73 results on '"Park, Kevin B."'
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2. Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo
3. Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate–induced liver injury
4. New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity
5. Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury
6. Observational infant exploratory [14C]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis
7. Understanding the pathophysiological regulatory role of microRNAs in acute liver failure
8. Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis
9. Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2
10. Biomarkers distinguish apoptotic and necrotic cell death during hepatic ischemia/reperfusion injury in mice
11. Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids
12. Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis
13. Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts
14. Promiscuous T-cell responses to drugs and drug-haptens
15. Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice
16. Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives
17. Proteome-Wide Analyses of Human Hepatocytes During Differentiation and Dedifferentiation
18. Mechanistic Biomarkers Provide Early and Sensitive Detection of Acetaminophen-Induced Acute Liver Injury at First Presentation to Hospital
19. Are we closer to finding biomarkers for identifying acute drug-induced liver injury?
20. Stem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet?
21. The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation
22. Human Leukocyte Antigen (HLA)-B*57:01-Restricted Activation of Drug-Specific T cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury
23. Selection of new chemical entities with decreased potential for adverse drug reactions
24. Research Highlights: Explanation for HLA-B*57:01-linked immune-mediated abacavir-induced hypersensitivity
25. Identification of endogenous normalizers for serum MicroRNAs by microarray profiling: U6 small nuclear RNA is not a reliable normalizer
26. The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors
27. Circulating microRNAs as potential markers of human drug-induced liver injury
28. Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury
29. HLA-A3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans
30. Immune pathomechanism of drug hypersensitivity reactions
31. Acyl glucuronides: the good, the bad and the ugly
32. Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB
33. Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells
34. Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis
35. Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1
36. TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole
37. Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway
38. HLA-B locus in Caucasian patients with carbamazepine hypersensitivity
39. Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury
40. Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis
41. Stimulation of human T cells with sulfonamides and sulfonamide metabolites
42. RECOGNITION OF SULFAMETHOXAZOLE AND ITS REACTIVE METABOLITES BY DRUG-SPECIFIC T CELLS FROM ALLERGIC INDIVIDUALS
43. Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA‐B*57:01 binding and T‐cell activation
44. Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA‐B*57:01 binding and T‐cell activation.
45. Observational infant exploratory [14C]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis
46. Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients
47. In Vitro Priming of Naı̈ve T-cells with p-Phenylenediamine and Bandrowski’s Base
48. Blood Kidney Injury Molecule-1 Is a Biomarker of Acute and Chronic Kidney Injury and Predicts Progression to ESRD in Type I Diabetes
49. Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells
50. Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients.
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