = 4.23, p < 0.0001]. Reduction in operative time showed a mean difference of −8.45 minutes [95% CI (−15.04 to −1.86), z = 2.51, p = 0.01]. Stone clearance was not shown to differ significantly between experimental and control groups, with a risk ratio of 1.28 [95% CI (0.89 to 1.84), z = 1.31, p = 0.19]. Conclusions: This meta-analysis revealed that the routine use of TXA at time of PCNL reduces the rates of blood transfusion, mean Hgb drop, and operative time. With the low cost of TXA and strong safety profile, stronger consideration should be given to the routine use of TXA during PCNL by endoscopic surgeons. [ABSTRACT FROM AUTHOR]

The social acceptance of children with and without intellectual disabilities was examined in an inclusive, summer recreational program. Participants were 67 children entering Grades 3 through 6, of which 29 were identified as having a mild intellectual disability. Children were recruited from economically and racially diverse urban school districts. Results showed that children with and without intellectual disabilities were equally accepted by their peers. Specifically, 95% of children without intellectual disabilities indicated that they liked to "hang out with" at least 1 child with an intellectual disability. Results also indicated that the majority of children without intellectual disabilities made at least 1 new friend with another child with an intellectual disability. The features of recreational programming that promote social inclusion are discussed. [ABSTRACT FROM AUTHOR]

Abstract: Tamaki Estuary in northern New Zealand is a mixed-energy estuary that comprises three facies zones: (1) a wave- and tide-influenced inlet with sandspit; (2) a tide-dominated, funnel-shaped zone with wide intertidal flats and sandy tidal bars, and (3) a mixed fluvial influenced and tidal meandering upper zone. Each zone preserves a Holocene record of sedimentation that was reconstructed using six cores ranging between 3- and 6-m depth. Sample analyses included textural and mineralogical composition, organic and carbonate content, and radiocarbon dating of in situ shells. The Tamaki Estuary valley fill consists of transgressive marine sands and tidal bar sands in the lower estuary, mud and sand facies in the middle estuary, and mud and peat facies in the upper estuary. These facies were deposited in a marine–fluvial complex that included barriers, tidal flats and peat swamps. Based on radiocarbon dating, marine transgression in the Tamaki Estuary started at least 7500yr BP. Transgressive System Tract (TST) sediments were deposited on a pre-Early Holocene surface composed of massive compact grey plastic mud. Sediments of this initial transgressive stage consist of sandy muds with shell material in the lower estuary and mud to muddy sands with thin peat layers in the upper estuary. Deposition of Highstand System Tract (HST) sediments coincided with sea-level stabilisation at or near present day levels ca 6500yr BP and HST sedimentation continues to the present day. In addition to conventional lithostratigraphic characterization, the mineralogical composition of the sediments, in particular the proportion of quartz and feldspar (i.e. Q/F ratio), is proposed as a diagnostic tool for distinguishing depositional system tracts in siliciclastic sequences. [Copyright &y& Elsevier]

Abstract: Objectives. : Amplification of the 11q13 locus is commonly observed in a number of human cancers including both breast and ovarian cancer. Cyclin D1 and EMS1 have been implicated as candidate oncogenes involved in the emergence of amplification at this locus. Detailed analysis of the 11q13 amplicon in breast cancer led to the discovery of four regions of amplification suggesting the involvement of other genes. Here, we investigate the role of EMSY, a recently described BRCA2 interacting protein, as a key element of the 11q13 amplicon in ovarian cancer. EMSY maps to 11q13.5 and is amplified in 13% of breast and 17% of ovarian carcinomas. Methods. : EMSY amplification was assessed by fluorescent in-situ hybridization (FISH) in 674 ovarian cancers in a tissue microarray and correlated with histopathological subtype and tumor grade. A detailed map of the 11q13 amplicon in 51 cases of ovarian cancer was obtained using cDNA-array-based comparative genomic hybridization (aCGH). To further characterize the role of EMSY within this amplicon, we evaluated both the amplification profiles and RNA expression levels of EMSY and two other genes from the 11q13 amplicon in an additional series of 22 ovarian carcinomas. Results. : EMSY amplification was seen in 52/285 (18%) high grade papillary serous carcinomas, 4/27 (15%) high grade endometrioid carcinomas, 3/38 (8%) clear cell carcinomas, and 3/10 (30%) undifferentiated carcinomas. aCGH mapping of 11q13 in ovarian cancer showed that EMSY localized to the region with the highest frequency of copy number gain. Cyclin D1 and EMS1 showed a lower frequency of copy number gain. A highly significant correlation between EMSY gene amplification and RNA expression was also observed (P = 0.0001). This was a stronger correlation than for other genes at 11q13 including Cyclin D1 and PAK1. Conclusions. : These findings support the role of EMSY as a key oncogene within the 11q13 amplicon in ovarian cancer. [Copyright &y& Elsevier]

Background: Prognosis research is on the rise, its importance recognised because chronic health conditions and diseases are increasingly common and costly. Prognosis systematic reviews are needed to collate and synthesise these research findings, especially to help inform effective clinical decision-making and healthcare policy. A detailed, comprehensive search strategy is central to any systematic review. However, within prognosis research, this is challenging due to poor reporting and inconsistent use of available indexing terms in electronic databases. Whilst many published search filters exist for finding clinical trials, this is not the case for prognosis studies. This systematic review aims to identify and compare existing methodological filters developed and evaluated to identify prognosis studies of any of the three main types: overall prognosis, prognostic factors, and prognostic [risk prediction] models. Methods: Primary studies reporting the development and/or evaluation of methodological search filters to retrieve any type of prognosis study will be included in this systematic review. Multiple electronic bibliographic databases will be searched, grey literature will be sought from relevant organisations and websites, experts will be contacted, and citation tracking of key papers and reference list checking of all included papers will be undertaken. Titles will be screened by one person, and abstracts and full articles will be reviewed for inclusion independently by two reviewers. Data extraction and quality assessment will also be undertaken independently by two reviewers with disagreements resolved by discussion or by a third reviewer if necessary. Filters' characteristics and performance metrics reported in the included studies will be extracted and tabulated. To enable comparisons, filters will be grouped according to database, platform, type of prognosis study, and type of filter for which it was intended. Discussion: This systematic review will identify all existing validated prognosis search filters and synthesise evidence about their applicability and performance. These findings will identify if current filters provide a proficient means of searching electronic bibliographic databases or if further prognosis filters are needed and can feasibly be developed for systematic searches of prognosis studies. [ABSTRACT FROM AUTHOR]

Background: Western publicly funded health care systems increasingly rely on interdisciplinary teams to support primary care delivery and management of chronic conditions. This knowledge synthesis focuses on what is known in the academic and grey literature about optimal structural characteristics of teams. Its goal is to assess which factors contribute to the effective functioning of interdisciplinary primary care teams and improved health system outcomes, with specific focus on (i) team structure contribution to team process, (ii) team process contribution to primary care goals, and (iii) team structure contribution to primary care goals. Methods and design: The systematic search of academic literature focuses on four chronic conditions and co-morbidities. Within this scope, qualitative and quantitative studies that assess the effects of team characteristics (funding, governance, organization) on care process and patient outcomes will be searched. Electronic databases (Ovid MEDLINE, Embase, CINAHL, PAIS, Web of Science) will be searched systematically. Online web-based searches will be supported by the Grey Matters Tool. Studies will be included, if they report on interdisciplinary primary care in publicly funded Western health systems, and address the relationships between team structure, process, and/or patient outcomes. Studies will be selected in a three-stage screening process (title/abstract/full text) by two independent reviewers in each stage. Study quality will be assessed using the Mixed Methods Assessment Tool. An a priori framework will be applied to data extraction, and a narrative framework approach is used for the synthesis. Discussion: Using an integrated knowledge translation approach, an electronic decision support tool will be developed for decision makers. It will be searchable along two axes of inquiry: (i) what primary care goals are supported by specific team characteristics and (ii) how should teams be structured to support specific primary care goals? The results of this evidence review will contribute directly to the design of interdisciplinary primary care teams. The optimized design will support the goals of primary care, contributing to the improved health of populations. [ABSTRACT FROM AUTHOR]

The article offers information on prevalence and factors associated with nonalcoholic fatty liver diseases (NAFLD) among persons infected with HIV but not infected with hepatitis C virus (HCV). The study defines NAFLD as steatosis among patients without hepatitis coinfection or excessive alcohol use and cited its prevalence identified through ultrasound examination and liver biopsies. It shows that NAFLD is related to low high-density lipoprotein and high triglyceride levels.

Gastric duplication cysts are rare congenital anomalies that are mostly discovered in children but can remain asymptomatic and undetected into adulthood. Malignant transformation in gastric duplications is extremely rare, with most reported cases being adenocarcinomas. Herein, the authors report the first case of a high-grade neuroendocrine carcinoma arising in a gastric duplication cyst in a 40-year-old Asian male. This case highlights that duplication cysts should be included in the differential diagnosis of cystic masses of the gastrointestinal tract in adult, as well as pediatric, patients and emphasizes the importance of complete surgical resection and meticulous pathologic examination of these congenital anomalies. [ABSTRACT FROM AUTHOR]

Employers' negative attitudes and fears have long been a barrier to the employment of individuals with disabilities. Accordingly, attitude literature on the employment of people with disabilities has focused almost exclusively on employers. However, due to their influence over business practices, the successful employment of people with disabilities is also contingent on the views of the consumer. This study extends previous studies that focused on the attitudes of employers, and went directly to the consumer. Consumer attitudes toward companies that hire individuals with disabilities were assessed through a national public survey (N=803). Most of the participants (75%) had direct experience with people with disabilities in a work environment. Moreover, these experiences were positive. All participants responded positively towards companies that are socially responsible, including 92% of consumers who felt more favorable toward those that hire individuals with disabilities. The participants also had strong positive beliefs about the value and benefits of hiring people with disabilities, with 87% specifically agreeing that they would prefer to give their business to companies that hire individuals with disabilities. Implications of consumer support on company hiring practices are discussed. [ABSTRACT FROM AUTHOR]

Fossil foraminiferal faunas were studied in four, short, late Holocene cores (two localities) from the low tidal, estuarine fringes of the Waitemata Harbour, which is surrounded by New Zealand''s largest city, Auckland. All cores record similar major changes in their fossil content since the arrival of humans (ca. 1300 AD), with faunal changes continuing through to the 1970s. Molluscs have disappeared from all cores, and the foraminiferal faunas have switched from dominantly calcareous (Ammonia association) to dominantly agglutinated (Textularia–Schlerochorella, Miliammina–Haplophragmoides associations). A two-step change is evident, with an intermediate mixed calcareous-agglutinated faunal zone (1950s–1970s), characterised by peak abundances (13–20%) of Elphidium gunteri and Elphidium excavatum s.l.The faunal changes in each core since human colonisation replicate the faunal zonation in a low tidal transect of surface samples going up the Rangitopuni Estuary at the head of the Waitemata Harbour. Canonical correspondence analyses of the foraminiferal and environmental proxy data from the cores and the modern estuary transect indicate that faunal changes can be largely attributed to decreasing salinity, and additionally lowered pH (causing carbonate dissolution) in the more brackish Rangitopuni Estuary core locality. There is a weak correlation with increased nutrients (TOC, N, P), but sediment grain size and increasing heavy metal concentrations played no major part in producing the faunal changes.In the estuary transect, complete dissolution of calcareous foraminiferal shells varies between years, but occurs upstream where pH falls below ∼7.5. The absence of deformed foraminiferal shells in any cores suggests that neither natural environmental stress nor heavy metal concentrations (Pb 40–100 ppm; Zn 130–250 ppm) were sufficient for these to be generated.All cores contain a major hiatus between the prehuman and late European (post 1950) periods, coincident with mollusc shell layers and the first major change in foraminiferal faunas. The decrease in salinity, indicated by faunal changes, was probably a result of increased freshwater runoff associated with forest clearance in Polynesian (ca. 1300–1840) and early European (1840–1900) times. Faunal changes were more significant because of more severe salinity decreases in Rangitopuni Estuary cores with its larger catchment. Sedimentation has increased throughout the harbour since the 1950s, as a result of land modifications associated with accelerating urban subdivisions. More faunal changes linked to further decreased salinity, occurred in the 1970s, probably attributable to an increase in impervious surfaces (roofs and paved areas) with the rapid growth of Auckland city. [Copyright &y& Elsevier]

Glutamate release from rod photoreceptors is dependent on a sustained calcium influx through L-type calcium channels. Missense mutations in the CA CNA 1F gene in patients with incomplete X-linked congenital stationary night blindness implicate the Cav1.4 calcium channel subtype. Here, we describe the functional and pharmacological properties of transiently expressed human Cav1.4 calcium channels. Cav1.4 is shown to encode a dihydropyridine-sensitive calcium channel with unusually slow inactivation kinetics that are not affected by either calcium ions or by coexpression of ancillary calcium channel β subunits. Additionally, the channel supports a large window current and activates near -40 mV in 2 mM external calcium, making Cav1.4 ideally suited for tonic calcium influx at typical photoreceptor resting potentials. Introduction of base pair changes associated with four incomplete X-linked congenital night blindness mutations showed that only the G369D alteration affected channel activation properties. Immunohistochemical analyses show that, in contrast with previous reports, Cav1.4 is widely distributed outside the retina, including in the immune system, thus suggesting a broader role in human physiology. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 43-year-old man who was presented at the emergency department with weakness and dyspnea. The presence of a concentric pericardial effusion that was causing tamponade was revealed during transthoracic echocardiography. The patient underwent resection of the mass when final results of pathologic studies confirmed a cavernous hemangioma.