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Introduction: The Pittsburgh Sleep Quality Questionnaire is capable of covering different stages of sleep, and it is regarded as one of the best ones available, and checking for its validity and reliability among depressed patients is a step in this direction. The aim of this study was to evaluate the reliability and validity of the Persian version of the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) questionnaires in patients with depression. Methods: In this study, 93 depressed patients were in the study group, and 100 patients were in the control group. The Persian translation of the PSQI and ESS questionnaires and the Beck Depression Inventory (BDI) were at the disposal of both validity and reliability of PSQI and ESS, and its correlation with BDI scores were analyzed. Results: In our study, Cronbach's alpha coefficient of the PSQI questionnaire was 0.821. According to the PSQI and BDI-II scores, the results between the PSQI and ESS scores were significantly correlated. Conclusion: Using the Persian PSQI and ESS questionnaires to evaluate sleep quality and daytime sleepiness in patients with depression provides a reliable and valid measure for subjective sleep quality in clinical practice and research.