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BackgroundTuberculosis (TB) is one of the most infectious diseases that can be fatal. Its early diagnosis and treatment can significantly reduce the mortality rate. In the literature, several computer-aided diagnosis (CAD) tools have been proposed for the efficient diagnosis of TB from chest radiograph (CXR) images. However, the majority of previous studies adopted conventional handcrafted feature-based algorithms. In addition, some recent CAD tools utilized the strength of deep learning methods to further enhance diagnostic performance. Nevertheless, all these existing methods can only classify a given CXR image into binary class (either TB positive or TB negative) without providing further descriptive information. ObjectiveThe main objective of this study is to propose a comprehensive CAD framework for the effective diagnosis of TB by providing visual as well as descriptive information from the previous patients’ database. MethodsTo accomplish our objective, first we propose a fusion-based deep classification network for the CAD decision that exhibits promising performance over the various state-of-the-art methods. Furthermore, a multilevel similarity measure algorithm is devised based on multiscale information fusion to retrieve the best-matched cases from the previous database. ResultsThe performance of the framework was evaluated based on 2 well-known CXR data sets made available by the US National Library of Medicine and the National Institutes of Health. Our classification model exhibited the best diagnostic performance (0.929, 0.937, 0.921, 0.928, and 0.965 for F1 score, average precision, average recall, accuracy, and area under the curve, respectively) and outperforms the performance of various state-of-the-art methods. ConclusionsThis paper presents a comprehensive CAD framework to diagnose TB from CXR images by retrieving the relevant cases and their clinical observations from the previous patients’ database. These retrieval results assist the radiologist in making an effective diagnostic decision related to the current medical condition of a patient. Moreover, the retrieval results can facilitate the radiologists in subjectively validating the CAD decision.

BackgroundThe early diagnosis of various gastrointestinal diseases can lead to effective treatment and reduce the risk of many life-threatening conditions. Unfortunately, various small gastrointestinal lesions are undetectable during early-stage examination by medical experts. In previous studies, various deep learning–based computer-aided diagnosis tools have been used to make a significant contribution to the effective diagnosis and treatment of gastrointestinal diseases. However, most of these methods were designed to detect a limited number of gastrointestinal diseases, such as polyps, tumors, or cancers, in a specific part of the human gastrointestinal tract. ObjectiveThis study aimed to develop a comprehensive computer-aided diagnosis tool to assist medical experts in diagnosing various types of gastrointestinal diseases. MethodsOur proposed framework comprises a deep learning–based classification network followed by a retrieval method. In the first step, the classification network predicts the disease type for the current medical condition. Then, the retrieval part of the framework shows the relevant cases (endoscopic images) from the previous database. These past cases help the medical expert validate the current computer prediction subjectively, which ultimately results in better diagnosis and treatment. ResultsAll the experiments were performed using 2 endoscopic data sets with a total of 52,471 frames and 37 different classes. The optimal performances obtained by our proposed method in accuracy, F1 score, mean average precision, and mean average recall were 96.19%, 96.99%, 98.18%, and 95.86%, respectively. The overall performance of our proposed diagnostic framework substantially outperformed state-of-the-art methods. ConclusionsThis study provides a comprehensive computer-aided diagnosis framework for identifying various types of gastrointestinal diseases. The results show the superiority of our proposed method over various other recent methods and illustrate its potential for clinical diagnosis and treatment. Our proposed network can be applicable to other classification domains in medical imaging, such as computed tomography scans, magnetic resonance imaging, and ultrasound sequences.

The accurate recognition of a brain tumor (BT) is crucial for accurate diagnosis, intervention planning, and the evaluation of post-intervention outcomes. Conventional methods of manually identifying and delineating BTs are inefficient, prone to error, and time-consuming. Subjective methods for BT recognition are biased because of the diffuse and irregular nature of BTs, along with varying enhancement patterns and the coexistence of different tumor components. Hence, the development of an automated diagnostic system for BTs is vital for mitigating subjective bias and achieving speedy and effective BT segmentation. Recently developed deep learning (DL)-based methods have replaced subjective methods; however, these DL-based methods still have a low performance, showing room for improvement, and are limited to heterogeneous dataset analysis. Herein, we propose a DL-based parallel features aggregation network (PFA-Net) for the robust segmentation of three different regions in a BT scan, and we perform a heterogeneous dataset analysis to validate its generality. The parallel features aggregation (PFA) module exploits the local radiomic contextual spatial features of BTs at low, intermediate, and high levels for different types of tumors and aggregates them in a parallel fashion. To enhance the diagnostic capabilities of the proposed segmentation framework, we introduced the fractal dimension estimation into our system, seamlessly combined as an end-to-end task to gain insights into the complexity and irregularity of structures, thereby characterizing the intricate morphology of BTs. The proposed PFA-Net achieves the Dice scores (DSs) of 87.54%, 93.42%, and 91.02%, for the enhancing tumor region, whole tumor region, and tumor core region, respectively, with the multimodal brain tumor segmentation (BraTS)-2020 open database, surpassing the performance of existing state-of-the-art methods. Additionally, PFA-Net is validated with another open database of brain tumor progression and achieves a DS of 64.58% for heterogeneous dataset analysis, surpassing the performance of existing state-of-the-art methods. [ABSTRACT FROM AUTHOR]