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13 results on '"Parikh, Niyati"'

2. Standardization and harmonization of distributed multi-center proteotype analysis supporting precision medicine studies

Author

Xuan, Yue, Bateman, Nicholas W., Gallien, Sebastien, Goetze, Sandra, Zhou, Yue, Navarro, Pedro, Hu, Mo, Parikh, Niyati, Hood, Brian L., Conrads, Kelly A., Loosse, Christina, Kitata, Reta Birhanu, Piersma, Sander R., Chiasserini, Davide, Zhu, Hongwen, Hou, Guixue, Tahir, Muhammad, Macklin, Andrew, Khoo, Amanda, Sun, Xiuxuan, Crossett, Ben, Sickmann, Albert, Chen, Yu-Ju, Jimenez, Connie R., Zhou, Hu, Liu, Siqi, Larsen, Martin R., Kislinger, Thomas, Chen, Zhinan, Parker, Benjamin L., Cordwell, Stuart J., Wollscheid, Bernd, and Conrads, Thomas P.

Published
2020
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3. Proteomic Alterations Associated with Residual Disease in Neoadjuvant Chemotherapy Treated Ovarian Cancer Tissues

Author

Penick, Emily R., primary, Bateman, Nicholas W., additional, Rojas, Christine, additional, Magana, Cuauhtemoc, additional, Conrads, Kelly, additional, Zhou, Ming, additional, Hood, Brian L., additional, Wang, Guisong, additional, Parikh, Niyati, additional, Huang, Ying, additional, Darcy, Kathleen M., additional, Casablanca, Yovanni, additional, Mhawech-Fauceglia, Paulette, additional, Maxwell, G. Larry, additional, and Conrads, Thomas, additional

Published
2022
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4. Additional file 1 of Proteomic alterations associated with residual disease in neoadjuvant chemotherapy treated ovarian cancer tissues

Author

Penick, Emily R., Bateman, Nicholas W., Rojas, Christine, Magana, Cuauhtemoc, Conrads, Kelly, Zhou, Ming, Hood, Brian L., Wang, Guisong, Parikh, Niyati, Huang, Ying, Darcy, Kathleen M., Casablanca, Yovanni, Mhawech-Fauceglia, Paulette, Conrads, Thomas P., and Maxwell, G. Larry

Abstract

Additional file 1: Figure S1. Clinical model to determine surgical algorithm for ovarian cancer patients. A diagnostic surgery is first conducted to determine feasibility of optimal cytoreduction in women found to have ovarian cancer. If patients are determined by the surgeon to have disease burden that is likely to achieve optimally cytoreduction (R0), then patients undergo Primary Debulking Surgery (PDS). If optimal debulking is determined to be unlikely (R1), patients have tissue specimens collected at the diagnostic surgery, but otherwise cytoreduction is not attempted. These patients were subsequently referred for neoadjuvant chemotherapy (NACT) postoperatively and then scheduled for Interval Debulking Surgery (IDS) after three or more cycles of chemotherapy. Figure S2. Comparison of proteins significantly altered between patients with residual disease (R1) versus no residual disease (R0) in pre-NACT ovarian cancer tissue.

Published
2022
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5. Signal integration by the two-component signal transduction response regulator CpxR

Author

Wolfe, Alan J., Parikh, Niyati, Lima, Bruno P., and Zemaitaitis, Bozena

Subjects
Escherichia coli -- Physiological aspects, Cellular signal transduction -- Research, Genetic transcription -- Research, Genetic epistasis -- Research, Protein folding -- Genetic aspects, Bacterial proteins -- Genetic aspects, Bacterial proteins -- Properties, Biological sciences
Abstract

The CpxAR two-component signal transduction system in Escherichia coli and other pathogens senses diverse envelope stresses and promotes the transcription of a variety of genes that remedy these stresses. An important member of the CpxAR regulon is cpxP. The CpxA-dependent transcription of cpxP has been linked to stresses such as misfolded proteins and alkaline pH. It also has been proposed that acetyl phosphate, the intermediate of the phosphotransacetylase (Pta)-acetate kinase (AckA) pathway, can activate the transcription of cpxP in a CpxA-independent manner by donating its phosphoryl group to CpxR. We tested this hypothesis by measuring the transcription of cpxP using mutants with mutations in the CpxAR pathway, mutants with mutations in the Pta-AckA pathway, and mutants with a combination of both types of mutations. From this epistasis analysis, we learned that CpxR integrates diverse stimuli. The stimuli that originate in the envelope depend on CpxA, while those associated with growth and central metabolism depend on the Pta-AckA pathway. While CpxR could receive a phosphoryi group from acetyl phosphate, this global signal was not the primary trigger for CpxR activation associated with the Pta-AckA pathway. On the strength of these results, we contend that the interactions between central metabolism and signal transduction can be quite complex and that successful investigations of such interactions must include a complete epistatic analysis.

Published
2008

6. Standardization and Harmonization of Distributed Multi-National Proteotype Analysis supporting Precision Medicine Studies

Author

Xuan, Yue, primary, Bateman, Nicholas W., additional, Gallien, Sebastien, additional, Goetze, Sandra, additional, Zhou, Yue, additional, Navarro, Pedro, additional, Hu, Mo, additional, Parikh, Niyati, additional, Hood, Brian L., additional, Conrads, Kelly A., additional, Loosse, Christina, additional, Kitata, Reta Birhanu, additional, Piersma, Sander R., additional, Chiasserini, Davide, additional, Zhu, Hongwen, additional, Hou, Guixue, additional, Tahir, Muhammad, additional, Macklin, Andrew, additional, Khoo, Amanda, additional, Sun, Xiuxuan, additional, Crossett, Ben, additional, Sickmann, Albert, additional, Chen, Yu-Ju, additional, Jimenez, Connie R., additional, Zhou, Hu, additional, Liu, Siqi, additional, Larsen, Martin R., additional, Kislinger, Thomas, additional, Chen, Zhinan, additional, Parker, Benjamin L., additional, Cordwell, Stuart J., additional, Wollscheid, Bernd, additional, and Conrads, Thomas P., additional

Published
2020
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7. Abstract 4709: Extensive intratumor proteogenomic heterogeneity revealed by multiregion sampling in a high-grade serous ovarian tumor specimen

Author

Hunt, Allison L., primary, Bateman, Nicholas W., additional, Wang, Guisong, additional, Parikh, Niyati, additional, Oliver, Julie, additional, Mitchell, Dave, additional, Gist, Glenn, additional, Hood, Brian L., additional, Zhou, Ming, additional, Blanton, Brian, additional, Conrads, Kelly A., additional, Hamilton, Chad A., additional, Darcy, Kathleen M., additional, Shriver, Craig D., additional, Casablanca, Yovanni, additional, Maxwell, George L., additional, and Conrads, Thomas P., additional

Published
2019
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