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12 results on '"Parikh, H. M."'

1. Relationship between insulin sensitivity and gene expression in human skeletal muscle

Author

Parikh, H. M., Elgzyri, T., Alibegovic, A., Hiscock, N., Ekström, O., Eriksson, K. -F, Vaag, A., Groop, L. C., Ström, Kristoffer, Hansson, O., Parikh, H. M., Elgzyri, T., Alibegovic, A., Hiscock, N., Ekström, O., Eriksson, K. -F, Vaag, A., Groop, L. C., Ström, Kristoffer, and Hansson, O.

Abstract

Background: Insulin resistance (IR) in skeletal muscle is a key feature of the pre-diabetic state, hypertension, dyslipidemia, cardiovascular diseases and also predicts type 2 diabetes. However, the underlying molecular mechanisms are still poorly understood. Methods: To explore these mechanisms, we related global skeletal muscle gene expression profiling of 38 non-diabetic men to a surrogate measure of insulin sensitivity, i.e. homeostatic model assessment of insulin resistance (HOMA-IR). Results: We identified 70 genes positively and 110 genes inversely correlated with insulin sensitivity in human skeletal muscle, identifying autophagy-related genes as positively correlated with insulin sensitivity. Replication in an independent study of 9 non-diabetic men resulted in 10 overlapping genes that strongly correlated with insulin sensitivity, including SIRT2, involved in lipid metabolism, and FBXW5 that regulates mammalian target-of-rapamycin (mTOR) and autophagy. The expressions of SIRT2 and FBXW5 were also positively correlated with the expression of key genes promoting the phenotype of an insulin sensitive myocyte e.g.PPARGC1A. Conclusions: The muscle expression of 180 genes were correlated with insulin sensitivity. These data suggest that activation of genes involved in lipid metabolism, e.g.SIRT2, and genes regulating autophagy and mTOR signaling, e.g.FBXW5, are associated with increased insulin sensitivity in human skeletal muscle, reflecting a highly flexible nutrient sensing.

Published
2021
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7. Further studies on the -adrenoceptor blocking action of -adrenoceptor blocking agents.

Author

Gulati OD, Parikh HM, and Raghunath PR

Subjects
Adrenergic alpha-Antagonists antagonists & inhibitors, Adrenergic beta-Antagonists antagonists & inhibitors, Animals, Butoxamine pharmacology, Catecholamines pharmacology, Cocaine pharmacology, Dose-Response Relationship, Drug, Epinephrine pharmacology, In Vitro Techniques, Isoproterenol pharmacology, Levobunolol pharmacology, Male, Methoxamine pharmacology, Neurons metabolism, Norepinephrine metabolism, Norepinephrine pharmacology, Phenoxybenzamine pharmacology, Phenylephrine pharmacology, Potassium Chloride pharmacology, Propranolol pharmacology, Rats, Seminal Vesicles drug effects, Tyramine pharmacology, Adrenergic alpha-Antagonists pharmacology, Adrenergic beta-Antagonists pharmacology
Published
1973
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9. A clinical trial of alpha-methyldopa (Aldomet) and hydrochlorthiazide (Dichlotride) alone and in combination in hypertension.

Author

Vaidya PM, Munshi CP, Sawkar LA, Parikh HM, and Gulati OD

Subjects
Adult, Clinical Trials as Topic, Drug Interactions, Female, Humans, Hydrochlorothiazide adverse effects, Hypertension complications, Hypokalemia chemically induced, Male, Methyldopa adverse effects, Middle Aged, Hydrochlorothiazide therapeutic use, Hypertension drug therapy, Methyldopa therapeutic use
Published
1971

10. Effect of imipramine on adrenergic responses.

Author

Shaikh AA, Gulati OD, and Parikh HM

Subjects
Angiotensin II pharmacology, Animals, Blood Vessels drug effects, Carotid Arteries physiology, Dogs, Drug Synergism, Ear, External blood supply, Epinephrine antagonists & inhibitors, Female, In Vitro Techniques, Isoproterenol pharmacology, Male, Muscle Contraction drug effects, Norepinephrine pharmacology, Phenylephrine antagonists & inhibitors, Rabbits, Reflex drug effects, Spleen drug effects, Vagotomy, Vagus Nerve physiology, Blood Pressure drug effects, Heart drug effects, Imipramine pharmacology, Muscle, Smooth drug effects
Published
1973

11. Plasma free insulin-like activity in normal and diabetic subjects.

Author

Parikh IK, Dave BT, Shah CP, Patel DG, Parikh HM, and Gulati OD

Subjects
Adolescent, Adult, Aged, Child, Child, Preschool, Diabetes Complications, Diabetic Nephropathies complications, Female, Humans, Infant, Infections complications, Male, Methods, Middle Aged, Obesity complications, Time Factors, Diabetes Mellitus blood, Insulin blood
Published
1970

12. An investigation of alpha-methyl amino-acids and their derivatives on isolated tissue preparations.

Author

Gulati OD, Parikh HM, Ringe SY, and Sherlekar ML

Subjects
Animals, Cocaine pharmacology, Disulfiram pharmacology, Dopamine pharmacology, Ear, External drug effects, Heart drug effects, Ileum drug effects, In Vitro Techniques, Metaraminol pharmacology, Methyldopa antagonists & inhibitors, Methyldopa pharmacology, Methyltyrosines pharmacology, Normetanephrine pharmacology, Perfusion, Rabbits, Rats, Reserpine pharmacology, Sodium, Tyramine antagonists & inhibitors, Amino Acids pharmacology, Reserpine antagonists & inhibitors, Tyramine pharmacology
Abstract

1. The ability of alpha-methyl amino-acids and their corresponding amines to restore the sympathomimetic actions of tyramine, and the uptake of the amino-acids and the amines, were studied in isolated tissue preparations obtained from reserpine pretreated animals.2. Tyramine relaxed isolated rat ileum preparations from non-reserpinized rats but not from reserpine treated animals. alpha-Methyldopa, alpha-methylnoradrenaline and lower concentrations of metaraminol restored the responses of reserpinized preparations. alpha-Methyldopamine, alpha-methyl-m-tyrosine, alpha-methyl-p-tyrosine and higher concentrations of metaraminol did not do so. The restoring effect of alpha-methyldopa was blocked by disulphiram. alpha-Methyl-p-tyrosine or alpha-methyl-m-tyrosine blocked the restoring action of alpha-methyldopa but not of alpha-methylnoradrenaline. Cocaine blocked the restoration of responses to tyramine by alpha-methylnoradrenaline but not by alpha-methyldopa. alpha-Methyldopa and alpha-methylnoradrenaline failed to restore responses to tyramine in the presence of sodium-free Tyrode solution.3. Tyramine increased the perfusion pressure in isolated rabbit ear preparations obtained from non-reserpinized animals but was very much less active in preparations obtained from reserpine treated animals. alpha-Methyldopa, alpha-methyl-m-tyrosine, alpha-methylnoradrenaline, alpha-methyl-p-tyrosine and metaraminol restored the effects of tyramine. alpha-Methyldopamine did not do so. The restoring effect of alpha-methyldopa and alpha-methyl-m-tyrosine was blocked by disulfiram. alpha-Methyl-p-tyrosine blocked the restoring effect of alpha-methyl-m-tyrosine.4. Tyramine produced positive inotropic effects in isolated rabbit heart preparations. This was either reduced or absent in preparations obtained from reserpine pretreated animals. alpha-Methyldopa, alpha-methylnoradrenaline, alpha-methyl-m-tyrosine and metaraminol restored the responses to tyramine. alpha-Methyldopamine and alpha-methyl-p-tyrosine did not do so.

Published
1970
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