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2,279 results on '"Park, Jae Yong"'

3. Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Author

Shi, Jianxin, Shiraishi, Kouya, Choi, Jiyeon, Matsuo, Keitaro, Chen, Tzu-Yu, Dai, Juncheng, Hung, Rayjean J, Chen, Kexin, Shu, Xiao-Ou, Kim, Young Tae, Landi, Maria Teresa, Lin, Dongxin, Zheng, Wei, Yin, Zhihua, Zhou, Baosen, Song, Bao, Wang, Jiucun, Seow, Wei Jie, Song, Lei, Chang, I-Shou, Hu, Wei, Chien, Li-Hsin, Cai, Qiuyin, Hong, Yun-Chul, Kim, Hee Nam, Wu, Yi-Long, Wong, Maria Pik, Richardson, Brian Douglas, Funderburk, Karen M, Li, Shilan, Zhang, Tongwu, Breeze, Charles, Wang, Zhaoming, Blechter, Batel, Bassig, Bryan A, Kim, Jin Hee, Albanes, Demetrius, Wong, Jason YY, Shin, Min-Ho, Chung, Lap Ping, Yang, Yang, An, She-Juan, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young-Chul, Caporaso, Neil E, Chang, Jiang, Ho, James Chung Man, Kubo, Michiaki, Daigo, Yataro, Song, Minsun, Momozawa, Yukihide, Kamatani, Yoichiro, Kobayashi, Masashi, Okubo, Kenichi, Honda, Takayuki, Hosgood, Dean H, Kunitoh, Hideo, Patel, Harsh, Watanabe, Shun-ichi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Horinouchi, Hidehito, Tsuboi, Masahiro, Hamamoto, Ryuji, Goto, Koichi, Ohe, Yuichiro, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Hara, Megumi, Nishida, Yuichiro, Takeuchi, Kenji, Wakai, Kenji, Matsuda, Koichi, Murakami, Yoshinori, Shimizu, Kimihiro, Suzuki, Hiroyuki, Saito, Motonobu, Ohtaki, Yoichi, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Dai, Hongji, Machiela, Mitchell J, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Lee, Victor Ho Fun, Chang, Gee-Chen, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Seow, Adeline, Park, Jae Yong, and Kweon, Sun-Seog

Subjects
Genetics, Cancer, Clinical Research, Human Genome, Prevention, Lung, Lung Cancer, Tobacco, Tobacco Smoke and Health, 2.1 Biological and endogenous factors, Aetiology, Respiratory, Humans, Genome-Wide Association Study, Genetic Predisposition to Disease, Adenocarcinoma of Lung, Asia, Eastern, Lung Neoplasms, Polymorphism, Single Nucleotide
Abstract

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.

Published
2023

5. Diagnostic and prognostic implications of bacteremia in patients with complicated pleural infection

Author

Kim Chang Ho, Park Ji Eun, Cha Jung Guen, Lim Jae Kwang, Park Jongmin, Lee Yong Hoon, Choi Sun Ha, Seo Hyewon, Yoo Seung Soo, Lee Shin Yup, Cha Seung Ick, Park Jae Yong, and Lee Jaehee

Subjects
pleural infection, empyema, bacteremia, outcome, microbiology, Medicine, Specialties of internal medicine, RC581-951
Abstract

The clinical significance of bacteremia in patients with complicated pleural infection is still uncertain. We aimed to examine the incidence and clinical significance of bacteremia in patients with complicated pleural infection.

Published
2024
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17. On second order linear sequences of composite numbers

Author

Ismailescu, Dan, Ko, Adrienne, Lee, Celine, and Park, Jae Yong

Subjects
Mathematics - Number Theory
Abstract

In this paper we present a new proof of the following 2010 result of Dubickas, Novikas, and Siurys: Let $(a,b)\in \mathbb{Z}^2$ and let $(x_n)_{n\ge 0}$ be the sequence defined by some initial values $x_0$ and $x_1$ and the second order linear recurrence \begin{equation*} x_{n+1}=ax_n+bx_{n-1} \end{equation*} for $n\ge 1$. Suppose that $b\neq 0$ and $(a,b)\neq (2,-1), (-2, -1)$. Then there exist two relatively prime positive integers $x_0$, $x_1$ such that $|x_n|$ is a composite integer for all $n\in \mathbb{N}$. The above theorem extends a result of Graham who solved the problem when $(a,b)=(1,1)$.

Published
2018

25. High‐Performance Ceramic Catalyst Filters with Textured Waveguides for Efficient Removal of Volatile Organic Compounds.

Author

Kim, Jawon, Park, Jeonghyeon, Koo, Min Seok, Cho, Won Seok, Moon, Seokho, Hwang, Inyong, Kim, Jaerim, Park, Jae Yong, Ham, Dong Jin, Lee, Hyun Chul, and Kim, Jong Kyu

Subjects
CRYSTAL filters, VOLATILE organic compounds, ELECTRIC power, LIGHT emitting diodes, AIR purification
Abstract

The cordierite‐based ceramic catalyst filter (CCF) has attracted considerable attention as a promising future air purification system due to its ability to filtrate particulate matter (PM), as well as decompose volatile organic compounds (VOCs) through ultraviolet (UV)‐activated photocatalytic reactions. Its performance, however, is strictly limited because majority of UV photons are absorbed near the entrance of the high‐aspect‐ratio air‐flow channels, thus, only a limited portion of photocatalysts is activated during the flow of polluted air. In this study, a high‐performance CCF is presented featuring textured waveguides (TWs) aligned with an array of UV light‐emitting diodes (LEDs) emitting at a peak wavelength of 365 nm, which are inserted into an array of high‐aspect‐ratio channels. TWs ensure the delivery of UV photons deep inside channels via total internal reflection and scattering, enabling the activation of majority of photocatalysts, resulting in remarkable improvement in VOCs removal efficiency. The proposed CCF system exhibits much higher formaldehyde (HCHO) removal efficiency by 70% compared to conventional CCF systems even subjected to much lower UV light power densities. It is strongly believed that it is possible to further improve the removal efficiency, while maintaining effective PM filtering and ultralow electrical power consumption, by optimization of the geometry of the CCF system with TWs. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Pectoralis Muscle Area as a Predictor of Mortality in Patients Hospitalized with Bronchiectasis Exacerbation

Author

Seo, Hyewon, primary, Cha, Seung-Ick, additional, Park, Jongmin, additional, Lim, Jae-Kwang, additional, Lee, Won Kee, additional, Park, Ji-Eun, additional, Choi, Sun Ha, additional, Lee, Yong Hoon, additional, Yoo, Seung-Soo, additional, Lee, Shin-Yup, additional, Lee, Jaehee, additional, Kim, Chang-Ho, additional, and Park, Jae-Yong, additional

Published
2024
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35. Clinical impact of pleural fluid carcinoembryonic antigen on therapeutic strategy and efficacy in lung adenocarcinoma patients with malignant pleural effusion

Author

Lee, Jaehee, primary, Lee, Deok Heon, additional, Park, Ji Eun, additional, Lee, Yong Hoon, additional, Choi, Sun Ha, additional, Seo, Hyewon, additional, Yoo, Seung Soo, additional, Lee, Shin Yup, additional, Cha, Seung-Ick, additional, Park, Jae Yong, additional, and Kim, Chang Ho, additional

Published
2024
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45. Analysis of interfacial charges in aged co-host emitting layer of organic light-emitting diodes using impedance spectroscopy.

Author

Boo, So-Young, Raji, Akeem, Park, Jae-Yong, Park, Somi, Lee, Jonghee, and Lee, Jae-Hyun

Abstract

This study investigated the charge injection and accumulation characteristics of organic light-emitting diodes (OLEDs) generated by spontaneous orientation polarization (SOP) of organic molecules. SOP enhances the electrical characteristics of OLED devices, such as charge injection and transport, by adjusting the interfacial charge density between the organic layers within the device. An OLED device with a mixed co-host emitting layer was fabricated to examine the degradation effect of SOP after electrical aging. Impedance spectroscopy (IS) revealed the presence of interfacial charges originating from the SOP of small molecules within the electron transport layer (ETL), in both pristine and aged devices. Furthermore, the IS simulation results using equivalent circuits were successfully interpreted based on the electrical properties of each organic layer in the pristine and aged devices. The electrical properties of the ETL, which contained 1,3,5-tris(N-phenyl benzimidazole-2-yl)benzene (TPBi), were degraded, reducing hole accumulation and electron injection. [ABSTRACT FROM AUTHOR]

Published
2024
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