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467 results on '"Park, Jun-kyu"'

4. Preliminary Investigation on Efficacy and Safety of Substance P-Coated Stent for Promoting Re-Endothelialization: A Porcine Coronary Artery Restenosis Model

Author

Park, Dae Sung, Oh, Seok, Jin, Yu Jeong, Na, Mi Hyang, Kim, Munki, Kim, Jeong Ha, Hyun, Dae Young, Cho, Kyung Hoon, Hong, Young Joon, Kim, Ju Han, Ahn, Youngkeun, Hermida-Prieto, Manuel, Vázquez-Rodríguez, José Manuel, Gutiérrez-Chico, Juan Luis, Mariñas-Pardo, Luis, Lim, Kyung Seob, Park, Jun-Kyu, Byeon, Dae-Heung, Cho, Young-Nan, Kee, Seung-Jung, Sim, Doo Sun, and Jeong, Myung Ho

Published
2024
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19. The difference and variation of gut bacterial community and host physiology can support adaptation during and after overwintering in frog population.

Author

PARK, Jun‐Kyu and DO, Yuno

Subjects
*FROG populations, *BACTERIAL communities, *PHYSIOLOGY, *OXYGEN saturation, *GUT microbiome, *PHYSIOLOGICAL adaptation, *HOMEOSTASIS, *BACTERIAL population
Abstract

The hibernation of amphibians can offer a unique window into overwintering adaptation processes and host–gut microbiota interactions through changes in metabolic availability and homeostasis. We attempted to identify differences in the physiology and gut microbiome during and after hibernation in Japanese wrinkled frogs (Glandirana rugosa), an aquatic overwintering amphibian. After hibernation, the high alpha and beta diversity of the gut bacterial community appears to reflect the more diverse and complex environmental conditions. During winter, Proteobacteria dominated the majority of the gut bacterial community, likely due to high oxygen saturation. After hibernation, Firmicutes and Bacteroidetes increased, which are supportive of host metabolism by gut microbiota. Corticosterone also showed high values and variances after hibernation, presumably allowing the population to remain adaptable across a broad range of environmental gradients. Innate immunity was high after hibernation but exhibited low variation among populations, which supports the idea of a prioritized investment in immunity after hibernation. Blood biochemistry suggests that aquatic overwintering frogs have a mechanism to adapt through overhydration and regulate homeostasis through water excretion associated with the kidney and urine after hibernation. Frog populations exhibit variations and adaptability in gut microbiota and physiology during and after hibernation: Through this, they may demonstrate an adaptive response that regulates metabolic availability in preparation for unpredictable environmental changes. We also propose that the maintenance of Proteobacteria during hibernation can support the colonization of Firmicutes and Bacteroidetes after hibernation, underscoring the need to study the complex effects of gut microbiota across multiple life stages. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Poly-l-lactide Polymer-Based Triple Drug-Eluting Stent with Abciximab, Alpha-Lipoic Acid and Sirolimus in Porcine Coronary Restenosis Model

Author

Park, Jun-Kyu, Kim, Sung Soo, Kim, Hyun Kuk, Nah, Jae-Woon, Kim, Han Byul, Bae, In Ho, Park, Dae Sung, Shim, Jae Won, Lee, Min Young, Kim, Joong Sun, Koo, Bon-Sang, Jeong, Kang-Jin, Jin, Yeong Bae, Kim, Sun-Uk, Lee, Sang-Rae, Na, Joo-Young, Sim, Doo Sun, Hong, Young Joon, Lim, Kyung Seob, and Jeong, Myung Ho

Published
2020
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41. Phylogenetic Constraints and Ecological Implications of Gut Bacterial Communities in Necrophagous Flies.

Author

Park, Woong-Bae, Park, Jun-Kyu, and Do, Yuno

Subjects
*BACTERIAL communities, *GUT microbiome, *SPRING, *SPECIES diversity, *INFORMATION processing, *COMMUNITY centers
Abstract

This study examines the gut bacterial communities of four necrophagous fly species: Lucilia illustris, L. caesar, Chrysomya megacephala, and C. pinguis. The gut bacterial communities exhibited significant variation across species, showcasing a diverse range of bacterial phyla, classes, and genera. Each species harbored a unique set of bacteria, yet there was considerable overlap in taxa among species. Species richness was comparable across all species. However, measures that account for both richness and evenness, such as the Shannon diversity index and the inverse Simpson's diversity index, indicated significant differences between species, especially between L. illustris and C. pinguis. The functional profiles of the gut bacterial communities mainly centered on metabolic and environmental information processing functions, with no marked differences between species. While this study had limitations in data collection, it still revealed a significant correlation between the phylogenetic distances of some fly species and the distances of their gut bacterial communities. This supports the hypothesis that the gut microbiota is not random but is influenced by the host's evolutionary history or seasons. We confirmed that an association between phylogeny and gut bacterial community structure, as determined through entanglement analysis, exists. The study focused on only five individuals from the four fly species sampled during spring and summer, which might affect the generalizability of the results. Future research would benefit from replicating this study with a larger sample size across various seasons to ensure the more widespread applicability of the findings. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Additional file 5 of Rapid remodeling observed at mid-term in-vivo study of a smart reinforced acellular vascular graft implanted on a rat model

Author

Obiweluozor, Francis O., Kayumov, Mukhammad, Kwak, Yujin, Cho, Hwa-Jin, Park, Chan-Hee, Park, Jun-kyu, Jeong, Yun-Jin, Lee, Dong-Weon, Kim, Do-Wan, and Jeong, In-Seok

Abstract

Additional file 5: Figure 1. Tissue remodeling and extracellular matrix deposition in the explanted graft at 3 months as compared to native aorta. Cross-sectional images of native vessel and regenerated grafts (top row and bottom row respectively) were immunostained to examine the endothelial cells, smooth muscle cells, and myosin heavy chain. Endothelial cells were stained with vWF antibody (1st column; green and Dapi stained blue). Smooth muscle cells were stained with α–smooth muscle antibody. Figure 2. H&E staining of PCL/PDO graft at 12 weeks indicating remnants of PCL/PDO in the neo-vessel- yellow dotted arrow (51 μm). scale bar = 100 μm. Figure 3. Longitudinal section of collagen stained PCL/PDO graft explant at 12 weeks stained. a) Collagen I & III staining was counterstained with Dapi-merge. b) Collagen I&III staining alone. White dotted line indicates anastomosis site. Figure 4. (a) Fabrication process of graft. (b&c) Morphology of the luminal and outer surface of the scaffold respectively. (d) Pore area measurement using image. J (p = 0.0001). (e) In vitro cumulative drug release of dipyridamole from nanofibers containing various concentrations of drug (PCL/PDO + 5%DY, PCL/PDO + 7%DY, and PCL/PDO + 10%DY). The insert shows a higher magnification view of the area indicated with a red dotted circle.

Published
2023
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