1. Association between APOE ε2 and Aβ burden in patients with Alzheimer- and vascular-type cognitive impairment.
- Author
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Lee, Jin San, Lee, Hyejoo, Park, Seongbeom, Choe, Yeongsim, Park, Yu Hyun, Cheon, Bo Kyoung, Hahn, Alice, Ossenkoppele, Rik, Kim, Hee Jin, Kim, Seonwoo, Yoo, Heejin, Jang, Hyemin, Cho, Soo Hyun, Kim, Seung Joo, Kim, Jun Pyo, Jung, Young Hee, Park, Key-Chung, DeCarli, Charles, Weiner, Michael W, Na, Duk L, and Seo, Sang Won
- Subjects
Neurodegenerative ,Brain Disorders ,Genetics ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Human Genome ,Acquired Cognitive Impairment ,Aging ,Neurosciences ,Dementia ,Alzheimer's Disease ,Clinical Research ,Aetiology ,2.1 Biological and endogenous factors ,Aged ,Aged ,80 and over ,Alzheimer Disease ,Amyloid beta-Peptides ,Apolipoprotein E2 ,Body Burden ,Cognitive Dysfunction ,Cross-Sectional Studies ,Dementia ,Vascular ,Female ,Genetic Predisposition to Disease ,Genotype ,Heterozygote ,Humans ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Positron-Emission Tomography ,Prevalence ,Clinical Sciences ,Cognitive Sciences ,Neurology & Neurosurgery - Abstract
ObjectiveTo investigate the association between APOE genotype and β-amyloid (Aβ) burden, as measured by PET in patients with subcortical vascular cognitive impairment (SVCI) and those with Alzheimer disease-related cognitive impairment (ADCI).MethodsThis was a cross-sectional study of 310 patients with SVCI and 999 with ADCI. To evaluate the effects of APOE genotype or diagnostic group on Aβ positivity, we performed multivariate logistic regression analyses. Further distinctive underlying features of latent subgroups were examined by employing a latent class cluster analysis approach.ResultsIn comparison with ε3 homozygotes, in the ADCI group, ε2 carriers showed a lower frequency of Aβ positivity (odds ratio [OR] 0.43, 95% confidence interval [CI] 0.23-0.79), while in the SVCI group, ε2 carriers showed a higher frequency of Aβ positivity (OR 2.26, 95% CI 1.02-5.01). In particular, we observed an interaction effect of ε2 carrier status and diagnostic group on Aβ positivity (OR 5.12, 95% CI 1.93-13.56), in that relative to ε3 homozygotes, there were more Aβ-positive ε2 carriers in the SVCI group than in the ADCI group. We also identified latent subgroups of Aβ-positive APOE ε2 carriers with SVCI and Aβ-positive APOE ε4 carriers with ADCI.ConclusionsOur findings suggest that APOE ε2 is distinctly associated with Aβ deposition in patients with SVCI and those with ADCI. Our findings further suggest that there is a distinctive subgroup of Aβ-positive APOE ε2 carriers with SVCI among patients with cognitive impairment.
- Published
- 2020