521 results on '"Parker, Corette"'
Search Results
2. Serum Cotinine and Adverse Cardiovascular Outcomes: A Cross-sectional Secondary Analysis of the nuMoM2b Heart Health Study
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Theilen, Lauren H, McNeil, Rebecca B, Hunter, Shannon, Grobman, William A, Parker, Corette B, Catov, Janet M, Pemberton, Victoria L, Ehrenthal, Deborah B, Haas, David M, Hoffman, Matthew K, Chung, Judith H, Mukhtar, Farhana, Arzumanyan, Zorayr, Mercer, Brian, Parry, Samuel, Saade, George R, Simhan, Hyagriv N, Wapner, Ronald J, Silver, Robert M, and Network, for the NHLBI nuMoM2b Heart Health Study
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Clinical Research ,Tobacco ,Prevention ,Cardiovascular ,Tobacco Smoke and Health ,Reproductive health and childbirth ,Respiratory ,Good Health and Well Being ,Pregnancy ,Humans ,Female ,Adult ,Cotinine ,Cross-Sectional Studies ,Tobacco Smoke Pollution ,Metabolic Syndrome ,Dyslipidemias ,pregnancy ,cross-sectional studies ,tobacco smoke ,nicotine ,smokers ,pregnancy outcome ,cardiovascular diseases ,NHLBI nuMoM2b Heart Health Study Network ,Clinical Sciences ,Paediatrics and Reproductive Medicine ,Obstetrics & Reproductive Medicine ,Paediatrics ,Reproductive medicine ,Midwifery - Abstract
ObjectiveWe aimed to (1) compare serum cotinine with self-report for ascertaining smoking status among reproductive-aged women; (2) estimate the relative odds of adverse cardiovascular (CV) outcomes among women by smoking status; (3) assess whether the association between adverse pregnancy outcomes (APOs) and CV outcomes varies by smoking status.Study designWe conducted a cross-sectional study of the nuMoM2b Heart Health Study. Women attended a study visit 2 to 7 years after their first pregnancy. The exposure was smoking status, determined by self-report and by serum cotinine. Outcomes included incident chronic hypertension (HTN), metabolic syndrome (MetS), and dyslipidemia. Multivariable logistic regression estimated odds ratios (ORs) for each outcome by smoking status.ResultsOf 4,392 women with serum cotinine measured, 3,610 were categorized as nonsmokers, 62 as secondhand smoke exposure, and 720 as smokers. Of 3,144 women who denied tobacco smoke exposure, serum cotinine was consistent with secondhand smoke exposure in 48 (1.5%) and current smoking in 131 (4.2%) After adjustment for APOs, smoking defined by serum cotinine was associated with MetS (adjusted OR [aOR] = 1.52, 95% confidence interval [CI]: 1.21, 1.91) and dyslipidemia (aOR = 1.28, 95% CI: 1.01, 1.62). When stratified by nicotine exposure, nonsmokers with an APO in their index pregnancy had higher odds of stage 1 (aOR = 1.64, 95% CI: 1.32, 2.03) and stage 2 HTN (aOR = 2.92, 95% CI: 2.17, 3.93), MetS (aOR = 1.76, 95% CI: 1.42, 2.18), and dyslipidemia (aOR = 1.55, 95% CI: 1.25, 1.91) relative to women with no APO. Results were similar when smoking exposure was defined by self-report.ConclusionWhether determined by serum cotinine or self-report, smoking is associated with subsequent CV outcomes in reproductive-aged women. APOs are also independently associated with CV outcomes in women.Key points· Cotinine was detected in 5.7% of reported nonsmokers.. · Smoking and APOs were independently associated with CV health.. · Smoking was associated with MetS and dyslipidemia..
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- 2023
3. The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort
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Knapp, Emily A, Kress, Amii M, Parker, Corette B, Page, Grier P, McArthur, Kristen, Gachigi, Kennedy K, Alshawabkeh, Akram N, Aschner, Judy L, Bastain, Theresa M, Breton, Carrie V, Bendixsen, Casper G, Brennan, Patricia A, Bush, Nicole R, Buss, Claudia, Camargo, Carlos A, Catellier, Diane, Cordero, José F, Croen, Lisa, Dabelea, Dana, Deoni, Sean, D’Sa, Viren, Duarte, Cristiane S, Dunlop, Anne L, Elliott, Amy J, Farzan, Shohreh F, Ferrara, Assiamira, Ganiban, Jody M, Gern, James E, Giardino, Angelo P, Towe-Goodman, Nissa R, Gold, Diane R, Habre, Rima, Hamra, Ghassan B, Hartert, Tina, Herbstman, Julie B, Hertz-Picciotto, Irva, Hipwell, Alison E, Karagas, Margaret R, Karr, Catherine J, Keenan, Kate, Kerver, Jean M, Koinis-Mitchell, Daphne, Lau, Bryan, Lester, Barry M, Leve, Leslie D, Leventhal, Bennett, LeWinn, Kaja Z, Lewis, Johnnye, Litonjua, Augusto A, Lyall, Kristen, Madan, Juliette C, McEvoy, Cindy T, McGrath, Monica, Meeker, John D, Miller, Rachel L, Morello-Frosch, Rachel, Neiderhiser, Jenae M, O’Connor, Thomas G, Oken, Emily, O’Shea, Michael, Paneth, Nigel, Porucznik, Christina A, Sathyanarayana, Sheela, Schantz, Susan L, Spindel, Eliot R, Stanford, Joseph B, Stroustrup, Annemarie, Teitelbaum, Susan L, Trasande, Leonardo, Volk, Heather, Wadhwa, Pathik D, Weiss, Scott T, Woodruff, Tracey J, Wright, Rosalind J, Zhao, Qi, Jacobson, Lisa P, and Outcomes, on behalf of program collaborators for Environmental Influences on Child Health
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Public Health ,Health Sciences ,Human Genome ,Prevention ,Nutrition ,Pediatric ,Behavioral and Social Science ,Genetics ,Clinical Research ,Pediatric Research Initiative ,2.2 Factors relating to the physical environment ,Aetiology ,Good Health and Well Being ,Child ,Humans ,United States ,Environmental Exposure ,Cohort Studies ,Child Health ,Air Pollution ,Outcome Assessment ,Health Care ,adolescent ,child ,child development ,child health ,child well-being ,cohort studies ,environmental exposure ,epidemiologic methods ,Mathematical Sciences ,Medical and Health Sciences ,Epidemiology - Abstract
The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort Study (EWC), a collaborative research design comprising 69 cohorts in 31 consortia, was funded by the National Institutes of Health (NIH) in 2016 to improve children's health in the United States. The EWC harmonizes extant data and collects new data using a standardized protocol, the ECHO-Wide Cohort Data Collection Protocol (EWCP). EWCP visits occur at least once per life stage, but the frequency and timing of the visits vary across cohorts. As of March 4, 2022, the EWC cohorts contributed data from 60,553 children and consented 29,622 children for new EWCP data and biospecimen collection. The median (interquartile range) age of EWCP-enrolled children was 7.5 years (3.7-11.1). Surveys, interviews, standardized examinations, laboratory analyses, and medical record abstraction are used to obtain information in 5 main outcome areas: pre-, peri-, and postnatal outcomes; neurodevelopment; obesity; airways; and positive health. Exposures include factors at the level of place (e.g., air pollution, neighborhood socioeconomic status), family (e.g., parental mental health), and individuals (e.g., diet, genomics).
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- 2023
4. Placental protein levels in maternal serum are associated with adverse pregnancy outcomes in nulliparous patients.
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Haas, David, Mercer, Brian, Silver, Robert, Simhan, Hyagriv, Saade, George, Reddy, Uma, Parker, Corette, Parry, Samuel, Carper, Benjamin, Grobman, William, Wapner, Ronald, and Chung, Judith
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A disintegrin and metalloproteinase domain-containing protein 12 ,endoglin ,placental growth factor ,preeclampsia ,pregnancy-associated plasma protein A ,preterm birth ,small for gestational age ,soluble fms-like tyrosine kinase-1 ,stillbirth ,vascular endothelial growth factor ,Biomarkers ,Case-Control Studies ,Child ,Female ,Fetal Growth Retardation ,Humans ,Infant ,Newborn ,Placenta ,Placenta Growth Factor ,Pre-Eclampsia ,Pregnancy ,Pregnancy Outcome ,Pregnancy Proteins ,Premature Birth ,Stillbirth ,Vascular Endothelial Growth Factor A ,Vascular Endothelial Growth Factor Receptor-1 - Abstract
BACKGROUND: The Eunice Kennedy Shriver National Institute of Child Health and Human Development Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be was established to investigate the underlying causes and pathophysiological pathways associated with adverse pregnancy outcomes in nulliparous gravidas. OBJECTIVE: This study aimed to study placental physiology and identify novel biomarkers concerning adverse pregnancy outcomes, including preterm birth (medically indicated and spontaneous), preeclampsia, small-for-gestational-age neonates, and stillbirth. We measured levels of placental proteins in the maternal circulation in the first 2 trimesters of pregnancy. STUDY DESIGN: Maternal serum samples were collected at 2 study visits (6-13 weeks and 16-21 weeks), and levels of 9 analytes were measured. The analytes we measured were vascular endothelial growth factor, placental growth factor, endoglin, soluble fms-like tyrosine kinase-1, A disintegrin and metalloproteinase domain-containing protein 12, pregnancy-associated plasma protein A, free beta-human chorionic gonadotropin, inhibin A, and alpha-fetoprotein. The primary outcome was preterm birth between 20 0/7 and 36 6/7 weeks of gestation. The secondary outcomes were spontaneous preterm births, medically indicated preterm births, preeclampsia, small-for-gestational-age neonates, and stillbirth. RESULTS: A total of 10,038 eligible gravidas were enrolled in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be cohort, from which a nested case-control study was performed comparing 800 cases with preterm birth (466 spontaneous preterm births, 330 medically indicated preterm births, and 4 unclassified preterm births), 568 with preeclampsia, 406 with small-for-gestational-age birth, and 49 with stillbirth with 911 controls who delivered at term without complications. Although levels of each analyte generally differed between cases and controls at 1 or 2 visits, the odds ratios revealed a
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- 2022
5. Association between aspirin use during pregnancy and cardiovascular risk factors 2–7 years after delivery: The nuMoM2b Heart Health Study
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Theilen, Lauren H, Greenland, Philip, Varagic, Jasmina, Catov, Janet, Shanks, Anthony, Thorsten, Vanessa, Parker, Corette B, McNeil, Rebecca, Mercer, Brian, Hoffman, Matthew, Wapner, Ronald, Haas, David, Simhan, Hyagriv, Grobman, William, Chung, Judith H, Levine, Lisa D, Barnes, Shannon, Bairey Merz, Noel, Saade, George, and Silver, Robert M
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Clinical Research ,Hypertension ,Heart Disease ,Cardiovascular ,Prevention ,Reproductive health and childbirth ,Good Health and Well Being ,Aspirin ,Cardiovascular Diseases ,Diabetes Mellitus ,Type 2 ,Female ,Heart Disease Risk Factors ,Humans ,Pre-Eclampsia ,Pregnancy ,Prospective Studies ,Risk Factors ,Cardiovascular prevention ,Maternal health ,Pregnancy as a window to future health ,Pregnancy complications ,Adverse pregnancy outcomes ,Paediatrics and Reproductive Medicine ,Reproductive medicine - Abstract
ObjectivesTo evaluate the association between aspirin use during first pregnancy and later maternal cardiovascular risk.Study designIn this secondary analysis of a prospective cohort, we included participants who carried their first pregnancy to 20 + weeks, had data regarding aspirin use, and attended a study visit 2-7 years following delivery. The exposure was aspirin use during the first pregnancy. We calculated aspirin use propensity scores from logistic regression models including baseline variables associated with aspirin use in pregnancy and cardiovascular risk. Outcomes of interest were incident cardiovascular-related diagnoses 2-7 years following delivery. Robust Poisson regression calculated the risk of outcomes by aspirin exposure, adjusting for the aspirin use propensity score.Main outcome measuresThe primary outcome was a composite of incident cardiovascular diagnoses at the time of the study visit: cardiovascular events, chronic hypertension, metabolic syndrome, prediabetes or type 2 diabetes, dyslipidemia, and chronic kidney disease.ResultsOf 4,480 women included, 84 (1.9%) reported taking aspirin during their first pregnancy. 52.6% of participants in the aspirin-exposed group and 43.0% in the unexposed group had the primary outcome. After adjusting for the aspirin use propensity scores, aspirin use during the first pregnancy was not associated with any of the outcomes.ConclusionWe did not detect an association between aspirin use during the first pregnancy and cardiovascular-related diagnoses 2-7 years later. Our study was only powered to detect a large difference in relative risk, so we cannot rule out a smaller difference that may be clinically meaningful.
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- 2022
6. Sleep-disordered Breathing in Pregnancy and after Delivery: Associations with Cardiometabolic Health.
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Facco, Francesca L, Redline, Susan, Hunter, Shannon M, Zee, Phyllis C, Grobman, William A, Silver, Robert M, Louis, Judette M, Pien, Grace W, Mercer, Brian, Chung, Judith H, Bairey Merz, C Noel, Haas, David M, Nhan-Chang, Chia-Ling, Simhan, Hyagriv N, Schubert, Frank P, Parry, Samuel, Reddy, Uma, Saade, George R, Hoffman, Matthew K, Levine, Lisa D, Wapner, Ronald J, Catov, Janet M, and Parker, Corette B
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Clinical Research ,Prevention ,Sleep Research ,Lung ,Cardiovascular ,Reproductive health and childbirth ,Good Health and Well Being ,Cardiovascular Diseases ,Female ,Humans ,Odds Ratio ,Oxygen ,Polysomnography ,Pregnancy ,Risk Factors ,Sleep Apnea Syndromes ,sleep disordered breathing ,pregnancy ,postpartum ,cardiometabolic health ,hypertension ,sleep-disordered breathing ,Medical and Health Sciences ,Respiratory System - Abstract
Rationale: Knowledge gaps exist regarding health implications of sleep-disordered breathing (SDB) identified in pregnancy and/or after delivery. Objectives: To determine whether SDB in pregnancy and/or after delivery is associated with hypertension (HTN) and metabolic syndrome (MS). Methods: nuMoM2b-HHS (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be Heart Health Study) (N = 4,508) followed participants initially recruited during their first pregnancy. Participants returned for a visit 2-7 years after pregnancy. This study examined a subgroup who underwent SDB assessments during their first pregnancy (n = 1,964) and a repeat SDB assessment after delivery (n = 1,222). Two SDB definitions were considered: 1) apnea-hypopnea index (AHI) ⩾ 5 and 2) oxygen desaturation index (ODI) ⩾ 5. Associations between SDB and incident HTN and MS were evaluated with adjusted risk ratios (aRRs). Measurements and Main Results: The aRR for MS given an AHI ⩾ 5 during pregnancy was 1.44 (95% confidence interval [CI], 1.08-1.93), but no association with HTN was found. ODI ⩾ 5 in pregnancy was associated with both an increased risk for HTN (aRR, 2.02; 95% CI, 1.30-3.14) and MS (aRR, 1.53; 95% CI, 1.19-1.97). Participants with an AHI ⩾ 5 in pregnancy that persisted after delivery were at higher risk for both HTN (aRR, 3.77; 95% CI, 1.84-7.73) and MS (aRR, 2.46; 95% CI, 1.59-3.76). Similar associations were observed for persistent ODI ⩾ 5 after delivery. Conclusions: An AHI ⩾ 5 in pregnancy was associated with an increased risk of MS. An ODI ⩾ 5 in pregnancy was significantly associated with both HTN and MS. Participants with persistent elevations in AHI and ODI during pregnancy and at 2-7 years after delivery were at the highest risk for HTN and MS. Clinical trial registered with www.clinicaltrials.gov (NCT02231398).
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- 2022
7. Factors associated with duration of breastfeeding in women giving birth for the first time
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Haas, David M, Yang, Ziyi, Parker, Corette B, Chung, Judith, Parry, Samuel, Grobman, William A, Mercer, Brian M, Simhan, Hyagriv N, Silver, Robert M, Wapner, Ronald J, Saade, George R, Greenland, Philip, Merz, Noel Bairey, Reddy, Uma M, and Pemberton, Victoria L
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Reproductive Medicine ,Midwifery ,Biomedical and Clinical Sciences ,Health Sciences ,Clinical Research ,Prevention ,Contraception/Reproduction ,Reproductive health and childbirth ,Breast Feeding ,Cohort Studies ,Female ,Hispanic or Latino ,Humans ,Odds Ratio ,Parturition ,Pregnancy ,Breastfeeding ,Longevity ,Nulliparous patients ,nuMoM2b study and the nuMoM2b Heart Health Study ,Nursing ,Paediatrics and Reproductive Medicine ,Public Health and Health Services ,Obstetrics & Reproductive Medicine ,Reproductive medicine - Abstract
ObjectiveTo examine maternal, psychosocial, and pregnancy factors associated with breastfeeding for at least 6 months in those giving birth for the first time.MethodsWe performed a planned secondary analysis of an observational cohort study of 5249 women giving birth for the first time. Women were contacted at least 6 months after delivery and provided information regarding breastfeeding initiation, duration, and exclusivity. Maternal demographics, psychosocial measures, and delivery methods were compared by breastfeeding groups.Results4712 (89.8%) of the women breastfed at some point, with 2739 (58.2%) breastfeeding for at least 6 months. Of those who breastfed, 1161 (24.7% of the entire cohort), breastfed exclusively for at least 6 months. In the multivariable model among those who ever breastfed, not smoking in the month prior to delivery (adjusted odds ratio [aOR] 2.04, 95%CI 1.19-3.45), having a Master's degree of higher (aOR 1.89, 95%CI 1.51-2.36), having a planned pregnancy (aOR 1.48, 95%CI 1.27-1.73), older age (aOR 1.02, 95% CI, 1.01-1.04), lower BMI (aOR 0.96 95% CI 0.95-0.97), and having less anxiety measured during pregnancy (aOR 0.990, 95%CI 0.983-0.998) were associated with breastfeeding for at least 6 months. Compared to non-Hispanic White women, Hispanic women, while being more likely to breastfeed initially (aOR 1.40, 95%CI 1.02-1.92), were less likely to breastfeed for 6 months (aOR 0.72, 95%CI 0.59-0.88). While non-Hispanic Black women were less likely than non-Hispanic White women to initiate breastfeeding (aOR 0.68, 95%CI 0.51-0.90), the odds of non-Hispanic Black women of continuing to breastfeed for at least 6 months was similar to non-Hispanic White women (aOR 0.92, 95%CI 0.71-1.19).ConclusionsIn this cohort of women giving birth for the first time, duration of breastfeeding was associated with several characteristics which highlight groups at greater risk of not breastfeeding as long as currently recommended.Trial registrationNCT01322529 (nuMoM2b) and NCT02231398 (nuMoM2b-Heart Health).
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- 2022
8. Association of second trimester uterine artery Doppler parameters with maternal hypertension 2–7 years after delivery
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Miller, Eliza C, Carper, Benjamin, Bello, Natalie A, Merz, C Noel Bairey, Greenland, Philip, Levine, Lisa D, Haas, David M, Grobman, William A, McNeil, Rebecca B, Chung, Judith H, Jolley, Jennifer, Saade, George R, Silver, Robert M, Simhan, Hyagriv N, Wapner, Ronald J, Parker, Corette B, and Networks, NIH NICHD nuMoM2b and NHLBI nuMoM2b Heart Health Study
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Clinical Research ,Hypertension ,Prevention ,Cardiovascular ,Reproductive health and childbirth ,Good Health and Well Being ,Pregnancy ,Preeclampsia ,Vascular ultrasound ,Doppler ,Biomarkers ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
BackgroundReduced uterine artery compliance is associated with adverse pregnancy outcomes (APOs) and may indicate underlying maternal cardiovascular pathology. We investigated associations between second trimester uterine artery Doppler (UAD) parameters and incident maternal hypertension 2-7 years after delivery.MethodsA cohort of 10,038 nulliparous US participants was recruited early in pregnancy. A subgroup of 3739, without baseline hypertension and with complete follow-up visits 2-7 years after delivery, were included in this analysis. We investigated UAD indicators of compliance including: 1) early diastolic notch; 2) resistance index (RI); and 3) pulsatility index (PI). We defined hypertension as systolic blood pressure ≥130 mmHg, diastolic ≥80 mmHg, or antihypertensive medication use. We calculated odds ratios (OR) and 95 % confidence intervals (95%CI) for associations between UAD parameters and hypertension, adjusting for age, obesity, race/ethnicity, insurance, smoking, and APOs.ResultsA total of 187 (5 %) participants developed hypertension after the index pregnancy. Presence of early diastolic notch on UAD was not associated with incident hypertension. Increased RI and PI correlated with higher odds of hypertension (RI: adjusted OR 1.15 [95 % CI 1.03-1.30]; PI: adjusted OR 1.03 [95%CI 1.01-1.05] for each 0.1 unit increase). Maximum RI above 0.84 or maximum PI above 2.3 more than doubled the odds of incident hypertension (RI: adjusted OR 2.49, 95%CI 1.45-4.26; PI: adjusted OR 2.36, 95%CI 1.45-3.86).ConclusionHigher resistance and pulsatility indices measured on second trimester UAD were associated with increased odds of incident hypertension 2-7 years later, and may be biomarkers of higher maternal cardiovascular risk.
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- 2021
9. Objectively assessed sleep-disordered breathing during pregnancy and infant birthweight
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Hawkins, Parker, Corette B, Redline, Susan, Larkin, Jacob C, Zee, Phyllis P, Grobman, William A, Silver, Robert M, Louis, Judette M, Pien, Grace W, Basner, Robert C, Chung, Judith H, Haas, David M, Nhan-Chang, Chia-Ling, Simhan, Hyagriv N, Blue, Nathan R, Parry, Samuel, Reddy, Uma, Facco, Francesca, and Networks, NICHD NuMoM2b and NHLBI NuMoM2b Heart Health Study
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Pediatric ,Mental Health ,Lung ,Clinical Research ,Prevention ,Sleep Research ,Reproductive health and childbirth ,Birth Weight ,Cohort Studies ,Female ,Gestational Age ,Humans ,Infant ,Infant ,Newborn ,Infant ,Small for Gestational Age ,Pregnancy ,Sleep Apnea Syndromes ,Abnormal fetal growth ,Sleep-disordered breathing ,Sleep apnea ,Nocturnal hypoxemia ,NICHD NuMoM2b and NHLBI NuMoM2b Heart Health Study Networks ,Clinical Sciences ,Psychology ,Neurology & Neurosurgery ,Clinical sciences ,Clinical and health psychology - Abstract
BackgroundSleep-disordered breathing (SDB) in pregnancy is associated with adverse maternal outcomes. The relationship between SDB and infant birthweight is unclear. This study's primary aim is to determine if objectively measured SDB in pregnancy is associated with infant birthweight.MethodsWe measured SDB objectively in early (6-15 weeks' gestation) and mid (22-31 weeks' gestation) pregnancy in a large cohort of nulliparous women. SDB was defined as an Apnea-Hypopnea Index ≥5 and in secondary analyses we also examined measures of nocturnal hypoxemia. We used a modified Poisson regression approach to estimate relative risks (RR) of large-for-gestational-age (LGA: >90th percentile for gestational age) and small-for-gestational-age (SGA:
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- 2021
10. Early Pregnancy Atherogenic Profile in a First Pregnancy and Hypertension Risk 2 to 7 Years After Delivery
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Catov, Janet M, McNeil, Rebecca B, Marsh, Derek J, Mercer, Brian M, Merz, C Noel Bairey, Parker, Corette B, Pemberton, Victoria L, Saade, George R, Chen, Yii‐Der, Chung, Judith H, Ehrenthal, Deborah B, Grobman, William A, Haas, David M, Parry, Samuel, Polito, LuAnn, Reddy, Uma M, Silver, Robert M, Simhan, Hyagriv N, Wapner, Ronald J, Kominiarek, Michelle, Kreutz, Rolf, Levine, Lisa D, Greenland, Philip, and Study, for the NHLBI nuMoM2b Heart Health
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Cardiovascular ,Diabetes ,Hypertension ,Clinical Research ,Prevention ,Reproductive health and childbirth ,Good Health and Well Being ,Adult ,Atherosclerosis ,Biomarkers ,Blood Pressure ,Diabetes ,Gestational ,Female ,Follow-Up Studies ,Humans ,Incidence ,Infant ,Newborn ,Male ,Pregnancy ,Pregnancy Complications ,Cardiovascular ,Pregnancy Outcome ,Retrospective Studies ,Risk Factors ,Time Factors ,United States ,high blood pressure ,hypertension ,lipids ,preeclampsia ,pregnancy ,pregnancy and postpartum ,NHLBI nuMoM2b Heart Health Study ,preeclampsia/pregnancy ,Cardiorespiratory Medicine and Haematology ,Cardiovascular medicine and haematology - Abstract
Background Cardiovascular risk in young adulthood is an important determinant of lifetime cardiovascular disease risk. Women with adverse pregnancy outcomes (APOs) have increased cardiovascular risk, but the relationship of other factors is unknown. Methods and Results Among 4471 primiparous women, we related first-trimester atherogenic markers to risk of APO (hypertensive disorders of pregnancy, preterm birth, small for gestational age), gestational diabetes mellitus (GDM) and hypertension (130/80 mm Hg or antihypertensive use) 2 to 7 years after delivery. Women with an APO/GDM (n=1102) had more atherogenic characteristics (obesity [34.2 versus 19.5%], higher blood pressure [systolic blood pressure 112.2 versus 108.4, diastolic blood pressure 69.2 versus 66.6 mm Hg], glucose [5.0 versus 4.8 mmol/L], insulin [77.6 versus 60.1 pmol/L], triglycerides [1.4 versus 1.3 mmol/L], and high-sensitivity C-reactive protein [5.6 versus 4.0 nmol/L], and lower high-density lipoprotein cholesterol [1.8 versus 1.9 mmol/L]; P
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- 2021
11. Associations of perceived prenatal stress and adverse pregnancy outcomes with perceived stress years after delivery
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Monk, Catherine, Webster, Rachel S, McNeil, Rebecca B, Parker, Corette B, Catov, Janet M, Greenland, Philip, Bairey Merz, C Noel, Silver, Robert M, Simhan, Hyagriv N, Ehrenthal, Deborah B, Chung, Judith H, Haas, David M, Mercer, Brian M, Parry, Samuel, Polito, LuAnn, Reddy, Uma M, Saade, George R, and Grobman, William A
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Midwifery ,Health Sciences ,Contraception/Reproduction ,Hypertension ,Clinical Research ,Conditions Affecting the Embryonic and Fetal Periods ,Perinatal Period - Conditions Originating in Perinatal Period ,Pediatric ,Pediatric Research Initiative ,Clinical Trials and Supportive Activities ,Reproductive health and childbirth ,Good Health and Well Being ,Adult ,Cohort Studies ,Diabetes ,Gestational ,Female ,Humans ,Hypertension ,Pregnancy-Induced ,Infant ,Newborn ,Perception ,Pre-Eclampsia ,Pregnancy ,Pregnancy Complications ,Pregnancy Outcome ,Pregnancy Trimester ,First ,Pregnancy Trimester ,Third ,Premature Birth ,Prospective Studies ,Risk Factors ,Stress ,Psychological ,United States ,Prenatal maternal stress ,Adverse pregnancy outcomes ,Perceived stress ,Preterm birth ,Preeclampsia ,NICHD nuMoM2b and NHLBI nuMoM2b Heart Health Study Networks ,Psychology ,Cognitive Sciences ,Psychiatry ,Applied and developmental psychology ,Clinical and health psychology - Abstract
Maternal stress is a risk factor for adverse pregnancy outcomes (APOs). This study evaluates the associations of prenatal stress and APOs with maternal stress years after pregnancy. The 10-item Perceived Stress Scale (PSS) (0-40 range) was completed in the first and third trimesters, and 2-7 years after delivery among a subsample (n = 4161) of nulliparous women enrolled at eight US medical centers between 2010 and 2013 in a prospective, observational cohort study. Demographics, medical history, and presence of APOs (gestational diabetes (GDM), hypertensive disorders of pregnancy (HDP), preeclampsia (PE), and medically indicated or spontaneous preterm birth (miPTB, sPTB)) were obtained. The associations of prenatal PSS and the presence of APOs with PSS scores years after delivery were estimated using multivariable linear regression. Mean PSS scores were 12.5 (95% CI 12.3, 12.7) and 11.3 (95% CI 11.1, 11.5) in the first and third trimesters respectively and 14.9 (95% CI 14.7, 15.1) 2-7 years later, an average increase of 2.4 points (95% CI 2.2, 2.6) from the start of pregnancy. Regressing PSS scores after delivery on first-trimester PSS and PSS increase through pregnancy showed positive associations, with coefficients (95% CI) of 2.8 (2.7, 3.0) and 1.5 (1.3, 1.7) per 5-point change, respectively. Adding APO indicator variables separately showed higher PSS scores for women with HDP (0.7 [0.1, 1.3]), PE (1.3 [0.6, 2.1]), and miPTB (1.3 [0.2, 2.4]), but not those with GDM or sPTB. In this geographically and demographically diverse sample, prenatal stress and some APOs were positively associated with stress levels 2-7 years after pregnancy.ClinicalTrials.gov Registration number NCT02231398.
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- 2020
12. Later sleep timing is associated with an increased risk of preterm birth in nulliparous women
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Facco, Francesca L, Parker, Corette B, Hunter, Shannon, Reid, Kathryn J, Zee, Phyllis P, Silver, Robert M, Pien, Grace, Chung, Judith H, Louis, Judette M, Haas, David M, Nhan-Chang, Chia-Ling, Simhan, Hyagriv N, Parry, Samuel, Wapner, Ronald J, Saade, George R, Mercer, Brian M, Bickus, Melissa, Reddy, Uma M, Grobman, William A, and Networks, NICHD NuMoM2b and NHLBI NuMoM2b Heart Health Study
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Paediatrics ,Reproductive Medicine ,Biomedical and Clinical Sciences ,Behavioral and Social Science ,Preterm ,Low Birth Weight and Health of the Newborn ,Sleep Research ,Basic Behavioral and Social Science ,Clinical Research ,Pediatric ,Perinatal Period - Conditions Originating in Perinatal Period ,Infant Mortality ,Reproductive health and childbirth ,Good Health and Well Being ,Female ,Gestational Age ,Humans ,Infant ,Newborn ,Pregnancy ,Pregnancy Outcome ,Premature Birth ,Prospective Studies ,Sleep ,pregnancy ,preterm birth ,sleep duration ,sleep midpoint ,sleep timing ,NICHD NuMoM2b and NHLBI NuMoM2b Heart Health Study Networks ,Reproductive medicine - Abstract
BackgroundAlthough uterine contractions have a diurnal periodicity and increase in frequency during hours of darkness, data on the relationship between sleep duration and sleep timing patterns and preterm birth are limited.ObjectiveWe sought to examine the relationship of self-reported sleep duration and timing in pregnancy with preterm birth.Study designIn the prospective Nulliparous Pregnancy Outcome Study: Monitoring Mothers-to-be cohort, women completed a survey of sleep patterns at 6-13 weeks gestation (visit 1) and again at 22-29 weeks gestation (visit 3). Additionally, at 16-21 weeks gestation (visit 2), a subgroup completed a weeklong actigraphy recording of their sleep. Weekly averages of self-reported sleep duration and sleep midpoint were calculated. A priori, sleep duration of 5 am) was associated with preterm birth . Women with a late sleep midpoint (>5 am) in early pregnancy had a preterm birth rate of 9.5%, compared with 6.9% for women with sleep midpoint ≤5 am (P=.005). Similarly, women with a late sleep midpoint had a higher rate of spontaneous preterm birth (6.2% vs 4.4%; P=.019). Comparable results were observed for women with a late sleep midpoint at visit 3 (all preterm birth 8.9% vs 6.6%; P=.009; spontaneous preterm birth 5.9% vs 4.3%; P=.023). All adjusted analyses on self-reported sleep midpoint (models 1 and 2) maintained statistical significance (P
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- 2019
13. Prospective Evaluation of Maternal Sleep Position Through 30 Weeks of Gestation and Adverse Pregnancy Outcomes.
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Silver, Robert M, Hunter, Shannon, Reddy, Uma M, Facco, Francesca, Gibbins, Karen J, Grobman, William A, Mercer, Brian M, Haas, David M, Simhan, Hyagriv N, Parry, Samuel, Wapner, Ronald J, Louis, Judette, Chung, Judith M, Pien, Grace, Schubert, Frank P, Saade, George R, Zee, Phyllis, Redline, Susan, and Parker, Corette B
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Pediatric ,Sleep Research ,Conditions Affecting the Embryonic and Fetal Periods ,Neurosciences ,Clinical Research ,Perinatal Period - Conditions Originating in Perinatal Period ,Reproductive health and childbirth ,Good Health and Well Being ,Adult ,Female ,Gestational Age ,Humans ,Hypertension ,Pregnancy-Induced ,Infant ,Newborn ,Infant ,Small for Gestational Age ,Logistic Models ,Posture ,Pregnancy ,Pregnancy Complications ,Pregnancy Outcome ,Pregnancy Trimesters ,Prospective Studies ,Risk Factors ,Sleep ,Sleep Wake Disorders ,Stillbirth ,Young Adult ,Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (NuMoM2b) Study ,Paediatrics and Reproductive Medicine ,Obstetrics & Reproductive Medicine ,Reproductive medicine - Abstract
ObjectiveTo examine the relationship between prospectively assessed maternal sleep position and subsequent adverse pregnancy outcomes.MethodsThis was a secondary analysis of a prospective observational multicenter cohort study of nulliparous women with singleton gestations who were enrolled between October 2010 and May 2014. Participants had three study visits that were not part of clinical care. They prospectively completed in-depth sleep questionnaires between 6 0/7 and 13 6/7 weeks of gestation and 22 0/7 and 29 6/7 weeks of gestation, the first and third study visits. A subset of women also underwent level 3 home sleep tests using the Embletta Gold device. The primary outcome was a composite of adverse pregnancy outcomes such as stillbirth, a small-for-gestational-age newborn, and gestational hypertensive disorders.ResultsA total of 8,706 (of 10,038) women had data from at least one sleep questionnaire and for pregnancy outcomes, and they comprised the population for this analysis. The primary outcome occurred in 1,903 pregnancies (22%). There was no association between reported non-left lateral or supine sleep during the last week of the first visit (adjusted odds ratio [aOR] 1.00 [95% CI 0.89-1.14]) or third visit (aOR 0.99 [95% CI 0.89-1.11] and the composite or any individual outcome, except for an apparent protective effect for stillbirth at the third visit (aOR 0.27 (95% CI 0.09-0.75). Women with objectively measured supine sleep position for at least 50% of the time were no more likely than those in the supine position 50% or less of the time to have the composite adverse outcome.ConclusionsGoing to sleep in the supine or right lateral position, as self-reported before the development of pregnancy outcome and objectively assessed through 30 weeks of gestation, was not associated with an increased risk of stillbirth, a small-for-gestational-age newborn, or gestational hypertensive disorders.
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- 2019
14. Association of Adverse Pregnancy Outcomes With Hypertension 2 to 7 Years Postpartum
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Haas, David M, Parker, Corette B, Marsh, Derek J, Grobman, William A, Ehrenthal, Deborah B, Greenland, Philip, Merz, C Noel Bairey, Pemberton, Victoria L, Silver, Robert M, Barnes, Shannon, McNeil, Rebecca B, Cleary, Kirsten, Reddy, Uma M, Chung, Judith H, Parry, Samuel, Theilen, Lauren H, Blumenthal, Elizabeth A, Levine, Lisa D, Mercer, Brian M, Simhan, Hyagriv, Polito, LuAnn, Wapner, Ronald J, Catov, Janet, Chen, Ida, Saade, George R, and Study, for the NHLBI nuMoM2b Heart Health
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Cardiovascular ,Hypertension ,Perinatal Period - Conditions Originating in Perinatal Period ,Preterm ,Low Birth Weight and Health of the Newborn ,Pediatric ,Clinical Research ,Infant Mortality ,Contraception/Reproduction ,Prevention ,Reproductive health and childbirth ,Good Health and Well Being ,Adult ,Birth Weight ,Blood Pressure ,Female ,Gestational Age ,Humans ,Incidence ,Infant ,Newborn ,Infant ,Premature ,Infant ,Small for Gestational Age ,Pregnancy ,Pregnancy Complications ,Pregnancy Outcome ,Prognosis ,Prospective Studies ,Risk Assessment ,Risk Factors ,Time Factors ,United States ,Young Adult ,adverse pregnancy outcomes ,hypertension ,risk ,preeclampsia ,preterm birth ,NHLBI nuMoM2b Heart Health Study ,Cardiorespiratory Medicine and Haematology - Abstract
Background Identifying pregnancy-associated risk factors before the development of major cardiovascular disease events could provide opportunities for prevention. The objective of this study was to determine the association between outcomes in first pregnancies and subsequent cardiovascular health. Methods and Results The Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-be Heart Health Study is a prospective observational cohort that followed 4484 women 2 to 7 years (mean 3.2 years) after their first pregnancy. Adverse pregnancy outcomes (defined as hypertensive disorders of pregnancy, small-for-gestational-age birth, preterm birth, and stillbirth) were identified prospectively in 1017 of the women (22.7%) during this pregnancy. The primary outcome was incident hypertension (HTN). Women without adverse pregnancy outcomes served as controls. Risk ratios (RR) and 95% CIs were adjusted for age, smoking, body mass index, insurance type, and race/ethnicity at enrollment during pregnancy. The overall incidence of HTN was 5.4% (95% CI 4.7% to 6.1%). Women with adverse pregnancy outcomes had higher adjusted risk of HTN at follow-up compared with controls (RR 2.4, 95% CI 1.8-3.1). The association held for individual adverse pregnancy outcomes: any hypertensive disorders of pregnancy (RR 2.7, 95% CI 2.0-3.6), preeclampsia (RR 2.8, 95% CI 2.0-4.0), and preterm birth (RR 2.7, 95% CI 1.9-3.8). Women who had an indicated preterm birth and hypertensive disorders of pregnancy had the highest risk of HTN (RR 4.3, 95% CI 2.7-6.7). Conclusions Several pregnancy complications in the first pregnancy are associated with development of HTN 2 to 7 years later. Preventive care for women should include a detailed pregnancy history to aid in counseling about HTN risk. Clinical Trial Registration URL: http://www.clinicaltrials.gov Unique identifier: NCT02231398.
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- 2019
15. Association of Adverse Pregnancy Outcomes With Self-Reported Measures of Sleep Duration and Timing in Women Who Are Nulliparous.
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Facco, Francesca L, Parker, Corette B, Hunter, Shannon, Reid, Kathryn J, Zee, Phyllis C, Silver, Robert M, Haas, David M, Chung, Judith H, Pien, Grace W, Nhan-Chang, Chia-Ling, Simhan, Hyagriv N, Parry, Samuel, Wapner, Ronald J, Saade, George R, Mercer, Brian M, Torres, Caroline, Knight, Jordan, Reddy, Uma M, and Grobman, William A
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Sleep Research ,Clinical Research ,Reproductive health and childbirth ,Good Health and Well Being ,Adult ,Cohort Studies ,Correlation of Data ,Female ,Gestational Age ,Humans ,Parity ,Pregnancy ,Pregnancy Complications ,Pregnancy Outcome ,Prospective Studies ,Sleep Deprivation ,Sleep Wake Disorders ,Time Factors ,gestational diabetes ,hypertension ,pregnancy ,sleep duration ,sleep midpoint ,NICHD NuMoM2b and NHLBI NuMoM2b Heart Health Study Networks ,Clinical Sciences ,Other Medical and Health Sciences ,Psychology ,Neurology & Neurosurgery - Abstract
Study objectivesTo examine the relationship of self-reported sleep during pregnancy with adverse pregnancy outcomes. A secondary objective was to describe the concordance between self-reported and objectively assessed sleep during pregnancy.MethodsIn this prospective cohort, women completed a survey of sleep patterns at 6 to 13 weeks' gestation (visit 1) and again at 22 to 29 weeks' gestation (visit 3). Additionally, at 16 to 21 weeks (visit 2), a subgroup completed a week-long sleep diary coincident with an actigraphy recording. Weekly averages of self-reported sleep duration and sleep midpoint were calculated. A priori, sleep duration < 7 hours was defined as "short," and sleep midpoint after 5:00 AM was defined as "late." The relationship of these sleep abnormalities with hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM) was determined.ResultsOf the 10,038 women enrolled, sleep survey data were available for 7,524 women at visit 1 and 7,668 women at visit 3. A total of 752 women also provided ≥ 5 days of sleep diary data coincident with actigraphy at visit 2. We did not observe any consistent relationship between self-reported short sleep and HDP or GDM. There was an association between self-reported late sleep midpoint and GDM (visit 1 adjusted odds ratio 1.67, 95% confidence interval 1.17, 2.38; visit 2 adjusted odds ratio 1.73, 95% confidence interval 1.23, 2.43). At visit 2, 77.1% of participants had concordance between their diary and actigraphy for short sleep duration, whereas 94.3% were concordant for sleep midpoint.ConclusionsSelf-reported sleep midpoint, which is more accurate than self-reported sleep duration, is associated with the risk of GDM.Clinical trial registrationRegistry: ClinicalTrials.gov, Title: Pregnancy as a Window to Future Cardiovascular Health: Adverse Pregnancy Outcomes as Predictors of Increased Risk Factors for Cardiovascular Disease, Identifier: NCT02231398, URL: https://clinicaltrials.gov/ct2/show/NCT02231398.
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- 2018
16. Patterns of leisure-time physical activity across pregnancy and adverse pregnancy outcomes
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Catov, Janet M, Parker, Corette B, Gibbs, Bethany Barone, Bann, Carla M, Carper, Benjamin, Silver, Robert M, Simhan, Hyagriv N, Parry, Samuel, Chung, Judith H, Haas, David M, Wapner, Ronald J, Saade, George R, Mercer, Brian M, Bairey-Merz, C Noel, Greenland, Philip, Ehrenthal, Deborah B, Barnes, Shannon E, Shanks, Anthony L, Reddy, Uma M, Grobman, William A, and for the NICHD NuMoM2b and NHLBI NuMoM2b Heart Health Study Network
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Clinical Research ,Contraception/Reproduction ,Nutrition ,Prevention ,Pediatric ,Perinatal Period - Conditions Originating in Perinatal Period ,Reproductive health and childbirth ,Metabolic and endocrine ,Good Health and Well Being ,Adult ,Black or African American ,Diabetes ,Gestational ,Exercise ,Female ,Gestational Age ,Hispanic or Latino ,Humans ,Hypertension ,Pregnancy-Induced ,Infant ,Newborn ,Infant ,Small for Gestational Age ,Leisure Activities ,Obesity ,Odds Ratio ,Pregnancy ,Pregnancy Outcome ,Premature Birth ,Smoking ,Young Adult ,Physical activity ,Gestational diabetes ,Preterm birth ,NICHD NuMoM2b and NHLBI NuMoM2b Heart Health Study Network ,Medical and Health Sciences ,Education ,Nutrition and dietetics ,Epidemiology ,Sports science and exercise - Abstract
BackgroundAlthough leisure-time physical activity (PA) contributes to overall health, including pregnancy health, patterns across pregnancy have not been related to birth outcomes. We hypothesized that women with sustained low leisure-time PA would have excess risk of adverse pregnancy outcomes, and that changing patterns across pregnancy (high to low and low to high) may also be related to risk of adverse pregnancy outcomes.MethodsNulliparous women (n = 10,038) were enrolled at 8 centers early in pregnancy (mean gestational age in weeks [SD] = 12.05 [1.51]. Frequency, duration, and intensity (metabolic equivalents) of up to three leisure activities reported in the first, second and third trimesters were analyzed. Growth mixture modeling was used to identify leisure-time PA patterns across pregnancy. Adverse pregnancy outcomes (preterm birth, [PTB, overall and spontaneous], hypertensive disorders of pregnancy [HDP], gestational diabetes [GDM] and small-for-gestational-age births [SGA]) were assessed via chart abstraction.ResultsFive patterns of leisure-time PA across pregnancy were identified: High (35%), low (18%), late decreasing (24%), early decreasing (10%), and early increasing (13%). Women with sustained low leisure-time PA were younger and more likely to be black or Hispanic, obese, or to have smoked prior to pregnancy. Women with low vs. high leisure-time PA patterns had higher rates of PTB (10.4 vs. 7.5), HDP (13.9 vs. 11.4), and GDM (5.7 vs. 3.1, all p
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- 2018
17. Association between aspirin use during pregnancy and cardiovascular risk factors 2–7 years after delivery: The nuMoM2b Heart Health Study
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Theilen, Lauren H., Greenland, Philip, Varagic, Jasmina, Catov, Janet, Shanks, Anthony, Thorsten, Vanessa, Parker, Corette B., McNeil, Rebecca, Mercer, Brian, Hoffman, Matthew, Wapner, Ronald, Haas, David, Simhan, Hyagriv, Grobman, William, Chung, Judith H., Levine, Lisa D., Barnes, Shannon, Bairey Merz, Noel, Saade, George, and Silver, Robert M.
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- 2022
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18. Elevated prenatal maternal sex hormones, but not placental aromatase, are associated with child neurodevelopment
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Firestein, Morgan R., Romeo, Russell D., Winstead, Hailey, Goldman, Danielle A., Grobman, William A., Haas, David, Mercer, Brian, Parker, Corette, Parry, Samuel, Reddy, Uma, Silver, Robert, Simhan, Hyagriv, Wapner, Ronald J., and Champagne, Frances A.
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- 2022
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19. Preeclampsia at delivery is associated with lower serum vitamin D and higher antiangiogenic factors: a case control study
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Seifer, David B., Lambert-Messerlian, Geralyn, Palomaki, Glenn E., Silver, Robert M., Parker, Corette, Rowland Hogue, Carol J., Stoll, Barbara J., Saade, George R., Goldenberg, Robert L., Dudley, Donald J., Bukowski, Radek, Pinar, Halit, and Reddy, Uma M.
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- 2022
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20. Large-Scale Proteomics in Early Pregnancy and Hypertensive Disorders of Pregnancy.
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Greenland, Philip, Segal, Mark R., McNeil, Rebecca B., Parker, Corette B., Pemberton, Victoria L., Grobman, William A., Silver, Robert M., Simhan, Hyagriv N., Saade, George R., Ganz, Peter, Mehta, Priya, Catov, Janet M., Bairey Merz, C. Noel, Varagic, Jasmina, Khan, Sadiya S., Parry, Samuel, Reddy, Uma M., Mercer, Brian M., Wapner, Ronald J., and Haas, David M.
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- 2024
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21. Prescription and Other Medication Use in Pregnancy
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Haas, David M, Marsh, Derek J, Dang, Danny T, Parker, Corette B, Wing, Deborah A, Simhan, Hyagriv N, Grobman, William A, Mercer, Brian M, Silver, Robert M, Hoffman, Matthew K, Parry, Samuel, Iams, Jay D, Caritis, Steve N, Wapner, Ronald J, Esplin, M Sean, Elovitz, Michal A, Peaceman, Alan M, Chung, Judith, Saade, George R, and Reddy, Uma M
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Clinical Research ,Chronic Pain ,Clinical Trials and Supportive Activities ,Pain Research ,Reproductive health and childbirth ,Adult ,Ethnicity ,Female ,Humans ,Longitudinal Studies ,Nonprescription Drugs ,Parity ,Polypharmacy ,Pregnancy ,Pregnancy Complications ,Pregnancy Outcome ,Pregnancy Trimester ,First ,Prescription Drugs ,Prospective Studies ,United States ,Paediatrics and Reproductive Medicine ,Obstetrics & Reproductive Medicine ,Reproductive medicine - Abstract
ObjectiveTo characterize prescription and other medication use in a geographically and ethnically diverse cohort of women in their first pregnancy.MethodsIn a prospective, longitudinal cohort study of nulliparous women followed through pregnancy from the first trimester, medication use was chronicled longitudinally throughout pregnancy. Structured questions and aids were used to capture all medications taken as well as reasons they were taken. Total counts of all medications taken including number in each category and class were captured. Additionally, reasons the medications were taken were recorded. Trends in medications taken across pregnancy and in the first trimester were determined.ResultsOf the 9,546 study participants, 9,272 (97.1%) women took at least one medication during pregnancy with 9,139 (95.7%) taking a medication in the first trimester. Polypharmacy, defined as taking at least five medications, occurred in 2,915 (30.5%) women. Excluding vitamins, supplements, and vaccines, 73.4% of women took a medication during pregnancy with 55.1% taking one in the first trimester. The categories of drugs taken in pregnancy and in the first trimester include the following: gastrointestinal or antiemetic agents (34.3%, 19.5%), antibiotics (25.5%, 12.6%), and analgesics (23.7%, 15.6%, which includes 3.6%; 1.4% taking an opioid pain medication).ConclusionIn this geographically and ethnically diverse cohort of nulliparous pregnant women, medication use was nearly universal and polypharmacy was common.Clinical trial registrationClinicalTrials.gov, NCT01322529.
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- 2018
22. Predictors of sleep-disordered breathing in pregnancy
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Louis, Judette M, Koch, Matthew A, Reddy, Uma M, Silver, Robert M, Parker, Corette B, Facco, Francesca L, Redline, Susan, Nhan-Chang, Chia-Ling, Chung, Judith H, Pien, Grace W, Basner, Robert C, Grobman, William A, Wing, Deborah A, Simhan, Hyagriv N, Haas, David M, Mercer, Brian M, Parry, Samuel, Mobley, Daniel, Carper, Benjamin, Saade, George R, Schubert, Frank P, and Zee, Phyllis C
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Clinical Research ,Lung ,Sleep Research ,Neurosciences ,Behavioral and Social Science ,Mental Health ,Reproductive health and childbirth ,Adolescent ,Adult ,Blood Pressure ,Body Mass Index ,Female ,Humans ,Hypertension ,Maternal Age ,Polysomnography ,Pregnancy ,Pregnancy Complications ,Prevalence ,Risk Factors ,Sleep Apnea Syndromes ,Snoring ,Young Adult ,home sleep test ,pregnancy ,sleep-disordered breathing ,prediction ,Paediatrics and Reproductive Medicine ,Obstetrics & Reproductive Medicine - Abstract
BACKGROUND:Sleep-disordered breathing (SDB) is common in pregnancy, but there are limited data on predictors. OBJECTIVES:The objective of this study was to develop predictive models of sleep-disordered breathing during pregnancy. STUDY DESIGN:Nulliparous women completed validated questionnaires to assess for symptoms related to snoring, fatigue, excessive daytime sleepiness, insomnia, and restless leg syndrome. The questionnaires included questions regarding the timing of sleep and sleep duration, work schedules (eg, shift work, night work), sleep positions, and previously diagnosed sleep disorders. Frequent snoring was defined as self-reported snoring ≥3 days per week. Participants underwent in-home portable sleep studies for sleep-disordered breathing assessment in early (6-15 weeks gestation) and mid pregnancy (22-31 weeks gestation). Sleep-disordered breathing was characterized by an apnea hypopnea index that included all apneas, plus hypopneas with ≥3% oxygen desaturation. For primary analyses, an apnea hypopnea index ≥5 events per hour was used to define sleep-disordered breathing. Odds ratios and 95% confidence intervals were calculated for predictor variables. Predictive ability of the logistic models was estimated with area under the receiver-operating-characteristic curves, along with sensitivities, specificities, and positive and negative predictive values and likelihood ratios. RESULTS:Among 3705 women who were enrolled, data were available for 3264 and 2512 women in early and mid pregnancy, respectively. The corresponding prevalence of sleep-disordered breathing was 3.6% and 8.3%, respectively. At each time point in gestation, frequent snoring, chronic hypertension, greater maternal age, body mass index, neck circumference, and systolic blood pressure were associated most strongly with an increased risk of sleep-disordered breathing. Logistic regression models that included current age, body mass index, and frequent snoring predicted sleep-disordered breathing in early pregnancy, sleep-disordered breathing in mid pregnancy, and new onset sleep-disordered breathing in mid pregnancy with 10-fold cross-validated area under the receiver-operating-characteristic curves of 0.870, 0.838, and 0.809. We provide a supplement with expanded tables, integrated predictiveness, classification curves, and an predicted probability calculator. CONCLUSION:Among nulliparous pregnant women, logistic regression models with just 3 variables (ie, age, body mass index, and frequent snoring) achieved good prediction of prevalent and incident sleep-disordered breathing. These results can help with screening for sleep-disordered breathing in the clinical setting and for future clinical treatment trials.
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- 2018
23. Racial Disparities in Adverse Pregnancy Outcomes and Psychosocial Stress
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Grobman, William A, Parker, Corette B, Willinger, Marian, Wing, Deborah A, Silver, Robert M, Wapner, Ronald J, Simhan, Hyagriv N, Parry, Samuel, Mercer, Brian M, Haas, David M, Peaceman, Alan M, Hunter, Shannon, Wadhwa, Pathik, Elovitz, Michal A, Foroud, Tatiana, Saade, George, and Reddy, Uma M
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Infant Mortality ,Contraception/Reproduction ,Behavioral and Social Science ,Clinical Research ,Perinatal Period - Conditions Originating in Perinatal Period ,Pediatric ,Preterm ,Low Birth Weight and Health of the Newborn ,Mental Health ,Basic Behavioral and Social Science ,Aetiology ,2.3 Psychological ,social and economic factors ,Reproductive health and childbirth ,Good Health and Well Being ,Adult ,Ethnicity ,Female ,Health Status Disparities ,Humans ,Hypertension ,Pregnancy-Induced ,Infant ,Newborn ,Infant ,Small for Gestational Age ,Pregnancy ,Pregnancy Outcome ,Premature Birth ,Prospective Studies ,Self Report ,Stress ,Psychological ,White People ,Eunice Kennedy Shriver National Institute of Child Health and Human Development Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b) Network* ,Paediatrics and Reproductive Medicine ,Obstetrics & Reproductive Medicine ,Reproductive medicine - Abstract
ObjectiveTo assess the relationships between self-reported psychosocial stress and preterm birth, hypertensive disease of pregnancy, and small-for-gestational-age (SGA) birth and to assess the extent to which these relationships account for racial and ethnic disparities in these adverse outcomes.MethodsSelf-reported measures of psychosocial stress (perceived stress, depression, racism, anxiety, resilience, and social support) were collected during pregnancy among a racially and ethnically diverse cohort of women enrolled in a prospective observational study of nulliparous women with singleton pregnancies, from eight clinical sites across the United States, between October 2010 and May 2014. The associations of preterm birth, hypertensive disease of pregnancy, and SGA birth with the self-reported measures of psychosocial stress as well as with race and ethnicity were evaluated.ResultsThe study included 9,470 women (60.4% non-Hispanic white, 13.8% non-Hispanic black, 16.7% Hispanic, 4.0% Asian, and 5.0% other). Non-Hispanic black women were significantly more likely to experience any preterm birth, hypertensive disease of pregnancy, and SGA birth than were non-Hispanic white women (12.2% vs 8.0%, 16.7% vs 13.4%, and 17.2% vs 8.6%, respectively; P
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- 2018
24. Objectively measured short sleep duration and later sleep midpoint in pregnancy are associated with a higher risk of gestational diabetes
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Facco, Francesca L, Grobman, William A, Reid, Kathryn J, Parker, Corette B, Hunter, Shannon M, Silver, Robert M, Basner, Robert C, Saade, George R, Pien, Grace W, Manchanda, Shalini, Louis, Judette M, Nhan-Chang, Chia-Ling, Chung, Judith H, Wing, Deborah A, Simhan, Hyagriv N, Haas, David M, Iams, Jay, Parry, Samuel, and Zee, Phyllis C
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Diabetes ,Pediatric ,Hypertension ,Sleep Research ,Perinatal Period - Conditions Originating in Perinatal Period ,Clinical Research ,Reproductive health and childbirth ,Metabolic and endocrine ,Good Health and Well Being ,Actigraphy ,Adult ,Body Mass Index ,Cohort Studies ,Diabetes ,Gestational ,Female ,Humans ,Hypertension ,Pregnancy-Induced ,Personnel Staffing and Scheduling ,Pregnancy ,Racial Groups ,Sleep Initiation and Maintenance Disorders ,United States ,Young Adult ,actigraphy ,gestational diabetes ,hypertension ,pregnancy outcomes ,sleep duration ,sleep midpoint ,sleep quality ,Paediatrics and Reproductive Medicine ,Obstetrics & Reproductive Medicine ,Reproductive medicine - Abstract
BackgroundExperimental and epidemiologic data suggest that among nonpregnant adults, sleep duration may be an important risk factor for chronic disease. Although pregnant women commonly report poor sleep, few studies objectively evaluated the quality of sleep in pregnancy or explored the relationship between sleep disturbances and maternal and perinatal outcomes.ObjectiveOur objective was to examine the relationship between objectively assessed sleep duration, timing, and continuity (measured via wrist actigraphy) and maternal cardiovascular and metabolic morbidity specific to pregnancy.Study designThis was a prospective cohort study of nulliparous women. Women were recruited between 16 0/7 and 21 6/7 weeks' gestation. They were asked to wear a wrist actigraphy monitor and complete a daily sleep log for a period of 7 consecutive days. The primary sleep exposure variables were the averages of the following over the total valid nights (minimum 5, maximum 7 nights): short sleep duration during the primary sleep period (5 am), and top quartile of minutes of wake time after sleep onset and sleep fragmentation index. The primary outcomes of interest were a composite of hypertensive disorders of pregnancy (mild, severe, or superimposed preeclampsia; eclampsia; or antepartum gestational hypertension) and gestational diabetes mellitus. We used χ2 tests to assess associations between sleep variables and categorical baseline characteristics. Crude odds ratios and 95% confidence intervals were estimated from univariate logistic regression models to characterize the magnitude of the relationship between sleep characteristics and hypertensive disorders of pregnancy and gestational diabetes. For associations significant in univariate analysis, multiple logistic regression was used to explore further the association of sleep characteristics with pregnancy outcomes.ResultsIn all, 901 eligible women consented to participate; 782 submitted valid actigraphy studies. Short sleep duration and a later sleep midpoint were associated with an increased risk of gestational diabetes (odds ratio, 2.24; 95% confidence interval, 1.11-4.53; and odds ratio, 2.58; 95% confidence interval, 1.24-5.36, respectively) but not of hypertensive disorders. A model with both sleep duration and sleep midpoint as well as their interaction term revealed that while there was no significant interaction between these exposures, the main effects of both short sleep duration and later sleep midpoint with gestational diabetes remained significant (adjusted odds ratio, 2.06; 95% confidence interval, 1.01-4.19; and adjusted odds ratio, 2.37; 95% confidence interval, 1.13-4.97, respectively). Additionally, after adjusting separately for age, body mass index, and race/ethnicity, both short sleep duration and later sleep midpoint remained associated with gestational diabetes. No associations were demonstrated between the sleep quality measures (wake after sleep onset, sleep fragmentation) and hypertensive disorders or gestational diabetes.ConclusionOur results demonstrate a relationship between short sleep duration and later sleep midpoint with gestational diabetes. Our data suggest independent contributions of these 2 sleep characteristics to the risk for gestational diabetes in nulliparous women.
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- 2017
25. Association of second trimester uterine artery Doppler parameters with maternal hypertension 2–7 years after delivery
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Miller, Eliza C., Carper, Benjamin, Bello, Natalie A., Bairey Merz, C. Noel, Greenland, Philip, Levine, Lisa D., Haas, David M., Grobman, William A., McNeil, Rebecca B., Chung, Judith H., Jolley, Jennifer, Saade, George R., Silver, Robert M., Simhan, Hyagriv N., Wapner, Ronald J., and Parker, Corette B.
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- 2021
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26. Variation in self-identified most stressful life event by outcome of previous pregnancy in a population-based sample interviewed 6–36 months following delivery
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Stanhope, Kaitlyn K., Temple, Jeff R., Bann, Carla, Parker, Corette B., Dudley, Donald, and Hogue, Carol J.R.
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- 2021
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27. Objectively assessed sleep-disordered breathing during pregnancy and infant birthweight
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Hawkins, Marquis, Parker, Corette B., Redline, Susan, Larkin, Jacob C., Zee, Phyllis P., Grobman, William A., Silver, Robert M., Louis, Judette M., Pien, Grace W., Basner, Robert C., Chung, Judith H., Haas, David M., Nhan-Chang, Chia-Ling, Simhan, Hyagriv N., Blue, Nathan R., Parry, Samuel, Reddy, Uma, and Facco, Francesca
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- 2021
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28. Racial or Ethnic and Socioeconomic Inequalities in Adherence to National Dietary Guidance in a Large Cohort of US Pregnant Women
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Bodnar, Lisa M, Simhan, Hyagriv N, Parker, Corette B, Meier, Heather, Mercer, Brian M, Grobman, William A, Haas, David M, Wing, Deborah A, Hoffman, Matthew K, Parry, Samuel, Silver, Robert M, Saade, George R, Wapner, Ronald, Iams, Jay D, Wadhwa, Pathik D, Elovitz, Michal, Peaceman, Alan M, Esplin, Sean, Barnes, Shannon, and Reddy, Uma M
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Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Nutrition and Dietetics ,Reproductive Medicine ,Prevention ,Nutrition ,Metabolic and endocrine ,Cardiovascular ,Reduced Inequalities ,Adult ,Cohort Studies ,Cross-Sectional Studies ,Diet ,Ethnicity ,Female ,Food Quality ,Humans ,Micronutrients ,Nutrition Assessment ,Nutrition Policy ,Patient Compliance ,Pregnancy ,Pregnant Women ,Prospective Studies ,Socioeconomic Factors ,Surveys and Questionnaires ,United States ,Young Adult ,Dietary guidance ,Healthy Eating Index ,Preconception ,Pregnancy inequalities ,Clinical Sciences ,Anthropology ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundThe significance of periconceptional nutrition for optimizing offspring and maternal health and reducing social inequalities warrants greater understanding of diet quality among US women.ObjectiveOur objective was to evaluate racial or ethnic and education inequalities in periconceptional diet quality and sources of energy and micronutrients.DesignCross-sectional analysis of data from the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be cohort.Participants and settingNulliparous women (N=7,511) were enrolled across eight US medical centers from 2010 to 2013.Main outcome measuresA semiquantitative food frequency questionnaire assessing usual dietary intake during the 3 months around conception was self-administered during the first trimester. Diet quality, measured using the Healthy Eating Index-2010 (HEI-2010), and sources of energy and micronutrients were the outcomes.Statistical analysesDifferences in diet quality were tested across maternal racial or ethnic and education groups using F tests associated with analysis of variance and χ2 tests.ResultsHEI-2010 score increased with higher education, but the increase among non-Hispanic black women was smaller than among non-Hispanic whites and Hispanics (interaction P value
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- 2017
29. Sleep During Pregnancy: The nuMoM2b Pregnancy and Sleep Duration and Continuity Study
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Reid, Kathryn J, Facco, Francesca L, Grobman, William A, Parker, Corette B, Herbas, Marcos, Hunter, Shannon, Silver, Robert M, Basner, Robert C, Saade, George R, Pien, Grace W, Manchanda, Shalini, Louis, Judette M, Nhan-Chang, Chia-Lang, Chung, Judith H, Wing, Deborah A, Simhan, Hyagriv N, Haas, David M, Iams, Jay, Parry, Samuel, and Zee, Phyllis C
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Sleep Research ,Behavioral and Social Science ,Clinical Research ,Reproductive health and childbirth ,Actigraphy ,Adult ,Age Factors ,Body Mass Index ,Ethnicity ,Female ,Humans ,Insurance Coverage ,Insurance ,Health ,Pregnancy ,Prospective Studies ,Racial Groups ,Sleep ,Smoking ,Time Factors ,Wakefulness ,Young Adult ,pregnancy ,sleep duration ,sleep quality ,epidemiology ,epidemiology. ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery - Abstract
To characterize sleep duration, timing and continuity measures in pregnancy and their association with key demographic variables. Multisite prospective cohort study. Women enrolled in the nuMoM2b study (nulliparous women with a singleton gestation) were recruited at the second study visit (16-21 weeks of gestation) to participate in the Sleep Duration and Continuity substudy. Women 9 hours. In multivariable models including age, race/ethnicity, body mass index, insurance status, and recent smoking history, sleep duration was significantly associated with race/ethnicity and insurance status, while time in bed was only associated with insurance status. Sleep continuity measures and sleep midpoint were significantly associated with all covariates in the model, with the exception of age for fragmentation index and smoking for wake after sleep onset. Our results demonstrate the relationship between sleep and important demographic characteristics during pregnancy.
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- 2017
30. Predictive Accuracy of Serial Transvaginal Cervical Lengths and Quantitative Vaginal Fetal Fibronectin Levels for Spontaneous Preterm Birth Among Nulliparous Women.
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Esplin, M Sean, Elovitz, Michal A, Iams, Jay D, Parker, Corette B, Wapner, Ronald J, Grobman, William A, Simhan, Hyagriv N, Wing, Deborah A, Haas, David M, Silver, Robert M, Hoffman, Matthew K, Peaceman, Alan M, Caritis, Steve N, Parry, Samuel, Wadhwa, Pathik, Foroud, Tatiana, Mercer, Brian M, Hunter, Shannon M, Saade, George R, and Reddy, Uma M
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Adolescent ,Adult ,Area Under Curve ,Biomarkers: analysis ,Cervical Length Measurement: methods ,Cervix Uteri: anatomy & histology ,Female ,Fetus ,Fibronectins: analysis ,Gestational Age ,Humans ,Parity ,Predictive Value of Tests ,Pregnancy ,Premature Birth: diagnosis ,ethnology ,Prospective Studies ,ROC Curve ,Vagina: chemistry ,Young Adult - Abstract
Spontaneous preterm birth is a leading cause of infant mortality. Prediction, largely based on prior pregnancy outcomes, is not possible in women pregnant for the first time.To assess the accuracy of universal screening to predict spontaneous preterm birth in nulliparous women using serial measurements of vaginal fetal fibronectin levels and cervical length.A prospective observational cohort study of nulliparous women with singleton pregnancies, from 8 clinical sites across the United States between October 2010 and May 2014. Women and clinicians were blinded to results unless cervical shortening less than 15 mm was identified.Transvaginal cervical length and quantitative vaginal fetal fibronectin levels were reviewed at 2 study visits 4 or more weeks apart.Spontaneous preterm birth at less than 37 weeks was the primary outcome. Cervical length and quantitative fetal fibronectin were considered independently and together at each visit. Measurement distributions were compared for spontaneous preterm birth vs all other births. Spontaneous preterm birth before 32 weeks was a secondary outcome.The study included 9410 women (median age, 27.0 [interquartile range, 9.0] years; 60.7% non-Hispanic white, 13.8% non-Hispanic black, 16.5% Hispanic, 4.0% Asian, and 5.1% other), of whom 474 (5.0%) had spontaneous preterm births, 335 (3.6%) had medically indicated preterm births, and 8601 (91.4%) had term births. Among women with spontaneous preterm birth, cervical length of 25 mm or less occurred in 35 of 439 (8.0%) at 16 to 22 weeks' gestation and in 94 of 403 (23.3%) at 22 to 30 weeks' gestation. Fetal fibronectin levels of 50 ng/mL or greater at 16 to 22 weeks identified 30 of 410 women (7.3%) with spontaneous preterm birth and 31 of 384 (8.1%) at 22 to 30 weeks. The area under the receiver operating characteristic curve for screening between 22 and 30 weeks for fetal fibronectin level alone was 0.59 (95% CI, 0.56-0.62), for transvaginal cervical length alone was 0.67 (95% CI, 0.64-0.70), and for the combination as continuous variables was 0.67 (95% CI, 0.64-0.70).Among nulliparous women with singleton pregnancies, quantitative vaginal fetal fibronectin and serial transvaginal ultrasound cervical length had low predictive accuracy for spontaneous preterm birth. These findings do not support routine use of these tests in such women.
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- 2017
31. Psychometric properties of stress and anxiety measures among nulliparous women.
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Bann, Carla M, Parker, Corette B, Grobman, William A, Willinger, Marian, Simhan, Hyagriv N, Wing, Deborah A, Haas, David M, Silver, Robert M, Parry, Samuel, Saade, George R, Wapner, Ronald J, Elovitz, Michal A, Miller, Emily S, and Reddy, Uma M
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Adult ,Anxiety: diagnosis ,Female ,Humans ,Parity ,Pregnancy ,Pregnancy Complications: diagnosis ,Pregnant Women: psychology ,Psychiatric Status Rating Scales: standards ,Psychometrics: instrumentation ,Stress ,Psychological: diagnosis ,Young Adult - Abstract
To examine the psychometric properties of three measures, the perceived stress scale (PSS), pregnancy experience scale (PES), and state trait anxiety inventory (STAI), for assessing stress and anxiety during pregnancy among a large sample of nulliparous women.The sample included 10,002 pregnant women participating in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nMoM2b). Internal consistency reliability was assessed with Cronbach's alpha and factorial validity with confirmatory factor analyses. Intraclass correlations (ICCs) were calculated to determine stability of PSS scales over time. Psychometric properties were examined for the overall sample, as well as subgroups based on maternal age, race/ethnicity and language.All three scales demonstrated good internal consistency reliability. Confirmatory factor analyses supported the factor structures of the PSS and the PES. However, a one-factor solution of the trait-anxiety subscale from the STAI did not fit well; a two-factor solution, splitting the items into factors based on direction of item wording (positive versus negative) provided a better fit. Scores on the PSS were generally stable over time (ICC = 0.60). Subgroup analyses revealed a few items that did not perform well on Spanish versions of the scales.Overall, the scales performed well, suggesting they could be useful tools for identifying women experiencing high levels of stress and anxiety during pregnancy and allowing for the implementation of interventions to help reduce maternal stress and anxiety.
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- 2017
32. Association Between Sleep-Disordered Breathing and Hypertensive Disorders of Pregnancy and Gestational Diabetes Mellitus
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Facco, Francesca L, Parker, Corette B, Reddy, Uma M, Silver, Robert M, Koch, Matthew A, Louis, Judette M, Basner, Robert C, Chung, Judith H, Nhan-Chang, Chia-Ling, Pien, Grace W, Redline, Susan, Grobman, William A, Wing, Deborah A, Simhan, Hyagriv N, Haas, David M, Mercer, Brian M, Parry, Samuel, Mobley, Daniel, Hunter, Shannon, Saade, George R, Schubert, Frank P, and Zee, Phyllis C
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Hypertension ,Cardiovascular ,Perinatal Period - Conditions Originating in Perinatal Period ,Sleep Research ,Lung ,Clinical Research ,Contraception/Reproduction ,Pediatric ,Reproductive health and childbirth ,Adolescent ,Adult ,Diabetes ,Gestational ,Female ,Gestational Age ,Humans ,Hypertension ,Pregnancy-Induced ,Incidence ,Polysomnography ,Pre-Eclampsia ,Pregnancy ,Pregnancy Trimesters ,Prevalence ,Prospective Studies ,Risk Factors ,Severity of Illness Index ,Sleep Apnea Syndromes ,United States ,Young Adult ,Paediatrics and Reproductive Medicine ,Obstetrics & Reproductive Medicine - Abstract
ObjectiveTo estimate whether sleep-disordered breathing during pregnancy is a risk factor for the development of hypertensive disorders of pregnancy and gestational diabetes mellitus (GDM).MethodsIn this prospective cohort study, nulliparous women underwent in-home sleep-disordered breathing assessments in early (6-15 weeks of gestation) and midpregnancy (22-31 weeks of gestation). Participants and health care providers were blinded to the sleep test results. An apnea-hypopnea index of 5 or greater was used to define sleep-disordered breathing. Exposure-response relationships were examined, grouping participants into four apnea-hypopnea index groups: 0, greater than 0 to less than 5, 5 to less than 15, and 15 or greater. The study was powered to test the primary hypothesis that sleep-disordered breathing occurring in pregnancy is associated with an increased incidence of preeclampsia. Secondary outcomes were rates of hypertensive disorders of pregnancy, defined as preeclampsia and antepartum gestational hypertension, and GDM. Crude and adjusted odds ratios and 95% confidence intervals (CIs) were calculated from univariate and multivariate logistic regression models.ResultsThree thousand seven hundred five women were enrolled. Apnea-hypopnea index data were available for 3,132 (84.5%) and 2,474 (66.8%) women in early and midpregnancy, respectively. The corresponding prevalence of sleep-disordered breathing was 3.6% and 8.3%. The prevalence of preeclampsia was 6.0%, hypertensive disorders of pregnancy 13.1%, and GDM 4.1%. In early and midpregnancy the adjusted odds ratios for preeclampsia when sleep-disordered breathing was present were 1.94 (95% CI 1.07-3.51) and 1.95 (95% CI 1.18-3.23), respectively; hypertensive disorders of pregnancy 1.46 (95% CI 0.91-2.32) and 1.73 (95% CI 1.19-2.52); and GDM 3.47 (95% CI 1.95-6.19) and 2.79 (95% CI 1.63-4.77). Increasing exposure-response relationships were observed between apnea-hypopnea index and both hypertensive disorders and GDM.ConclusionThere is an independent association between sleep-disordered breathing and preeclampsia, hypertensive disorders of pregnancy, and GDM.
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- 2017
33. Racial/Ethnic Disparities in Measures of Self-reported Psychosocial States and Traits during Pregnancy
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Grobman, William A, Parker, Corette, Wadhwa, Pathik D, Willinger, Marian, Simhan, Hyagriv, Silver, Bob, Wapner, Ron J, Parry, Samuel, Mercer, Brian, Haas, David, Peaceman, Alan M, Hunter, Shannon, Wing, Deborah, Caritis, Steve, Esplin, Sean, Hoffman, Matt, Ludmir, Jack, Iams, Jay, Long, Emily, Saade, George, and Reddy, Uma M
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Midwifery ,Health Sciences ,Basic Behavioral and Social Science ,Mental Health ,Behavioral and Social Science ,Clinical Research ,Good Health and Well Being ,Adult ,Female ,Health Status Disparities ,Healthcare Disparities ,Humans ,Logistic Models ,Pregnancy ,Pregnancy Complications ,Prospective Studies ,Psychiatric Status Rating Scales ,Racial Groups ,Self Report ,Socioeconomic Factors ,Stress ,Psychological ,United States ,Young Adult ,psychosocial ,stress ,disparities ,pregnancy ,Eunice Kennedy Shriver National Institute of Child Health Human Development nuMoM2b Network ,Bethesda ,MD ,Clinical Sciences ,Paediatrics and Reproductive Medicine ,Obstetrics & Reproductive Medicine ,Paediatrics ,Reproductive medicine - Abstract
Background The aim of this study was to determine whether racial/ethnic differences in psychosocial measures, independent of economic status, exist among a large population of pregnant nulliparas. Methods Between October 2010 and September 2013, nulliparous women at eight U.S. medical centers were followed longitudinally during pregnancy and completed validated instruments to quantify several psychosocial domains: Cohen Perceived Stress Scale, trait subscale of the Spielberger Anxiety Inventory, Connor-Davidson Resilience Scale, Multidimensional Scale of Perceived Social Support, Krieger Racism Scale, Edinburgh Postnatal Depression Scale, and the Pregnancy Experience Scale. Scores were stratified and compared by self-reported race, ethnicity, and income. Results Complete data were available for 8,128 of the 10,038 women enrolled in the study. For all measures, race and ethnicity were significantly associated (p 0.05) except on the Krieger racism survey and the Edinburgh depression survey, which were exacerbated among NHB women with higher income (interaction, p
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- 2016
34. DLK1: A Novel Biomarker of Placental Insufficiency in Stillbirth and Live Birth.
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Page, Jessica M., Allshouse, Amanda A., Gaffney, Jessica E., Roberts, Victoria H. J., Thorsten, Vanessa, Gibbins, Karen J., Dudley, Donald J., Saade, George, Goldenberg, Robert L., Stoll, Barbara J., Hogue, Carol J., Bukowski, Radek, Parker, Corette, Conway, Deborah, Reddy, Uma M., Varner, Michael W., Frias, Antonio E., and Silver, Robert M.
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FETAL malnutrition ,CROSS-sectional method ,PLACENTA ,SMALL for gestational age ,CALCIUM-binding proteins ,FETAL growth retardation ,LOGISTIC regression analysis ,ENZYME-linked immunosorbent assay ,PREGNANCY outcomes ,PERINATAL death ,DESCRIPTIVE statistics ,ODDS ratio ,GESTATIONAL age ,RESEARCH ,GROWTH factors ,COMPARATIVE studies ,BIOMARKERS ,MEMBRANE proteins ,REGRESSION analysis - Abstract
Objective Delta-like homolog 1 (DLK1) is a growth factor that is reduced in maternal sera in pregnancies with small for gestational age neonates. We sought to determine if DLK1 is associated with stillbirth (SB), with and without placental insufficiency. Study Design A nested case-control study was performed using maternal sera from a multicenter case-control study of SB and live birth (LB). SB and LB were stratified as placental insufficiency cases (small for gestational age <5% or circulatory lesions on placental histopathology) or normal placenta controls (appropriate for gestational age and no circulatory lesions). Enzyme-linked immunosorbent assay (ELISA) was used to measure DLK1. The mean difference in DLK1 was compared on the log scale in an adjusted linear regression model with pairwise differences, stratified by term/preterm deliveries among DLK1 results in the quantifiable range. In exploratory analysis, geometric means were compared among all data and the proportion of "low DLK1" (less than the median value for gestational age) was compared between groups and modeled using linear and logistic regression, respectively. Results Overall, 234 SB and 234 LB were analyzed; 246 DLK1 values were quantifiable within the standard curve. Pairwise comparisons of case and control DLK1 geometric means showed no significant differences between groups. In exploratory analysis of all data, adjusted analysis revealed a significant difference for the LB comparison only (SB: 71.9 vs. 99.1 pg/mL, p = 0.097; LB: 37.6 vs. 98.1 pg/mL, p = 0.005). In exploratory analysis of "low DLK1," there was a significant difference between the odds ratio of having "low DLK1" between preterm cases and controls for both SB and LB. There were no significant differences in geometric means nor "low DLK1" between SB and LB. Conclusion In exploratory analysis, more placental insufficiency cases in preterm SB and LB had "low DLK1." However, low DLK1 levels were not associated with SB. Key Points Maternally circulating DLK1 is correlated with placental insufficiency. Maternally circulating DLK1 is not correlated with SB. DLK1 is a promising marker for placental insufficiency. [ABSTRACT FROM AUTHOR]
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- 2024
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35. Ultrasound Measurement of the Fetal Adrenal Gland as a Predictor of Spontaneous Preterm Birth
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Hoffman, Matthew K, Turan, Ozhan M, Parker, Corette B, Wapner, Ronald J, Wing, Deborah A, Haas, David M, Esplin, M. Sean, Parry, Samuel, Grobman, William A, Simhan, Hyagriv N, Myers, Stephen, Holder, Tommy E, Rumney, Pamela, Litton, Christian G, Silver, Robert M, Elovitz, Michal A, Peaceman, Alan M, Emery, Stephen, Mercer, Brian M, Koch, Matthew A, and Saade, George R
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- 2016
36. Pregnancy as a Window to Future Cardiovascular Health: Design and Implementation of the nuMoM2b Heart Health Study
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Haas, David M, Ehrenthal, Deborah B, Koch, Matthew A, Catov, Janet M, Barnes, Shannon E, Facco, Francesca, Parker, Corette B, Mercer, Brian M, Bairey-Merz, C. Noel, Silver, Robert M, Wapner, Ronald J, Simhan, Hyagriv N, Hoffman, Matthew K, Grobman, William A, Greenland, Philip, Wing, Deborah A, Saade, George R, Parry, Samuel, Zee, Phyllis C, Reddy, Uma M, Pemberton, Victoria L, and Burwen, Dale R
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- 2016
37. NuMoM2b Sleep-Disordered Breathing study: objectives and methods
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Facco, Francesca L, Parker, Corette B, Reddy, Uma M, Silver, Robert M, Louis, Judette M, Basner, Robert C, Chung, Judith H, Schubert, Frank P, Pien, Grace W, Redline, Susan, Mobley, Daniel R, Koch, Matthew A, Simhan, Hyagriv N, Nhan-Chang, Chia-Ling, Parry, Samuel, Grobman, William A, Haas, David M, Wing, Deborah A, Mercer, Brian M, Saade, George R, and Zee, Phyllis C
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Sleep Research ,Pediatric ,Conditions Affecting the Embryonic and Fetal Periods ,Clinical Research ,Behavioral and Social Science ,Infant Mortality ,Neurosciences ,Preterm ,Low Birth Weight and Health of the Newborn ,Cardiovascular ,Lung ,Contraception/Reproduction ,Perinatal Period - Conditions Originating in Perinatal Period ,Reproductive health and childbirth ,Good Health and Well Being ,Adolescent ,Adult ,Clinical Protocols ,Double-Blind Method ,Female ,Humans ,Polysomnography ,Pregnancy ,Pregnancy Complications ,Pregnancy Outcome ,Prospective Studies ,Research Design ,Risk Factors ,Sleep Apnea Syndromes ,Young Adult ,home sleep test ,methods ,pregnancy ,sleep-disordered breathing ,sleep ,Paediatrics and Reproductive Medicine ,Obstetrics & Reproductive Medicine ,Reproductive medicine - Abstract
ObjectiveThe objective of the Sleep Disordered Breathing substudy of the Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-be (nuMoM2b) is to determine whether sleep disordered breathing during pregnancy is a risk factor for adverse pregnancy outcomes.Study designNuMoM2b is a prospective cohort study of 10,037 nulliparous women with singleton gestations that was conducted across 8 sites with a central Data Coordinating and Analysis Center. The Sleep Disordered Breathing substudy recruited 3702 women from the cohort to undergo objective, overnight in-home assessments of sleep disordered breathing. A standardized level 3 home sleep test was performed between 6(0)-15(0) weeks' gestation (visit 1) and again between 22(0)-31(0) weeks' gestation (visit 3). Scoring of tests was conducted by a central Sleep Reading Center. Participants and their health care providers were notified if test results met "urgent referral" criteria that were based on threshold levels of apnea hypopnea indices, oxygen saturation levels, or electrocardiogram abnormalities but were not notified of test results otherwise. The primary pregnancy outcomes to be analyzed in relation to maternal sleep disordered breathing are preeclampsia, gestational hypertension, gestational diabetes mellitus, fetal growth restriction, and preterm birth.ResultsObjective data were obtained at visit 1 on 3261 women, which was 88.1% of the studies that were attempted and at visit 3 on 2511 women, which was 87.6% of the studies that were attempted. Basic characteristics of the substudy cohort are reported in this methods article.ConclusionThe substudy was designed to address important questions regarding the relationship of sleep-disordered breathing on the risk of preeclampsia and other outcomes of relevance to maternal and child health.
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- 2015
38. A description of the methods of the Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be (nuMoM2b)
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Haas, David M, Parker, Corette B, Wing, Deborah A, Parry, Samuel, Grobman, William A, Mercer, Brian M, Simhan, Hyagriv N, Hoffman, Matthew K, Silver, Robert M, Wadhwa, Pathik, Iams, Jay D, Koch, Matthew A, Caritis, Steve N, Wapner, Ronald J, Esplin, M. Sean, Elovitz, Michal A, Foroud, Tatiana, Peaceman, Alan M, Saade, George R, Willinger, Marian, and Reddy, Uma M
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- 2015
39. Interpregnancy interval and risk of stillbirth: a population-based case control study
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Gupta, Priya M., Freedman, Alexa A., Kramer, Michael R., Goldenberg, Robert L., Willinger, Marian, Stoll, Barbara J., Silver, Robert M., Dudley, Donald J., Parker, Corette B., and Hogue, Carol J.R.
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- 2019
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40. Placental protein levels in maternal serum are associated with adverse pregnancy outcomes in nulliparous patients
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Parry, Samuel, Carper, Benjamin A., Grobman, William A., Wapner, Ronald J., Chung, Judith H., Haas, David M., Mercer, Brian, Silver, Robert M., Simhan, Hyagriv N., Saade, George R., Reddy, Uma M., and Parker, Corette B.
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- 2022
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41. Association between Sleep Disordered Breathing and Neonatal Outcomes in Nulliparous Individuals
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Delgado, Arlin, additional, Kendle, Anthony M., additional, Randis, Tara, additional, Donda, Keyur, additional, Salemi, Jason L., additional, Facco, Francesca L., additional, Parker, Corette B., additional, Reddy, Uma M., additional, Silver, Robert M., additional, Basner, Robert C., additional, Chung, Judith H., additional, Schubert, Frank P., additional, Pien, Grace W., additional, Redline, Susan, additional, Parry, Samuel, additional, Grobman, William A., additional, Zee, Phyllis C., additional, and Louis, Judette M., additional
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- 2023
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42. Characteristics of Stillbirths Associated With Diabetes in a Diverse U.S. Cohort
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Page, Jessica M., Allshouse, Amanda A., Cassimatis, Irina, Smid, Marcela C., Arslan, Erol, Thorsten, Vanessa, Parker, Corette, Varner, Michael W., Dudley, Donald J., Saade, George R., Goldenberg, Robert L., Stoll, Barbara J., Hogue, Carol J., Bukowski, Radek, Conway, Deborah, Pinar, Halit, Reddy, Uma M., and Silver, Robert M.
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- 2020
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43. Fetal death certificate data quality: a tale of two U.S. counties
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Christiansen-Lindquist, Lauren, Silver, Robert M., Parker, Corette B., Dudley, Donald J., Koch, Matthew A., Reddy, Uma M., Saade, George R., Goldenberg, Robert L., and Hogue, Carol J.R.
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- 2017
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44. The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort.
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Knapp, Emily, Knapp, Emily, Kress, Amii, Parker, Corette, Page, Grier, McArthur, Kristen, Gachigi, Kennedy, Alshawabkeh, Akram, Aschner, Judy, Bastain, Theresa, Breton, Carrie, Bendixsen, Casper, Brennan, Patricia, Camargo, Carlos, Catellier, Diane, Cordero, José, Croen, Lisa, Dabelea, Dana, Deoni, Sean, DSa, Viren, Duarte, Cristiane, Dunlop, Anne, Elliott, Amy, Farzan, Shohreh, Ferrara, Assiamira, Ganiban, Jody, Gern, James, Giardino, Angelo, Towe-Goodman, Nissa, Gold, Diane, Habre, Rima, Hamra, Ghassan, Hartert, Tina, Herbstman, Julie, Hipwell, Alison, Karagas, Margaret, Karr, Catherine, Keenan, Kate, Kerver, Jean, Koinis-Mitchell, Daphne, Lau, Bryan, Lester, Barry, Leve, Leslie, Leventhal, Bennett, LeWinn, Kaja, Lewis, Johnnye, Litonjua, Augusto, Lyall, Kristen, Madan, Juliette, McEvoy, Cindy, McGrath, Monica, Meeker, John, Miller, Rachel, Wright, Rosalind, Zhao, Qi, Jacobson, Lisa, Influences On Child Health Outcomes, On, Neiderhiser, Jenae, OConnor, Thomas, Oken, Emily, OShea, Michael, Paneth, Nigel, Porucznik, Christina, Sathyanarayana, Sheela, Schantz, Susan, Spindel, Eliot, Stanford, Joseph, Stroustrup, Annemarie, Teitelbaum, Susan, Trasande, Leonardo, Volk, Heather, Weiss, Scott, Wadhwa, Pathik, Woodruff, Tracey, Morello-Frosch, Rachel, Hertz-Picciotto, Irva, Bush, Nicole, Buss, Claudia, Knapp, Emily, Knapp, Emily, Kress, Amii, Parker, Corette, Page, Grier, McArthur, Kristen, Gachigi, Kennedy, Alshawabkeh, Akram, Aschner, Judy, Bastain, Theresa, Breton, Carrie, Bendixsen, Casper, Brennan, Patricia, Camargo, Carlos, Catellier, Diane, Cordero, José, Croen, Lisa, Dabelea, Dana, Deoni, Sean, DSa, Viren, Duarte, Cristiane, Dunlop, Anne, Elliott, Amy, Farzan, Shohreh, Ferrara, Assiamira, Ganiban, Jody, Gern, James, Giardino, Angelo, Towe-Goodman, Nissa, Gold, Diane, Habre, Rima, Hamra, Ghassan, Hartert, Tina, Herbstman, Julie, Hipwell, Alison, Karagas, Margaret, Karr, Catherine, Keenan, Kate, Kerver, Jean, Koinis-Mitchell, Daphne, Lau, Bryan, Lester, Barry, Leve, Leslie, Leventhal, Bennett, LeWinn, Kaja, Lewis, Johnnye, Litonjua, Augusto, Lyall, Kristen, Madan, Juliette, McEvoy, Cindy, McGrath, Monica, Meeker, John, Miller, Rachel, Wright, Rosalind, Zhao, Qi, Jacobson, Lisa, Influences On Child Health Outcomes, On, Neiderhiser, Jenae, OConnor, Thomas, Oken, Emily, OShea, Michael, Paneth, Nigel, Porucznik, Christina, Sathyanarayana, Sheela, Schantz, Susan, Spindel, Eliot, Stanford, Joseph, Stroustrup, Annemarie, Teitelbaum, Susan, Trasande, Leonardo, Volk, Heather, Weiss, Scott, Wadhwa, Pathik, Woodruff, Tracey, Morello-Frosch, Rachel, Hertz-Picciotto, Irva, Bush, Nicole, and Buss, Claudia
- Abstract
The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort Study (EWC), a collaborative research design comprising 69 cohorts in 31 consortia, was funded by the National Institutes of Health (NIH) in 2016 to improve childrens health in the United States. The EWC harmonizes extant data and collects new data using a standardized protocol, the ECHO-Wide Cohort Data Collection Protocol (EWCP). EWCP visits occur at least once per life stage, but the frequency and timing of the visits vary across cohorts. As of March 4, 2022, the EWC cohorts contributed data from 60,553 children and consented 29,622 children for new EWCP data and biospecimen collection. The median (interquartile range) age of EWCP-enrolled children was 7.5 years (3.7-11.1). Surveys, interviews, standardized examinations, laboratory analyses, and medical record abstraction are used to obtain information in 5 main outcome areas: pre-, peri-, and postnatal outcomes; neurodevelopment; obesity; airways; and positive health. Exposures include factors at the level of place (e.g., air pollution, neighborhood socioeconomic status), family (e.g., parental mental health), and individuals (e.g., diet, genomics).
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- 2023
45. A Diagnostic for Cox Regression with Discrete Failure-Time Models
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Parker, Corette B. and Delong, Elizabeth R.
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- 2000
46. Prospective Evaluation of Maternal Sleep Position Through 30 Weeks of Gestation and Adverse Pregnancy Outcomes
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Silver, Robert M., Hunter, Shannon, Reddy, Uma M., Facco, Francesca, Gibbins, Karen J., Grobman, William A., Mercer, Brian M., Haas, David M., Simhan, Hyagriv N., Parry, Samuel, Wapner, Ronald J., Louis, Judette, Chung, Judith M., Pien, Grace, Schubert, Frank P., Saade, George R., Zee, Phyllis, Redline, Susan, and Parker, Corette B.
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- 2020
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47. Adverse Pregnancy Outcomes and Future Metabolic Syndrome.
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Ehrenthal, Deborah B., McNeil, Rebecca B., Crenshaw, Emma G., Bairey Merz, C. Noel, Grobman, William A., Parker, Corette B., Greenland, Philip, Pemberton, Victoria L., Zee, Phyllis C., Scifres, Christina M., Polito, LuAnn, and Saade, George
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METABOLIC syndrome risk factors ,HYPERTENSION in pregnancy ,RELATIVE medical risk ,MOTHERS ,PREMATURE infants ,CONFIDENCE intervals ,ANTHROPOMETRY ,AGE distribution ,SELF-evaluation ,ACQUISITION of data ,PREGNANT women ,PREGNANCY outcomes ,RISK assessment ,SURVEYS ,RESEARCH funding ,MEDICAL records ,METABOLIC syndrome ,MATERNAL age ,HEALTH insurance ,DESCRIPTIVE statistics ,GESTATIONAL diabetes ,COLLECTION & preservation of biological specimens ,BODY mass index ,SMOKING ,LONGITUDINAL method ,DISEASE complications - Abstract
Background: Metabolic syndrome (MetS) is associated with a history of gestational diabetes (GDM), hypertensive disorders of pregnancy (HDP), and preterm birth (PTB), but it is unclear whether this association is due to the pregnancy complication(s) or prepregnancy/early pregnancy confounders. The study examines the association of GDM, HDP, and PTB with MetS 2–7 years later, independent of early pregnancy factors. Materials and Methods: Large, diverse cohort of nulliparous pregnant people with singleton gestations enrolled during their first trimester and who attended a follow-up study visit 2–7 years after delivery. The longitudinal cohort was recruited from eight medical centers across the United States. Using standardized protocols, anthropometry, biospecimens, and surveys were collected at study visits and pregnancy outcomes were abstracted from medical records. We estimated the relative risk of prevalent MetS at the follow-up study visit for participants with GDM, HDP, or PTB (vs. no complications), adjusting for early pregnancy age, body mass index, self-reported race/ethnicity, insurance type, and smoking status. Results: Of 4,402 participants, 738 (16.8%) had MetS at follow-up: 13.1% (441/3,365) among those with no complications, and 27.9% (290/1,002) among those with complications. MetS occurred in 39.0% of GDM (73/187, adjusted relative risk [aRR] = 1.75; 95% confidence interval [CI] 1.42–2.16); 29.2% of HDP (176/603, aRR = 1.49; 95% CI 1.27–1.75); and 29.7% of PTB (113/380, aRR = 1.78; 95% CI 1.49–2.12). Those who had both HDP and PTB (n = 113) had an aRR = 1.95 (95% CI 1.50–2.54). Conclusions: People whose pregnancies were complicated by GDM, HDP, or PTB are at a higher risk of MetS within 2–7 years after delivery, independent of early pregnancy risk factors. The highest MetS risk follows pregnancies complicated by both HDP and PTB. [ABSTRACT FROM AUTHOR]
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- 2023
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48. Role of early second-trimester uterine artery Doppler screening to predict small-for-gestational-age babies in nulliparous women
- Author
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Parry, Samuel, Sciscione, Anthony, Haas, David M., Grobman, William A., Iams, Jay D., Mercer, Brian M., Silver, Robert M., Simhan, Hyagriv N., Wapner, Ronald J., Wing, Deborah A., Elovitz, Michal A., Schubert, Frank P., Peaceman, Alan, Esplin, Sean M., Caritis, Steve, Nageotte, Michael P., Carper, Benjamin A., Saade, George R., Reddy, Uma M., and Parker, Corette B.
- Published
- 2017
- Full Text
- View/download PDF
49. Potentially Preventable Stillbirth in a Diverse U.S. Cohort
- Author
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Page, Jessica M., Thorsten, Vanessa, Reddy, Uma M., Dudley, Donald J., Hogue, Carol J. Rowland, Saade, George R., Pinar, Halit, Parker, Corette B., Conway, Deborah, Stoll, Barbara J., Coustan, Donald, Bukowski, Radek, Varner, Michael W., Goldenberg, Robert L., Gibbins, Karen, and Silver, Robert M.
- Published
- 2018
- Full Text
- View/download PDF
50. Predictive Accuracy of Serial Transvaginal Cervical Lengths and Quantitative Vaginal Fetal Fibronectin Levels for Spontaneous Preterm Birth Among Nulliparous Women
- Author
-
Esplin, M. Sean, Elovitz, Michal A., Iams, Jay D., Parker, Corette B., Wapner, Ronald J., Grobman, William A., Simhan, Hyagriv N., Wing, Deborah A., Haas, David M., Silver, Robert M., Hoffman, Matthew K., Peaceman, Alan M., Caritis, Steve N., Parry, Samuel, Wadhwa, Pathik, Foroud, Tatiana, Mercer, Brian M., Hunter, Shannon M., Saade, George R., and Reddy, Uma M.
- Published
- 2017
- Full Text
- View/download PDF
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