50 results on '"Park D. I."'
Search Results
2. Risk of post-polypectomy bleeding after endoscopic mucosal resection in patients receiving antiplatelet medication: comparison between the continue and hold groups
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Park, D. I., additional
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- 2023
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3. P266 Potential oral microbial markers for differential diagnosis of Crohn’s disease and ulcerative colitis using machine learning model
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Park, S K, primary, Kim, H, additional, Kim, S, additional, Lee, C W, additional, Jung, Y, additional, Choi, C H, additional, Kang, S B, additional, Kim, T O, additional, Bang, K B, additional, Chun, J, additional, Cha, J M, additional, Im, J P, additional, Ahn, K S, additional, and Park, D I, additional
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- 2023
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4. OP024 Long-term safety and efficacy of the anti-MAdCAM monoclonal antibody SHP647 for the treatment of Crohn’s disease: the OPERA II study
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D’Haens, G R, Reinisch, W, Lee, S D, Tarabar, D, Louis, E, Kłopocka, M, Klaus, J, Schreiber, S, Park, D I, Hébuterne, X, Cataldi, F, Banerjee, A, Gorelick, K, and Sandborn, W J
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- 2018
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5. P144 Changes of fecal metabolic and lipidomic features by anti-tumor necrosis factor treatment and prediction of clinical remission in patients with ulcerative colitis
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Shin Shin, S, primary, Kim, S Y, additional, Park, S J, additional, Im, J P, additional, Kim, H J, additional, Lee, K M, additional, Kim, J W, additional, Jung, S A, additional, Lee, J, additional, Kang, S B, additional, Shin, S J, additional, Kim, E S, additional, Kim, Y S, additional, Kim, T O, additional, Kim, H S, additional, Park, D I, additional, Kim, H K, additional, Kim, Y H, additional, Teng, D, additional, Kim, J H, additional, Kim, W, additional, Saeed, M, additional, Moon, J M, additional, Kim, K, additional, Choi, C H, additional, and Choi, H K, additional
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- 2022
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6. P560 Clinical outcomes of vedolizumab maintenance treatment for Korean patients with inflammatory bowel disease who failed anti-TNF therapy: A KASID prospective multicenter cohort study
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Oh, K, primary, Kim, J, additional, Kim, N, additional, Yoon, H, additional, Lee, K M, additional, Park, D I, additional, Choi, C H, additional, Lee, C K, additional, Eun, C S, additional, Kang, S B, additional, Kim, E S, additional, Kim, Y S, additional, Jung, S A, additional, Jung, Y, additional, Kim, T O, additional, Park, S J, additional, Im, J P, additional, Seo, G S, additional, and Ye, B D, additional
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- 2021
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7. DOP67 Comparison of the pharmacokinetics of CT-P13 between Crohn’s Disease and Ulcerative Colitis in biologic-naïve patients; a prospective multi-center observational study of the KASID
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Kim, E S, primary, Park, D I, additional, Kim, H J, additional, Lee, Y J, additional, Koo, J S, additional, Kim, E S, additional, Yoon, H, additional, Lee, J H, additional, Kim, J W, additional, Shin, S J, additional, Kim, H W, additional, Kim, H S, additional, Park, Y S, additional, Kim, Y S, additional, Kim, T O, additional, Lee, J, additional, Choi, C H, additional, Han, D S, additional, and Chun, J, additional
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- 2021
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8. P348 Clinical outcomes and response predictors of vedolizumab treatment for anti-TNF-failed patients with IBD in Korea: A prospective multicenter cohort study
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Kim, J, primary, Yoon, H, additional, Lee, K M, additional, Jung, S A, additional, Park, D I, additional, Choi, C H, additional, Kim, E S, additional, Jung, Y, additional, Eun, C S, additional, Kim, T O, additional, Kang, S B, additional, Kim, Y S, additional, Seo, G S, additional, Lee, C K, additional, Im, J P, additional, Park, S J, additional, Byeon, J S, additional, Myung, S J, additional, Yang, S K, additional, and Ye, B D, additional
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- 2020
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- View/download PDF
9. P494 The efficacy and safety of adalimumab for patients with moderately to severely active ulcerative colitis and predictors of response in Korea
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Shin Shin, S, primary, Park, S J, additional, Kim, Y, additional, Im, J P, additional, Kim, H J, additional, Lee, K M, additional, Kim, J W, additional, Jung, S A, additional, Lee, J, additional, Kang, S B, additional, Shin, S J, additional, Kim, E S, additional, Kim, Y S, additional, Kim, T O, additional, Kim, H S, additional, Park, D I, additional, Kim, H K, additional, Kim, Y H, additional, Kim, D H, additional, Teng, D, additional, Kim, J H, additional, Kim, W Y, additional, and Choi, C H, additional
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- 2020
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10. P691 Corticosteroids usage in patients with inflammatory bowel disease: Results of a multi-national audit in Asia
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Kim, D H, primary, Park, D I, additional, Kobayashi, T, additional, Ahuja, V, additional, Jang, B I, additional, Cao, Q, additional, Lee, Y J, additional, and Ran, Z, additional
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- 2020
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11. Withdrawal of azathioprine in luminal Crohnʼs disease treated with infliximab maintenance therapy: a retrospective case-control study
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CHOI, G J, PARK, D I, PARK, J H, KIM, H J, CHO, Y K, SOHN, C I, JEON, W K, and KIM, B I
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- 2010
12. High resolution anorectal manometry-comparison with water perfusion manometry and defecography: 134
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SOHN, C.-I., PARK, J.-H., RHEE, P.-L., PARK, M.-I., KWON, J.-G., PARK, D.-I., CHO, Y.-K., KIM, H.-J., JEON, W.-K., and KIM, B.-I.
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- 2010
13. Change of insulin sensitivity in hepatitis C patients with normal insulin sensitivity; a 5-year prospective follow-up study variation of insulin sensitivity in HCV patients
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Park, S. K., Cho, Y. K., Park, J. H., Kim, H. J., Park, D. I., Sohn, C. I., Jeon, W. K., and Kim, B. I.
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- 2010
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14. Impact of non-alcoholic fatty liver disease on microalbuminuria in patients with prediabetes and diabetes
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Hwang, S. T., Cho, Y. K., Yun, J. W., Park, J. H., Kim, H. J., Park, D. I., Sohn, C. I., Jeon, W. K., Kim, B. I., Rhee, E. J., Oh, K. W., Lee, W. Y., and Jin, W.
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- 2010
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15. High resolution anorectal manometrycomparison with water perfusion manometry and defecography
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SEO, H I, LEE, J W, PARK, J H, PARK, D I, JEON, W K, and SOHN, C I
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- 2009
16. Endoscopic evaluation of significant gastrointestinal lesions in patients with iron deficiency with and without anaemia: a Korean Association for the Study of Intestinal Disease Study
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Park, J. S., Park, D. I., Park, S. K., Choi, J. S., Kim, Y. H., Chang, D. K., Son, H. J., Kim, J. E., Kim, J. O., Lee, S. H., Kim, H. S., Sin, J. E., Lee, S. G., Lee, S.-Y., Park, S. J., Park, C. H., Baek, I. H., Jang, B. I., Jeen, Y. T., and Huh, K. C.
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- 2009
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17. Gene amplification and protein overexpression of HER-2/neu in human extrahepatic cholangiocarcinoma as detected by chromogenic in situ hybridization and immunohistochemistry: its prognostic implication in node-positive patients
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Kim, H. J., Yoo, T. W., Park, D. I., Park, J. H., Cho, Y. K., Sohn, C. I., Jeon, W. K., Kim, B. I., Kim, M. K., Chae, S. W., and Sohn, J. H.
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- 2007
18. Clinical features associated with improvement of fatty liver disease
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PARK, S. H., KIM, B. I., KIM, H. J., KIM, H., KIM, S. H., PARK, D. I., CHO, Y. K., SUNG, I. K., SOHN, C. I., JEON, W. K., and KEUM, D. K.
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- 2005
19. Large expert-curated database for benchmarking document similarity detection in biomedical literature search
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Brown, P, Zhou, Y, Tan, A, El-Esawi, M, Liehr, T, Blanck, O, Gladue, D, Almeida, G, Cernava, T, Sorzano, C, Yeung, A, Engel, M, Chandrasekaran, A, Muth, T, Staege, M, Daulatabad, S, Widera, D, Zhang, J, Meule, A, Honjo, K, Pourret, O, Yin, C, Zhang, Z, Cascella, M, Flegel, W, Goodyear, C, van Raaij, M, Bukowy-Bieryllo, Z, Campana, L, Kurniawan, N, Lalaouna, D, Huttner, F, Ammerman, B, Ehret, F, Cobine, P, Tan, E, Han, H, Xia, W, Mccrum, C, Dings, R, Marinello, F, Nilsson, H, Nixon, B, Voskarides, K, Yang, L, Costa, V, Bengtsson-Palme, J, Bradshaw, W, Grimm, D, Kumar, N, Martis, E, Prieto, D, Sabnis, S, Amer, S, Liew, A, Perco, P, Rahimi, F, Riva, G, Zhang, C, Devkota, H, Ogami, K, Basharat, Z, Fierz, W, Siebers, R, Tan, K, Boehme, K, Brenneisen, P, Brown, J, Dalrymple, B, Harvey, D, Ng, G, Werten, S, Bleackley, M, Dai, Z, Dhariwal, R, Gelfer, Y, Hartmann, M, Miotla, P, Tamaian, R, Govender, P, Gurney-Champion, O, Kauppila, J, Zhang, X, Echeverria, N, Subhash, S, Sallmon, H, Tofani, M, Bae, T, Bosch, O, Cuiv, P, Danchin, A, Diouf, B, Eerola, T, Evangelou, E, Filipp, F, Klump, H, Kurgan, L, Smith, S, Terrier, O, Tuttle, N, Ascher, D, Janga, S, Schulte, L, Becker, D, Browngardt, C, Bush, S, Gaullier, G, Ide, K, Meseko, C, Werner, G, Zaucha, J, Al-Farha, A, Greenwald, N, Popoola, S, Rahman, S, Xu, J, Yang, S, Hiroi, N, Alper, O, Baker, C, Bitzer, M, Chacko, G, Debrabant, B, Dixon, R, Forano, E, Gilliham, M, Kelly, S, Klempnauer, K, Lidbury, B, Lin, M, Lynch, I, Ma, W, Maibach, E, Mather, D, Nandakumar, K, Ohgami, R, Parchi, P, Tressoldi, P, Xue, Y, Armitage, C, Barraud, P, Chatzitheochari, S, Coelho, L, Diao, J, Doxey, A, Gobet, A, Hu, P, Kaiser, S, Mitchell, K, Salama, M, Shabalin, I, Song, H, Stevanovic, D, Yadollahpour, A, Zeng, E, Zinke, K, Alimba, C, Beyene, T, Cao, Z, Chan, S, Gatchell, M, Kleppe, A, Piotrowski, M, Torga, G, Woldesemayat, A, Cosacak, M, Haston, S, Ross, S, Williams, R, Wong, A, Abramowitz, M, Effiong, A, Lee, S, Abid, M, Agarabi, C, Alaux, C, Albrecht, D, Atkins, G, Beck, C, Bonvin, A, Bourke, E, Brand, T, Braun, R, Bull, J, Cardoso, P, Carter, D, Delahay, R, Ducommun, B, Duijf, P, Epp, T, Eskelinen, E, Fallah, M, Farber, D, Fernandez-Triana, J, Feyerabend, F, Florio, T, Friebe, M, Furuta, S, Gabrielsen, M, Gruber, J, Grybos, M, Han, Q, Heinrich, M, Helantera, H, Huber, M, Jeltsch, A, Jiang, F, Josse, C, Jurman, G, Kamiya, H, de Keersmaecker, K, Kristiansson, E, de Leeuw, F, Li, J, Liang, S, Lopez-Escamez, J, Lopez-Ruiz, F, Marchbank, K, Marschalek, R, Martin, C, Miele, A, Montagutelli, X, Morcillo, E, Nicoletti, R, Niehof, M, O'Toole, R, Ohtomo, T, Oster, H, Palma, J, Paterson, R, Peifer, M, Portilla, M, Portillo, M, Pritchard, A, Pusch, S, Raghava, G, Roberts, N, Ross, K, Schuele, B, Sergeant, K, Shen, J, Stella, A, Sukocheva, O, Uversky, V, Vanneste, S, Villet, M, Viveiros, M, Vorholt, J, Weinstock, C, Yamato, M, Zabetakis, I, Zhao, X, Ziegler, A, Aizat, W, Atlas, L, Bridges, K, Chakraborty, S, Deschodt, M, Domingues, H, Esfahlani, S, Falk, S, Guisado, J, Kane, N, Kueberuwa, G, Lau, C, Liang, D, Liu, E, Luu, A, Ma, C, Ma, L, Moyer, R, Norris, A, Panthee, S, Parsons, J, Peng, Y, Pinto, I, Reschke, C, Sillanpaa, E, Stewart, C, Uhle, F, Yang, H, Zhou, K, Zhu, S, Ashry, M, Bergsland, N, Berthold, M, Chen, C, Colella, V, Cuypers, M, Eskew, E, Fan, X, Gajda, M, Gonzalezlez-Prendes, R, Goodin, A, Graham, E, Groen, E, Gutierrez-Sacristan, A, Habes, M, Heffler, E, Higginbottom, D, Janzen, T, Jayaraman, J, Jibb, L, Jongen, S, Kinyanjui, T, Koleva-Kolarova, R, Li, Z, Liu, Y, Lund, B, Lussier, A, Mier, P, Moore, M, Nagler, K, Orme, M, Pearson, J, Prajapati, A, Saito, Y, Troder, S, Uchendu, F, Verloh, N, Voutchkova, D, Abu-Zaid, A, Bakkach, J, Baumert, P, Dono, M, Hanson, J, Herbelet, S, Hobbs, E, Kulkarni, A, Liu, S, Loft, N, Reddan, T, Senghore, T, Vindin, H, Xu, H, Bannon, R, Chen, B, Cheung, J, Cooper, J, Esnakula, A, Feghali, K, Ghelardi, E, Gnasso, A, Horbar, J, Lai, H, Ma, R, Pan, Z, Peres, M, Pranata, R, Seow, E, Sydes, M, Testoni, I, Westermair, A, Yang, Y, Afnan, M, Albiol, J, Albuquerque, L, Amir, S, Amiya, E, Amorim, R, An, Q, Andersen, S, Aplin, J, Argyropoulos, C, Asmann, Y, Assaeed, A, Atanasov, A, Atchison, D, Avery, S, Avillach, P, Baade, P, Backman, L, Badie, C, Baldi, A, Ball, E, Bardot, O, Barnett, A, Basner, M, Batra, J, Bazanova, O, Beale, A, Beddoe, T, Bell, M, Berezikov, E, Berners-Price, S, Bernhardt, P, Berry, E, Bessa, T, Billington, C, Birch, J, Blakely, R, Blaskovich, M, Blum, R, Boelaert, M, Bogdanos, D, Bosch, C, Bourgoin, T, Bouvard, D, Boykin, L, Bradley, G, Braun, D, Brownlie, J, Bruhl, A, Burt, A, Butler, L, Byrareddy, S, Byrne, H, Cabantous, S, Calatayud, S, Candal, E, Carlson, K, Casillas, S, Castelvetro, V, Caswell, P, Cavalli, G, Cerovsky, V, Chagoyen, M, Chen, D, Chen, H, Chen, J, Chen, Y, Cheng, C, Cheng, J, Chinapaw, M, Chinopoulos, C, Cho, W, Chong, L, Chowdhury, D, Chwalibog, A, Ciresi, A, Cockcroft, S, Conesa, A, Cook, P, Cooper, D, Coqueret, O, Corea, E, Costa, A, Costa, E, Coupland, C, Crawford, S, Cruz, A, Cui, H, Cui, Q, Culver, D, D'Angiulli, A, Dahms, T, Daigle, F, Dalgleish, R, Danielsen, H, Darras, S, Davidson, S, Day, D, Degirmenci, V, Demaison, L, Devriendt, K, Ding, J, Dogan, Y, Dong, X, Donner, C, Dressick, W, Drevon, C, Duan, H, Ducho, C, Dumaz, N, Dwarakanath, B, Ebell, M, Eisenhardt, S, Elkum, N, Engel, N, Erickson, T, Fairhead, M, Faville, M, Fejzo, M, Festa, F, Feteira, A, Flood-Page, P, Forsayeth, J, Fox, S, Franks, S, Frentiu, F, Frilander, M, Fu, X, Fujita, S, Galea, I, Galluzzi, L, Gani, F, Ganpule, A, Garcia-Alix, A, Gedye, K, Giordano, M, Giunta, C, Gleeson, P, Goarant, C, Gong, H, Gora, D, Gough, M, Goyal, R, Graham, K, Grande-Perez, A, Graves, P, Greidanus, H, Grice, D, Grunau, C, Gumulya, Y, Guo, Y, Gurevich, V, Gusev, O, Hacker, E, Hage, S, Hagen, G, Hahn, S, Haller, D, Hammerschmidt, S, Han, J, Han, R, Handfield, M, Hapuarachchi, H, Harder, T, Hardingham, J, Heck, M, Heers, M, Hew, K, Higuchi, Y, Hilaire, C, Hilton, R, Hodzic, E, Hone, A, Hongoh, Y, Hu, G, Huber, H, Hueso, L, Huirne, J, Hurt, L, Idborg, H, Ikeo, K, Ingley, E, Jakeman, P, Jensen, A, Jia, H, Jia, S, Jiang, J, Jiang, X, Jin, Y, Jo, D, Johnson, A, Johnston, M, Jonscher, K, Jorens, P, Jorgensen, J, Joubert, J, Jung, S, Junior, A, Kahan, T, Kamboj, S, Kang, Y, Karamanos, Y, Karp, N, Kelly, R, Kenna, R, Kennedy, J, Kersten, B, Khalaf, R, Khalid, J, Khatlani, T, Khider, T, Kijanka, G, King, S, Kluz, T, Knox, P, Kobayashi, T, Koch, K, Kohonen-Corish, M, Kong, X, Konkle-Parker, D, Korpela, K, Kostrikis, L, Kraiczy, P, Kratz, H, Krause, G, Krebsbach, P, Kristensen, S, Kumari, P, Kunimatsu, A, Kurdak, H, Kwon, Y, Lachat, C, Lagisz, M, Laky, B, Lammerding, J, Lange, M, Larrosa, M, Laslett, A, Laverman, G, Leclair, E, Lee, K, Lee, M, Li, G, Lieb, K, Lim, Y, Lindsey, M, Line, P, Liu, D, Liu, F, Liu, H, Lloyd, V, Lo, T, Locci, E, Loidl, J, Lorenzen, J, Lorkowski, S, Lovell, N, Lu, H, Lu, W, Lu, Z, Luengo, G, Lundh, L, Lysy, P, Mabb, A, Mack, H, Mackey, D, Mahdavi, S, Maher, P, Maher, T, Maity, S, Malgrange, B, Mamoulakis, C, Mangoni, A, Manke, T, Manstead, A, Mantalaris, A, Marsal, J, Marschall, H, Martin, F, Martinez-Raga, J, Martinez-Salas, E, Mathieu, D, Matsui, Y, Maza, E, Mccutcheon, J, Mckay, G, Mcmillan, B, Mcmillan, N, Meads, C, Medina, L, Merrick, B, Metzger, D, Meunier, F, Michaelis, M, Micheau, O, Mihara, H, Mintz, E, Mizukami, T, Moalic, Y, Mohapatra, D, Monteiro, A, Montes, M, Moran, J, Morozov, S, Mort, M, Murai, N, Murphy, D, Murphy, S, Murray, S, Naganawa, S, Nammi, S, Nasios, G, Natoli, R, Nguyen, F, Nicol, C, van Nieuwerburgh, F, Nilsen, E, Nobile, C, O'Mahony, M, Ohlsson, S, Olatunbosun, O, Olofsson, P, Ortiz, A, Ostrikov, K, Otto, S, Outeiro, T, Ouyang, S, Paganoni, S, Page, A, Palm, C, Paradies, Y, Parsons, M, Parsons, N, Pascal, P, Paul, E, Peckham, M, Pedemonte, N, Pellizzon, M, Petrelli, M, Pichugin, A, Pinto, C, Plevris, J, Pollesello, P, Polz, M, Ponti, G, Porcelli, P, Prince, M, Quinn, G, Quinn, T, Ramula, S, Rappsilber, J, Rehfeldt, F, Reiling, J, Remacle, C, Rezaei, M, Riddick, E, Ritter, U, Roach, N, Roberts, D, Robles, G, Rodrigues, T, Rodriguez, C, Roislien, J, Roobol, M, Rowe, A, Ruepp, A, van Ruitenbeek, J, Rust, P, Saad, S, Sack, G, Santos, M, Saudemont, A, Sava, G, Schrading, S, Schramm, A, Schreiber, M, Schuler, S, Schymkowitz, J, Sczyrba, A, Seib, K, Shi, H, Shimada, T, Shin, J, Shortt, C, Silveyra, P, Skinner, D, Small, I, Smeets, P, So, P, Solano, F, Sonenshine, D, Song, J, Southall, T, Speakman, J, Srinivasan, M, Stabile, L, Stasiak, A, Steadman, K, Stein, N, Stephens, A, Stewart, D, Stine, K, Storlazzi, C, Stoynova, N, Strzalka, W, Suarez, O, Sultana, T, Sumant, A, Summers, M, Sun, G, Tacon, P, Tanaka, K, Tang, H, Tanino, Y, Targett-Adams, P, Tayebi, M, Tayyem, R, Tebbe, C, Telfer, E, Tempel, W, Teodorczyk-Injeyan, J, Thijs, G, Thorne, S, Thrift, A, Tiffon, C, Tinnefeld, P, Tjahjono, D, Tolle, F, Toth, E, Del Tredici, A, Tsapas, A, Tsirigotis, 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- Abstract
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical science.
- Published
- 2019
20. Large expert-curated database for benchmarking document similarity detection in biomedical literature search
- Author
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Brown, P., Zhou, Y., Tan, A. -C., El-Esawi, M. A., Liehr, T., Blanck, O., Gladue, D. P., Almeida, G. M. F., Cernava, T., Sorzano, C. O., Yeung, A. W. K., Engel, M. S., Chandrasekaran, A. R., Muth, T., Staege, M. S., Daulatabad, S. V., Widera, D., Zhang, J., Meule, A., Honjo, K., Pourret, O., Yin, C. -C., Zhang, Z., Cascella, M., Flegel, W. A., Goodyear, C. S., van Raaij, M. J., Bukowy-Bieryllo, Z., Campana, L. G., Kurniawan, N. A., Lalaouna, D., Huttner, F. J., Ammerman, B. A., Ehret, F., Cobine, P. A., Tan, E. -C., Han, H., Xia, W., Mccrum, C., Dings, R. P. M., Marinello, F., Nilsson, H., Nixon, B., Voskarides, K., Yang, L., Costa, V. D., Bengtsson-Palme, J., Bradshaw, W., Grimm, D. G., Kumar, N., Martis, E., Prieto, D., Sabnis, S. C., Amer, S. E. D. R., Liew, A. W. C., Perco, P., Rahimi, F., Riva, G., Zhang, C., Devkota, H. P., Ogami, K., Basharat, Z., Fierz, W., Siebers, R., Tan, K. H., Boehme, K. A., Brenneisen, P., Brown, J. A. L., Dalrymple, B. P., Harvey, D. 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D., Braubach, O., Cai, Y., Campbell, M., Catry, T., Chen, X., Cheng, S., Chung, H. -J., Chavez-Fumagalli, M. A., Conway, A., Costa, B. M., Cyr, N., Dean, L. T., Denzel, M. S., Dlamini, S. V., Dudley, K. J., Dufies, M., Ecke, T., Eckweiler, D., Eixarch, E., El-Adawy, H., Emmrich, J. V., Eustace, A. J., Falter-Wagner, C. M., Farhoudi, R., Fuss, J., Gao, J., Gill, M. R., Gloyn, L., Goggs, R., Govinden, U., Greene, G., Greiff, V., Grundle, D. S., Gruneberg, P., Gumede, N., Haore, G., Harrison, P., Hoenner, X., Hojsgaard, D., Hori, H., Ikonomopoulou, M. P., Jeurissen, P., Johnson, D. M., Kabra, D., Kamagata, K., Karmakar, C., Kasian, O., Kaye, L. K., Khan, M. M., Kim, Y. -M., Kish, J. K., Kobold, S., Kohanbash, G., Kohls, G., Kugler, J. -M., Kumar, G., Lacy-Colson, J., Latif, A., Lauschke, V. M., Li, B., Lim, C. J., Liu, X., Lu, J. -J., Lu, Q., Mahavadi, P., Marzocchi, U., Mcgarrigle, C. A., van Meerten, T., Min, R., Moal, I., Molari, M., Molleman, L., Mondal, S. 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M., Valenti, A., Verlot, P., Walker, M., Wang, J., Welter, D., Winslade, M., Wu, D., Wu, Y. -R., Xiao, H., Xu, B., Xu, Z., Yang, D., Yang, M., Yankilevich, P., You, Y., Yu, C., Zhan, J., Zhang, G., Zhang, K., Zhang, T., Zhao, G., Zhao, J., Zhou, X., Zhu, Z., Ajani, P. A., Anazodo, U. C., Bagloee, S. A., Bail, K., Bar, I., Bathelt, J., Benkeser, D., Bernier, M. L., Blanchard, A. M., Boakye, D. W., Bonatsos, V., Boon, M. H., Bouboulis, G., Bromfield, E., Brown, J., Bul, K. C. M., Burton, K. J., Butkowski, E. G., Carroll, G., Chao, F., Charrier, E. E., Chen, Y. -C., Chenguang, Choi, J. R., Christoffersen, T., Comel, J. C., Cosse, C., Cui, Y., van Dessel, P., Dhaval, Diodato, D., Duffey, M., Dutt, A., Egea, L. G., El-Said, M., Faye, M., Fernandez-Fernandez, B., Foley, K. G., Founou, L. L., Fu, F., Gadelkareem, R. A., Galimov, E., Garip, G., Gemmill, A., Gouil, Q., Grey, J., Gridneva, Z., Grothe, M. J., Grebert, T., Guerrero, F., Guignard, L., Haenssgen, M. J., Hasler, D., Holgate, J. Y., Huang, A., Hulse-Kemp, A. M., Jean-Quartier, C., Jeon, S. -M., Jia, Y., Jutzeler, C., Kalatzis, P., Karim, M., Karsay, K., Keitel, A., Kempe, A., Keown, J. R., Khoo, C. M., Khwaja, N., Kievit, R. A., Kosanic, S., Koutoukidis, D. A., Kramer, P., Kumar, D., Kirag, N., Lanza, G., Le, T. D., Leem, J. W., Leightley, D., Leite, A., Lercher, L., Li, Y., Lim, R., Lima, L. R. A., Lin, L., Ling, T., Liu, Y., Liu, Z., Lu, Y., Lum, F. M., Luo, H., Machhi, J., Macleod, A., Macwan, I., Madala, H. R., Madani, N., de Maio, N., Makowiecki, K., Mallinson, D. J., Margelyte, R., Maria, C., Markonis, Y., Marsili, L., Mavoa, S., Mcwilliams, L., Megersa, M., Souto-Maior, C., Menichetti, J., Mercieca-Bebber, R., Miller, J. J., Minde, D. -P. M., Minges, A., Mishra, E., Mishra, V. R., Moores, C., Morrice, N., Moskalensky, A. E., Navarin, N., Negera, E., Nolet, P., Nordberg, A., Norden, R., Nowicki, J. P., Olova, N., Olszewski, P., Onzima, R., Pan, C. -L., Park, C., Park, D. I., Park, S., Patil, C. D., Pedro, S. A., Perry, S. R., Peter, J., Peterson, B. M., Pezzuolo, A., Pozdnyakov, I., Qian, S., Qin, L., Rafe, A., Raote, I., Raza, A., Rebl, H., Refai, O., Regan, T., Richa, T., Richardson, M. F., Robinson, K. R., Rossoni, L., Rouet, R., Safaei, S., Schneeberger, P. H. H., Schwotzer, D., Sebastian, A., Selinski, J., Seltmann, S., Sha, F., Shalev, N., Shang, J. -L., Singer, J., Singh, M., Smith, T., Solomon-Moore, E., Song, L., Soraggi, S., Stanley, R., Steckhan, N., Strobl, F., Subissi, L., Supriyanto, I., Surve, C. R., Suzuki, T., Syme, C., Sorelius, K., Tang, Y., Tantawy, M., Tennakoon, S., Teseo, S., Toelzer, C., Tomov, N., Tovar, M., Tran, L., Tripathi, S., Tuladhar, A. M., Ukubuiwe, A. C., Ung, C. O. L., Valgepea, K., Vatanparast, H., Vidal, A., Wang, Q., Watari, R., Webster, R., Wei, J., Wibowo, D., Wingenbach, T. S. H., Xavier, R. M., Xiao, S., Xiong, P., Xu, S., Yao, R., Yao, W., Yin, Q., Zaitsu, M., Zeineb, Z., Zhan, X. -Y., Zhang, R., Zhang, W., Zheng, S., Zhou, B., Ahmad, H., Akinwumi, S. A., Albery, G. F., Alhowimel, A., Ali, J., Alshehri, M., Alsuhaibani, M., Anikin, A., Azubuike, S. O., Bach-Mortensen, A., Baltiansky, L., Bartas, M., Belachew, K. Y., Bhardwaj, V., Binder, K., Bland, N. S., Boah, M., Bullen, B., Calabro', Giovanna Elisa, Callahan, T. J., Cao, B., Chalmers, K., Chang, W., Che, Z., Chen, A. T. Y., Chen, Z., Choi, Y., Chowdhury, M. A. K., Christensen, M. R., Cooke, R. S. C., Cottini, M., Covington, N. V., Cunningham, C., Delarocque, J., Devos, L., Dhar, A. R., Ding, K. -F., Dong, K., Dong, Z., Dreyer, N., Ekstrand, C., Fardet, T., Feleke, B. E., Feurer, T., Freitas, A., Gao, T., Gebremedhin, Giganti, F., Grabowski, P., Guerra-Mora, J. R., Guo, C., Guo, X., Gupta, H., He, S., Heijne, M., Heinemann, S., Hogrebe, A., Huang, Z., Iskander-Rizk, S., Iyer, L. M., Jahan, Y., James, A. S., Joel, E., Joffroy, B., Jegousse, C., Kambondo, G., Karnati, P., Kaya, C., Ke, A., Kelly, D., Kickert, R., Kidibule, P. E., Kieselmann, J. P., Kim, H. J., Kitazawa, T., Lamberts, A., Liang, H., Linn, S. N., Litfin, T., Liusuo, W., Lygirou, V., Mahato, A. K., Mai, Z. -M., Major, R. W., Mali, S., Mallis, P., Mao, W., Marvin-Dowle, K., Mason, L. D., Merideth, B., Merino-Plaza, M. J., Merlaen, B., Messina, R., Mishra, A. K., Muhammad, J., Musinguzi, C., Nanou, A., Naqash, A., Nguyen, J. T., Nguyen, T. T. H., Ni, D., Nida, Notcovich, S., Ohst, B., Ollivier, Q. R., Osses, D. F., Peng, X., Plantinga, A., Pulia, M., Rafiq, M., Raman, A., Raucher-Chene, Rawski, R., Ray, A., Razak, L. A., Rudolf, K., Rusch, P., Sadoine, M. L., Schmidt, A., Schurr, R., Searles, S., Sharma, S., Sheehan, B., Shi, C., Shohayeb, B., Sommerlad, A., Strehlow, J., Sun, X., Sundar, R., Taherzadeh, G., Tahir, N. D. M., Tang, J., Testa, J., Tian, Z., Tingting, Q., Verheijen, G. P., Vickstrom, C., Wang, T., Wang, X., Wang, Z., Wei, P., Wilson, A., Wyart, Yassine, A. -A., Yousefzadeh, A., Zare, A., Zeng, Z., Zhang, H., Zhou, J., Zhu, D., Adamo, V., Adeyemo, A. A., Aggelidou, M., Al-Owaifeer, A. M., Al-Riyami, A. Z., Alzghari, S. K., Andersen, V., Angus, K., Asaduzzaman, M., Asady, H., Ato, D., Bai, X., Baines, R. L., Ballantyne, M., Ban, B., Beck, J., Ben-Nafa, W., Black, E., Blancher, A., Blankstein, R., Bodagh, N., Borges, P., Brooks, A., Brox-Ponce, J., Brunetti, A., Canham, C. D., Carninci, P., Carvajal, R., Chang, S. C., Chao, J., Chatterjee, P., Chen, L., Chhatriwalla, A. K., Chikowe, I., Chuang, T. -J., Collevatti, R. G., Cornejo, D. A. V., Cuenda, A., Dao, M., Dauga, D., Deng, Z., Devkota, K., Doan, L. V., Elewa, Y. H. A., Fan, D., Faruk, M., Feifei, S., Ferguson, T. S., Fleres, F., Foster, E. J., Foster, S., Furer, T., Gao, Y., Garcia-Rivera, E. J., Gazdar, A., George, R. B., Ghosh, S., Gianchecchi, E., Gleason, J. M., Hackshaw, A., Hall, A., Hall, R., Harper, P., Hogg, W. E., Huang, G., Hunter, K. E., Ijzerman, A. P., Jesus, C., Jian, G., Lewis, J. S., Kanj, S. S., Kaur, H., Kheir, F., Kichatova, V. S., Kiyani, M., Klein, R., Kovesi, T., Kraschnewski, J. L., Kumar, A. P., Labutin, D., Lazo-Langner, A., Leclercq, G., Li, M., Li, Q., Li, T., Liao, W. -T., Liao, Z. -Y., Lin, J., Lizer, J., Lobreglio, G., Lowies, C., Lu, C., Majeed, H., Martin, A., Martinez-Sobrido, L., Meresh, E., Middelveen, M., Mohebbi, A., Mota, J., Mozaheb, Z., Muyaya, L., Nandhakumar, A., Ng, S. H. X., Obeidat, M., Oh, D. -H., Owais, M., Pace-Asciak, P., Panwar, A., Patterson, C., Penagos-Tabaree, F., Pianosi, P. T., Pinzi, V., Pridans, C., Psaroulaki, A., Pujala, R. K., Pulido-Arjona, L., Qi, P. -F., Rahman, P., Rai, N. K., Rassaf, T., Refardt, J., Ricciardi, Walter, Riess, O., Rovas, A., Sacks, F. M., Saleh, S., Sampson, C., Schmutz, A., Sepanski, R., Sharma, N., Spearman, P., Subramaniapillai, M., Swali, R., Tan, C. M., Tellechea, J. I., Thomas, L. -M., Tong, X., Vavvas, D. G., Veys, R., Vitriol, V., Wang, H. -D., Waugh, J., Webb, S. A., Williams, B. A., Workman, A. D., Xiang, T., Xie, L. -X., Xu, T., Yang, C., Yoon, J. G., Yuan, C. M., Zaritsky, A., Zhao, H., Zuckerman, H., Lyu, R., Pullan, W., Calabro G. E. (ORCID:0000-0003-0259-3797), and Ricciardi W. (ORCID:0000-0002-5655-688X)
- Abstract
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical science.
- Published
- 2019
21. OP08 Long-term efficacy and pharmacodynamics of the anti-mucosal addressin cell adhesion molecule-1 (MAdCAM-1) monoclonal antibody SHP647 in Crohn’s disease: the OPERA II study
- Author
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D’Haens, G, primary, Reinisch, W, additional, Lee, S D, additional, Tarabar, D, additional, Louis, E, additional, Kłopocka, M, additional, Klaus, J, additional, Schreiber, S, additional, Park, D I, additional, Hébuterne, X, additional, Gorelick, K J, additional, Martin, S W, additional, Banerjee, A, additional, Nagy, P, additional, Wang, Y, additional, Cataldi, F, additional, and Sandborn, W J, additional
- Published
- 2019
- Full Text
- View/download PDF
22. P477 The efficacy of adalimumab for the treatment of Korean patients with ulcerative colitis and predictors of response: Preliminary results
- Author
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Choi, C H, primary, Park, S J, additional, Im, J P, additional, Kim, H J, additional, Lee, K -M, additional, Kim, J W, additional, Jung, S -A, additional, Lee, J, additional, Kang, S B, additional, Shin, S J, additional, Kim, E S, additional, Kim, Y S, additional, Kim, T O, additional, Kim, H -S, additional, Park, D I, additional, Kim, H K, additional, Jin, J Y, additional, and Teng, D, additional
- Published
- 2018
- Full Text
- View/download PDF
23. P517 The effects and adherence of Asacol® comparing 2.4 g once daily with 800 mg three times or 1200 mg twice daily for maintain therapy in the ulcerative colitis: Prospective multicentre randomised study
- Author
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Park, S -K, primary, Eun, C S, additional, Seo, G S, additional, Lim, J, additional, Kim, T O, additional, and Park, D I, additional
- Published
- 2018
- Full Text
- View/download PDF
24. Delineation of molecular pathway activities of the chronic antidepressant treatment response suggests important roles for glutamatergic and ubiquitin–proteasome systems
- Author
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Park, D I, primary, Dournes, C, additional, Sillaber, I, additional, Ising, M, additional, Asara, J M, additional, Webhofer, C, additional, Filiou, M D, additional, Müller, M B, additional, and Turck, C W, additional
- Published
- 2017
- Full Text
- View/download PDF
25. Weight loss and waist reduction is associated with improvement in gastroesophageal disease reflux symptoms: A longitudinal study of 15 295 subjects undergoing health checkups
- Author
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Park, S.‐K., primary, Lee, T., additional, Yang, H.‐J., additional, Park, J. H., additional, Sohn, C. I., additional, Ryu, S., additional, and Park, D. I., additional
- Published
- 2016
- Full Text
- View/download PDF
26. Long-term Clinical Outcomes of Urban Versus Rural Environment in Korean Patients with Crohn's Disease: Results from the CONNECT Study
- Author
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Jung, Y. S., primary, Park, D. I., additional, Ye, B. D., additional, Cheon, J. H., additional, Kim, Y. S., additional, Kim, Y. H., additional, Kim, J. S., additional, Chae, H. S., additional, Baik, G. H., additional, and Han, D. S., additional
- Published
- 2015
- Full Text
- View/download PDF
27. Weight loss and waist reduction is associated with improvement in gastroesophageal disease reflux symptoms: A longitudinal study of 15 295 subjects undergoing health checkups.
- Author
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Park, S.‐K., Lee, T., Yang, H.‐J., Park, J. H., Sohn, C. I., Ryu, S., and Park, D. I.
- Subjects
WEIGHT loss ,WAIST circumference ,GASTROESOPHAGEAL reflux ,LOGISTIC regression analysis ,BODY mass index - Abstract
Background General obesity and abdominal obesity is an established risk factor of gastroesophageal reflux disease ( GERD). However, the influence of weight or waist change on improvement of GERD is unclear. Our aim was to investigate if weight loss or waist reduction improves GERD symptoms and esophagitis. Methods A retrospective longitudinal study of 15 295 subjects who underwent gastroscopy for a health checkup and reported GERD symptoms between 2011 and 2013, and repeated a checkup until 2014 was conducted. The improvement of GERD symptoms and esophagitis according to weight loss (≥−2, −0.5 to −2 kg/m
2 in body mass index [ BMI]), waist reduction (≥−5, −0.1 to −0.5 cm) and baseline BMI/waist circumference ( WC) categories was assessed using logistic regression. Key Results Weight loss or waist reduction was associated with improvement in GERD symptoms only in subjects with general or abdominal obesity. Among subjects with general obesity ( BMI ≥25 kg/m2 ) and decreased ≥2 kg/m2 in BMI, the adjusted odds ratio ( OR) of improvement in GERD symptoms was 2.34 (95% confidence interval [ CI] 1.70-2.83). Among subjects with abdominal obesity ( WC ≥90 cm) and decreased ≥5 cm in WC, the corresponding OR was 2.16 (95% CI 1.56-2.90). There was no association between weight loss or waist reduction and improvement in esophagitis. Conclusions & Inferences Weight loss or waist reduction was associated with improvement in GERD symptoms only in subjects with general or abdominal obesity. Weight loss or waist reduction will be an important treatment option in obese patients. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
28. Erratum: Comparison of Guaiac-Based and Quantitative Immunochemical Fecal Occult Blood Testing in a Population at Average Risk Undergoing Colorectal Cancer Screening
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Park, D I, primary, Ryu, S, additional, Kim, Y-H, additional, Lee, S H, additional, Lee, C K, additional, Eun, C S, additional, and Han, D S, additional
- Published
- 2012
- Full Text
- View/download PDF
29. Endoscopic evaluation of significant gastrointestinal lesions in patients with iron deficiency with and without anaemia: a Korean Association for the Study of Intestinal Disease Study
- Author
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Park, J. S., primary, Park, D. I., additional, Park, S. K., additional, Choi, J. S., additional, Kim, Y. H., additional, Chang, D. K., additional, Son, H. J., additional, Kim, J. E., additional, Kim, J. O., additional, Lee, S. H., additional, Kim, H. S., additional, Sin, J. E., additional, Lee, S. G., additional, Lee, S.-Y., additional, Park, S. J., additional, Park, C. H., additional, Baek, I. H., additional, Jang, B. I., additional, Jeen, Y. T., additional, and Huh, K. C., additional
- Published
- 2008
- Full Text
- View/download PDF
30. Delineation of molecular pathway activities of the chronic antidepressant treatment response suggests important roles for glutamatergic and ubiquitin–proteasome systems
- Author
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Park, D I, Dournes, C, Sillaber, I, Ising, M, Asara, J M, Webhofer, C, Filiou, M D, Müller, M B, and Turck, C W
- Abstract
The aim of this study was to identify molecular pathways related to antidepressant response. We administered paroxetine to the DBA/2J mice for 28 days. Following the treatment, the mice were grouped into responders or non-responders depending on the time they spent immobile in the forced swim test. Hippocampal metabolomics and proteomics analyses revealed that chronic paroxetine treatment affects glutamate-related metabolite and protein levels differentially in the two groups. We found significant differences in the expression of N-methyl-d-aspartate receptor and neuronal nitric oxide synthase proteins between the two groups, without any significant alterations in the respective transcript levels. In addition, we found that chronic paroxetine treatment altered the levels of proteins associated with the ubiquitin–proteasome system (UPS). The soluble guanylate cyclase-β1, proteasome subunit α type-2 and ubiquitination levels were also affected in peripheral blood mononuclear cells from antidepressant responder and non-responder patients suffering from major depressive disorder. We submit that the glutamatergic system and UPS have a crucial role in the antidepressant treatment response in both mice and humans.
- Published
- 2017
- Full Text
- View/download PDF
31. The Clinical Significance of Common Bile-Duct Dilatation in Patients without Biliary Symptoms or Causative Lesions on Ultrasonography
- Author
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Kim, J.-E., primary, Lee, J. K., additional, Lee, K. T., additional, Park, D. I., additional, Hyun, J. G., additional, Paik, S. W., additional, Rhee, J. C., additional, Choi, K. W., additional, and Lim, J. H., additional
- Published
- 2001
- Full Text
- View/download PDF
32. Risk Factors Suggesting Malignant Transformation of Gastric Adenoma: Univariate and Multivariate Analysis
- Author
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Park, D. I., primary, Rhee, P.-L., additional, Kim, J.-E., additional, Hyun, J. G., additional, Kim, Y.-H., additional, Son, H. J., additional, Kim, J. J., additional, Paik, S. W., additional, Rhee, J. C., additional, Choi, K. W., additional, and Oh, Y. L., additional
- Published
- 2001
- Full Text
- View/download PDF
33. Intelligent user interface for intelligent multimedia repository
- Author
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Rhee, Phill-Kyu, primary, Kim, Yong-Hwan, additional, Sim, B. S., additional, Zhoo, Z. C., additional, and Park, D-I, additional
- Published
- 1997
- Full Text
- View/download PDF
34. Clinical outcomes and risk factors of post-polypectomy coagulation syndrome: a multicenter, retrospective, case-control study.
- Author
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Cha, J M, Lim, K S, Lee, S H, Joo, Y E, Hong, S P, Kim, T I, Kim, H G, Park, D I, Kim, S E, Yang, D H, and Shin, J E
- Published
- 2013
- Full Text
- View/download PDF
35. Criteria for decision making after endoscopic resection of well-differentiated rectal carcinoids with regard to potential lymphatic spread.
- Author
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Park, C. H., Cheon, J. H., Kim, J. O., Shin, J. E., Jang, B. I., Shin, S. J., Jeen, Y. T., Lee, S. H., Ji, J. S., Han, D. S., Jung, S. A., Park, D. I., Baek, I. H., Kim, S. H., and Chang, D. K.
- Subjects
MEDICAL decision making ,SURGICAL excision ,CARCINOID ,RECTAL diseases ,ENDOSCOPY - Abstract
Background and study aim: Rectal carcinoids are low-grade malignancies that are usually treated by endoscopic resection. However, on pathologic examination, resection margins that are positive for carcinoid cells are frequently found. Patient outcomes were reviewed after endoscopic resection of rectal carcinoids and the clinical significance of possible residual disease, as defined by pathologic and endoscopic examination, was evaluated. Patients and methods: The medical records and endoscopic findings of 347 patients presenting with rectal carcinoids to 14 university hospitals in Korea between January 1999 and June 2007 were retrospectively analyzed. Results: A total of 304 patients were treated with endoscopic resection, and 43 patents were treated with surgery. In the endoscopic resection group, the complete resection rate was 88.2% based on endoscopic appearance (CR-E) and 60.2% based on pathologic evaluation (CR-P). The agreement between CR-E and CR-P was low (κ = 0.192). No residual tumors were found in 77 of 85 patients (90.6 %) who were CR-E but not CR-P and who had endoscopic biopsy taken at 24-month follow-up. The receiver-operating characteristic curve identified an optimal cut-off value of 10.5 mm, at which the sensitivity and the specificity for metastasis were 100% and 89%, respectively. The risk factors for metastasis by multivariate analysis were tumor size, increased mitotic rate, and lymphovascular invasion. Conclusions: Endoscopic resection is a safe and effective modality for treating well-differentiated rectal carcinoids smaller than 10mm in diameter. Discrepancies were observed between CR-E and CR-P. The risk factors for metastasis were tumor size, increased mitotic rate, and lymphovascular invasion. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
36. Intelligent user interface for intelligent multimedia repository.
- Author
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Rhee, Phill-Kyu, Kim, Yong-Hwan, Sim, B. S., Zhoo, Z. C., and Park, D-I
- Published
- 1997
- Full Text
- View/download PDF
37. Diagnostic Yield of Advanced Colorectal Neoplasia at Colonoscopy, According to Indications: An Investigation from the Korean Association for the Study of Intestinal Diseases (KASID).
- Author
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Park, D. I., Kim, Y. H., Kim, H. S., Kim, W. H., Kim, T. I., Kim, H. J., Yang, S. K., Byeon, J. S., Lee, M. S., Jung, I. K., Chung, M. K., Jung, S. A., Jeen, Y. T., Choi, J. H., Choi, H., Han, D. S., and Song, J. S.
- Published
- 2006
- Full Text
- View/download PDF
38. Interaction between cyclooxygenase-2 and inducible nitric oxide synthase in gastric cancer.
- Author
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Son, Hee Jung, Kim, Young Ho, Park, Dong Il, Kim, Jae J., Rhee, Poong Lyul, Paik, Seung Woon, Choi, Kyoo Wan, Song, Sang Yong, Rhee, Jong Chul, Son, H J, Kim, Y H, Park, D I, Kim, J J, Rhee, P L, Paik, S W, Choi, K W, Song, S Y, and Rhee, J C
- Published
- 2001
- Full Text
- View/download PDF
39. The analysis of resectability and survival in pancreatic cancer patients with vascular invasion.
- Author
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Park, Dong Il, Lee, Jong Kyun, Kim, Jee-Eun, Hyun, Jae Geun, Shim, Sang Gun, Lee, Kyu Taek, Palk, Seung Woon, Rhee, Jong Chul, Choi, Kyoo Wan, Lim, Jae Hoon, Kim, Yong Il, Park, D I, Lee, J K, Kim, J E, Hyun, J G, Shim, S G, Lee, K T, Palk, S W, Rhee, J C, and Choi, K W
- Published
- 2001
- Full Text
- View/download PDF
40. Microstructures of copper thin films prepared by chemical vapor deposition
- Author
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Cho, N.-I. and Park, D. I.
- Published
- 1997
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41. Decarbopalladation of π-Allylpalladium Intermediates Formed from Palladium-Catalyzed Arylations of 3-Allen-1-ols
- Author
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Oh, C. H., Jung, S. H., Bang, S. Y., and Park, D. I.
- Abstract
Unusual palladium-catalyzed arylative fragmentations of acyclic 3-allen-1-ols were observed. Oxidative addition of Pd(0) to aryl halides would form the arylpalladium halides, which added to the central carbon of allenes via carbopalladation to form the π-allylpalladium intermediates. The π-allylpalladium intermediates would be reductively eliminated via carbon−carbon cleavage to give the arylated dienes and the α-hydroxyalkylpalladium intermediates, which were further reductively eliminated to the corresponding aldehydes. - Published
- 2002
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42. Diagnostic relevance of overexpressions of PKC-θ and DOG-1 and KIT/PDGFRA gene mutations in extragastrointestinal stromal tumors: A Korean six-centers study of 28 cases
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Kim, K. -H, Nelson, S. D., Kim, D. -H, Choi, K. U., Kim, S. J., Min, K. -W, Jang, K. -S, Paik, S. S., Oh, Y. -H, Chae, S. W., Sohn, J. H., Kim, H. J., Cho, Y. K., Kim, B. I., Park, D. I., Sohn, C. I., Oh, S., Choi, S. H., Choi, Y. J., Woo, H. -Y, Park, Y. L., Park, S. J., Lee, S. H., Seungho Ryu, Do, S. -I, Kang, G., Kim, K., Cho, Y. H., and Pyo, J. -S
- Subjects
Receptor, Platelet-Derived Growth Factor alpha ,Base Sequence ,Chloride Channels ,Gastrointestinal Stromal Tumors ,Mutation ,Republic of Korea ,Humans ,Immunohistochemistry ,Polymerase Chain Reaction ,Anoctamin-1 ,Protein Kinase C ,DNA Primers ,Neoplasm Proteins - Abstract
We investigated the clinicopathological and immunohistochemical characteristics, genetic aberrations and prognostic factors in 28 patients with extragastrointestinal stromal tumors (EGISTs) from six centers in South Korea.Immunohistochemistry was performed for c-KIT (CD117), PKC-θ (protein kinase C theta), DOG-1 (discovered on GIST-1), CD34, alpha-smooth muscle actin (α-SMA), vimentin, desmin and S-100 protein. Genetic analyses for the KIT gene (exon 9, 11, 13 and 17) and the platelet-derived growth factor receptor alpha (PDGFRA) gene (exons 12 and 18) were performed by direct sequencing of PCR products. The relationships of various clinicopathological characteristics and outcomes were also examined.Of the tumor samples, 78.6% (22/28) were located in the intra-abdominal cavity including the omentum and mesentery, and 10.7% (3/28) were located in the retroperitoneum. All patients were older than 39 years. The median size of the tumors was 10 cm for the maximum diameter. When first detected, 57.1% of EGISTs were large in size, measuring more than 10 cm. Tumors that were larger than 10 cm were found more frequently among tumors with more than 10 mitoses per 50 high-power fields (HPFs) and this finding was statistically significant (p0.05). Based on immunohistochemical results, the EGISTs were positive for c-KIT in 96.4% (27/28) of samples, PKC-θ in 82.1% (23/28), DOG-1 in 85.7% (24/28), PDGFRA in 82.1% (23/28), CD34 in 67.9% (19/28), vimentin in 100% (28/28), α-SMA in 28.6% (8/28), S-100 protein in 39.3% (11/28) and desmin in 28.6% (8/28). c-KIT, DOG-1 and PKC-θ immunostains were sensitive and specific, but the PDGFRA stain was not specific for EGISTs. c-KIT expression was correlated with DOG-1 expression (p0.05). One c-KIT-negative EGIST was also negative for DOG-1, but positive for PDGFRA and PKC-θ immunostains. Out of all EGISTs, 57.1% had tumor necrosis and most of these were more than 10 cm in size, and had obvious nuclear atypia and high mitotic counts (10/50 HPFs). Overall survival (OS) was correlated with tumor size10 cm, tumor necrosis, obvious nuclear atypia, mitotic counts10/50 HPFs and epithelioid or mixed cell type (p0.05). Eleven EGISTs (44.0%) had mutations in the KIT gene and 6 (24.0%) had mutations in the PDGFRA gene, the most common being missense mutations or deletions affecting exon 11 of the KIT gene (n=9) or exon 18 of the PDGFRA gene (n=6). Three cases showed co-existence of both KIT and PDGFRA gene mutations. There were no mutations of exon 17 of KIT and exon 12 of PDGFRA genes.The c-KIT, PKC-θ and DOG-1 antigens are the most sensitive and specific immunomarkers for confirming EGISTs. PKC-θ and PDGFRA immunostains are helpful markers for c-KIT-negative EGISTs. Survival analyses indicated that tumor size10 cm, mitotic rate10/50 HPFs, tumor necrosis, obvious nuclear atypia, and epithelioid or mixed cell type were significant predictors of survival. We found that the combination of these parameters helped to predict aggressive tumor behavior and may be useful for predicting the prognosis of EGISTs. The majority of gene mutations were identified in exon 11 of the KIT gene or exon 18 of the PDGFRA gene. The pattern of KIT and PDGFRA mutations in EGISTs was essentially similar to the one in GISTs. From the immunohistochemistry and molecular genetics perspective, EGISTs may be a special subtype of GISTs. Both immunohistochemical and molecular evaluation are useful for classifying tumors as EGISTs.
43. Pathological Predictors for Defining a Therapeutic Strategy for Early Colon Cancer after Endoscopic Resection: Multicenter Retrospective Analysis from Surgically Resected Specimens
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Lee, S. -H, Cho, H. D., Park, D. I., Heo, W. J., Sohn, J. H., Kim, S. -E, Cho, M. S., Shin, J. E., Lee, W. A., Han, D. S., Oh, Y. H., Park, S. J., Chang, H. K., Kim, E. Y., Cho, C. H., Kim, S. J., and Young Hwangbo
44. An Analysis of the Tolerance to Crosstalk Noise of a Pulse Width Modulation System
- Author
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Park, D. I.-H., primary and Love, R. D., additional
- Published
- 1983
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45. The effect of ganglioside GQ1b on the NMDA receptor signaling pathway in H19-7 cells and rat hippocampus.
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Jung WR, Kim HG, Shin MK, Park DI, and Kim KL
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- Animals, Cell Line, Cyclic AMP Response Element-Binding Protein metabolism, Cyclic AMP-Dependent Protein Kinases metabolism, Gangliosides pharmacology, Hippocampus drug effects, Male, Mitogen-Activated Protein Kinase 1 metabolism, Mitogen-Activated Protein Kinase 3 metabolism, Phosphorylation, Rats, Rats, Sprague-Dawley, Receptors, N-Methyl-D-Aspartate biosynthesis, Signal Transduction, Gangliosides physiology, Hippocampus physiology, Receptors, N-Methyl-D-Aspartate physiology
- Abstract
Gangliosides, sialic acid-containing glycosphingolipids, are related to various synaptic functions in the rat brain. Previously, we investigated the behavioral effects of the ganglioside GQ1b on learning and memory using the Y-maze and Morris water maze test. GQ1b-treated rats showed highly increased memory performance on the Y-maze and the Morris water maze test. In this study, we determined the role of GQ1b on the activation of the N-methyl-d-aspartate (NMDA) receptor signaling pathway in H19-7 rat hippocampal cells and the hippocampus of rats. After 12 h of treatment with GQ1b, the expression levels of NMDA receptor subunit 2A and 2B were increased in H19-7 cells and the hippocampus of rats. In addition, treatment of GQ1b increased the tyrosine phosphorylation of NR2B that may enhance NMDA receptor synaptic activation and enhancement of NMDA receptors. Also, following GQ1b treatment, the phosphorylation of extracellular signal-regulated kinases (ERK1/2) and protein kinase A, a cAMP activated protein kinase (PKA) increased in H19-7 cells and the hippocampus of rats. These increases resulted in an increase in the phosphorylation of cAMP response element binding protein (CREB). These results suggest that GQ1b might facilitate the activation of the NMDA receptor signaling pathway in the hippocampus of rats, an effect which is dependent on ERK1/2, PKA and CREB phosphorylation. Also, these data support our previous result that GQ1b improves the learning and memory of rats.
- Published
- 2010
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46. Quality and effect of single dose versus split dose of polyethylene glycol bowel preparation for early-morning colonoscopy.
- Author
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Park JS, Sohn CI, Hwang SJ, Choi HS, Park JH, Kim HJ, Park DI, Cho YK, Jeon WK, and Kim BI
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- Colonic Diseases diagnosis, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Humans, Male, Middle Aged, Patient Compliance, Prospective Studies, Time Factors, Colonoscopy methods, Enema methods, Polyethylene Glycols administration & dosage, Surface-Active Agents administration & dosage
- Abstract
Background and Study Aims: The conventional procedure of ingestion of an entire dose of polyethylene glycol solution on the day before early-morning colonoscopy may result in poor bowel preparation. The aim of this study was to evaluate the efficacy and effect of a split-dose ingestion of polyethylene glycol for early-morning colonoscopy., Methods: A total of 303 age- and sex-matched consecutive individuals presenting for medical check-ups were randomly assigned to receive either 4 L of polyethylene glycol solution with a soft diet on the day before colonoscopy (n = 152; group A), or 3 L of polyethylene glycol solution with a soft diet on the preceding day and then 1 L of the solution on the day of colonoscopy (n = 151; group B). The quality of bowel preparation was evaluated using the Ottawa scale, and the time to cecal intubation and the technical difficulty during the procedure were also recorded., Results: There was no difference in compliance between group A (single-dose) and group B (split-dose). The quality of bowel preparation was better in group B compared with group A. When the participants were categorized according to compliance (good compliance, 116 in group A, 119 in group B; poor compliance, 36 in group A, 32 in group B), the quality of the bowel preparation had a higher score in the good compliance compared with the poor compliance group, and in group B this difference was usually significant., Conclusions: Split-dose bowel preparation with polyethylene glycol solution provided a better quality preparation than the conventional method for patients undergoing early-morning colonoscopy.
- Published
- 2007
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47. Role of autonomic dysfunction in patients with functional dyspepsia.
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Park DI, Rhee PL, Kim YH, Sung IK, Son HJ, Kim JJ, Paik SW, Rhee JC, and Choi KW
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- Abdominal Pain etiology, Adult, Autonomic Nervous System Diseases complications, Blood Pressure physiology, Dyspepsia etiology, Female, Gastric Emptying physiology, Heart Rate physiology, Humans, Male, Prospective Studies, Autonomic Nervous System physiopathology, Autonomic Nervous System Diseases physiopathology, Dyspepsia physiopathology
- Abstract
Background: The role of autonomic dysfunction in patients with functional dyspepsia is not completely understood., Aims: 1. to prospectively assess abnormalities of autonomic function in patients with functional dyspepsia, 2. to assess whether autonomic dysfunction in these patients is associated with a. visceral hypersensitivity or b. delayed gastric emptying or c. severity of dyspeptic symptoms., Patients: A series of 28 patients with functional dyspepsia and 14 healthy volunteers without gastrointestinal symptoms were studied., Methods: All patients and controls were submitted to a battery of five standard cardiovascular autonomic reflex tests, dyspeptic questionnaire, gastric barostat tests and gastric emptying tests., Results: 1. Autonomic function tests showed that both sympathetic and parasympathetic scores of dyspeptic patients were significantly higher than in controls; 2. visceral hypersensitivity was confirmed in dyspeptics in response to proximal gastric distension, demonstrating lower pain threshold; 3. delayed gastric emptying occurred more frequently in patients with functional dyspepsia than in controls; 4. epigastric pain and epigastric burning were significantly more prevalent in patients with definite evidence of autonomic dysfunction; 5. No significant association was found between presence of autonomic dysfunction and presence of visceral hypersensitivity or presence of delayed gastric emptying in patients with functional dyspepsia., Conclusions: We concluded that a possible role of autonomic dysfunction in eliciting dyspeptic symptoms could not be determined from alterations in visceral hypersensitivity or delayed gastric emptying. Autonomic dysfunction might not be the major explanation for symptoms associated with functional dyspepsia.
- Published
- 2001
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48. Inducible nitric oxide synthase expression in gastroduodenal diseases infected with Helicobacter pylori.
- Author
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Son HJ, Rhee JC, Park DI, Kim YH, Rhee PL, Koh KC, Paik SW, Choi KW, and Kim JJ
- Subjects
- Adult, Aged, Bacterial Proteins metabolism, Chronic Disease, DNA, Bacterial analysis, Duodenal Ulcer microbiology, Duodenal Ulcer pathology, Female, Gastric Mucosa enzymology, Gastric Mucosa pathology, Gastritis microbiology, Gastritis pathology, Helicobacter Infections microbiology, Helicobacter Infections pathology, Humans, Male, Middle Aged, Nitric Oxide Synthase Type II, Pyloric Antrum enzymology, Pyloric Antrum pathology, Reverse Transcriptase Polymerase Chain Reaction, Stomach Neoplasms microbiology, Stomach Neoplasms pathology, Stomach Ulcer microbiology, Stomach Ulcer pathology, Antigens, Bacterial, Duodenal Ulcer enzymology, Gastritis enzymology, Helicobacter Infections metabolism, Helicobacter pylori, Nitric Oxide Synthase metabolism, Stomach Neoplasms enzymology, Stomach Ulcer enzymology
- Abstract
Background: Nitric oxide (NO) is synthesized enzymatically from L-arginine by NO synthase, which is measured by inducible NO synthase (iNOS). Helicobacter pylori (H. pylori) infection produces a state of chronic immunostimulation in the gastric epithelium. Infection with cagA+ H. pylori has greater degree of gastric inflammation and epithelial cell damage. Therefore, we compared the levels of iNOS in patients with H. pylori infection in relation to cagA status and H. pylori-related disease., Materials and Methods: One hundred and seven patients, including 51 patients with gastric cancer, 12 patients with gastric ulcer, 18 patients with duodenal ulcer and 26 patients with chronic gastritis, were enrolled in this study. Biopsies from the antrum and body were obtained for histologic examination, culture and reverse transcriptionase-PCR (RT-PCR) for detection of iNOS gene expression. The presence of H. pylori was confirmed by Giemsa staining or culture and the gene expression of cagA in H. pylori isolates was confirmed by PCR., Results: H. pylori infection was detected in 70.1% (75/107) and cagA was detected in 84.8% (28/33). iNOS expression was detected in 49.5% (53/107) and there was no significant difference in iNOS expression according to H. pylori infection nor the cagA status in the gastroduodenal diseases. However, iNOS expression was more frequently detected in gastric cancer than the other H. pylori-related diseases (64.7% vs. 35.7%, p <.05)., Conclusion: Although NO was thought be involved in the gastric carcinogenesis, the level of NO production was not related to H. pylori infection or cagA status.
- Published
- 2001
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49. Metered-dose inhaler technique of patients in an urban ED: prevalence of incorrect technique and attempt at education.
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Shrestha M, Parupia H, Andrews B, Kim SW, Martin MS, Park DI, and Gee E
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- Emergency Service, Hospital, Humans, Prevalence, Self Administration, Texas, Time Factors, Urban Population, Anti-Asthmatic Agents administration & dosage, Asthma drug therapy, Nebulizers and Vaporizers, Patient Education as Topic
- Abstract
The metered-dose inhaler (MDI) techniques of 125 asthma patients who presented to a county hospital emergency department (ED) were evaluated. Correct technique was divided into 7 steps. Twenty-one percent of the patients performed all 7 steps correctly. Mean number of steps +/- SD performed correctly was 4.8 +/- 1.7. Verbal individualized instruction was used to improve the technique of patients whose technique was less than perfect. The instruction required a mean +/- SD of 8.3 +/- 5.8 minutes (range, 0 to 30) for all 7 steps to be done correctly at least once. All patients were able to perform all steps correctly after instruction. The amount of time required for teaching was proportional to the number of steps performed incorrectly. The Vitalograph Aerosol Inhalation Monitor was used to verify correct patient technique and as a teaching aid with variable success. Education in proper use of the MDI is important in the overall care of the asthma patient; however, instruction requires a definite time commitment and may not be feasible for all patients in a busy ED. For some patients, alternatives that require less lengthy instruction, such as the use of breath-actuated devices, spacers, and reservoirs, may be required.
- Published
- 1996
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50. Insights into the topography of mitochondrial carnitine palmitoyltransferase gained from the use of proteases.
- Author
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McGarry JD, Brown NF, Inthanousay PP, Park DI, Cook BA, and Foster DW
- Subjects
- Animals, Endopeptidases, Male, Models, Chemical, Rats, Rats, Sprague-Dawley, Acyl Coenzyme A metabolism, Carnitine O-Palmitoyltransferase chemistry, Malonyl Coenzyme A metabolism, Mitochondria, Heart enzymology, Mitochondria, Liver enzymology, Protease Inhibitors metabolism
- Published
- 1992
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