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The study investigated PM2.5 and heavy metal pollutant concentrations in Seoul and Wonju, South Korea, emphasizing the importance of considering PM2.5 chemical constituents for health impact assessments. While PM2.5 concentrations were similar between the two cities with slight variations, heavy metal concentrations differed significantly. Regional sources, PM2.5 composition, and meteorological conditions influenced these variations. Exposure to Fe was highest in all areas, with some heavy metals exceeding permissible levels, stressing the need to consider regional characteristics in assessments. Different heavy metals influence health risks differently in each city. When examining the HI (the summation of the hazard quotient for heavy metals), Seoul remained below an HI value of 1, while Wonju exceeded this threshold when exposed to CTE concentrations. In Seoul, As had a significant health impact of PM2.5, while in Wonju, Mn was more influential. Source apportionment confirmed different pollution sources in Seoul and Wonju, affecting the distribution of PM2.5 constituents in the atmosphere. Effective PM2.5 management requires a comprehensive approach considering chemical constituents and health impacts not just mass-based PM2.5 management, emphasizing regional-specific assessments and policy considerations to mitigate health risks. Therefore, tailored management strategies based on regional characteristics are necessary. [ABSTRACT FROM AUTHOR]

Given the growing global demand for seafood, it is imperative to conduct a comprehensive study on the prevalence and persistence patterns of pathogenic bacteria and viruses associated with specific seafood varieties. This assessment thoroughly examines the safety of seafood products, considering the diverse processing methods employed in the industry. The importance of understanding the behavior of foodborne pathogens, such as Salmonella typhimurium, Vibrio parahaemolyticus, Clostridium botulinum, Listeria monocytogenes, human norovirus, and hepatitis A virus, is emphasized by recent cases of gastroenteritis outbreaks linked to contaminated seafood. This analysis examines outbreaks linked to seafood in the United States and globally, with a particular emphasis on the health concerns posed by pathogenic bacteria and viruses to consumers. Ensuring the safety of seafood is crucial since it directly relates to consumer preferences on sustainability, food safety, provenance, and availability. The review focuses on assessing the frequency, growth, and durability of infections that arise during the processing of seafood. It utilizes next‐generation sequencing to identify the bacteria responsible for these illnesses. Additionally, it analyzes methods for preventing and intervening of infections while also considering the forthcoming challenges in ensuring the microbiological safety of seafood products. This evaluation emphasizes the significance of the seafood processing industry in promptly responding to evolving consumer preferences by offering current information on seafood hazards and future consumption patterns. To ensure the continuous safety and sustainable future of seafood products, it is crucial to identify and address possible threats. [ABSTRACT FROM AUTHOR]

Saikosaponin D (SSD), derived from Bupleurum falcatum L., has various pharmacological properties, including immunoregulatory, anti-inflammatory, and anti-allergic effects. Several studies have investigated the anti-tumor effects of SSD on cancer in multiple organs. However, its role in colorectal cancer (CRC) remains unclear. Therefore, this study aimed to elucidate the suppressive effects of SSD on CRC cell survival and metastasis. SSD reduced the survival and colony formation ability of CRC cells. SSD-induced autophagy and apoptosis in CRC cells were measured using flow cytometry. SSD treatment increased LC3B and p62 autophagic factor levels in CRC cells. Moreover, SSD-induced apoptosis occurred through the cleavage of caspase-9, caspase-3, and PARP, along with the downregulation of the Bcl-2 family. In the in vivo experiment, a reduction in the number of metastatic tumor nodules in the lungs was observed after the oral administration of SSD. Based on these results, SSD inhibits the metastasis of CRC cells to the lungs by inducing autophagy and apoptosis. In conclusion, SSD suppressed the proliferation and metastasis of CRC cells, suggesting its potential as a novel substance for the metastatic CRC treatment. [ABSTRACT FROM AUTHOR]

This study aimed to identify factors influencing compliance with social distancing, a key nonpharmaceutical intervention during the early stages of the coronavirus disease (COVID-19) pandemic. The study population comprised 182 758 Koreans who participated in the 2020 Community Health Survey. Personal characteristics were classified into sociodemographic, health behavioral, and psychosocial factors, and factors associated with social distancing compliance were identified. Health behaviors and psychosocial factors were highly related to compliance with social distancing. Approximately 13% of smokers were less likely to practice physical distancing and 50% of high-risk drinkers were less likely to limit going out or attending gatherings and events. Higher concern about COVID-19 and a more positive perception of the government's response policy were associated with a higher compliance with social distancing. Strategic public health policies considering the characteristics of the public are needed to enhance compliance with nonpharmaceutical interventions during disease outbreaks lacking effective treatments and vaccines. [ABSTRACT FROM AUTHOR]

Effective contact tracing is critical to controlling the spread of coronavirus disease (COVID-19) (1). South Korea adopted a rigorous contact-tracing program comprising traditional shoe-leather epidemiology and new methods to track [...]

Since the first imported case of coronavirus disease (COVID-19) was confirmed in South Korea on January 20, 2020, a sharp increase in the number of COVID-19 cases has been observed, [...]