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733 results on '"Parker, Jane E."'

1. Plant NLR immunity activation and execution: a biochemical perspective

Author

Parker, Jane E, speaker and Gehring, Mary, moderator

Abstract

Plants deploy cell-surface and intracellular receptors to detect pathogen attack and trigger innate immune responses. Inside host cells, families of nucleotide-binding/leucine-rich repeat (NLR) proteins serve as pathogen sensors or downstream mediators of immune defence outputs and cell death, which prevent disease. Established genetic underpinnings of NLR-mediated immunity revealed various strategies plants adopt to combat rapidly evolving microbial pathogens. The molecular mechanisms of NLR activation and signal transmission to components controlling immunity execution were less clear. Here, we review recent protein structural and biochemical insights to plant NLR sensor and signalling functions. When put together, the data show how different NLR families, whether sensors or signal transducers, converge on nucleotide-based second messengers and cellular calcium to confer immunity. Although pathogen-activated NLRs in plants engage plant-specific machineries to promote defence, comparisons with mammalian NLR immune receptor counterparts highlight some shared working principles for NLR immunity across kingdoms.

Published
2024
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3. Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1

Author

Johanndrees, Oliver, Baggs, Erin L, Uhlmann, Charles, Locci, Federica, Läßle, Henriette L, Melkonian, Katharina, Käufer, Kiara, Dongus, Joram A, Nakagami, Hirofumi, Krasileva, Ksenia V, Parker, Jane E, and Lapin, Dmitry

Subjects
Prevention, Arabidopsis, Arabidopsis Proteins, Disease Susceptibility, DNA-Binding Proteins, Phylogeny, Plant Diseases, Plant Immunity, Biological Sciences, Agricultural and Veterinary Sciences, Plant Biology & Botany
Abstract

Toll/Interleukin-1 receptor (TIR) domains are integral to immune systems across all kingdoms. In plants, TIRs are present in nucleotide-binding leucine-rich repeat (NLR) immune receptors, NLR-like, and TIR-only proteins. Although TIR-NLR and TIR signaling in plants require the ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) protein family, TIRs persist in species that have no EDS1 members. To assess whether particular TIR groups evolved with EDS1, we searched for TIR-EDS1 co-occurrence patterns. Using a large-scale phylogenetic analysis of TIR domains from 39 algal and land plant species, we identified 4 TIR families that are shared by several plant orders. One group occurred in TIR-NLRs of eudicots and another in TIR-NLRs across eudicots and magnoliids. Two further groups were more widespread. A conserved TIR-only group co-occurred with EDS1 and members of this group elicit EDS1-dependent cell death. In contrast, a maize (Zea mays) representative of TIR proteins with tetratricopeptide repeats was also present in species without EDS1 and induced EDS1-independent cell death. Our data provide a phylogeny-based plant TIR classification and identify TIRs that appear to have evolved with and are dependent on EDS1, while others have EDS1-independent activity.

Published
2023

6. Genetic strategies for improving crop yields

Author

Bailey-Serres, Julia, Parker, Jane E, Ainsworth, Elizabeth A, Oldroyd, Giles ED, and Schroeder, Julian I

Subjects
Zero Hunger, Acclimatization, Animals, Crop Production, Crops, Agricultural, Fertilizers, Food Supply, Global Warming, Humans, Plant Diseases, Rain, Sustainable Development, General Science & Technology
Abstract

The current trajectory for crop yields is insufficient to nourish the world's population by 20501. Greater and more consistent crop production must be achieved against a backdrop of climatic stress that limits yields, owing to shifts in pests and pathogens, precipitation, heat-waves and other weather extremes. Here we consider the potential of plant sciences to address post-Green Revolution challenges in agriculture and explore emerging strategies for enhancing sustainable crop production and resilience in a changing climate. Accelerated crop improvement must leverage naturally evolved traits and transformative engineering driven by mechanistic understanding, to yield the resilient production systems that are needed to ensure future harvests.

Published
2019

8. The receptor kinase SRF3 coordinates iron-level and flagellin dependent defense and growth responses in plants

Author

Platre, Matthieu Pierre, Satbhai, Santosh B., Brent, Lukas, Gleason, Matias F., Cao, Min, Grison, Magali, Glavier, Marie, Zhang, Ling, Gaillochet, Christophe, Goeschl, Christian, Giovannetti, Marco, Enugutti, Balaji, Neveu, Julie, von Reth, Marcel, Alcázar, Ruben, Parker, Jane E., Vert, Grégory, Bayer, Emmanuelle, and Busch, Wolfgang

Published
2022
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9. The EDS1–PAD4–ADR1 node mediates Arabidopsis pattern-triggered immunity

Author

Pruitt, Rory N., Locci, Federica, Wanke, Friederike, Zhang, Lisha, Saile, Svenja C., Joe, Anna, Karelina, Darya, Hua, Chenlei, Fröhlich, Katja, Wan, Wei-Lin, Hu, Meijuan, Rao, Shaofei, Stolze, Sara C., Harzen, Anne, Gust, Andrea A., Harter, Klaus, Joosten, Matthieu H. A. J., Thomma, Bart P. H. J., Zhou, Jian-Min, Dangl, Jeffery L., Weigel, Detlef, Nakagami, Hirofumi, Oecking, Claudia, Kasmi, Farid El, Parker, Jane E., and Nürnberger, Thorsten

Published
2021
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26. Arabidopsis PHYTOALEXIN DEFICIENT 4 promotes the maturation and nuclear accumulation of immune-related cysteine protease RD19.

Author

Zeng, Yanhong, Zheng, Zichao, Hessler, Giuliana, Zou, Ke, Leng, Junchen, Bautor, Jaqueline, Stuttmann, Johannes, Xue, Li, Parker, Jane E, and Cui, Haitao

Subjects
PHYTOALEXINS, CYSTEINE, ARABIDOPSIS, PSEUDOMONAS syringae, DISEASE resistance of plants
Abstract

Arabidopsis PHYTOALEXIN DEFICIENT 4 (PAD4) has an essential role in pathogen resistance as a heterodimer with ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1). Here we investigated an additional PAD4 role in which it associates with and promotes the maturation of the immune-related cysteine protease RESPONSIVE TO DEHYDRATION 19 (RD19). We found that RD19 and its paralog RD19c promoted EDS1- and PAD4-mediated effector-triggered immunity to an avirulent Pseudomonas syringae strain, DC3000, expressing the effector AvrRps4 and basal immunity against the fungal pathogen Golovinomyces cichoracearum. Overexpression of RD19, but not RD19 protease-inactive catalytic mutants, in Arabidopsis transgenic lines caused EDS1- and PAD4-dependent autoimmunity and enhanced pathogen resistance. In these lines, RD19 maturation to a pro-form required its catalytic residues, suggesting that RD19 undergoes auto-processing. In transient assays, PAD4 interacted preferentially with the RD19 pro-protease and promoted its nuclear accumulation in leaf cells. Our results lead us to propose a model for PAD4-stimulated defense potentiation. PAD4 promotes maturation and nuclear accumulation of processed RD19, and RD19 then stimulates EDS1–PAD4 dimer activity to confer pathogen resistance. This study highlights potentially important additional PAD4 functions that eventually converge on canonical EDS1–PAD4 dimer signaling in plant immunity. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Arabidopsis Topless-related 1 mitigates physiological damage and growth penalties of induced immunity

Author

Griebel, Thomas, Lapin, Dmitry, Locci, Federica, Kracher, Barbara, Bautor, Jaqueline, Concia, Lorenzo, Benhamed, Moussa, Parker, Jane E., Sub Translational Plant Biology, and Translational Plant Biology

Subjects
ChIP-Seq, 500 Naturwissenschaften und Mathematik::580 Pflanzen (Botanik)::580 Pflanzen (Botanik), Physiology, corepressor, Plant Science, Topless-related 1, immunity, resilience
Abstract

Transcriptional corepressors of the Topless (TPL) family regulate plant hormone and immunity signaling. The lack of a genome-wide profile of their chromatin associations limits understanding of the TPL family roles in transcriptional regulation. Chromatin immunoprecipitation with sequencing (ChIP-Seq) was performed on Arabidopsis thaliana lines expressing GFP-tagged Topless-related 1 (TPR1-GFP) with and without constitutive immunity via Enhanced Disease Susceptibility 1 (EDS1). RNA-Seq profiling of the TPR1-GFP lines and pathogen-infected tpl/tpr mutants, combined with measuring immunity, growth, and physiological parameters was employed to investigate TPL/TPR roles in immunity and defense homeostasis. TPR1 was enriched at promoter regions of c. 1400 genes and c. 10% of the detected binding required EDS1 immunity signaling. In a tpr1 tpl tpr4 (t3) mutant, resistance to bacteria was slightly compromised, and defense-related transcriptional reprogramming was weakly reduced or enhanced, respectively, at early (< 1 h) and late 24 h stages of bacterial infection. The t3 plants challenged with bacteria or pathogen-associated molecular pattern nlp24 displayed photosystem II dysfunctions. Also, t3 plants were hypersensitive to phytocytokine pep1 at the level of root growth inhibition. Transgenic expression of TPR1 rescued these t3 physiological defects. We propose that TPR1 and TPL family proteins function in Arabidopsis to reduce detrimental effects associated with activated transcriptional immunity.

Published
2023

35. Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1

Author

Sub Translational Plant Biology, Sub Plant-Microbe Interactions, Plant Microbe Interactions, Translational Plant Biology, Johanndrees, Oliver, Baggs, Erin L, Uhlmann, Charles, Locci, Federica, Läßle, Henriette L, Melkonian, Katharina, Käufer, Kiara, Dongus, Joram A, Nakagami, Hirofumi, Krasileva, Ksenia V, Parker, Jane E, Lapin, Dmitry, Sub Translational Plant Biology, Sub Plant-Microbe Interactions, Plant Microbe Interactions, Translational Plant Biology, Johanndrees, Oliver, Baggs, Erin L, Uhlmann, Charles, Locci, Federica, Läßle, Henriette L, Melkonian, Katharina, Käufer, Kiara, Dongus, Joram A, Nakagami, Hirofumi, Krasileva, Ksenia V, Parker, Jane E, and Lapin, Dmitry

Published
2023

36. Arabidopsis Topless-related 1 mitigates physiological damage and growth penalties of induced immunity

Author

Sub Translational Plant Biology, Translational Plant Biology, Griebel, Thomas, Lapin, Dmitry, Locci, Federica, Kracher, Barbara, Bautor, Jaqueline, Concia, Lorenzo, Benhamed, Moussa, Parker, Jane E, Sub Translational Plant Biology, Translational Plant Biology, Griebel, Thomas, Lapin, Dmitry, Locci, Federica, Kracher, Barbara, Bautor, Jaqueline, Concia, Lorenzo, Benhamed, Moussa, and Parker, Jane E

Published
2023

39. Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1

Author

Johanndrees, Oliver, primary, Baggs, Erin L, additional, Uhlmann, Charles, additional, Locci, Federica, additional, Läßle, Henriette L, additional, Melkonian, Katharina, additional, Käufer, Kiara, additional, Dongus, Joram A, additional, Nakagami, Hirofumi, additional, Krasileva, Ksenia V, additional, Parker, Jane E, additional, and Lapin, Dmitry, additional

Published
2022
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40. EDS1complexes are not required forPRRresponses and executeTNL‐ETIfrom the nucleus inNicotiana benthamiana

Author

Zönnchen, Josua, primary, Gantner, Johannes, additional, Lapin, Dmitry, additional, Barthel, Karen, additional, Eschen‐Lippold, Lennart, additional, Erickson, Jessica L., additional, Villanueva, Sergio Landeo, additional, Zantop, Stefan, additional, Kretschmer, Carola, additional, Joosten, Matthieu H. A. J., additional, Parker, Jane E., additional, Guerois, Raphael, additional, and Stuttmann, Johannes, additional

Published
2022
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45. Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity

Author

Huang, Shijia, primary, Jia, Aolin, additional, Song, Wen, additional, Hessler, Giuliana, additional, Meng, Yonggang, additional, Sun, Yue, additional, Xu, Lina, additional, Laessle, Henriette, additional, Jirschitzka, Jan, additional, Ma, Shoucai, additional, Xiao, Yu, additional, Yu, Dongli, additional, Hou, Jiao, additional, Liu, Ruiqi, additional, Sun, Huanhuan, additional, Liu, Xiaohui, additional, Han, Zhifu, additional, Chang, Junbiao, additional, Parker, Jane E., additional, and Chai, Jijie, additional

Published
2022
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46. TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity

Author

Jia, Aolin, primary, Huang, Shijia, additional, Song, Wen, additional, Wang, Junli, additional, Meng, Yonggang, additional, Sun, Yue, additional, Xu, Lina, additional, Laessle, Henriette, additional, Jirschitzka, Jan, additional, Hou, Jiao, additional, Zhang, Tiantian, additional, Yu, Wenquan, additional, Hessler, Giuliana, additional, Li, Ertong, additional, Ma, Shoucai, additional, Yu, Dongli, additional, Gebauer, Jan, additional, Baumann, Ulrich, additional, Liu, Xiaohui, additional, Han, Zhifu, additional, Chang, Junbiao, additional, Parker, Jane E., additional, and Chai, Jijie, additional

Published
2022
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47. Recognition of Microbe- and Damage-Associated Molecular Patterns by Leucine-Rich Repeat Pattern Recognition Receptor Kinases Confers Salt Tolerance in Plants

Author

Loo, Eliza P.-I., primary, Tajima, Yuri, additional, Yamada, Kohji, additional, Kido, Shota, additional, Hirase, Taishi, additional, Ariga, Hirotaka, additional, Fujiwara, Tadashi, additional, Tanaka, Keisuke, additional, Taji, Teruaki, additional, Somssich, Imre E., additional, Parker, Jane E., additional, and Saijo, Yusuke, additional

Published
2022
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50. EDS1 complexes are not required for PRR responses and execute TNL‐ETI from the nucleus in Nicotiana benthamiana

Author

Zönnchen, Josua, Gantner, Johannes, Lapin, Dmitry, Barthel, Karen, Eschen‐Lippold, Lennart, Erickson, Jessica L., Villanueva, Sergio Landeo, Zantop, Stefan, Kretschmer, Carola, Joosten, Matthieu H. A. J., Parker, Jane E., Guerois, Raphael, Stuttmann, Johannes, Zönnchen, Josua, Gantner, Johannes, Lapin, Dmitry, Barthel, Karen, Eschen‐Lippold, Lennart, Erickson, Jessica L., Villanueva, Sergio Landeo, Zantop, Stefan, Kretschmer, Carola, Joosten, Matthieu H. A. J., Parker, Jane E., Guerois, Raphael, and Stuttmann, Johannes

Abstract

Heterodimeric complexes incorporating the lipase-like proteins EDS1 with PAD4 or SAG101 are central hubs in plant innate immunity. EDS1 functions encompass signal relay from TIR domain-containing intracellular NLR-type immune receptors (TNLs) towards RPW8-type helper NLRs (RNLs) and, in Arabidopsis thaliana, bolstering of signaling and resistance mediated by cell-surface pattern recognition receptors (PRRs). Increasing evidence points to the activation of EDS1 complexes by small molecule binding. We used CRISPR/Cas-generated mutant lines and agroinfiltration-based complementation assays to interrogate functions of EDS1 complexes in Nicotiana benthamiana. We did not detect impaired PRR signaling in N. benthamiana lines deficient in EDS1 complexes or RNLs. Intriguingly, in assays monitoring functions of SlEDS1-NbEDS1 complexes in N. benthamiana, mutations within the SlEDS1 catalytic triad could abolish or enhance TNL immunity. Furthermore, nuclear EDS1 accumulation was sufficient for N. benthamiana TNL (Roq1) immunity. Reinforcing PRR signaling in Arabidopsis might be a derived function of the TNL/EDS1 immune sector. Although Solanaceae EDS1 functionally depends on catalytic triad residues in some contexts, our data do not support binding of a TNL-derived small molecule in the triad environment. Whether and how nuclear EDS1 activity connects to membrane pore-forming RNLs remains unknown.

Published
2022

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