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4. Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration

Author

Scarfe, Lauren, Taylor, Arthur, Sharkey, Jack, Harwood, Rachel, Barrow, Michael, Comenge, Joan, Beeken, Lydia, Astley, Cai, Santeramo, Ilaria, Hutchinson, Claire, Ressel, Lorenzo, Smythe, Jon, Austin, Eric, Levy, Raphael, Rosseinsky, Matthew J., Adams, Dave J., Poptani, Harish, Park, Brian K., Murray, Patricia, and Wilm, Bettina

Published
2018
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7. Imaging technologies for monitoring the safety, efficacy and mechanisms of action of cell-based regenerative medicine therapies in models of kidney disease

Author

Sharkey, Jack, Scarfe, Lauren, Santeramo, Ilaria, Garcia-Finana, Marta, Park, Brian K, Poptani, Harish, Wilm, Bettina, Taylor, Arthur, and Murray, Patricia

Subjects
Pharmacology, Cell tracking, Biodistribution, Kidney function, Multispectral optoacoustic tomography, Preclinical imaging, Stem cells
Abstract

The incidence of end stage kidney disease is rising annually and it is now a global public health problem. Current treatment options are dialysis or renal transplantation, which apart from their significant drawbacks in terms of increased morbidity and mortality, are placing an increasing economic burden on society. Cell-based Regenerative Medicine Therapies (RMTs) have shown great promise in rodent models of kidney disease, but clinical translation is hampered due to the lack of adequate safety and efficacy data. Furthermore, the mechanisms whereby the cell-based RMTs ameliorate injury are ill-defined. For instance, it is not always clear if the cells directly replace damaged renal tissue, or whether paracrine effects are more important. Knowledge of the mechanisms responsible for the beneficial effects of cell therapies is crucial because it could lead to the development of safer and more effective RMTs in the future. To address these questions, novel in vivo imaging strategies are needed to monitor the biodistribution of cell-based RMTs and evaluate their beneficial effects on host tissues and organs, as well as any potential adverse effects. In this review we will discuss how state-of-the-art imaging modalities, including bioluminescence, magnetic resonance, nuclear imaging, ultrasound and an emerging imaging technology called multispectral optoacoustic tomography, can be used in combination with various imaging probes to track the fate and biodistribution of cell-based RMTs in rodent models of kidney disease, and evaluate their effect on renal function.

Published
2016
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10. UHRF1 regulation of the Keap1–Nrf2 pathway in pancreatic cancer contributes to oncogenesis

Author

Abu‐Alainin, Wafa, primary, Gana, Thompson, additional, Liloglou, Triantafillos, additional, Olayanju, Adedamola, additional, Barrera, Lawrence N, additional, Ferguson, Robert, additional, Campbell, Fiona, additional, Andrews, Timothy, additional, Goldring, Christopher, additional, Kitteringham, Neil, additional, Park, Brian K, additional, Nedjadi, Taoufik, additional, Schmid, Michael C, additional, Slupsky, Joseph R, additional, Greenhalf, William, additional, Neoptolemos, John P, additional, and Costello, Eithne, additional

Published
2015
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13. Reduction of anterior glenohumeral dislocations: a new closed reduction technique.

Author

Gage, Mark J., Park, Brian K., and Strauss, Eric J.

Abstract

Objective: A new closed reduction technique for anterior glenohumeral dislocations and tuberosity fracture dislocations is introduced. Methods: Forty-one consecutive patients with an acute anterior glenohumeral dislocation or tuberosity fracture dislocation underwent closed reduction by an orthopaedic surgeon employing this new method. Results: Closed reduction was successful in 88% of patients using the reduction maneuver. Associated fracture with glenohumeral dislocation did not influence the success rate of the reduction maneuver. An assistant was needed in 15% of cases. No complications related to the reduction maneuver were noted amongst the cohort. Conclusion: This novel reduction technique is safe demonstrating excellent success rates both for anterior shoulder dislocations and tuberosity fracture-dislocations. [ABSTRACT FROM AUTHOR]

Published
2017
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15. Anatomic variant of the inferior lateral cutaneous branch of the radial nerve during the posterior approach to the humerus: a case report.

Author

Li Sun, Park, Brian K., Gupta, Salil, Capo, John T., Yoon, Richard S., and Liporace, Frank A.

Subjects
*RADIAL nerve, *HEAD injuries, *ARM bones, *HUMERUS injuries, *WOUNDS & injuries, *THERAPEUTICS
Abstract

Iatrogenic injury during the posterior approach to the humerus during operative fixation is not an uncommon occurrence. A comprehensive understanding of the normal anatomy and its variants is of paramount importance in order to avoid such injury. Typically, the inferior lateral cutaneous branch of the radial nerve originates towards the distal end of the humerus at the inferior portion of the spiral groove. Here, we report an important variant of this nerve, which originated significantly more proximal than expected, further emphasizing the importance of identification, dissection and protection of the radial nerve and its major branches. [ABSTRACT FROM AUTHOR]

Published
2015
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19. Revision of Failed Hip Resurfacing and Large Metal-on-Metal Total Hip Arthroplasty Using Dual-Mobility Components

Author

Lindeque, Bennie G.P., Snir, Nimrod, Park, Brian K., Garofolo, Garret, and Marwin, Scott E.

Abstract

Revision of metal-on-metal (MoM) total hip arthroplasty (THA) or hip resurfacing is associated with high complication rates. The authors propose dual-mobility components as a surgical option and present short- to mid-term results of MoM hips revised with dual-mobility components. Eighteen consecutive hips that underwent revision of MoM THA or hip resurfacing using dual-mobility components were identified. At final follow-up (mean, 17.5 months), the visual analog scale, modified Harris Hip Score, and SF-12 scores had all improved (Revision of metal-on-metal (MoM) total hip arthroplasty (THA) or hip resurfacing is associated with high complication rates. The authors propose dual-mobility components as a surgical option and present short- to mid-term results of MoM hips revised with dual-mobility components. Eighteen consecutive hips that underwent revision of MoM THA or hip resurfacing using dual-mobility components were identified. At final follow-up (mean, 17.5 months), the visual analog scale, modified Harris Hip Score, and SF-12 scores had all improved (P<.05, P<.01, and P<.05, respectively). There were no dislocations or other complications. Revision of failed MoM THA or hip resurfacing using a dual-mobility device is an effective strategy. [Orthopedics.2015; 38(6):369–374.]

Published
2015
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