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This study compares older adult learning in Korean and Japanese sample populations, paying special attention to learning after age 70. Surveys with nearly identical questionnaires were conducted in the Bundang Senior Welfare Center in Korea (N = 549, mean age 73.6 years) and at Osaka Prefecture Senior College in Japan (N = 1,491, 787, mean age = 67.4, 69.5 years). The main results are as follows: (a) in terms of learning needs, selected ratios of topics of "life review" and "communication with other seniors" increased as respondents increased in age from their 60s to 70s in both countries; (b) attitudes toward learning and social activities changed from "Novelty" to "Continuity" to "Disengagement" as respondents increased in age in both countries; and (c) the threshold age to old age was identified at around 75 years, not 70 years, particularly in Korean data. These results suggest that old age is a diverse period, and that creating ways to facilitate learning after age 70 is an urgent issue in the field of educational gerontology.

Simple Summary: Recognized as a promising target for anti-cancer treatment, PGF has the potential to overcome resistance to existing angiogenesis inhibitors. In this study, we aimed to identify target indications for PGF across various cancer types using bioinformatics analysis. We analyzed PGF gene function, molecular pathways, protein interactions, gene expression, mutations, survival prognosis, and tumor immune infiltration associated with PGF. The identified target diseases for PGF inhibitors included adrenocortical carcinoma, kidney cancers, liver hepatocellular carcinoma, stomach adenocarcinoma, and uveal melanoma. These findings highlight the potential of targeting PGF as a therapeutic strategy in these specific cancer types. The expression of the placental growth factor (PGF) in cancer cells and the tumor microenvironment can contribute to the induction of angiogenesis, supporting cancer cell metabolism by ensuring an adequate blood supply. Angiogenesis is a key component of cancer metabolism as it facilitates the delivery of nutrients and oxygen to rapidly growing tumor cells. PGF is recognized as a novel target for anti-cancer treatment due to its ability to overcome resistance to existing angiogenesis inhibitors and its impact on the tumor microenvironment. We aimed to integrate bioinformatics evidence using various data sources and analytic tools for target-indication identification of the PGF target and prioritize the indication across various cancer types as an initial step of drug development. The data analysis included PGF gene function, molecular pathway, protein interaction, gene expression and mutation across cancer type, survival prognosis and tumor immune infiltration association with PGF. The overall evaluation was conducted given the totality of evidence, to target the PGF gene to treat the cancer where the PGF level was highly expressed in a certain tumor type with poor survival prognosis as well as possibly associated with poor tumor infiltration level. PGF showed a significant impact on overall survival in several cancers through univariate or multivariate survival analysis. The cancers considered as target diseases for PGF inhibitors, due to their potential effects on PGF, are adrenocortical carcinoma, kidney cancers, liver hepatocellular carcinoma, stomach adenocarcinoma, and uveal melanoma. [ABSTRACT FROM AUTHOR]

This study examined the longitudinal relationship of early elementary predictors to adolescent depression 7 years later. The sample consisted of 938 students who have been part of a larger longitudinal study that started in 1993. Data collected from parents, teachers, and youth self-reports on early risk factors when students were in 1st and 2nd grade were compared to adolescent self-reported depression 7 years later. Regression analyses were conducted with each risk factor separately and combined, while also examining gender and the gender x risk factor interaction. Results showed that the risk factors predominately in the individual characteristic group (depression, anxiety, and antisocial behavior) were predictive of depression 7 years later. Gender differences among the longitudinal risk factors were also found in relation to adolescent depression. Discussion of the results focuses on the practice of children's mental health assessment and implications for the development of prevention and intervention programs for depression. (Contains 3 tables, 3 figures, and 1 note.)

Introduction Regulations of the United States Air Force (USAF) prohibit male members from growing beards. Shaving waivers can be issued to airmen who are not able to shave due to various medical conditions such as pseudofolliculitis barbae, a condition that predominantly affects Blacks/African-Americans. Beard growth has been anecdotally associated with a negative impact on career progression. This study sought to establish if shaving waivers are associated with delays in promotion and, if present, if this association leads to racial bias. Materials and Methods An online survey that collected information relating to shaving waivers and demographic data was emailed to all air force male members at 12 randomly selected air force bases. Generalized linear models were conducted to test the waiver group difference in promotion time controlling for rank and the covariates of race/ethnicity, level of education, professional military education completion, and disciplinary action. Results A total of 51,703 survey invitations were emailed to members, and 10,383 complete responses were received (20.08% response rate). The demographics of the study cohort closely matched that of the USAF. Shaving waivers were associated with a longer time to promotion (P  = .0003). The interaction between race and waiver status was not significant, indicating that shaving waivers are associated with a similarly longer time to promotion in individuals of all races. However, 64.18% of those in the waiver group were Black/African-American despite only being 12.85% of the study cohort. Conclusions This study found an association between shaving waivers and delayed promotions. The majority of the waiver group was Black/African-American, which may lead to a racially discriminatory effect of the male grooming standards of the USAF. [ABSTRACT FROM AUTHOR]