1,169 results on '"Park, B. Kevin"'
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2. Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
3. Human OATP1B1 (SLCO1B1) transports sulfated bile acids and bile salts with particular efficiency
4. Immune drug-induced liver disease and drugs
5. Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies
6. Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury
7. Retraction Note: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity
8. Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance–based detection in vivo
9. Expression of Concern to: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatoxicity
10. Increased Resistance to Acetaminophen Hepatotoxicity in Mice Lacking Glutathione S-Transferase Pi
11. Roles of Nrf2 in drug and chemical toxicity
12. Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms
13. Supplementary Figure S3. from Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus
14. Supplementary Table S1. from Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus
15. SUPPLEMENTARY DATA from Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus
16. Data from MDM2 Regulates Dihydrofolate Reductase Activity through Monoubiquitination
17. Supplementary Figure 1 from MDM2 Regulates Dihydrofolate Reductase Activity through Monoubiquitination
18. Supplementary Figure 2 from MDM2 Regulates Dihydrofolate Reductase Activity through Monoubiquitination
19. From mice to men: Murine models of colorectal cancer for use in translational research
20. In Vivo Tumorigenicity of the 20q11.21 Amplicon in an Engraftment Model of hPSCs and Differentiated Liver Cells
21. Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing
22. Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds
23. Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study
24. New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity
25. The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death
26. A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
27. Where are we now with paracetamol?
28. Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man
29. The Keap1-Nrf2 Cellular Defense Pathway: Mechanisms of Regulation and Role in Protection Against Drug-Induced Toxicity
30. Toxicological Consequences of Drug–Drug Interactions
31. Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications
32. PEG and PEG conjugates toxicity: towards an understanding of the toxicity of PEG and its relevance to PEGylated biologicals
33. The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone
34. Stem cell–derived models to improve mechanistic understanding and prediction of human drug‐induced liver injury
35. MIST AND THE FUTURE
36. Application of Pluripotent Stem Cells in Drug-Induced Liver Injury Safety Assessment
37. Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies
38. Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis
39. Immune pathomechanism of drug hypersensitivity reactions
40. Adverse Drug Reactions As Cause Of Admission To Hospital: Prospective Analysis Of 18 820 Patients
41. Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation
42. Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver
43. Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines
44. Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening
45. Stimulation of human T cells with sulfonamides and sulfonamide metabolites
46. Systems analysis of miRNA biomarkers to inform drug safety
47. Activation of Flucloxacillin-Specific CD8+ T-Cells With the Potential to Promote Hepatocyte Cytotoxicity in a Mouse Model
48. MicroRNA-122: A Novel Hepatocyte-Enriched in vitro Marker of Drug-Induced Cellular Toxicity
49. Multiple reaction monitoring for quantitative biomarker analysis in proteomics and metabolomics
50. Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells
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