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197 results on '"Park, Sin-Hye"'

1. Feasibility of Regional Lymphadenectomy for Stomach-Preserving Surgery in Early Gastric Cancer Omitting Sentinel Node Navigation: A Post Hoc Analysis of the SENORITA Trial

Author

Park, Sin Hye, Kim, Young-Woo, Min, Jae-Seok, Yoon, Hong Man, An, Ji Yeong, Eom, Bang Wool, Hur, Hoon, Lee, Young Joon, Cho, Gyu Seok, Park, Young-Kyu, Jung, Mi Ran, Park, Ji-Ho, Hyung, Woo Jin, Jeong, Sang-Ho, Kook, Myeong-Cherl, Han, Mira, Nam, Byung-Ho, and Ryu, Keun Won

Published
2024
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6. Advancements in Therapeutic Approaches for Degenerative Tendinopathy: Evaluating Efficacy and Challenges.

Author

Morya, Vivek Kumar, Shahid, Hamzah, Lang, Jun, Kwak, Mi Kyung, Park, Sin-Hye, and Noh, Kyu-Cheol

Subjects
TENDON injuries, TENDINOPATHY, REGENERATIVE medicine, THERAPEUTICS, TENDONS
Abstract

Degenerative tendinopathy results from the accumulation of minor injuries following unsuccessful tendon repair during acute tendon injuries. The process of tendon repair is prolonged and varies between individuals, making it susceptible to reinjury. Moreover, treating chronic tendinopathy often requires expensive and extensive rehabilitation, along with a variety of combined therapies to facilitate recovery. This condition significantly affects the quality of life of affected individuals, underscoring the urgent need for more efficient and cost-effective treatment options. Although traditional treatments have improved significantly and are being used as substitutes for surgical interventions, the findings have been inconsistent and conflicting. This review aims to clarify these issues by exploring the strengths and limitations of current treatments as well as recent innovations in managing various forms of degenerative tendinopathy. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Association between dietary carotenoid intake and breast cancer risk: a case–control study among Korean women.

Author

Park, Sin-Hye, Lee, Jeonghee, Jung, So-Youn, Park, Sohyun, Kang, Young-Hee, and Kim, Jeongseon

Subjects
*KOREANS, *CAROTENOIDS, *BREAST cancer, *DISEASE risk factors, *FOOD consumption, *CASE-control method
Abstract

The association between dietary carotenoids and breast cancer (BC) risks were inconsistent. Therefore, this study investigated the association between dietary carotenoid and BC risks among Korean women. We recruited participants from the National Cancer Centre of Korea. Odds ratios and 95% confidence intervals were calculated with a logistic regression model. There was an inverse association between dietary carotenoid subclasses and BC risks; in particular, a higher intake of β-carotene and lutein/zeaxanthin was associated with reduced BC risks. After subgroup analysis with estrogen receptor (ER)/progesterone receptor (PR) status, there was similar trend among ER-/PR- women. We further investigated which foods contribute to the carotenoid intake. A higher intake of radish leaves, kale, and bracken was associated with lowered BC risks. Accordingly, dietary carotenoid, particularly β-carotene and lutein/zeaxanthin, appears to be associated with a lower risk of BC among Korean women. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Eucalyptol Ameliorates Retinal Microvascular Defects through Modulating ER Stress and Angiopoietin–Tie Signaling in Diabetic Eyes.

Author

Kim, Dong Yeon, Park, Sin-Hye, Yoon, Zaee, Kim, Jimin, Kang, Min-Kyung, and Kang, Young-Hee

Subjects
*VASCULAR endothelial growth factors, *ORAL drug administration, *RETINAL blood vessels, *MACULAR edema, *ENDOPLASMIC reticulum
Abstract

Loss of the inner blood–retinal barrier (BRB) integrity is a main feature of ocular diseases such as diabetic macular edema. However, there is a lack of clarity on how inner BRB function is modulated within the diabetic retina. The current study examined whether eucalyptol inhibited inner BRB destruction and aberrant retinal angiogenesis in 33 mM glucose-exposed human retinal microvascular endothelial (RVE) cells and db/db mice. This study further examined the molecular mechanisms underlying endothelial dysfunction including retinal endoplasmic reticulum (ER) stress and angiopoietin (Ang)/Tie axis in conjunction with vascular endothelial growth factor (VEGF). Eucalyptol is a naturally occurring monoterpenoid and an achiral aromatic component of many plants including eucalyptus leaves. Nontoxic eucalyptol reduced the production of amyloid-β (Aβ) protein in glucose-loaded RVE cells and in diabetic mice. This natural compound blocked apoptosis of Aβ-exposed RVE cells in diabetic mouse eyes by targeting ER stress via the inhibition of PERK-eIF2α-ATF4-CHOP signaling. Eucalyptol promoted activation of the Ang-1/Tie-2 pathway and dual inhibition of Ang-2/VEGF in Aβ-exposed RVE cells and in diabetic eyes. Supply of eucalyptol reversed the induction of junction proteins in glucose/Aβ-exposed RVE cells within the retina and reduced permeability. In addition, oral administration of eucalyptol reduced vascular leaks in diabetic retinal vessels. Taken together, these findings clearly show that eucalyptol inhibits glucose-induced Aβ-mediated ER stress and manipulates Ang signaling in diabetic retinal vessels, which ultimately blocks abnormal angiogenesis and loss of inner BRB integrity. Therefore, eucalyptol provides new treatment strategies for diabetes-associated RVE defects through modulating diverse therapeutic targets including ER stress, Ang-1/Tie-2 signaling, and Ang-2/VEGF. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Standard follow-up after curative surgery for advanced gastric cancer: secondary analysis of a multicentre randomized clinical trial (KLASS-02)

Author

Park, Sin Hye, primary, Hyung, Woo Jin, additional, Yang, Han-Kwang, additional, Park, Young-Kyu, additional, Lee, Hyuk-Joon, additional, An, Ji Yeong, additional, Kim, Wook, additional, Kim, Hyoung-Il, additional, Kim, Hyung-Ho, additional, Ryu, Seung Wan, additional, Hur, Hoon, additional, Kim, Min-Chan, additional, Kong, Seong-Ho, additional, Cho, Gyu Seok, additional, Kim, Jin-Jo, additional, Park, Do Joong, additional, Kim, Young-Woo, additional, Kim, Jong Won, additional, Lee, Joo-Ho, additional, Han, Sang-Uk, additional, and Ryu, Keun Won, additional

Published
2023
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28. A Comprehensive and Comparative Review of Global Gastric Cancer Treatment Guidelines

Author

Eom, Sang Soo, primary, Choi, Wonyoung, additional, Eom, Bang Wool, additional, Park, Sin Hye, additional, Kim, Soo Jin, additional, Kim, Young Il, additional, Man Yoon, Hong, additional, Lee, Jong Yeul, additional, Kim, Chan Gyoo, additional, Kim, Hark Kyun, additional, Kook, Myeong-Cherl, additional, Choi, Il Ju, additional, Kim, Young-Woo, additional, Park, Young Iee, additional, and Ryu, Keun Won, additional

Published
2022
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31. Short and Long-Term Surgical Outcomes of Laparoscopic Total Gastrectomy Compared with Open Total Gastrectomy in Gastric Cancer Patients.

Author

Eom, Sang Soo, Park, Sin Hye, Eom, Bang Wool, Yoon, Hong Man, Kim, Young-Woo, and Ryu, Keun Won

Subjects
*STOMACH tumors, *LYMPHADENECTOMY, *LAPAROSCOPIC surgery, *SURGICAL complications, *RETROSPECTIVE studies, *SURGERY, *PATIENTS, *GASTRECTOMY, *TREATMENT effectiveness, *COMPARATIVE studies, *CANCER patients, *DESCRIPTIVE statistics, *PROGRESSION-free survival, *LONGITUDINAL method, *HEMORRHAGE, *OVERALL survival, *EVALUATION
Abstract

Simple Summary: Laparoscopic total gastrectomy (LTG) remains controversial in terms of its short- and long-term surgical outcomes in comparison to open total gastrectomy (OTG). This study aimed to compare the outcomes of LTG with OTG. There was no significant difference in short-term outcomes between the two groups. Additionally, the 3-year disease-free survival and 5-year overall survival rates were not significantly different between the two groups. Therefore, LTG could be an alternative approach to OTG. This study aimed to compare the efficacy of laparoscopic total gastrectomy (LTG) with that of open total gastrectomy (OTG) in terms of postoperative complications and long-term survival. We retrospectively reviewed the clinicopathological data of 560 patients, who underwent total gastrectomy between 2012 and 2016 at the National Cancer Center, Korea. Propensity-score matching (PSM) was performed to correct for discrepancies between the two groups. Matched variables included sex, age, body mass index, American Society of Anesthesiologists score, and pathological Tumor–Node–Metastasis stage. After PSM, 238 patients were included in this analysis. The rate of D2 lymph node dissection was significantly higher in the OTG group than in the LTG group. The estimated blood loss was significantly lower in the LTG group than in the OTG group. The overall complication rate was not significantly different between the two groups. There was no significant difference in the 3-year disease-free and 5-year overall survival rates between the two groups. LTG and OTG had comparable efficacies in gastric cancer patients regarding short- and long-term surgical outcomes. This study suggests that LTG could be an alternative approach to the OTG. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Asaronic Acid Inhibited Glucose-Triggered M2-Phenotype Shift Through Disrupting the Formation of Coordinated Signaling of IL-4Rα-Tyk2-STAT6 and GLUT1-Akt-mTOR-AMPK

Author

Oh, Hyeongjoo, primary, Park, Sin-Hye, additional, Kang, Min-Kyung, additional, Kim, Yun-Ho, additional, Lee, Eun-Jung, additional, Kim, Dong Yeon, additional, Kim, Soo-Il, additional, Oh, Su Yeon, additional, Na, Woojin, additional, Lim, Soon Sung, additional, and Kang, Young-Hee, additional

Published
2020
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