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24 results on '"Park, Kyungjoon"'

4. Amygdala Depotentiation and Fear Extinction

Author

Kim, Jeongyeon, Lee, Sukwon, Park, Kyungjoon, Hong, Ingie, Song, Beomjong, Son, Gihoon, Park, Heewoo, Kim, Woon Ryoung, Park, Eunjin, Choe, Han Kyung, Kim, Hyun, Lee, Changjoong, Sun, Woong, Kim, Kyungjin, Shin, Ki Soon, and Choi, Sukwoo

Published
2007
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6. Large-Scale Generation and Characterization of Homogeneous Populations of Migratory Cortical Interneurons from Human Pluripotent Stem Cells

Author

Ni, Peiyan, primary, Noh, Haneul, additional, Shao, Zhicheng, additional, Zhu, Qian, additional, Guan, Youxin, additional, Park, Joshua J., additional, Arif, Fatima, additional, Park, James M., additional, Abani, Chiderah, additional, Beaudreault, Cameron, additional, Park, Joy S., additional, Berry, Elizabeth, additional, Moghadam, Alexander, additional, Stanton, Patric, additional, Hutchinson, John N., additional, Andrews, Bill, additional, Faux, Clare, additional, Parnevelas, John, additional, Eisenberg, Leonard M., additional, Park, Kyungjoon, additional, Bolshakov, Vadim Y., additional, and Chung, Sangmi, additional

Published
2019
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10. The role of inositol 1,4,5-trisphosphate 3-kinase A in regulating emotional behavior and amygdala function

Author

Chung, Sooyoung, primary, Kim, Il Hwan, additional, Lee, Dongmin, additional, Park, Kyungjoon, additional, Kim, Joo Yeon, additional, Lee, Yeon Kyung, additional, Kim, Eun Joo, additional, Lee, Hyun Woo, additional, Choi, June-seek, additional, Son, Gi Hoon, additional, Sun, Woong, additional, Shin, Ki Soon, additional, and Kim, Hyun, additional

Published
2016
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13. Group I mGluR-dependent depotentiation in the lateral amygdala does not require the removal of calcium-permeable AMPA receptors

Author

Park, Kyungjoon, primary, Song, Sukwoon, additional, Hong, Ingie, additional, Song, Beomjong, additional, Kim, Jeongyeon, additional, Park, Sungmo, additional, Lee, Junuk, additional, Song, Sangho, additional, An, Bobae, additional, Kim, Jihye, additional, Lee, C. Justin, additional, Shin, Ki Soon, additional, Choi, Sukwoo, additional, and Lee, Sukwon, additional

Published
2014
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14. ABA Renewal Involves Enhancements in Both GluA2-Lacking AMPA Receptor Activity and GluA1 Phosphorylation in the Lateral Amygdala

Author

Park, Kyungjoon, primary, Song, Beomjong, additional, Kim, Jeongyeon, additional, Hong, Ingie, additional, Song, Sangho, additional, Lee, Junuk, additional, Park, Sungmo, additional, Kim, Jihye, additional, An, Bobae, additional, Lee, Hyun Woo, additional, Lee, Seungbok, additional, Kim, Hyun, additional, Lee, Justin C., additional, Lee, Sukwon, additional, and Choi, Sukwoo, additional

Published
2014
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15. GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal

Author

Lee, Sukwon, primary, Song, Beomjong, additional, Kim, Jeongyeon, additional, Park, Kyungjoon, additional, Hong, Ingie, additional, An, Bobae, additional, Song, Sangho, additional, Lee, Jiwon, additional, Park, Sungmo, additional, Kim, Jihye, additional, Park, Dongeun, additional, Lee, C Justin, additional, Kim, Kyungjin, additional, Shin, Ki Soon, additional, Tsien, Richard W, additional, and Choi, Sukwoo, additional

Published
2013
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17. Reversible Plasticity of Fear Memory-Encoding Amygdala Synaptic Circuits Even after Fear Memory Consolidation

Author

Hong, Ingie, primary, Kim, Jihye, additional, Lee, Junuk, additional, Park, Sungmo, additional, Song, Beomjong, additional, Kim, Jeongyeon, additional, An, Bobae, additional, Park, Kyungjoon, additional, Lee, Hyun Woo, additional, Lee, Seungbok, additional, Kim, Hyun, additional, Park, Sang-Hyun, additional, Eom, Khee Dong, additional, Lee, Sukwon, additional, and Choi, Sukwoo, additional

Published
2011
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23. Large-Scale Generation and Characterization of Homogeneous Populations of Migratory Cortical Interneurons from Human Pluripotent Stem Cells.

Author

Ni P, Noh H, Shao Z, Zhu Q, Guan Y, Park JJ, Arif F, Park JM, Abani C, Beaudreault C, Park JS, Berry E, Moghadam A, Stanton P, Hutchinson JN, Andrews B, Faux C, Parnevelas J, Eisenberg LM, Park K, Bolshakov VY, and Chung S

Abstract

During development, cortical interneurons (cINs) are generated from the ventral telencephalon, robustly migrate to the dorsal telencephalon, make local synaptic connections, and critically regulate brain circuitry by inhibiting other neurons. Thus, their abnormality is associated with various brain disorders. Human pluripotent stem cell (hPSC)-derived cINs can provide unlimited sources with which to study the pathogenesis mechanism of these disorders as well as provide a platform to develop novel therapeutics. By employing spinner culture, we could obtain a >10-fold higher yield of cIN progenitors compared to conventional culture without affecting their phenotype. Generated cIN spheres can be maintained feeder-free up to 10 months and are optimized for passaging and cryopreservation. In addition, we identified a combination of chemicals that synchronously matures generated progenitors into SOX6 + KI67 - migratory cINs and extensively characterized their maturation in terms of metabolism, migration, arborization, and electrophysiology. When transplanted into mouse brains, chemically matured migratory cINs generated grafts that efficiently disperse and integrate into the host circuitry without uncontrolled growth, making them an optimal cell population for cell therapy. Efficient large-scale generation of homogeneous migratory cINs without the need of feeder cells will play a critical role in the full realization of hPSC-derived cINs for development of novel therapeutics.

Published
2019
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24. Expression of Kir2.1 channels in astrocytes under pathophysiological conditions.

Author

Kang SJ, Cho SH, Park K, Yi J, Yoo SJ, and Shin KS

Subjects
Animals, Astrocytes cytology, Excitatory Amino Acid Agonists metabolism, Hippocampus cytology, Hippocampus metabolism, Homeostasis, Kainic Acid metabolism, Male, Mice, Mice, Inbred DBA, Patch-Clamp Techniques, Potassium Channels, Inwardly Rectifying genetics, Protein Subunits genetics, Seizures chemically induced, Astrocytes metabolism, Potassium metabolism, Potassium Channels, Inwardly Rectifying metabolism, Protein Subunits metabolism, Seizures physiopathology
Abstract

Astrocyte ion channels participate in ionic homeostasis in the brain. Inward rectifying potassium channels (Kir channels) in astrocytes have been particularly implicated in K(+) homeostasis because of their high open probability at resting potential and their increased conductance at high concentrations of extracellular K(+). We examined the expression of the Kir2.1 subunit, one of the Kir channel subunits, in the mouse brain by immunohistochemistry. Kir2.1 channels were widely distributed throughout the brain, with high expression in the olfactory bulb and the cerebellum. Interestingly, they were abundantly expressed in astrocytes of the olfactory bulb, while astrocytes in other brain regions including the hippocampus did not show any detectable expression. However, Kir2.1 channel-expressing cells were dramatically increased in the hippocampus by kainic acid-induced seizure and the cells were glial fibrillary acidic protein (GFAP)-positive, which confirms that astrocytes in the hippocampus express Kir2.1 channels under pathological conditions. Our results imply that Kir2.1 channels in astrocyte may be involved in buffering K(+) against accumulated extracellular K(+) caused by neuronal hyperexcitability under phathophysiological conditions.

Published
2008

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