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Raloxifene HCl (RLX) is a BCS class - II drug, used in osteoporosis. For RLX liquisolid compacts (LSC), selection of non volatile liquid vehicle, carrier, coating material, super disintegrant were done and they were developed by using Propylene Glycol (PG): Polyethylene Glycol (PEG) 600 as a combination of non volatile liquid vehicles, Avicel PH101 as a carrier, Aeroperl 300 as coating material and Kyron T 314 as super disintegrant. The optimized batch was characterized by tests like flow property, content uniformity of mass, weight variation, tablet hardness, friability, disintegration time, XRD (X-ray diffraction) study, in vitro drug release test. The results of in vitro drug release study of RLX optimized batch illustrated a remarkable improvement in the dissolution rate as compared to Reference product (Ralista) and pure drug with other parameters of tablet. Accelerated stability study of the optimized batch was done for 3 months (at 25°C ± 2°C temperature and 40% ± 5% Relative humidity) and showed no significant change in appearance, drug content and in vitro drug release. This study concluded that LSC of RLX prove as one of the suitable approach for developing stable solid oral dosage form of poorly water soluble drug - RLX. [ABSTRACT FROM AUTHOR]

The present study was aimed to increase the solubility of the poorly water soluble drug Telmisartan by using Surface solid dispersion (SSD) made of polymers like Poloxamer 407, PEG 6000 by Solvent evaporation method. The drug was solubilized by surfactants and/or polymers then adsorbed onto the surface of extremely fine carriers to increase its surface area and to form the SSD which give the more Surface area for absorption of the drug. A 22 full factorial design was used to investigate for each carrier the joint influence of formulation variables: Amount of carrier and adsorbent. Saturation solubility studies shows the improvement in solubility of drug batch SSD 8 give more solubility improvement than the other batch, in-vitro dissolution of pure drug, physical mixtures and SSDs were carried out in that SSDs were found to be effective in increasing the dissolution rate of Telmisartan in form of SSD when compared to pure drug. Also FT-IR spectroscopy, differential scanning calorimetry and X-ray diffractometry studies were carried out in order to characterize the drug and Surface solid dispersion. Furthermore, both DSC and X-ray diffraction showed a decrease in the melting enthalpy and reduced drug crystallinity consequently in SSDs. However, infrared spectroscopy revealed no drug interactions with the carriers. [ABSTRACT FROM AUTHOR]

Transferosomes containing an anti-fungal agent were prepared by Rotary Flask Evaporation -Sonication method. Eight batches were prepared in triplicate and vesicle size of each batch was determined. Plackett-Burman Design was employed to identify significant formulation and process parameters affecting vesicle size. The amount of lipid and surfactant, volume of ethanol and hydration medium as well as hydration time significantly affect the vesicle size. [ABSTRACT FROM AUTHOR]