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2. Entanglement between superconducting qubits and a tardigrade

Author

Lee, K. S., Tan, Y. P., Nguyen, L. H., Budoyo, R. P., Park, K. H., Hufnagel, C., Yap, Y. S., Møbjerg, N., Vedral, V., Paterek, T., and Dumke, R.

Subjects
Quantum Physics, Physics - Biological Physics
Abstract

Quantum and biological systems are seldom discussed together as they seemingly demand opposing conditions. Life is complex, "hot and wet" whereas quantum objects are small, cold and well controlled. Here, we overcome this barrier with a tardigrade -- a microscopic multicellular organism known to tolerate extreme physiochemical conditions via a latent state of life known as cryptobiosis. We observe coupling between the animal in cryptobiosis and a superconducting quantum bit and prepare a highly entangled state between this combined system and another qubit. The tardigrade itself is shown to be entangled with the remaining subsystems. The animal is then observed to return to its active form after 420 hours at sub 10 mK temperatures and pressure of $6\times 10^{-6}$ mbar, setting a new record for the conditions that a complex form of life can survive.

Published
2021
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5. Numerical Analysis of Slope Instability Due to Water Pipe Leakage

Author

Park, K. H., Ramnauth, G., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Atalar, Cavit, editor, and Çinicioğlu, Feyza, editor

Published
2023
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7. Positron production using a 9 MeV electron linac for the GBAR experiment

Author

Charlton, M., Choi, J. J., Chung, M., Clade, P., Comini, P., Crepin, P-P., Crivelli, P., Dalkarov, O., Debu, P., Dodd, L., Douillet, A., Guellati-Khelifa, S., Hervieux, P-A., Hilico, L., Husson, A., Indelicato, P., Janka, G., Jonsell, S., Karr, J-P., Kim, B. H., Kim, E-S., Kim, S. K., Ko, Y., Kosinski, T., Kuroda, N., Latacz, B., Lee, H., Lee, J., Leite, A. M. M., Leveque, K., Lim, E., Liszkay, L., Lotrus, P., Louvradoux, T., Lunney, D., Manfredi, G., Mansoulie, B., Matusiak, M., Mornacchi, G., Nesvizhevsky, V. V., Nez, F., Niang, S., Nishi, R., Nourbaksh, S., Park, K. H., Paul, N., Perez, P., Procureur, S., Radics, B., Regenfus, C., Rey, J-M., Reymond, J-M., Reynaud, S., Rousse, J-Y., Rousselle, O., Rubbia, A., Rzadkiewicz, J., Sacquin, Y., Schmidt-Kaler, F., Staszczak, M., Tuchming, B., Vallage, B., Voronin, A., Welker, A., van der Werf, D. P., Wolf, S., Won, D., Wronka, S., Yamazaki, Y., and Yoo, K-H.

Subjects
Physics - Instrumentation and Detectors
Abstract

For the GBAR (Gravitational Behaviour of Antihydrogen at Rest) experiment at CERN's Antiproton Decelerator (AD) facility we have constructed a source of slow positrons, which uses a low-energy electron linear accelerator (linac). The driver linac produces electrons of 9 MeV kinetic energy that create positrons from bremsstrahlung-induced pair production. Staying below 10 MeV ensures no persistent radioactive activation in the target zone and that the radiation level outside the biological shield is safe for public access. An annealed tungsten-mesh assembly placed directly behind the target acts as a positron moderator. The system produces $5\times10^7$ slow positrons per second, a performance demonstrating that a low-energy electron linac is a superior choice over positron-emitting radioactive sources for high positron flux., Comment: published in NIM A. 33 pages 9 figures

Published
2020
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12. A New PLS-II In-Vacuum Undulator and Characterization of Undulator Radiation

Author

Kim, D-E., Lee, H-H., Park, K-H., Seo, H-S., Ha, T., Jeong, Y-G., Han, H-S., Lee, W. W., Huang, J-Y., Nam, S., Kim, K-R., and Shin, S.

Subjects
Physics - Accelerator Physics
Abstract

This paper describes the result of overall studies from development to characterization of undulator radiation. After three years of upgrading, PLS-II [1, 2] has been operating successfully since 21st March 2012. During the upgrade, we developed and installed an in-vacuum undulator (IVU) that generates brilliant X-ray beam. The IVU with 3 GeV electron beam generates undulator radiation up to ~ 21 keV using 11th higher harmonic. The characterizations of the undulator radiation at an X-ray beam line in PLS-II agreed well with the simulation. Based on this performance demonstration, the in-vacuum undulator is successfully operating at PLS-II., Comment: ICABU2015 conference (in Korea)

Published
2016
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17. Impact of antimicrobial treatment duration on outcome of Staphylococcus aureus bacteraemia: a cohort study

Author

Cho, J.E., Choi, Y.J., Park, J.I., Jung, S.-I., Kim, N.J., Park, W.B., Choe, P.G., Kim, N.-H., Lee, M.J., Kim, K.H., Kim, Y.K., Choi, H.K., Han, M.S., Kim, Y.-S., Cho, C.R., Song, H.S., Lee, Y.S., Kim, H.-I., Kiem, S.M., Kim, D.-K., Song, S.-A., Kang, M.J., Shin, J.G., Kim, C.-J., Song, K.-H., Park, K.-H., Kim, M., Oh, M.-d., Lee, S.H., Jang, H.-C., Kang, S.-J., Kim, H.Y., Cheon, S., Kwak, Y.G., Choi, H.J., Kwon, K.T., Jeon, J.H., Kim, E.S., and Kim, H.B.

Published
2019
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18. Study of the interactions of pions in the CALICE silicon-tungsten calorimeter prototype

Author

Adloff, C., Karyotakis, Y., Repond, J., Yu, J., Eigen, G., Mikami, Y., Watson, N. K., Wilson, J. A., Goto, T., Mavromanolakis, G., Thomson, M. A., Ward, D. R., Yan, W., Benchekroun, D., Hoummada, A., Khoulaki, Y., Apostolakis, J., Ribon, A., Uzhinskiy, V., Benyamna, M., Cârloganu, C., Fehr, F., Gay, P., Blazey, G. C., Chakraborty, D., Dyshkant, A., Francis, K., Hedin, D., Lima, J. G., Zutshi, V., Hostachy, J. -Y., Krastev, K., Morin, L., D'Ascenzo, N., Cornett, U., David, D., Fabbri, R., Falley, G., Gadow, K., Garutti, E., Göttlicher, P., Jung, T., Karstensen, S., Lucaci-Timoce, A. -I., Lutz, B., Meyer, N., Morgunov, V., Reinecke, M., Sefkow, F., Smirnov, P., Vargas-Trevino, A., Wattimena, N., Wendt, O., Feege, N., Groll, M., Haller, J., Heuer, R. -D., Morozov, S., Richter, S., Samson, J., Kaplan, A., Schultz-Coulon, H. -Ch., Shen, W., Tadday, A., Bilki, B., Norbeck, E., Onel, Y., Kim, E. J., Kim, G., Kim, D-W., Lee, K., Lee, S. C., Kawagoe, K., Tamura, Y., Dauncey, P. D., Magnan, A. -M., Yilmaz, H., Zorba, O., Bartsch, V., Postranecky, M., Warren, M., Wing, M., Green, M. G., Salvatore, F., Bedjidian, M., Kieffer, R., Laktineh, I., Fouz, M. -C., Bailey, D. S., Barlow, R. J., Kelly, M., Thompson, R. J., Danilov, M., Tarkovsky, E., Baranova, N., Karmanov, D., Korolev, M., Merkin, M., Voronin, A., Frey, A., Lu, S., Seidel, K., Simon, F., Soldner, C., Weuste, L., Bonis, J., Bouquet, B., Callier, S., Cornebise, P., Doublet, Ph., Giannelli, M. Faucci, Fleury, J., Li, H., Martin-Chassard, G., Richard, F., de la Taille, Ch., Poeschl, R., Raux, L., Seguin-Moreau, N., Wicek, F., Anduze, M., Boudry, V., Brient, J-C., Gaycken, G., Jeans, D., de Freitas, P. Mora, Musat, G., Reinhard, M., Rougé, A., Ruan, M., Vanel, J-Ch., Videau, H., Park, K-H., Zacek, J., Cvach, J., Gallus, P., Havranek, M., Janata, M., Marcisovsky, M., Polak, I., Popule, J., Tomasek, L., Tomasek, M., Ruzicka, P., Sicho, P., Smolik, J., Vrba, V., Zalesak, J., Belhorma, B., Belmir, M., Nam, S. W., Park, I. H., Yang, J., Chai, Jong-Seo, Kim, Jong-Tae, Kim, Geun-Bum, Kang, J., and Kwon, Y. -J.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

A prototype silicon-tungsten electromagnetic calorimeter for an ILC detector was tested in 2007 at the CERN SPS test beam. Data were collected with electron and hadron beams in the energy range 8 to 80 GeV. The analysis described here focuses on the interactions of pions in the calorimeter. One of the main objectives of the CALICE program is to validate the Monte Carlo tools available for the design of a full-sized detector. The interactions of pions in the Si-W calorimeter are therefore confronted with the predictions of various physical models implemented in the GEANT4 simulation framework.

Published
2010
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19. Construction and Commissioning of the CALICE Analog Hadron Calorimeter Prototype

Author

Adloff, C., Karyotakis, Y., Repond, J., Brandt, A., Brown, H., De, K., Medina, C., Smith, J., Li, J., Sosebee, M., White, A., Yu, J., Buanes, T., Eigen, G., Mikami, Y., Miller, O., Watson, N. K., Wilson, J. A., Goto, T., Mavromanolakis, G., Thomson, M. A., Ward, D. R., Yan, W., Benchekroun, D., Hoummada, A., Khoulaki, Y., Oreglia, M., Benyamna, M., Cârloganu, C., Gay, P., Ha, J., Blazey, G. C., Chakraborty, D., Dyshkant, A., Francis, K., Hedin, D., Lima, G., Zutshi, V., Babkin, V. A., Bazylev, S. N., Fedotov, Yu. I., Slepnev, V. M., Tiapkin, I. A., Volgin, S. V., Hostachy, J. -Y., Morin, L., D?Ascenzo, N., Cornett, U., David, D., Fabbri, R., Falley, G., Feege, N., Gadow, K., Garutti, E., Göttlicher, P., Jung, T., Karstensen, S., Korbel, V., Lucaci-Timoce, A. -I., Lutz, B., Meyer, N., Morgunov, V., Reinecke, M., Schätzel, S., Schmidt, S., Sefkow, F., Smirnov, P., Vargas-Trevino, A., Wattimena, N., Wendt, O., Groll, M., Heuer, R. -D., Richter, S., Samson, J., Kaplan, A., Schultz-Coulon, H. -Ch., Shen, W., Tadday, A., Bilki, B., Norbeck, E., Onel, Y., Kim, E. J., Kim, G., Kim, D-W., Lee, K., Lee, S. C., Kawagoe, K., Tamura, Y., Ballin, J. A., Dauncey, P. D., Magnan, A. -M., Yilmaz, H., Zorba, O., Bartsch, V., Postranecky, M., Warren, M., Wing, M., Giannelli, M. Faucci, Green, M. G., Salvatore, F., Kieffer, R., Laktineh, I., Fouz, M. C, Bailey, D. S., Barlow, R. J., Thompson, R. J., Batouritski, M., Dvornikov, O., Shulhevich, Yu., Shumeiko, N., Solin, A., Starovoitov, P., Tchekhovski, V., Terletski, A., Bobchenko, B., Chadeeva, M., Danilov, M., Markin, O., Mizuk, R., Novikov, E., Rusinov, V., Tarkovsky, E., Andreev, V., Kirikova, N., Komar, A., Kozlov, V., Soloviev, Y., Terkulov, A., Buzhan, P., Dolgoshein, B., Ilyin, A., Kantserov, V., Kaplin, V., Karakash, A., Popova, E., Smirnov, S., Baranova, N., Boos, E., Gladilin, L., Karmanov, D., Korolev, M., Merkin, M., Savin, A., Voronin, A., Topkar, A., Freyk, A., Kiesling, C., Lu, S., Prothmann, K., Seidel, K., Simon, F., Soldner, C., Weuste, L., Bouquet, B., Callier, S., Cornebise, P., Dulucq, F., Fleury, J., Li, H., Martin-Chassard, G., Richard, F., de la Taille, Ch., Poeschl, R., Raux, L., Ruan, M., Seguin-Moreau, N., Wicek, F., Anduze, M., Boudry, V., Brient, J-C., Gaycken, G., Cornat, R., Jeans, D., de Freitas, P. Mora, Musat, G., Reinhard, M., Rougé, A., Vanel, J-Ch., Videau, H., Park, K-H., Zacek, J., Cvach, J., Gallus, P., Havranek, M., Janata, M., Kvasnicka, J., Marcisovsky, M., Polak, I., Popule, J., Tomasek, L., Tomasek, M., Ruzicka, P., Sicho, P., Smolik, J., Vrba, V., Zalesak, J., Arestov, Yu., Ammosov, V., Chuiko, B., Gapienko, V., Gilitski, Y., Koreshev, V., Semak, A., Sviridov, Yu., Zaets, V., Belhorma, B., Belmir, M., Baird, A., Halsall, R. N., Nam, S. W., Park, I. H., Yang, J., Chai, Jong-Seo, Kim, Jong-Tae, Kim, Geun-Bum, Kim, Y., Kang, J., Kwon, Y. -J., Kim, Ilgoo, Lee, Taeyun, Park, Jaehong, Sung, Jinho, Itoh, S., Kotera, K., Nishiyama, M., Takeshita, T., Weber, S., and Zeitnitz, C.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

An analog hadron calorimeter (AHCAL) prototype of 5.3 nuclear interaction lengths thickness has been constructed by members of the CALICE Collaboration. The AHCAL prototype consists of a 38-layer sandwich structure of steel plates and highly-segmented scintillator tiles that are read out by wavelength-shifting fibers coupled to SiPMs. The signal is amplified and shaped with a custom-designed ASIC. A calibration/monitoring system based on LED light was developed to monitor the SiPM gain and to measure the full SiPM response curve in order to correct for non-linearity. Ultimately, the physics goals are the study of hadron shower shapes and testing the concept of particle flow. The technical goal consists of measuring the performance and reliability of 7608 SiPMs. The AHCAL was commissioned in test beams at DESY and CERN. The entire prototype was completed in 2007 and recorded hadron showers, electron showers and muons at different energies and incident angles in test beams at CERN and Fermilab., Comment: 36 pages, 32 figures

Published
2010
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21. Comparative outcomes of cefazolin versus nafcillin for methicillin-susceptible Staphylococcus aureus bacteraemia: a prospective multicentre cohort study in Korea

Author

Choi, S.-M., Park, K.U., Kim, C.J., Cho, J.E., Choi, Y.J., In Park, J., Kim, T.S., Choe, P.G., Park, W.B., Kim, N.-H., Lee, M.J., Choi, S.J., Jeon, J.H., Kim, D.-K., Song, S.-A., Kang, M.J., Shin, J.G., Yi, J., Park, S., Choi, H.K., Han, M.S., Cho, C.R., Song, H.S., Lee, Y.S., Kang, S.-J., Hwang, H.-J., Cheon, S., Hwang, J.H., Yun, S.J., Kwon, K.T., Shin, S.M., Lee, S., Song, K.-H., Jung, S.-I., Lee, S.H., Kim, Y.-S., Kwak, Y.G., Kim, Y.K., Kiem, S.M., Kim, H.-I., Kim, E.S., Park, K.-H., Kim, N.J., Jang, H.-C., and Kim, H.B.

Published
2018
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23. Selective Production of Co and Ni Powders Through Hydrothermal Reduction of Leach Solutions of a Synthetic Matte Containing Cu-Ni-Co-Fe-S

Author

Mishra, D., Park, K.-H., Sahu, K. K., Agrawal, A., Nam, C. W., Battle, Thomas, editor, Moats, Michael, editor, Cocalia, Violina, editor, Oosterhof, Harald, editor, Alam, Shafiq, editor, Allanore, Antoine, editor, Jones, Rodney, editor, Stubina, Nathan, editor, Anderson, Corby, editor, and Wang, Shijie, editor

Published
2016
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34. Phase 3, Randomized, 20-Month Study of the Efficacy and Safety of Bimatoprost Implant in Patients with Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 2)

Author

Bacharach, J., Tatham, A., Ferguson, G., Belalcazar, S., Thieme, H., Goodkin, M. L., Chen, M. Y., Guo, Q., Liu, J., Robinson, M. R., Bejanian, M., Wirta, D. L., Alezzandrini, A., Bercovich, G., Deromedis, P., Furno Sola, F., Gentile, C., Lerner, S., Lupinacci, A., Zeolite, C., Birt, C., Crichton, A., Gagne, S., Giunta, M., Harasymowycz, P., Jinapriya, D., Nicolela, M., Nixon, D., Saurel, P., Yan, D., Yuen, D., Arango, S., Martinez, A., Parra Restrepo, J. C., Korda, V., Kadlecova, J., Svacinova, J., Khairy, H., El Ibiary, H., El Sanabary, Z., Bell, K., Greslechner, R., Koch, J., Lorenz, K., Oberacher-Velten, I., Schmickler, S., Schuart, C., Bandello, F., Cagini, C., Figus, M., Mastropasqua, L., Rossetti, L., Uva, M. G., Thayanithi, S., Wells, A., Husain, R., Koh, V., Lim, D., Tin, A., Gous, P., Venter, L., Kee, C., Kook, M., Park, K. -H., Eraslan, M., Kayikcioglu, O., Yildirim, N., Bourne, R., Choudhary, A., Cordeiro, F., Dubois, V., Kirwan, J., Lim, S., Martin, K., Nithy, A., Prabhu, A., Amir, A., Barnebey, H., Beck, A., Bergstrom, L., Borisuth, N., Branch, J. D., Briggs, J., Bylsma, S., Chang, P., Christie, W., Cotter, F., Depenbusch, M., Goldberg, D. F., Greiner, J., Gupta, S., Gutmark, R., Han, Y., Heersink, S., Kahook, M., Khouri, A., Kim, J., Kushnick, H., Lin, C., Luchs, J., Maharaj, A., Mansberger, S. L., Mares, F., Miller-Ellis, E., Modi, S., Paul, M., Pitha, I., Saltzmann, R., Sato, M., Savestsky, M., Segal, B., Segal, Z., Serle, J., Sherwood, M., Singh, I., Smith, S. E., Song, J., Sorenson, R., Tenkman, L., Tekwani, N., Tubbs, C., Tyson, F., Vizzeri, G., Vold, S., Vu, Q., Warren, K. S., and Wirta, D.

Subjects
Adult, Male, medicine.medical_specialty, Intraocular pressure, genetic structures, Corneal Touch, Ocular hypertension, Glaucoma, Timolol, Young Adult, Double-Blind Method, Ophthalmology, Clinical endpoint, Humans, Medicine, Pharmacology (medical), Original Research Article, Antihypertensive Agents, Intraocular Pressure, Aged, Aged, 80 and over, Drug Implants, Dose-Response Relationship, Drug, Bimatoprost, business.industry, Middle Aged, medicine.disease, eye diseases, Female, Ocular Hypertension, sense organs, Implant, Ophthalmic Solutions, business, Glaucoma, Open-Angle, medicine.drug
Abstract

Objective To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10 and 15 µg bimatoprost implant in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). Methods This randomized, 20-month, multicenter, masked, parallel-group, phase 3 trial enrolled 528 patients with OAG or OHT and an open iridocorneal angle inferiorly in the study eye. Study eyes were administered 10 or 15 µg bimatoprost implant on day 1, week 16, and week 32, or twice-daily topical timolol maleate 0.5%. Primary endpoints were IOP and IOP change from baseline through week 12. Safety measures included treatment-emergent adverse events (TEAEs) and corneal endothelial cell density (CECD). Results Both 10 and 15 µg bimatoprost implant met the primary endpoint of noninferiority to timolol in IOP lowering through 12 weeks. Mean IOP reductions from baseline ranged from 6.2–7.4, 6.5–7.8, and 6.1–6.7 mmHg through week 12 in the 10 µg implant, 15 µg implant, and timolol groups, respectively. IOP lowering was similar after the second and third implant administrations. Probabilities of requiring no IOP-lowering treatment for 1 year after the third administration were 77.5% (10 µg implant) and 79.0% (15 µg implant). The most common TEAE was conjunctival hyperemia, typically temporally associated with the administration procedure. Corneal TEAEs of interest (primarily corneal endothelial cell loss, corneal edema, and corneal touch) were more frequent with the 15 than the 10 µg implant and generally were reported after repeated administrations. Loss in mean CECD from baseline to month 20 was ~ 5% in 10 µg implant-treated eyes and ~ 1% in topical timolol-treated eyes. Visual field progression (change in the mean deviation from baseline) was reduced in the 10 µg implant group compared with the timolol group. Conclusions The results corroborated the previous phase 3 study of the bimatoprost implant. The bimatoprost implant met the primary endpoint and effectively lowered IOP. The majority of patients required no additional treatment for 12 months after the third administration. The benefit-risk assessment favored the 10 over the 15 µg implant. Studies evaluating other administration regimens with reduced risk of corneal events are ongoing. The bimatoprost implant has the potential to improve adherence and reduce treatment burden in glaucoma. Clinicaltrials.gov Identifier NCT02250651. Supplementary Information The online version contains supplementary material available at 10.1007/s40265-021-01624-9.

Published
2021
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35. A Selection of SOI Puzzles and Tentative Answers

Author

Cristoloveanu, S., Bawedin, M., Na, K.-I., Van Den Daele, W., Park, K.-H., Pham-Nguyen, L., Wan, J., Tachi, K., Chang, S.-J., Ionica, I., Diab, A., Bae, Y.-H., Chroboczek, J. A., Ohata, A., Fenouillet-Beranger, C., Ernst, T., Augendre, E., Le Royer, C., Zaslavsky, A., Iwai, H., Nazarov, Alexei, editor, Colinge, J.-P., editor, Balestra, Francis, editor, Raskin, Jean-Pierre, editor, Gamiz, Francisco, editor, and Lysenko, V.S., editor

Published
2011
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36. Floating-Body SOI Memory: The Scaling Tournament

Author

Bawedin, M., Cristoloveanu, S., Hubert, A., Park, K. H., Martinez, F., Nazarov, Alexei, editor, Colinge, J.-P., editor, Balestra, Francis, editor, Raskin, Jean-Pierre, editor, Gamiz, Francisco, editor, and Lysenko, V.S., editor

Published
2011
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37. Entanglement in a qubit-qubit-tardigrade system

Author

Lee, K S, primary, Tan, Y P, additional, Nguyen, L H, additional, Budoyo, R P, additional, Park, K H, additional, Hufnagel, C, additional, Yap, Y S, additional, Møbjerg, N, additional, Vedral, V, additional, Paterek, T, additional, and Dumke, R, additional

Published
2022
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40. Entanglement in a qubit-qubit-tardigrade system

Author

Lee, K. S., Tan, Y. P., Nguyen, L. H., Budoyo, R. P., Park, K. H., Hufnagel, C., Yap, Y. S., Møbjerg, N., Vedral, V., Paterek, T., Dumke, R., Lee, K. S., Tan, Y. P., Nguyen, L. H., Budoyo, R. P., Park, K. H., Hufnagel, C., Yap, Y. S., Møbjerg, N., Vedral, V., Paterek, T., and Dumke, R.

Abstract

Quantum and biological systems are seldom discussed together as they seemingly demand opposing conditions. Life is complex, 'hot and wet' whereas quantum objects are small, cold and well controlled. Here, we overcome this barrier with a tardigrade—a microscopic multicellular organism known to tolerate extreme physicochemical conditions via a latent state of life known as cryptobiosis. We observe coupling between the animal in cryptobiosis and a superconducting quantum bit and prepare a highly entangled state between this combined system and another qubit. The tomographic data shows entanglement in the qubit-qubit-tardigrade system, with the tardigrade modelled as an ensemble of harmonic oscillators or collection of electric dipoles. The animal is then observed to return to its active form after 420 h at sub 10 mK temperatures and pressures below $6\times 10^{-6}$ mbar, setting a new record for the conditions that a complex form of life can survive., Quantum and biological systems are seldom discussed together as they seemingly demand opposing conditions. Life is complex, ‘hot and wet’ whereas quantum objects are small, cold and well controlled. Here, we overcome this barrier with a tardigrade—a microscopic multicellular organism known to tolerate extreme physicochemical conditions via a latent state of life known as cryptobiosis. We observe coupling between the animal in cryptobiosis and a superconducting quantum bit and prepare a highly entangled state between this combined system and another qubit. The tomographic data shows entanglement in the qubit-qubit-tardigrade system, with the tardigrade modelled as an ensemble of harmonic oscillators or collection of electric dipoles. The animal is then observed to return to its active form after 420 h at sub 10 mK temperatures and pressures below 6 × 10 − 6 mbar, setting a new record for the conditions that a complex form of life can survive.

Published
2022

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