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7 results on '"Parfenkova GA"'

1. [Middle molecules--a marker of endogenous intoxication (a review of the literature)].

Author

Parfenkova GA, Cherniad'eva IF, and Sitina VK

Subjects
Anemia etiology, Anemia metabolism, Animals, Hemoperfusion, Humans, Kidney Failure, Chronic diagnosis, Kidney Failure, Chronic metabolism, Kidney Failure, Chronic therapy, Molecular Weight, Peptides analysis, Peptides toxicity, Toxemia metabolism, Toxemia therapy, Toxins, Biological analysis, Toxins, Biological metabolism, Uremia diagnosis, Uremia metabolism, Peptides metabolism, Toxemia diagnosis
Published
1987

3. [Potential clinical use of an acid-stable proteinase inhibitor from human urine].

Author

Ogloblina OG, Belova LA, Malakhov VN, and Parfenkova GA

Subjects
Acute Disease, Adult, Animals, Aortitis enzymology, Aortitis therapy, Arteritis enzymology, Arteritis therapy, Dogs, Drug Evaluation, Drug Evaluation, Preclinical, Drug Stability, Female, Hemoperfusion methods, Humans, Pancreas enzymology, Pancreatitis enzymology, Pancreatitis therapy, Peptide Hydrolases blood, Protease Inhibitors isolation & purification, Protease Inhibitors urine, Sepharose, Takayasu Arteritis enzymology, Takayasu Arteritis therapy, Protease Inhibitors therapeutic use
Abstract

The method for the preparation of a specific proteinase adsorbent (acid-resistant human urinary proteinase inhibitor--UPI--immobilized on sepharose) has been developed. Proteinase adsorption using this adsorbent has proved highly effective in the treatment of acute pancreatitis with plasmasorption. High adsorption capacity of UPI-sepharose from plasma samples of patients with acute nonspecific aortoarteritis has been demonstrated in vitro. Determination of UPI activity in the human urine is an informative test for early tissue damage, as compared to plasma middle molecules assay. The former test may be used as a diagnostic technique in patients with parenchymal kidney injury and increased arterial pressure.

Published
1987

4. [Imbalance of the plasma proteinase-inhibitory system in familial hypercholesterolemia].

Author

Alidzhanova KhG, Ogloblina OG, Kukharchuk VV, Konovalov GA, Parfenkova GA, and Belova LA

Subjects
Adolescent, Adult, Coronary Disease enzymology, Coronary Disease genetics, Enzyme Activation, Female, Humans, Hyperlipoproteinemia Type II complications, Male, Middle Aged, Pancreatic Elastase genetics, Sex Factors, alpha 1-Antitrypsin genetics, Coronary Disease etiology, Hyperlipoproteinemia Type II enzymology, Pancreatic Elastase blood, alpha 1-Antitrypsin Deficiency
Published
1989

5. [Clinical value of determining the activity of elastase- and chymotrypsin-like proteinases in the plasma of patients with nonspecific aortoarteritis and arteriosclerosis].

Author

Parfenkova GA, Ogloblina OG, and Domba GIu

Subjects
Adolescent, Adult, Aortitis diagnosis, Arteriosclerosis diagnosis, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Severity of Illness Index, Aortitis enzymology, Arteriosclerosis enzymology, Chymotrypsin blood, Clinical Enzyme Tests, Pancreatic Elastase blood
Published
1989

6. [Activities of plasma proteinases and their acid-stable urinary inhibitors in patients with arterial hypertension].

Author

Parfenkova GA, Orloblina OG, and Sitina VK

Subjects
Adolescent, Adult, Child, Female, Humans, Hypertension, Renal etiology, Kidney Diseases complications, Male, Middle Aged, Toxins, Biological blood, Chymotrypsin blood, Glycoproteins urine, Hypertension, Renal metabolism, Pancreatic Elastase blood
Abstract

The data obtained allow to consider urine acid-stable proteinase inhibitor (ASPI) activity as an early and informative index of renal parenchyma damage in patients with renal symptomatic arterial hypertensions without significant urine changes. Urine ASPI activities seems to be useful in differentiation of patients with chronic glomerulonephritis without significant urine changes and patients with hypertensions.

Published
1988

7. [Clinical importance of determining the activity of an acid-stable proteinase inhibitor in the urine of arterial hypertension patients].

Author

Parfenkova GA, Ogloblina OG, and Sitina VK

Subjects
Adolescent, Adult, Chronic Disease, Drug Stability, Female, Glomerulonephritis diagnosis, Humans, Hypertension blood, Hypertension diagnosis, Male, Middle Aged, Peptides blood, Pyelonephritis diagnosis, Toxins, Biological blood, Hypertension urine, Protease Inhibitors urine
Abstract

The determination of urine acid-stable proteinase inhibitor activity proved to be more informative at the early stages of renal tissue lesions, as compared to measurement of intermediate molecule blood level. It can be used as a diagnostic test in patients with parenchymatous renal diseases accompanied by blood pressure elevation, and essential hypertension.

Published
1987

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