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3. Integrative analysis of spatial and single-cell transcriptome data from human pancreatic cancer reveals an intermediate cancer cell population associated with poor prognosis

Author

Kim, Seongryong, Leem, Galam, Choi, Junjeong, Koh, Yongjun, Lee, Suho, Nam, Sang-Hee, Kim, Jin Su, Park, Chan Hee, Hwang, Ho Kyoung, Min, Kyoung Il, Jo, Jung Hyun, Lee, Hee Seung, Chung, Moon Jae, Park, Jeong Youp, Park, Seung Woo, Song, Si Young, Shin, Eui-Cheol, Kang, Chang Moo, Bang, Seungmin, and Park, Jong-Eun

Published
2024
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4. Three-Dimensional Transthoracic Echocardiography for Semiautomated Analysis of the Tricuspid Annulus: Validation and Normal Values

Author

Prado, Aldo D., Filipini, Eduardo, Ronderos, Ricardo E., Samantha Hoschke-Edwards, Agatha Kwon, Scalia, Gregory M., Afonso, Tania Regina, Tude Rodridugues, Ana Clara, Thampinathan, Babitha, Sooriyakanthan, Maala, Tsang, Wendy, Wang, Yingbin, Zhang, Yu, Zhu, Tiangang, Wang, Zhilong, Alagesan, R., Balasubramanian, S., Ananth, R.V.A., Amuthan, Vivekanandan, Bansal, Manish, Kasliwal, Ravi R., Alizadehasl, Azin, Sadeghpour, Anita, Bossone, Eduardo, Nakao, Tomoko, Kawata, Takayuki, Hirokawa, Megumi, Sawada, Naoko, Daimon, Masao, Nabeshima, Yousuke, Takeuchi, Masaki, Fajardo, Pedro Gutierrez, Ogunyankin, Kofo O., Tucay, Edwin S., Yun, Hye Rim, Park, Seung Woo, Hwang, Ji-won, Monaghan, Mark J., Kirkpatrick, James N., Miyoshi, Tatsuya, Cotella, Juan I., Blitz, Alexandra, Clement, Alexandra, Tomaselli, Michele, Muraru, Denisa, Badano, Luigi P., Sauber, Natascha, Font Calvarons, Adria, Degel, Markus, Rucki, Agnieszka, Blankenhagen, Michael, Yamat, Megan, Schreckenberg, Marcus, Addetia, Karima, Asch, Federico M., Mor-Avi, Victor, and Lang, Roberto M.

Published
2025
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7. Variations in indexation of left atrial volume across different races

Author

Prado, Aldo D., Addetia, Karima, Bellino, Michele, Daimon, Masao, Fajardo, Pedro Gutierrez, Kasliwal, Ravi R., Kirkpatrick, James N., Monaghan, Mark J., Muraru, Denisa, Ogunyankin, Kofo O., Park, Seung Woo, Ronderos, Ricardo E., Sadeghpour, Anita, Scalia, Gregory M., Takeuchi, Masaaki, Tsang, Wendy, Tucay, Edwin S., Tude Rodrigues, Ana Clara, Vivekanandan, Amuthan, Zhang, Yun, Ferkh, Aaisha, Pathan, Faraz, Kizana, Eddy, Elhindi, James, Singh, Amita, Singulane, Cristiane Carvalho, Miyoshi, Tatsuya, Asch, Federico M., Lang, Roberto M., and Thomas, Liza

Published
2023
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9. Normal Values of Three-Dimensional Right Ventricular Size and Function Measurements: Results of the World Alliance Societies of Echocardiography Study

Author

Prado, Aldo D., Filipini, Eduardo, Kwon, Agatha, Hoschke-Edwards, Samantha, Afonso, Tania Regina, Thampinathan, Babitha, Sooriyakanthan, Maala, Zhu, Tiangang, Wang, Zhilong, Wang, Yingbin, Yin, Lixue, Li, Shuang, Alagesan, R., Balasubramanian, S., Ananth, R.V.A., Bansal, Manish, Badano, Luigi, Bossone, Eduardo, Di Vece, Davide, Bellino, Michele, Nakao, Tomoko, Kawata, Takayuki, Hirokawa, Megumi, Sawada, Naoko, Nabeshima, Yousuke, Yun, Hye Rim, Hwang, Ji-won, Addetia, Karima, Miyoshi, Tatsuya, Amuthan, Vivekanandan, Citro, Rodolfo, Daimon, Masao, Gutierrez Fajardo, Pedro, Kasliwal, Ravi R., Kirkpatrick, James N., Monaghan, Mark J., Muraru, Denisa, Ogunyankin, Kofo O., Park, Seung Woo, Ronderos, Ricardo E., Sadeghpour, Anita, Scalia, Gregory M., Takeuchi, Masaaki, Tsang, Wendy, Tucay, Edwin S., Tude Rodrigues, Ana Clara, Zhang, Yun, Singulane, Cristiane C., Hitschrich, Niklas, Blankenhagen, Michael, Degel, Markus, Schreckenberg, Marcus, Mor-Avi, Victor, Asch, Federico M., and Lang, Roberto M.

Published
2023
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10. Age-, Sex-, and Race-Based Normal Values for Left Ventricular Circumferential Strain from the World Alliance Societies of Echocardiography Study

Author

Singulane, Cristiane Carvalho, Miyoshi, Tatsuya, Mor-Avi, Victor, Cotella, Juan I., Schreckenberg, Marcus, Blankenhagen, Michael, Hitschrich, Niklas, Addetia, Karima, Amuthan, Vivekanandan, Citro, Rodolfo, Daimon, Masao, Gutiérrez-Fajardo, Pedro, Kasliwal, Ravi, Kirkpatrick, James N., Monaghan, Mark J., Muraru, Denisa, Ogunyankin, Kofo O., Park, Seung Woo, Tude Rodrigues, Ana Clara, Ronderos, Ricardo, Sadeghpour, Anita, Scalia, Gregory M., Takeuchi, Masaaki, Tsang, Wendy, Tucay, Edwin S., Zhang, Yun, Asch, Federico M., and Lang, Roberto M.

Published
2023
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11. Normal Values of Left Ventricular Mass by Two-Dimensional and Three-Dimensional Echocardiography: Results from the World Alliance Societies of Echocardiography Normal Values Study

Author

Lee, Linda, Cotella, Juan I., Miyoshi, Tatsuya, Addetia, Karima, Schreckenberg, Marcus, Hitschrich, Niklas, Blankenhagen, Michael, Amuthan, Vivekanandan, Citro, Rodolfo, Daimon, Masao, Gutiérrez-Fajardo, Pedro, Kasliwal, Ravi, Kirkpatrick, James N., Monaghan, Mark J., Muraru, Denisa, Ogunyankin, Kofo O., Park, Seung Woo, Tude Rodrigues, Ana Clara, Ronderos, Ricardo, Sadeghpour, Anita, Scalia, Gregory M., Takeuchi, Masaaki, Tsang, Wendy, Tucay, Edwin S., Zhang, Mei, Mor-Avi, Victor, Asch, Federico M., and Lang, Roberto M.

Published
2023
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12. Chemotherapy in Pancreatic Ductal Adenocarcinoma

Author

Lee, Hee Seung, Park, Seung Woo, Song, Si Young, Makuuchi, Masatoshi, editor, Kokudo, Norihiro, editor, Popescu, Irinel, editor, Belghiti, Jacques, editor, Han, Ho-Seong, editor, Takaori, Kyoichi, editor, and Duda, Dan G., editor

Published
2022
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15. Three-Dimensional Transthoracic Static and Dynamic Normative Values of the Mitral Valve Apparatus: Results from the Multicenter World Alliance Societies of Echocardiography Study

Author

Henry, Michael P., Cotella, Juan, Mor-Avi, Victor, Addetia, Karima, Miyoshi, Tatsuya, Schreckenberg, Marcus, Blankenhagen, Michael, Hitschrich, Niklas, Amuthan, Vivekanandan, Citro, Rodolfo, Daimon, Masao, Gutiérrez-Fajardo, Pedro, Kasliwal, Ravi, Kirkpatrick, James N., Monaghan, Mark J., Muraru, Denisa, Ogunyankin, Kofo O., Park, Seung Woo, Tude Rodrigues, Ana Clara, Ronderos, Ricardo, Sadeghpour, Anita, Scalia, Gregory, Takeuchi, Masaaki, Tsang, Wendy, Tucay, Edwin S., Zhang, Mei, Lang, Roberto M., and Asch, Federico M.

Published
2022
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17. Normal Values of Left Ventricular Size and Function on Three-Dimensional Echocardiography: Results of the World Alliance Societies of Echocardiography Study

Author

Prado, Aldo D., Filipini, Eduardo, Kwon, Agatha, Hoschke-Edwards, Samantha, Afonso, Tania Regina, Thampinathan, Babitha, Sooriyakanthan, Maala, Zhu, Tiangang, Wang, Zhilong, Wang, Yingbin, Yin, Lixue, Li, Shuang, Alagesan, R., Balasubramanian, S., Ananth, R.V.A., Bansal, Manish, Badano, Luigi, Bossone, Eduardo, Di Vece, Davide, Bellino, Michele, Nakao, Tomoko, Kawata, Takayuki, Hirokawa, Megumi, Sawada, Naoko, Nabeshima, Yousuke, Yun, Hye Rim, Hwang, Ji-Won, Addetia, Karima, Miyoshi, Tatsuya, Amuthan, Vivekanandan, Citro, Rodolfo, Daimon, Masao, Gutierrez Fajardo, Pedro, Kasliwal, Ravi R., Kirkpatrick, James N., Monaghan, Mark J., Muraru, Denisa, Ogunyankin, Kofo O., Park, Seung Woo, Ronderos, Ricardo E., Sadeghpour, Anita, Scalia, Gregory M., Takeuchi, Masaaki, Tsang, Wendy, Tucay, Edwin S., Tude Rodrigues, Ana Clara, Zhang, Yun, Hitschrich, Niklas, Blankenhagen, Michael, Degel, Markus, Schreckenberg, Marcus, Mor-Avi, Victor, Asch, Federico M., and Lang, Roberto M.

Published
2022
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18. Is early use of sodium-glucose cotransporter type 2 inhibitor (SGLT2i) necessary even in diabetic patients without cardiovascular disease: a prospective study regarding the effect of SGLT2i on left ventricular diastolic function.

Author

Jeon, Kina, Jang, Shin Yi, Lee, You-Bin, Kim, Jihoon, Kim, Darae, Chang, Sung-A, Park, Sung-Ji, Lee, Sang-Chol, Park, Seung Woo, Lee, Moon-Kyu, Kim, Eun Kyoung, and Hur, Kyu Yeon

Subjects
SODIUM-glucose cotransporter 2 inhibitors, CARDIOVASCULAR diseases risk factors, HYPERTENSION risk factors, TYPE 2 diabetes, DIABETIC cardiomyopathy, SODIUM-glucose cotransporters
Abstract

Background: There are insufficient studies to determine whether sodium-glucose cotransporter type 2 inhibitors (SGLT2i) will help reduce early diabetic cardiomyopathy, especially in patients without documented cardiovascular disease. Methods: We performed a single center, prospective observation study. A total of 90 patients with type 2 diabetes patients without established heart failure or atherosclerotic cardiovascular disease were enrolled. Echocardiography, cardiac enzyme, and glucose-control data were examined before and 3 months after the administration of SGLT2i (dapagliflozin 10 mg per day). Cardiovascular risk factors included hypertension, smoking, obesity, dyslipidemia, and old age. The primary end point was the change of E/e' before and after administration of SGLT2i. Results: Most patients (86.7%) had three or more cardiovascular risk factors, and about 32% had all five risk factors. Although the decrease in E/e' after the administration of SGLT2i was observed in 20% of enrolled patients, there was no significant difference in average E/e' value or left atrial volume index before and after the SGLT2i medication. Even in patients with all known risk factors including old age, E/e' value did not decrease after adding SGLT2i (8.9 ± 2.4 vs. 8.7 ± 3.2). There was a statistically significant difference in E/e' change after the SGLT2i administration between patients younger than 60 years and those older than 60 years (–0.7 ± 2.2 vs. 1.1 ± 2.8, P = 0.002). Conclusions: In type 2 diabetes patients without documented cardiovascular disease including heart failure, administration of SGLT2i showed no improvement in diastolic function profile. Further large-scale randomized studies are needed to determine who will benefit from potential cardiovascular events with early addition of SGLT2i. [ABSTRACT FROM AUTHOR]

Published
2025
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19. Long‐Term Outcomes of Neoadjuvant Therapy Versus Upfront Surgery for Resectable Pancreatic Ductal Adenocarcinoma.

Author

Shin, Kyung In, Yoon, Min Sung, Kim, Jee Hoon, Jang, Won Joon, Leem, Galam, Jo, Jung Hyun, Chung, Moon Jae, Park, Jeong Youp, Park, Seung Woo, Hwang, Ho Kyoung, Kang, Chang Moo, Kim, Seung‐seob, Park, Mi‐Suk, Lee, Hee Seung, and Bang, Seungmin

Subjects
NEOADJUVANT chemotherapy, TREATMENT effectiveness, PROPENSITY score matching, PANCREATIC duct, OVERALL survival, PANCREATIC surgery
Abstract

Introduction: This study aimed to compare the long‐term effects of neoadjuvant therapy and upfront surgery on overall survival (OS) and progression‐free survival (PFS) in patients with resectable pancreatic ductal adenocarcinoma (PDAC). Methods: We retrospectively analyzed 202 patients, including 167 who had upfront surgery and 35 who received neoadjuvant therapy followed by surgery. Surgical outcomes and survival rates were compared using propensity score matching to minimize selection bias. Results: Neoadjuvant therapy showed significantly longer 75% OS (72.7 months vs. 28.3 months, p = 0.032) and PFS (29.6 months vs. 13.2 months, p < 0.001) compared to upfront surgery. Additionally, neoadjuvant therapy demonstrated significant improvements in surgical outcomes, including higher R0 resection rates (74.3% vs. 49.5%, p = 0.034), reduced tumor size (22.0 mm vs. 28.0 mm, p = 0.001), and decreased lymphovascular invasion (20.0% vs. 52.4%, p = 0.001). Conclusion: Our study demonstrates the potential benefits of neoadjuvant therapy for resectable PDAC. The improved survival rates, delayed disease progression, and enhanced surgical outcomes underscore the potential of neoadjuvant therapy in addressing this aggressive disease. Despite limitations such as the retrospective design and small sample size, these findings support the effectiveness of neoadjuvant therapy in improving treatment outcomes for PDAC patients in real‐world settings. Further prospective studies are required to validate these results. This study suggests that neoadjuvant therapy in patients with resectable pancreatic cancer improves overall survival and surgical outcomes, while also delaying disease progression compared to upfront surgery. These findings underscore the pivotal role of neoadjuvant therapy in treatment strategies for resectable pancreatic cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Copper Catalysts Anchored on Cysteine-Functionalized Polydopamine-Coated Magnetite Particles: A Versatile Platform for Enhanced Coupling Reactions.

Author

Jo, Yu-Jeong, Park, Seung-Woo, Shin, Ueon Sang, and Kim, Seung-Hoi

Subjects
*COUPLING reactions (Chemistry), *HETEROGENEOUS catalysis, *COPPER, *CATALYTIC activity, *SULFHYDRYL group, *PALLADIUM catalysts, *COPPER catalysts
Abstract

Cysteine plays a crucial role in the development of an efficient copper-catalyst system, where its thiol group serves as a strong anchoring site for metal coordination. By immobilizing copper onto cysteine-modified, polydopamine-coated magnetite particles, this advanced catalytic platform exhibits exceptional stability and catalytic activity. Chemical modification of the polydopamine (PDA) surface with cysteine enhances copper salt immobilization, leading to the formation of the Fe3O4@PDA-Cys@Cu platform. This system was evaluated in palladium-free, copper-catalyzed Sonogashira coupling reactions, effectively catalyzing the coupling of terminal acetylenes with aryl halides. Additionally, the Fe3O4@PDA-Cys@Cu platform was employed in click reactions, confirming the enhanced catalytic efficiency due to increased copper content. The reusability of the platform was further investigated, demonstrating improved performance, especially in recyclability tests in click reaction, making it a promising candidate for sustainable heterogeneous catalysis. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Sex-, Age-, and Race-Related Normal Values of Right Ventricular Diastolic Function Parameters: Data from the World Alliance Societies of Echocardiography Study

Author

Carvalho Singulane, Cristiane, Singh, Amita, Miyoshi, Tatsuya, Addetia, Karima, Soulat-Dufour, Laurie, Schreckenberg, Marcus, Blankenhagen, Michael, Hitschrich, Niklas, Amuthan, Vivekanandan, Citro, Rodolfo, Daimon, Masao, Gutiérrez-Fajardo, Pedro, Kasliwal, Ravi, Kirkpatrick, James N., Monaghan, Mark J., Muraru, Denisa, Ogunyankin, Kofo O., Park, Seung Woo, Tude Rodrigues, Ana Clara, Ronderos, Ricardo, Sadeghpour, Anita, Scalia, Gregory M., Takeuchi, Masaaki, Tsang, Wendy, Tucay, Edwin S., Zhang, Yun, Mor-Avi, Victor, Asch, Federico M., and Lang, Roberto M.

Published
2022
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22. Normal Values of Aortic Root Size According to Age, Sex, and Race: Results of the World Alliance of Societies of Echocardiography Study

Author

Patel, Hena N., Miyoshi, Tatsuya, Addetia, Karima, Citro, Rodolfo, Daimon, Masao, Gutierrez Fajardo, Pedro, Kasliwal, Ravi R., Kirkpatrick, James N., Monaghan, Mark J., Muraru, Denisa, Ogunyankin, Kofo O., Park, Seung Woo, Ronderos, Ricardo E., Sadeghpour, Anita, Scalia, Gregory M., Takeuchi, Masaaki, Tsang, Wendy, Tucay, Edwin S., Tude Rodrigues, Ana Clara, Amuthan, Vivekanandan, Zhang, Yun, Schreckenberg, Marcus, Blankenhagen, Michael, Degel, Markus, Hitschrich, Niklas, Mor-Avi, Victor, Asch, Federico M., and Lang, Roberto M.

Published
2022
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23. Normal Values of Left Atrial Size and Function and the Impact of Age: Results of the World Alliance Societies of Echocardiography Study

Author

Singh, Amita, Carvalho Singulane, Cristiane, Miyoshi, Tatsuya, Prado, Aldo D., Addetia, Karima, Bellino, Michele, Daimon, Masao, Gutierrez Fajardo, Pedro, Kasliwal, Ravi R., Kirkpatrick, James N., Monaghan, Mark J., Muraru, Denisa, Ogunyankin, Kofo O., Park, Seung Woo, Ronderos, Ricardo E., Sadeghpour, Anita, Scalia, Gregory M., Takeuchi, Masaaki, Tsang, Wendy, Tucay, Edwin S., Tude Rodrigues, Ana Clara, Vivekanandan, Amuthan, Zhang, Yun, Schreckenberg, Marcus, Blankenhagen, Michael, Degel, Markus, Hitschrich, Niklas, Mor-Avi, Victor, Asch, Federico M., and Lang, Roberto M.

Published
2022
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26. Two-Dimensional Echocardiographic Right Ventricular Size and Systolic Function Measurements Stratified by Sex, Age, and Ethnicity: Results of the World Alliance of Societies of Echocardiography Study

Author

Addetia, Karima, Miyoshi, Tatsuya, Citro, Rodolfo, Daimon, Masao, Gutierrez Fajardo, Pedro, Kasliwal, Ravi R., Kirkpatrick, James N., Monaghan, Mark J., Muraru, Denisa, Ogunyankin, Kofo O., Park, Seung Woo, Ronderos, Ricardo E., Sadeghpour, Anita, Scalia, Gregory M., Takeuchi, Masaaki, Tsang, Wendy, Tucay, Edwin S., Tude Rodrigues, Ana Clara, Vivekanandan, Amuthan, Zhang, Yun, Schreckenberg, Marcus, Mor-Avi, Victor, Asch, Federico M., and Lang, Roberto M.

Published
2021
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29. Normal Values of Cardiac Output and Stroke Volume According to Measurement Technique, Age, Sex, and Ethnicity: Results of the World Alliance of Societies of Echocardiography Study

Author

Prado, Aldo D., Filipini, Eduardo, Kwon, Agatha, Hoschke-Edwards, Samantha, Afonso, Tania Regina, Thampinathan, Babitha, Sooriyakanthan, Maala, Zhu, Tiangang, Wang, Zhilong, Wang, Yingbin, Yin, Lixue, Li, Shuang, Alagesan, R., Balasubramanian, S., Ananth, R.V.A., Bansal, Manish, Alizadehasl, Azin, Badano, Luigi, Bossone, Eduardo, Di Vece, Davide, Bellino, Michele, Nakao, Tomoko, Kawata, Takayuki, Hirokawa, Megumi, Sawada, Naoko, Nabeshima, Yousuke, Yun, Hye Rim, Hwang, Ji-won, Patel, Hena N., Miyoshi, Tatsuya, Addetia, Karima, Henry, Michael P., Citro, Rodolfo, Daimon, Masao, Gutierrez Fajardo, Pedro, Kasliwal, Ravi R., Kirkpatrick, James N., Monaghan, Mark J., Muraru, Denisa, Ogunyankin, Kofo O., Park, Seung Woo, Ronderos, Ricardo E., Sadeghpour, Anita, Scalia, Gregory M., Takeuchi, Masaaki, Tsang, Wendy, Tucay, Edwin S., Tude Rodrigues, Ana Clara, Vivekanandan, Amuthan, Zhang, Yun, Schreckenberg, Marcus, Blankenhagen, Michael, Degel, Markus, Rossmanith, Alexander, Mor-Avi, Victor, Asch, Federico M., and Lang, Roberto M.

Published
2021
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32. Normal Values of Right Atrial Size and Function According to Age, Sex, and Ethnicity: Results of the World Alliance Societies of Echocardiography Study

Author

Prad, Aldo D., Kwon, Agatha, Hoschke-Edwards, Samantha, Afonso, Tania Regina, Thampinathan, Babitha, Sooriyakanthan, Maala, Zhu, Tiangang, Wang, Zhilong, Alagesan, R., Alizadehasl, Azin, Badano, Luigi, Nakao, Tomoko, Kawata, Takayuki, Hirokawa, Megumi, Sawada, Naoko, Yun, Hye Rim, Hwang, Ji-won, Soulat-Dufour, Laurie, Addetia, Karima, Miyoshi, Tatsuya, Citro, Rodolfo, Daimon, Masao, Fajardo, Pedro Gutierrez, Kasliwal, Ravi R., Kirkpatrick, James N., Monaghan, Mark J., Muraru, Denisa, Ogunyankin, Kofo O., Park, Seung Woo, Ronderos, Ricardo E., Sadeghpour, Anita, Scalia, Gregory M., Takeuchi, Masaaki, Tsang, Wendy, Tucay, Edwin S., Tude Rodrigues, Ana Clara, Vivekanandan, Amuthan, Zhang, Yun, Diehl, Markus, Schreckenberg, Marcus, Mor-Avi, Victor, Asch, Federico M., and Lang, Roberto M.

Published
2021
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34. A Study on Enhancing Axial Flux Motor Efficiency Using Cladding Core Technology.

Author

Park, Seung-Woo, Moon, Ju-Hyeong, Kang, Dong-Woo, and Su, Khac-Huan

Subjects
*SOFT magnetic materials, *SILICON steel, *ELECTRIC flux, *FINITE element method, *ACTINIC flux, *PERMANENT magnets
Abstract

With the rise of eco-friendly policies, advanced motor technologies are being developed to replace fossil fuel-based engines in the mobility industry. Axial flux motors, known for their ability to reduce size and increase output torque compared to radial flux motors, require different materials and manufacturing techniques. Specifically, the production of complex stator cores and segmented magnets presents significant challenges, often leading to higher costs. To address this issue, soft magnetic composite (SMC) materials, which offer greater design flexibility, are being explored for use in stator cores. However, soft magnetic composite materials exhibit lower permeability and saturation flux density compared to laminated silicon steel, resulting in reduced output torque and efficiency. This paper investigates the effects of stator geometry on axial flux motor performance and explores cladding core technology, which combines soft magnetic composite materials with silicon steel. By conducting finite element method (FEM) analysis to evaluate the output torque and efficiency based on the shape of the silicon steel within the cladding core, this study proposes an optimized cladding core design to enhance the efficiency and output torque of axial flux motors. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Survival predictors in patients with pancreatic cancer on liposomal irinotecan plus fluorouracil/leucovorin: a multicenter observational study.

Author

Keum, Jiyoung, Lee, Hee Seung, Park, Chan Su, Kim, Jeehoon, Jang, Wonjoon, Shin, Kyung In, Kang, Huapyong, Lee, Sang Hoon, Jo, Jung Hyun, Jang, Sung Ill, Chung, Moon Jae, Park, Jeong Youp, Park, Seung Woo, Cho, Jae Hee, and Bang, Seungmin

Abstract

Background: Approximately half of the patients with advanced pancreatic ductal adenocarcinoma (PDAC) receive subsequent lines of chemotherapy. Recently, the liposomal irinotecan (nal-IRI) plus 5-fluorouracil/leucovorin (5-FU/LV) regimen is recommended as subsequent lines of chemotherapy. However, little is known about the predictive factors for the nal-IRI + 5-FU/LV regimen, especially in patients with previous irinotecan (IRI) exposure. Objectives: We investigated the predictive factors associated with nal-IRI + 5-FU/LV treatment in patients with PDAC. Design: Multicenter, retrospective cohort study. Methods: This study included patients with advanced PDAC who received the nal-IRI + 5-FU/LV regimen for palliative purposes. Results: Overall, 268 patients were treated with nal-IRI + 5-FU/LV. The median overall survival (OS) was 7.9 months (95% confidence interval (CI): 7.0–8.8), while the median progression-free survival (PFS) was 2.6 months (95% CI: 1.9–3.2). An albumin level of<4.0 g/dL, neutrophil-to-lymphocyte ratio (NLR) of ⩾3.5, liver or peritoneal metastasis, and a history of >3 lines of palliative chemotherapy were associated with worse OS. An NLR of ⩾3.5 and liver metastasis were significant predictive factors for worse PFS. Previous exposure to IRI was not a significant predictor. Patients without prior IRI (no-IRI) treatment showed relatively longer OS and PFS compared to IRI responders and nonresponders, but these differences were not significant when compared specifically to the responders (OS: 8.8 vs 8.1 months, p = 0.388; PFS: 3.6 vs 2.6 months, p = 0.126). Conclusion: An NLR of ⩾3.5 and liver metastasis were associated with worse PFS. Prior IRI exposure was not a significant predictive factor for OS and PFS, especially in IRI responders. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Left Ventricular Diastolic Function in Healthy Adult Individuals: Results of the World Alliance Societies of Echocardiography Normal Values Study

Author

Prado, Aldo D., Filipini, Eduardo, Kwon, Agatha, Hoschke-Edwards, Samantha, Regina Afonso, Tania, Thampinathan, Babitha, Sooriyakanthan, Maala, Zhu, Tiangang, Wang, Zhilong, Wang, Yingbin, Zhang, Mei, Zhang, Yu, Yin, Lixue, Li, Shuang, Alagesan, R., Balasubramanian, S., Ananth, R.V.A., Bansal, Manish, Badano, Luigi P., Palermo, Chiara, Bossone, Eduardo, Di Vece, Davide, Bellino, Michele, Nakao, Tomoko, Kawata, Takayuki, Hirokawa, Megumi, Sawada, Naoko, Nabeshima, Yousuke, Yun, Hye Rim, Hwang, Ji-won, Fasawe, Dolapo, Miyoshi, Tatsuya, Addetia, Karima, Citro, Rodolfo, Daimon, Masao, Desale, Sameer, Fajardo, Pedro Gutierrez, Kasliwal, Ravi R., Kirkpatrick, James N., Monaghan, Mark J., Muraru, Denisa, Ogunyankin, Kofo O., Park, Seung Woo, Ronderos, Ricardo E., Sadeghpour, Anita, Scalia, Gregory M., Takeuchi, Masaaki, Tsang, Wendy, Tucay, Edwin S., Tude Rodrigues, Ana Clara, Vivekanandan, Amuthan, Zhang, Yun, Blitz, Alexandra, Lang, Roberto M., and Asch, Federico M.

Published
2020
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48. Similarities and Differences in Left Ventricular Size and Function among Races and Nationalities: Results of the World Alliance Societies of Echocardiography Normal Values Study

Author

Prado, Aldo D., Filipini, Eduardo, Kwon, Agatha, Hoschke-Edwards, Samantha, Afonso, Tania Regina, Thampinathan, Babitha, Sooriyakanthan, Maala, Zhu, Tiangang, Wang, Zhilong, Wang, Yingbin, Zhang, Mei, Zhang, Yu, Yin, Lixue, Li, Shuang, Alagesan, R., Balasubramanian, S., Ananth, R.V.A., Bansal, Manish, Badano, Luigi P., Palermo, Chiara, Bossone, Eduardo, Di Vece, Davide, Bellino, Michele, Nakao, Tomoko, Kawata, Takayuki, Hirokawa, Megumi, Sawada, Naoko, Nabeshima, Yousuke, Yun, Hye Rim, Hwang, Ji-won, Fasawe, Dolapo, Schreckenberg, Marcus, Ronderos, Ricardo, Scalia, Gregory, Tude Rodrigues, Ana Clara, Tsang, Wendy, Amuthan, V., Kasliwal, Ravi, Sadeghpour, Anita, Muraru, Denisa, Daimon, Masao, Takeuchi, Masaaki, Gutierrez-Fajardo, Pedro, Ogunyankin, Kofo O., Tucay, Edwin S., Woo Park, Seung, Monaghan, Mark J., Addetia, Karima, Kirkpatrick, James, Asch, Federico M., Miyoshi, Tatsuya, Citro, Rodolfo, Desale, Sameer, Fajardo, Pedro Gutierrez, Kasliwal, Ravi R., Kirkpatrick, James N., Park, Seung Woo, Ronderos, Ricardo E., Scalia, Gregory M., Vivekanandan, Amuthan, Zhang, Yun, Blitz, Alexandra, and Lang, Roberto M.

Published
2019
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