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1,159 results on '"Park, Sang Kyu"'

20. Rejections Are More Contagious than Choices: How Another's Decisions Shape Our Own.

Author

Nan, Lana Xianglan, Park, Sang Kyu, and Yang, Yang

Subjects
FRAMES (Social sciences), CONSUMER behavior, SOCIAL influence, REJECTION (Psychology), CHOICE (Psychology), INFLUENCER marketing
Abstract

Every day, we learn about others' decisions from various sources. We perceive some of these decisions as choices and others as rejections. Does the mere perception of another's decision as a choice versus as a rejection influence our own behavior? Are we more likely to conform to another's decision if we view it in one way or the other? The current research investigates the social influence of decision frames. Eight studies, including a field study conducted during a livestreaming event hosted by an influencer with over 1.5 million followers, find that people are more likely to conform to another's decision if it is perceived as a rejection than if it is perceived as a choice. This effect happens because consumers are more likely to attribute another's decision to product quality as opposed to personal preference, when consumers perceive another's decision as a rejection than as a choice. The inference about quality versus personal preference in turn increases conformity. This research bridges the existing literatures on decision framing, social influence, and perceptions of quality and personal preference, and it offers important implications for marketers and influencers. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Cellular metabolism of substance P produces neurokinin-1 receptor peptide agonists with diminished cyclic AMP signaling.

Author

Kriska, Tamas, Natarajan, Jayashree, Herrnreiter, Anja, Park, Sang-Kyu, Pfister, Sandra L., Thomas, Michael J., Widiapradja, Alexander, Levick, Scott P., and Campbell, William B.

Subjects
SUBSTANCE P receptors, CYCLIC adenylic acid, SUBSTANCE P, PEPTIDE receptors, SECOND messengers (Biochemistry), CELL physiology
Abstract

Substance P (SP) is released from sensory nerves in the arteries and heart. It activates neurokinin-1 receptors (NK1Rs) causing vasodilation, immune modulation, and adverse cardiac remodeling. The hypothesis was tested: SP and SP metabolites activate different second messenger signaling pathways. Macrophages, endothelial cells, and fibroblasts metabolized SP to N- and C-terminal metabolites to varying extents. SP 5–11 was the most abundant metabolite followed by SP 1–4, SP 7–11, SP 6–11, SP 3–11, and SP 8–11. In NK1R-expressing human embryonic kidney 293 (HEK293) cells, SP and some C-terminal SP metabolites stimulate the NK1R, promoting the dissociation of several Gα proteins, including Gαs and Gαq from their βγ subunits. SP increases intracellular calcium concentrations ([Ca]i) and cyclic 3′,5′-adenosine monophosphate (cAMP) accumulation with similar −log EC50 values of 8.5 ± 0.3 and 7.8 ± 0.1 M, respectively. N-terminal metabolism of SP by up to five amino acids and C-terminal deamidation of SP produce peptides that retain activity to increase [Ca]i but not to increase cAMP. C-terminal metabolism results in the loss of both activities. Thus, [Ca]i and cAMP signaling are differentially affected by SP metabolism. To assess the role of N-terminal metabolism, SP and SP 6–11 were compared with cAMP-mediated activities in NK1R-expressing 3T3 fibroblasts. SP inhibits nuclear factor κB (NF-κB) activity, cell proliferation, and wound healing and stimulates collagen production. SP 6–11 had little or no activity. Cyclooxygenase-2 (COX-2) expression is increased by SP but not by SP 6–11. Thus, metabolism may select the cellular response to SP by inhibiting or redirecting the second messenger signaling pathway activated by the NK1R. NEW & NOTEWORTHY: Endothelial cells, macrophages, and fibroblasts metabolize substance P (SP) to N- and C-terminal metabolites with SP 5–11 as the most abundant metabolite. SP activates neurokinin-1 receptors to increase intracellular calcium and cyclic AMP. In contrast, SP metabolites of N-terminal metabolism and C-terminal deamidation retain the ability to increase calcium but lose the ability to increase cyclic AMP. These new insights indicate that the metabolism of SP directs cellular functions by regulating specific signaling pathways. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Target-based discovery of a broad spectrum flukicide

Author

Sprague, Daniel J., primary, Park, Sang-Kyu, additional, Gramberg, Svenja, additional, Bauer, Lisa, additional, Rohr, Claudia M., additional, Chulkov, Evgeny G., additional, Smith, Emery, additional, Scampavia, Louis, additional, Spicer, Timothy P., additional, Haeberlein, Simone, additional, and Marchant, Jonathan S., additional

Published
2023
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