Search

Your search keyword '"Park, Ki Ho"' showing total 2,120 results
Start Over Author "Park, Ki Ho"
2,120 results on '"Park, Ki Ho"'

10. Classification of Visual Field Abnormalities in Highly Myopic Eyes without Pathologic Change

Author

Lin, Fengbin, Chen, Shida, Song, Yunhe, Li, Fei, Wang, Wei, Zhao, Zhenni, Gao, Xinbo, Wang, Peiyuan, Jin, Ling, Liu, Yuhong, Chen, Meiling, Liang, Xiaohong, Yang, Bin, Ning, Guili, Cheng, Ching-Yu, Healey, Paul R, Park, Ki Ho, Zangwill, Linda M, Aung, Tin, Ohno-Matsui, Kyoko, Jonas, Jost B, Weinreb, Robert N, Zhang, Xiulan, Group, Glaucoma Suspects with High Myopia Study, Liu, Yizhi, Lv, Lin, Friedman, David, Gao, Kai, Liu, Bingqian, Bressler, Neil M, He, Mingguang, Chen, Xiang, and Tang, Guangxian

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Eye Disease and Disorders of Vision, Neurosciences, Aging, Clinical Research, Clinical Trials and Supportive Activities, Eye, Glaucoma, Humans, Intraocular Pressure, Longitudinal Studies, Myopia, Optic Disk, Retrospective Studies, Scotoma, Vision Disorders, Visual Field Tests, Visual Fields, Classification system, High myopia, Visual field abnormalities, Glaucoma Suspects with High Myopia Study Group, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry, Ophthalmology and optometry
Abstract

PurposeTo develop a classification system of visual field (VF) abnormalities in highly myopic eyes with and without glaucoma.DesignSecondary analysis of VF data from a longitudinal cohort study.ParticipantsOne thousand eight hundred ninety-three VF tests from 1302 eyes (825 individuals).MethodsAll participants underwent VF testing (Humphrey 24-2 Swedish interactive threshold algorithm standard program; Carl Zeiss Meditec) and detailed ophthalmic examination. A comprehensive set of VF defect patterns was defined via observation of the 1893 VF reports, literature review, and consensus meetings. The classification system comprised 4 major types of VF patterns, including normal type, glaucoma-like defects (paracentral defect, nasal step, partial arcuate defect, arcuate defect), high myopia-related defects (enlarged blind spot, vertical step, partial peripheral rim, nonspecific defect), and combined defects (nasal step with enlarged blind spot). A subset (n = 1000) of the VFs was used to evaluate the interobserver and intraobserver agreement and weighted κ values of the classification system by 2 trained readers. The prevalence of various VF patterns and their associated factors were determined.Main outcome measuresThe classification of VF in highly myopic eyes and its associated risk factors.ResultsWe found that normal type, glaucoma-like defects, high myopia-related defects, and combined defects accounted for 74.1%, 10.8%, 15.0%, and 0.1% of all unique VF tests, respectively. The interobserver and intraobserver agreements were > 89%, and the corresponding κ values were 0.86 or more between readers. Both glaucoma-like and high myopia-related VF defects were associated with older age (odds ratios [ORs], 1.07 [95% confidence interval (CI), 1.04-1.10; P < 0.001] and 1.06 [95% CI, 1.04-1.10; P < 0.001]) and longer axial length (ORs, 1.65 [95% CI, 1.32-2.07; P < 0.001] and 1.37 [95% CI, 1.11-1.68; P = 0.003]). Longer axial length showed a stronger effect on the prevalence of glaucoma-like VF defects than on the prevalence of high myopia-related VF defects (P = 0.036).ConclusionsWe propose a new and reproducible classification system of VF abnormalities for nonpathologic high myopia. Applying a comprehensive classification system will facilitate communication and comparison of findings among studies.

Published
2022

20. Phacogoniotomy versus phacotrabeculectomy for advanced primary angle-closure glaucoma with cataract: A randomized non-inferiority trial

Author

Song, Yunhe, Lin, Fengbin, Lv, Aiguo, Zhang, Yao, Lu, Lan, Xie, Lin, Tang, Guangxian, Yuan, Huiping, Yang, Yangfan, Xu, Jiangang, Lu, Ping, Xiao, Meichun, Zhu, Xiaomin, Yan, Xiaowei, Song, Wulian, Li, Xiaoyan, Zhang, Hengli, Li, Fei, Wang, Zhenyu, Jin, Ling, Gao, Xinbo, Liang, Xiaohong, Zhou, Minwen, Zhao, Xiaohuan, Zhang, Yu, Chen, Weirong, Wang, Ningli, Tham, Clement C., Barton, Keith, Park, Ki Ho, Aung, Tin, Weinreb, Robert N., Tang, Li, Fan, Sujie, Lam, Dennis S.C., and Zhang, Xiulan

Published
2024
Full Text
View/download PDF

22. Influence of Goniotomy Size on Treatment Safety and Efficacy for Primary Open-Angle Glaucoma: A Multicenter Study

Author

Zhang, Yu, Yu, Ping, Zhang, Yingzhe, Sugihara, Kazunobu, Zhu, Xiaomin, Zhang, Yao, Yang, Xiao, Li, Xiaoyan, Liu, Yacong, Zhang, Hengli, Yan, Xiaowei, Zhang, Hengkai, Lin, Fengbin, Song, Yunhe, Gao, Xinbo, Yuan, Huiping, Tang, Guangxian, Zhou, Wenzong, Fan, Sujie, Dang, Guangfu, Tang, Li, Chen, Weirong, Wang, Ningli, Park, Ki Ho, Barton, Keith, Aung, Tin, Lam, Dennis S.C., Weinreb, Robert N., Xie, Lin, Tanito, Masaki, Zeng, Liuzhi, and Zhang, Xiulan

Published
2023
Full Text
View/download PDF

23. High Myopia Normative Database of Peripapillary Retinal Nerve Fiber Layer Thickness to Detect Myopic Glaucoma in a Chinese Population

Author

Zhang, Xiulan, Liu, Yizhi, Lv, Lin, Friedman, David S., Jonas, Jost B., Aung, Tin, Chen, Shida, Wang, Wei, Lin, Fengbin, Song, Yunhe, Wang, Peiyuan, Li, Fei, Gao, Kai, Liu, Bingqian, Liu, Yuhong, Chen, Meiling, Bressler, Neil M., Park, Ki Ho, Lam, Dennis S.C., He, Mingguang, Ohno-Matsui, Kyoko, Weinreb, Robert N., Cheng, Ching-Yu, Healey, Paul, Zangwill, Linda M., Chen, Xiang, Tang, Guangxian, Jin, Ling, Chong, Rachel S., Ran, An Ran, Wang, Zhenyu, Jiang, Jingwen, Kong, Kangjie, Sun, Jian, Wang, Deming, Tham, Clement C., Sun, Xiaodong, and Cheung, Carol Y.

Published
2023
Full Text
View/download PDF

27. Mouse Corneal Transplantation

Author

Chen, Peng, primary, Park, Ki Ho, additional, Zhang, Liqiang, additional, Lucas, Alexandra R., additional, Chandler, Heather L., additional, and Zhu, Hua, additional

Published
2022
Full Text
View/download PDF

35. Novel Role of the ALPI Gene Associated with Constipation Caused by Complement Component 3 Deficiency.

Author

Song, Hee Jin, Kim, Ji Eun, Roh, Yu Jeong, Seol, Ayun, Kim, Tae Ryeol, Park, Ki Ho, Park, Eun Seo, Hong, Jin Tae, Choi, Sun Il, and Hwang, Dae Youn

Subjects
COMPLEMENT (Immunology), OLIGONUCLEOTIDE arrays, INTESTINAL diseases, ALKALINE phosphatase, PHENOTYPES, OLFACTORY receptors
Abstract

Complement component 3 (C3) deficiency has recently been reported as one of the novel causes of constipation. To identify a unique gene specific to constipation caused by C3 deficiency, the total RNA extracted from the mid colon of C3 knockout (C3 KO) mice was hybridized to oligonucleotide microarrays, and the function of the candidate gene was verified in in vitro and in vivo models. C3 KO mice used for microarrays showed definite phenotypes of constipation. Overall, compared to the wild type (WT), 1237 genes were upregulated, and 1292 genes were downregulated in the C3 KO mice. Of these, the major genes included were lysine (K)-specific demethylase 5D (KDM5D), olfactory receptor 870 (Olfr870), pancreatic lipase (PNLIP), and alkaline phosphatase intestinal (ALPI). Specifically, the ALPI gene was selected as a novel gene candidate based on alterations during loperamide (Lop)-induced constipation and intestinal bowel disease (IBD). The upregulation of ALPI expression treated with acetate recovered the expression level of mucin-related genes in primary epithelial cells of C3 KO mice as well as most phenotypes of constipation in C3 KO mice. These results indicate that ALPI plays an important role as the novel gene associated with C3 deficiency-induced constipation. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

49. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Author

Aung, Tin, Ozaki, Mineo, Lee, Mei Chin, Schlötzer-Schrehardt, Ursula, Thorleifsson, Gudmar, Mizoguchi, Takanori, Igo, Robert P, Haripriya, Aravind, Williams, Susan E, Astakhov, Yury S, Orr, Andrew C, Burdon, Kathryn P, Nakano, Satoko, Mori, Kazuhiko, Abu-Amero, Khaled, Hauser, Michael, Li, Zheng, Prakadeeswari, Gopalakrishnan, Bailey, Jessica N Cooke, Cherecheanu, Alina Popa, Kang, Jae H, Nelson, Sarah, Hayashi, Ken, Manabe, Shin-ichi, Kazama, Shigeyasu, Zarnowski, Tomasz, Inoue, Kenji, Irkec, Murat, Coca-Prados, Miguel, Sugiyama, Kazuhisa, Järvelä, Irma, Schlottmann, Patricio, Lerner, S Fabian, Lamari, Hasnaa, Nilgün, Yildirim, Bikbov, Mukharram, Park, Ki Ho, Cha, Soon Cheol, Yamashiro, Kenji, Zenteno, Juan C, Jonas, Jost B, Kumar, Rajesh S, Perera, Shamira A, Chan, Anita SY, Kobakhidze, Nino, George, Ronnie, Vijaya, Lingam, Do, Tan, Edward, Deepak P, de Juan Marcos, Lourdes, Pakravan, Mohammad, Moghimi, Sasan, Ideta, Ryuichi, Bach-Holm, Daniella, Kappelgaard, Per, Wirostko, Barbara, Thomas, Samuel, Gaston, Daniel, Bedard, Karen, Greer, Wenda L, Yang, Zhenglin, Chen, Xueyi, Huang, Lulin, Sang, Jinghong, Jia, Hongyan, Jia, Liyun, Qiao, Chunyan, Zhang, Hui, Liu, Xuyang, Zhao, Bowen, Wang, Ya-Xing, Xu, Liang, Leruez, Stéphanie, Reynier, Pascal, Chichua, George, Tabagari, Sergo, Uebe, Steffen, Zenkel, Matthias, Berner, Daniel, Mossböck, Georg, Weisschuh, Nicole, Hoja, Ursula, Welge-Luessen, Ulrich-Christoph, Mardin, Christian, Founti, Panayiota, Chatzikyriakidou, Anthi, Pappas, Theofanis, Anastasopoulos, Eleftherios, Lambropoulos, Alexandros, Ghosh, Arkasubhra, Shetty, Rohit, Porporato, Natalia, Saravanan, Vijayan, Venkatesh, Rengaraj, Shivkumar, Chandrashekaran, Kalpana, Narendran, Sarangapani, Sripriya, Kanavi, Mozhgan R, Beni, Afsaneh Naderi, and Yazdani, Shahin

Subjects
Prevention, Human Genome, Rare Diseases, Genetics, Aetiology, 2.1 Biological and endogenous factors, Aged, 80 and over, Alleles, Amino Acid Oxidoreductases, Amino Acid Substitution, Asian People, Calcium Channels, Cell Adhesion, Exfoliation Syndrome, Extracellular Matrix, Eye, Female, Gene Expression Profiling, Genetic Predisposition to Disease, Genome-Wide Association Study, Haplotypes, Humans, Male, Molecular Chaperones, Mutation, Missense, Point Mutation, RNA, Messenger, Spheroids, Cellular, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Exfoliation syndrome (XFS) is the most common known risk factor for secondary glaucoma and a major cause of blindness worldwide. Variants in two genes, LOXL1 and CACNA1A, have previously been associated with XFS. To further elucidate the genetic basis of XFS, we collected a global sample of XFS cases to refine the association at LOXL1, which previously showed inconsistent results across populations, and to identify new variants associated with XFS. We identified a rare protective allele at LOXL1 (p.Phe407, odds ratio (OR) = 25, P = 2.9 × 10-14) through deep resequencing of XFS cases and controls from nine countries. A genome-wide association study (GWAS) of XFS cases and controls from 24 countries followed by replication in 18 countries identified seven genome-wide significant loci (P < 5 × 10-8). We identified association signals at 13q12 (POMP), 11q23.3 (TMEM136), 6p21 (AGPAT1), 3p24 (RBMS3) and 5q23 (near SEMA6A). These findings provide biological insights into the pathology of XFS and highlight a potential role for naturally occurring rare LOXL1 variants in disease biology.

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results