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177 results on '"Parikh, P.J."'

1. Future of Multidisciplinary Team in the Context of Adaptive Therapy.

Author

McNair, H.A., Milosevic, M.F., Parikh, P.J., and van der Heide, U.A.

Abstract

The implementation and early adoption of online adaptive radiotherapy (oART) has required the presence of clinicians, physicists and radiation therapists (RTT) at the treatment console. The impact on each of them is unique to their profession and must be considered for safe and efficient implementation. In the short term future, widespread adoption will depend on the development of innovative workflows, and rethinking of traditional roles and responsibilities may be required. For the future, technologies such as artificial intelligence promise to change the workflow significantly in terms of speed, automation and decision-making. However, overall communication within the team will persist in being one of the most important aspects. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Stereotactic MR-Guided On-Table Adaptive Radiation Therapy (SMART) for Patients with Borderline or Locally Advanced Pancreatic Cancer: Primary Endpoint Outcomes of a Prospective Phase II Multi-Center International Trial

Author

Parikh, P.J., primary, Lee, P., additional, Low, D., additional, Kim, J., additional, Mittauer, K.E., additional, Bassetti, M.F., additional, Glide-Hurst, C., additional, Raldow, A., additional, Yang, Y., additional, Portelance, L., additional, Zaki, B., additional, Kim, H., additional, Mancias, J.D., additional, Ng, J., additional, Pfeffer, R.M., additional, Mueller, A., additional, Kelly, P., additional, Boldrini, L., additional, Fuss, M., additional, and Chuong, M.D., additional

Published
2022
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6. Quality of Life after Ablative 5-Fraction Radiation Therapy from the Phase 2 SMART Pancreas Trial.

Author

Chuong, M.D., Parikh, P.J., Low, D., Kim, J., Mittauer, K.E., Bassetti, M.F., Glide-Hurst, C., Raldow, A., Yang, Y., Portelance, L., Zaki, B., Kim, H., Mancias, J.D., Ng, J., Pfeffer, R.M., Mueller, A., Kelly, P., Boldrini, L., Fuss, M., and Lee, P.

Subjects
*STEREOTACTIC radiotherapy, *CANCER radiotherapy, *PANCREATIC cancer, *INDUCTION chemotherapy, *DRUG dosage, *RADIOTHERAPY
Abstract

Prospective data demonstrate that non-ablative stereotactic body radiation therapy (SBRT) for pancreas cancer is well tolerated and results in stable patient-reported quality of life (QOL) although few studies have evaluated long-term QOL beyond ∼3 months after SBRT. Ablative SBRT (BED 10 ∼100 Gy) is increasingly being adopted and its effects on QOL are unknown. We now present QOL outcomes from a phase 2 trial evaluating ablative 5-fraction stereotactic MR-guided on-table adaptive radiation therapy (SMART) for borderline resectable and locally advanced pancreas cancer. The multi-center single-arm phase 2 SMART trial enrolled 136 patients from January 2019 to January 2022 who received ≥3 months of induction chemotherapy without disease progression and were treated on a 0.35T MR-guided device with a prescribed dose of 50 Gy in 5 fractions (BED 10 = 100 Gy). Intrafraction cine-MRI, soft tissue tracking, and automatic beam gating were mandatory. On-table adaptive replanning using an isotoxicity approach was performed prior to each fraction as needed. A secondary study endpoint was QOL using the NCCN-FACT FHSI-18 survey instrument at 3 times (T): prior to SMART (T1), 3 months after SMART (T2), and 12 months after SMART (T3). The total FHSI-18 score was calculated as a sum of the following subscale scores: disease related symptoms-physical, disease related symptoms-emotional, treatment side effects, and function/well-being. Surgery was performed in 44 patients (32.4%) after SMART. QOL assessment was completed at T1, T2, and T3 by 133 (97.8%) and 106 (77.9%), and 55 (40.4%) patients, respectively. Mean total score and subscale scores remained stable from T1-T2 or T1-T3. Mean individual question scores were stable from T1-T2 except for general pain (0.8 vs. 1.1; p=0.002) and localized stomach pain (1.0 vs. 1.3; p=0.013); a significant increase in pain scores was present among patients who had surgery after SMART while pain scores did not increase among those who did not have surgery. Mean individual scores were stable from T1-T3 except for increased stomach area pain (p<0.001) regardless of surgery and scores for feeling ill increased among patients who did not have surgery (p=0.004). This is the first prospective evaluation of QOL after ablative radiation therapy for pancreas cancer demonstrating that overall QOL remains stable at 3 and 12 months after SMART. Additional analysis is warranted to clarify factors significantly associated with QOL including disease progression and additional therapy after SMART. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Long-Term Multi-Institutional Outcomes of 5-Fraction Ablative Stereotactic MR-Guided Adaptive Radiation Therapy (SMART) for Inoperable Pancreas Cancer With Median Prescribed Biologically Effective Dose of 100 Gy10

Author

Chuong, M.D., primary, Kirsch, C., additional, Herrera, R., additional, Rubens, M., additional, Gungor, G., additional, Schaff, E.M., additional, Dolan, J., additional, Kim, J., additional, Mittauer, K.E., additional, Kotecha, R., additional, Gutierrez, A., additional, Doemer, A.J., additional, Ugurluer, G., additional, Kwon, D., additional, Khan, G., additional, Alvarez, D., additional, Ucar, A., additional, Asbun, H., additional, Ozyar, E., additional, and Parikh, P.J., additional

Published
2021
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8. GRECO-2: A Randomized, Phase 2 Study of Stereotactic Body Radiation Therapy (SBRT) in Combination with GC4711 in the Treatment of Unresectable or Borderline Resectable Nonmetastatic Pancreatic Cancer (PC)

Author

Hoffe, S., primary, Kim, D.W., additional, Malafa, M., additional, Costello, J., additional, Aguilera, T.A., additional, Beg, S.M., additional, Parikh, P.J., additional, Herman, J.M., additional, Terry, K., additional, Holmlund, J., additional, and Moser, E.C., additional

Published
2021
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11. Multi-Institutional Comparison of SC-TNT and LC-TNT for Rectal Cancer Non-Operative Management

Author

Moskalenko, M., primary, Kim, H., additional, Chin, R.I., additional, Roy, A., additional, Badiyan, S.N., additional, Bauer, P., additional, Fakhoury, K., additional, Henke, L.E., additional, Herter, W., additional, Lieu, C., additional, Moyer, A.M., additional, Mutch, M., additional, Parikh, P.J., additional, Pedersen, K., additional, Schefter, T., additional, Silviera, M., additional, Srivastava, G., additional, Vogel, J.D., additional, Chapman, B., additional, and Olsen, J.R., additional

Published
2021
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12. Patterns of Utilization and Clinical Adoption of 0.35 MR-Guided Radiation Therapy in the United States — Understanding the Transition to Adaptive, Ultra-Hypofractionated Treatments

Author

Chuong, M.D., primary, Clark, M.A., additional, Henke, L.E., additional, Kishan, A.U., additional, Portelance, L., additional, Parikh, P.J., additional, Nagar, H., additional, Rosenberg, S.A., additional, Mehta, M.P., additional, Abdelrhman, T.R., additional, Smith, A.J.T., additional, Seung, S.K., additional, Zaki, B., additional, and Mak, R.H., additional

Published
2021
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13. Magnetic Resonance Guided Stereotactic Ablative Radiation Therapy Versus External Beam RT with Chemotherapy For Pancreatic Cancer: Single Institution Toxicity Analysis Of Patients Treated In An Urban Academic Center

Author

Schaff, E.M., primary, Gartrelle, K.J., additional, Kirsch, C., additional, Siddiqui, F., additional, Ajlouni, M., additional, Dragovic, J., additional, Aref, I., additional, Shah, M.M., additional, Kwon, D., additional, Dobrosotskaya, I., additional, Shah, R., additional, Khan, G., additional, and Parikh, P.J., additional

Published
2020
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17. Prospective Phase I Trial of Concurrent Full Dose Gemcitabine/Nab-paclitaxel and Ablative Radiation Therapy for Borderline and Locally Advanced Pancreatic Cancer

Author

Kim, H., primary, Olsen, J.R., additional, Wang-Gillam, A., additional, Green, O.L., additional, Fields, R.C., additional, Hammill, C., additional, Strasberg, S., additional, Doyle, M.B., additional, Hawkins, W., additional, Suresh, R., additional, Tan, B., additional, Pedersen, K., additional, Henke, L.E., additional, DeWees, T.A., additional, Chapman, W., additional, Parikh, P.J., additional, and Roach, M.C., additional

Published
2019
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18. A Prospective Trial of Non-Operative Radiation Management of Adenocarcinoma of the Lower Rectum (NORMAL-R): Interim Analysis

Author

Kim, H., primary, Pedersen, K., additional, Hunt, S., additional, Glasgow, S., additional, Silviera, M., additional, Mutch, M., additional, Wise, P., additional, Smith, R., additional, Wang-Gillam, A., additional, Tan, B., additional, Lim, K.H., additional, Suresh, R., additional, Amin, M., additional, Wan, L., additional, Parikh, P.J., additional, and Roach, M.C., additional

Published
2019
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19. The transformation of radiation oncology using real-time magnetic resonance guidance: A review

Author

Hall, W.A., Paulson, E.S., Heide, U.A. van der, Fuller, C.D., Raaymakers, B.W., Lagendijk, J.J., Li, X.A., Jaffray, D.A., Dawson, L.A., Erickson, B., Verheij, M., Harrington, K.J., Sahgal, A., Lee, P., Parikh, P.J., Bassetti, M.F., Robinson, C.G., Minsky, B.D., Choudhury, A., Tersteeg, R., Schultz, C.J., Hall, W.A., Paulson, E.S., Heide, U.A. van der, Fuller, C.D., Raaymakers, B.W., Lagendijk, J.J., Li, X.A., Jaffray, D.A., Dawson, L.A., Erickson, B., Verheij, M., Harrington, K.J., Sahgal, A., Lee, P., Parikh, P.J., Bassetti, M.F., Robinson, C.G., Minsky, B.D., Choudhury, A., Tersteeg, R., and Schultz, C.J.

Abstract

Item does not contain fulltext, Radiation therapy (RT) is an essential component of effective cancer care and is used across nearly all cancer types. The delivery of RT is becoming more precise through rapid advances in both computing and imaging. The direct integration of magnetic resonance imaging (MRI) with linear accelerators represents an exciting development with the potential to dramatically impact cancer research and treatment. These impacts extend beyond improved imaging and dose deposition. Real-time MRI-guided RT is actively transforming the work flows and capabilities of virtually every aspect of RT. It has the opportunity to change entirely the delivery methods and response assessments of numerous malignancies. This review intends to approach the topic of MRI-based RT guidance from a vendor neutral and international perspective. It also aims to provide an introduction to this topic targeted towards oncologists without a speciality focus in RT. Speciality implications, areas for physician education and research opportunities are identified as they are associated with MRI-guided RT. The uniquely disruptive implications of MRI-guided RT are discussed and placed in context. We further aim to describe and outline important future changes to the speciality of radiation oncology that will occur with MRI-guided RT. The impacts on RT caused by MRI guidance include target identification, RT planning, quality assurance, treatment delivery, training, clinical workflow, tumour response assessment and treatment scheduling. In addition, entirely novel research areas that may be enabled by MRI guidance are identified for future investigation.

Published
2019

22. Rectal Cancer Downstaging is Significantly Improved with Different Regimens of Total Neoadjuvant Therapy

Author

Chapman, W., primary, Roxburgh, C., additional, Makhdoom, B., additional, Roy, A., additional, Youssef, F.F., additional, Brady, P., additional, Olsen, J.R., additional, Kim, H., additional, Pedersen, K., additional, Mutch, M., additional, Hunt, S., additional, Markovina, S., additional, Hajj, C., additional, Cercek, A., additional, Weiser, M., additional, and Parikh, P.J., additional

Published
2018
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29. NRG Oncology/RTOG 0529: Long-Term Outcomes of Dose-Painted Intensity Modulated Radiation Therapy, 5-Fluorouracil, and Mitomycin-C in Anal Canal Cancer

Author

Kachnic, L.A., primary, Winter, K., additional, Myerson, R.J., additional, Goodyear, M.D., additional, Abitbol, A.A., additional, Koenig, J.M., additional, Augspurger, M., additional, Schefter, T., additional, Katz, A.W., additional, Fisher, B., additional, Parikh, P.J., additional, Narayan, S., additional, and Crane, C.H., additional

Published
2017
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30. Pancreatic Adenocarcinoma Gross Tumor Volume Contouring on Computed Tomography as Compared With Magnetic Resonance Imaging: Results of an International Consensus Contouring Conference

Author

Hall, W.A., primary, Heerkens, H.D., additional, Paulson, E.S., additional, Meijer, G.J., additional, Kotte, A.N., additional, Knechtges, P., additional, Parikh, P.J., additional, Bassetti, M.F., additional, Lee, P., additional, Aitken, K.L., additional, Palta, M., additional, Myrehaug, S., additional, Koay, E.J., additional, Portelance, L., additional, Ben-Josef, E., additional, and Erickson, B.A., additional

Published
2017
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32. External Validation of the European Rectal Cancer Prognosis Model Using NRG Oncology RTOG 0822 Clinical Trial Data

Author

Zhong, H., primary, van Soest, J., additional, Wang, J., additional, Valentini, V., additional, Geng, H., additional, Huang, M., additional, Cheng, C., additional, Garofalo, M., additional, Hong, T.S., additional, Lerma, F.A., additional, Keech, J., additional, Anne, P.R., additional, Perera, F.E., additional, Oldenburg, N.B., additional, Parikh, P.J., additional, DeNittis, A.S., additional, Zaki, B., additional, Nowlan, A.W., additional, Zhang, B., additional, Dekker, A., additional, Zhang, Z., additional, and Xiao, Y., additional

Published
2017
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35. Adaptive MR-Guided Stereotactic Body Radiation Therapy (AMR-SBRT) for Oligometastatic or Unresectable Primary Abdominal Malignancies: Results of a Prospective Phase I Trial

Author

Henke, L.E., primary, Kashani, R., additional, Yang, D., additional, Zhao, T., additional, Green, O.L., additional, Wooten, H., additional, Rodriguez, V.L., additional, Olsen, L.A., additional, Markovina, S., additional, Robinson, C.G., additional, Bradley, J.D., additional, Michalski, J.M., additional, Mutic, S., additional, Parikh, P.J., additional, and Olsen, J.R., additional

Published
2016
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40. Multi-Institutional Investigation of Relative Pancreatic Tumor to Duodenal Motion in Magnetic Resonance Imaging Guided Radiation Therapy for Potential Online Adaptive Radiation Therapy

Author

Mittauer, K.E., primary, Rosenberg, S.A., additional, Geurts, M.W., additional, Chen, I., additional, Henke, L.E., additional, Olsen, J.R., additional, Kashani, R., additional, Wojcieszynski, A.P., additional, Harari, P.M., additional, Bayouth, J., additional, Labby, Z.E., additional, Hill, P.M., additional, Paliwal, B.R., additional, Parikh, P.J., additional, and Bassetti, M., additional

Published
2016
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41. Online Adaptive Magnetic Resonance–Guided (OAMR)-Stereotactic Body Radiation Therapy for Abdominal Malignancies: Prospective Dosimetric Results from a Phase 1 Trial

Author

Henke, L.E., primary, Olsen, J.R., additional, Green, O.L., additional, Yang, D., additional, Zhao, T., additional, Olsen, L.A., additional, Wooten, H., additional, Li, H., additional, Rodriguez, V.L., additional, McClain, B., additional, Curcuru, A., additional, Robinson, C.G., additional, Bradley, J.D., additional, Michalski, J.M., additional, Mutic, S., additional, Parikh, P.J., additional, and Kashani, R., additional

Published
2016
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46. Matched Pair Analysis of Sequential Short Course Radiation Therapy and FOLFOX Chemotherapy as Preoperative Therapy for Rectal Cancer: Improved DFS Compared to Institutional Controls Favors Near-Total Neoadjuvant Therapy

Author

Youssef, F.F., primary, Markovina, S., additional, Khwaja, S.S., additional, DeWees, T.A., additional, Hunt, S.R., additional, Tan, B.R., additional, Myerson, R.J., additional, Parikh, P.J., additional, and Olsen, J.R., additional

Published
2015
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47. Online Adaptive MR Guided Stereotactic Body Radiation Therapy for the Treatment of Oligometastatic Disease of the Abdomen and Central Thorax: Characterization of Potential Advantages

Author

Henke, L.E., primary, Kashani, R., additional, Yang, D., additional, Zhao, T., additional, Green, O.L., additional, Wooten, H., additional, Li, H., additional, Hu, Y., additional, Rodriguez, V.L., additional, Olsen, L.A., additional, Robinson, C.G., additional, Parikh, P.J., additional, Michalski, J.M., additional, Mutic, S., additional, and Olsen, J.R., additional

Published
2015
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