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Background. Several surveys have presented the quality of reports on randomized clinical trials (RCTs) published in general and specialty medical journals. The aim of these surveys was to raise scientific consciousness on methodological aspects pertaining to internal and external validity. These reviews have suggested that the methodological quality could be improved. Objective. We conducted a survey of reports on RCTs published in nursing journals to assess their methodological quality. The features we considered inclUded sample size, flow of participants, assessment of baseline comparability, randomization, blinding, and statistical analysis. Methods. We collected data from all reports of RCTs published between January 1994 and December 1997 in Applied Nursing Research, Heart &. Lung and Nursing Research. We hand-searched the journals and included all 54 articles in which authors reported that individuals have been randomly allocated to distinct groups. We collected data using a condensed form of the Consolidated Standards of Reporting Trials (CONSORT) statement for structured reporting of RGs [Begg et al.. 1996). Background A randomized clinical trial (RCT) provides the most valid basis for assessing the benefits of health care interventions. Results of a published RCT will be most influential on patient care if the reader can appreciate both the methodological quality of the trial and the quality of the report. The methodological quality of a trial itself depends on the accurate accomplishment of several fundamental steps. The quality of the report depends on whether the published RCT provides readers with adequate information on the design, Results. Sample size calculations were included in only 22% of the reports. Only 48% of the reports provided information about the type of randomization, and a mere 22% described blinding strategies. Comparisons of baseline characteristics using hypothesis tests were abusively produced in more than 76% of the reports. Excessive use and unstructured reports of significance testing were common [59%\. and all reports failed to provide magnitude of treatment differences with confidence intervals. Conclusions. Better methodological quality in reports of RCTs will contribute to increase the standards of nursing research. [ABSTRACT FROM AUTHOR]

Despite extensive research on the prevalence and mental health implications of problematic smartphone use in adolescents, the cognitive mechanisms underpinning its development, such as self-regulation, remain underexplored. This study aims to fill this research gap by investigating the developmental trajectories of self-regulation and problematic smartphone use among Canadian adolescents. Participants (N = 1303; 614 girls; Mage = 14.60 years, SD = 1.16 years) attended one of five public high schools in Southern British Columbia. Adolescents self-reported their self-regulation skills, as well as problematic smartphone use annually for three years. In line with developmental expectations, results indicated that both self-regulation and problematic smartphone use increased across the three years. Parallel latent growth models revealed significant intercept and positive slope differences for self-regulation and problematic smartphone use, showing that higher initial self-regulation predicted lower initial problematic smartphone use, and vice versa. Girls exhibited higher initial levels of problematic smartphone use, but gender differences in developmental trajectories were not observed. These findings emphasize the importance of early self-regulation skills in preventing the escalation of problematic smartphone use in adolescents, providing evidence-based insights for developing targeted interventions., (© 2024. Crown.)

Background: Despite well-established evidence showing that young sexual and gender minority (SGM) men experience disproportionate mental health and substance use inequities, few sexual health services provide mental health and substance use care. This qualitative study examined the experiences and perspectives about integrated care models within sexual health services among young SGM men experiencing mental health and substance use challenges., Methods: Semi-structured interviews were conducted with 50 SGM men aged 18-30 years who reported using substances with sex in Vancouver, Canada. Interviews were analyzed using thematic analysis., Results: Three themes were identified: 1) participants asserted that their sexual health, mental health and substance use-related health needs were interrelated and that not addressing all three concurrently could result in even more negative health outcomes. These concurrent health needs were described as stemming from the oppressive social conditions in which SGM men live. 2) Although sexual health clinics were considered a safe place to discuss sexual health needs, participants reported not being invited by health providers to engage in discussions about their mental health and substance use health-related needs. Participants also perceived how stigmas associated with mental health and substance use limited their ability to express and receive support. 3) Participants identified key characteristics they preferred and wanted within integrated care, including training for health providers on mental health and SGM men's health and connections (e.g., referral processes) between services. Participants also recommended integrating social support programs to help them address SGM-related social challenges., Conclusion: Our findings highlight that SGM men's sexual health, mental health and substance use-related health needs and preferences are interrelated and should be addressed together. Tailored training and resources as well as structural adaptations to improve communication channels and collaborative connections between health providers are required to facilitate the development of integrated care for young SGM men., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)

The objective of the present study was to examine developmental trajectories of cyber-aggression in early adolescence, as well as their relationship with predictive factors related to cyber-aggression (e.g., overt aggression, gender, and time spent online). Participants were 384 adolescents from the Lower Mainland of British Columbia, Canada who were in grade six and grade seven at Time 1 of the study (192 boys, Mage = 13.62 years, SD = 0.74 year). Three years of longitudinal data on cyber-aggression, overt aggression, and time spent online were collected via online self-report questionnaires. Findings indicated three different trajectories of cyber-aggression: (a) a low-increasing (85.7% of the sample), (b) a stable trajectory (9.3% of the sample), and (c) a high-decreasing trajectory (4.9% of the sample). Adolescents who reported higher scores on overt aggression and spent more time online were more likely to be in the stable or high-decreasing groups. These findings highlight the importance of studying subgroups regarding the developmental course of cyber-aggression in early adolescence. The implications of present study findings give insight into gender differences and overt aggression among youth to inform cyber-aggression intervention and prevention., Competing Interests: The authors declare no conflict of interest.

Background: Alcohol consumption is common among young men and occurs in many contexts. The sexualized substance use literature has generated some insight into the role of alcohol alongside other substances in the context of sex, though there remain opportunities for targeted and context-sensitive studies to examine the sexual practices and outcomes associated with alcohol, specifically., Methods: This interpretive description study explores how experiences and contexts of alcohol use feature in the sexual lives of young men who use substances with sex. Data collection involved in-depth interviews conducted between 2018 and 2021 in Vancouver, Canada, with N = 76 young men (ages 18-30; mean = 23.9 years) who use substances with sex, including men with diverse sexual identities. Data were analyzed in an iterative manner through a social constructivist lens and an interpretive description framework, leveraging constant comparison techniques., Findings: This analysis yielded three interconnected themes: (1) using alcohol for sexual(ity) freedoms; (2) backgrounding alcohol within a sexualized polysubstance milieu; and (3) navigating the risks and consequences of using alcohol with sex. Alcohol use was found to reduce inhibitions and support experimentation, including by facilitating the transgression of conservative or restrictive social and sexual norms. Alcohol was seldom explicitly classified as a sexualized substance, though it was evidently a widespread and normative social practice. This practice was associated with important risk and consequences, including with respect to consent, pregnancy and sexually transmitted and bloodborne infection risk, and sexual dysfunction., Conclusions: Findings from this study position alcohol as a backgrounded yet significantly influential substance that young men use with sex. The sexualized use of substances must be understood, and responded to, in a manner that is grounded in harm reduction and that considers the full spectrum of substances-inclusive of but not limited to alcohol-and associated benefits and risks that feature in young men's sexual lives. Specifically, sexual health and primary care providers working with young men should invite and open up meaningful conversation about how they may be using substances (including alcohol) with sex, while offering de-stigmatizing, sex-positive, and affirming education and supports to promote safer sex and substance use., (© 2023. The Author(s).)

Objective: To assess the impact of different non-pharmaceutical interventions (NPIs) on COVID-19 cases across Victoria and South Australia., Methods: Poisson regression models were fit to examine the effect of NPIs on weekly COVID-19 case numbers., Results: Mask-wearing in Victoria had a pronounced lag effect of two weeks with an incidence rate ratio (IRR) of 0.27 (95%CI 0.26-0.29). Similarly, the effect of border closure (IRR 0.18; 95%CI 0.14-0.22) in South Australia and lockdown (IRR 0.88; 95%CI 0.86-0.91) in Victoria showed a decrease in incidence two weeks after the introduction of these interventions., Conclusions: With the ongoing COVID-19 pandemic, varying levels of vaccination coverage rates and threats from variants of concern, NPIs are likely to remain in place. It is thus important to validate the effectiveness and timing of different interventions for disease control, as those that are more restrictive such as border control and lockdown can have an enormous impact on society., Implications for Public Health: Low case numbers and deaths in Australia's first wave of COVID-19 are thought to be due to the timely use of interventions. The observed two-week lag effect associated with a decrease in incidence provides justification for early implementation of NPIs for COVID-19 management and future pandemics., (© 2022 The Authors.)

As the COVID-19 global pandemic limited face-to-face social contact, mental health concerns increased for adolescents. Additionally, many adolescents turned to technology to communicate with their peers, which also raised concerns about adolescent smartphone addiction. However, research has yet to examine how mental health and technology engagement are related to adolescents' feelings of social connection-an important developmental predictor of wellbeing across the lifespan. Specifically, little is known regarding the relative risk of adolescents' mental health concerns, a known risk factor for social disconnection and isolation and smartphone addiction in contributing to feelings of social disconnection in the time of COVID-19. The present study investigated how mental health outcomes and smartphone addiction contributed to Canadian adolescents' ( n = 1753) feelings of social disconnection during COVID-19. Between October 2020 and May 2021, data were collected from five secondary schools in and around the lower mainland of British Columbia using an online-administered self-report questionnaire. Adolescents responded to questions about their smartphone addiction, internalizing problems, and an open-ended question about their feelings of connection to others. Findings from logistic regression analyses indicated that depression was a predictor of feeling socially disconnected: however, smartphone addiction was not associated with feelings of social disconnection during COVID-19. Implications of these findings can help inform the development of prevention programs targeting adolescents at risk for social disconnection in times of increased social isolation (e.g., a global pandemic). Specifically, these findings suggest that adolescents higher in depressive symptoms, and not those higher in smartphone addiction, are the ones most at risk.

Objectives: Assess the feasibility and impact of a continuous professional development (CPD) course on type 2 diabetes and depression on health professionals' intention to include sex and gender considerations in patient care., Design and Setting: In collaboration with CPD organisations and patient-partners, we conducted a mixed-methods feasibility controlled trial with postintervention measures in three Canadian provinces., Participants: Of 178 eligible health professionals, 127 completed questionnaires and 67 participated in semistructured group discussions., Intervention and Comparator: An interactive 1 hour CPD course, codesigned with patient-partners, on diabetes and depression that included sex and gender considerations (innovation) was compared with a similar course that did not include them (comparator)., Outcomes: Feasibility of recruitment and retention of CPD organisations and patient-partners throughout the study; adherence to planned activities; health professionals' intention to include sex and gender considerations in patient care as measured by the CPD-Reaction questionnaire; and barriers and facilitators using the Theoretical Domains Framework., Results: All recruited CPD organisations and patient-partners remained engaged throughout the study. All planned CPD courses occurred. Overall, 71% of eligible health professionals participated (63% under 44 years old; 79.5% women; 67.7% practising in French; 66.9% practising in Quebec; 78.8% in urban practice). After training, mean intention scores for the innovation (n=49) and control groups (n=78) were 5.65±0.19 and 5.19±0.15, respectively. Mean difference was -0.47 (CI -0.95 to 0.01; p=0.06). Adjusted for age, gender and practice settings, mean difference was -0.57 (CI -1.09 to -0.05; p=0.03). We identified eight theoretical domains related to barriers and six related to facilitators for providing sex-adapted and gender-adapted diabetes and depression care., Conclusions: CPD training on diabetes and depression that includes sex and gender considerations is feasible and, compared with CPD training that does not, may prompt health professionals to modify their care. Addressing identified barriers and facilitators could increase intention., Trial Registration Number: NCT03928132 with ClinicalTrials.gov; Post-results., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

This mixed-methods study explored adolescents' (n = 682) feelings of social connection in the time of the COVID-19 pandemic and examined potential risk (fear of missing out, problematic smartphone use) and protective (parent/peer attachment, smartphone use) factors to social disconnection. Data were collected from two schools in Canada using an online survey with questionnaires and open-ended questions. Three themes regarding adolescents' feelings of social connection during the pandemic were identified through thematic content analysis: (1) feeling socially connected, (2) feeling socially disconnected, and (3) feeling socially indifferent. Moreover, regression analysis identified secure peer attachments as a protective factor against social disconnection in the time of the COVID-19 pandemic, while fear of missing out was identified as an independent risk factor., (© 2021 Society for Research on Adolescence.)

The objective of this study was to identify how cannabis use features within the sexual lives of young sexual minority men who use substances, and how this might intersect with features of their contemporary socio-cultural contexts in a setting where non-medical cannabis was recently legalised: Vancouver, Canada. Forty-one sexual minority men ages 15 to 30 years were recruited between January and December 2018 to participate in in-depth, semi-structured 1-2 h interviews about their experiences of using substances (e.g. cannabis) for sex. Drawing on constant comparative analytic techniques, two themes emerged with regards to participants' perceptions of, and experiences with, the sexualised use of cannabis. First, participants described how they used cannabis for sex to increase sexual pleasure and lower inhibitions. Second, participants described using cannabis for sex to reduce feelings of anxiety and shame, and foster intimacy and connection with sexual partners. These findings identify how the sexualised use of cannabis functions as a 'strategic resource' for sexual minority men to deliberately achieve both physiological and psychoactive effects, while concurrently underscoring the extent to which the contexts, patterns and motivations associated with cannabis use for sex parallel those associated with this form of Chemsex.

Despite a growing body of evidence demonstrating that cannabis use is associated with mental illness among sexual and gender minority (SGM) men, little is known about the motivations, patterns and contexts that influence this relationship. Our study aimed to characterize how cannabis use features within the mental health-related experiences of young SGM men in Vancouver, Canada. From January to December 2018, semi-structured interviews were conducted with 50 SGM men ages 15 to 30 years to explore their experiences using cannabis. We draw on thematic analysis to reveal three themes regarding participants' experiences with cannabis use and mental health. First, participants experiences emphasized the interconnectedness of cannabis use, sexual, and mental health, including using cannabis to: (i) cope with mental health symptoms during sexual encounters (e.g., anxiety, sexual trauma-related stress); and (ii) substitute or replace other substances (e.g., crystal methamphetamine, MDMA) to reduce drug-related harms in Chemsex practices (e.g., decreased ability to consent, drug-induced psychosis). Second, participants discussed the instrumental use of cannabis to alleviate and address symptoms of mental health (e.g., depression, post-traumatic experiences). Third, participants described adverse effects of cannabis use on their mental health, including feelings of paranoia that they associated with cannabis use, as well as concerns around developing cannabis dependence. Our findings reveal important implications for public health policy on how cannabis can be used to manage experiences of mental health among young SGM men, while also highlighting the need to develop harm reduction services for those who may experience mental health-related harms., Competing Interests: Declarations of Interest None., (Copyright © 2020. Published by Elsevier B.V.)

Objectives: The goal of this study was to investigate socio-demographic and contextual factors in relation to the frequency of outdoor play in the neighbourhood in early childhood, drawing from a large sample of children in British Columbia, Canada., Methods: Parents/caregivers of 2280 4- to 5-year-old children completed the Childhood Experiences Questionnaire (CHEQ) in 2018. Binary logistic regression analyses were conducted to predict the likelihood of children participating in everyday outdoor play in their neighbourhood based on the child's gender, family ethnicity (i.e., European origin vs. other), household income (i.e., less vs. equal/more than CDN$75,000), population centre (i.e., urban vs. rural) and parent's trust in neighbours (i.e., trusting vs. not trusting neighbours to look out for children)., Results: Thirty-five percent of children in this study met recommendations of playing outdoors every day. Children whose parents perceived strong trust in neighbours were twice as likely to play outdoors in their neighbourhood every day, when compared with those whose parents perceived low trust in neighbours. Additionally, children from families with higher incomes (equal/more than $75,000) were significantly more likely to play outdoors daily than those with lower incomes, but only if they resided in rural areas. Last, children with European family backgrounds were 64% more likely to play outdoors every day compared with those with non-European backgrounds., Conclusion: Findings from this study contribute to an emerging body of work examining socio-economic, demographic and contextual factors associated with children meeting the recommendations for everyday outdoor play in their neighbourhood.

A lysosomal pathway, characterized by the partial rupture or labilization of lysosomal membranes (LLM) and cathepsin release into the cytosol, is evoked during the early events of 20-S-camptothecin lactone (CPT)-induced apoptosis in human cancer cells, including human histiocytic lymphoma U-937 cells. These lysosomal events begin rapidly and simultaneously with mitochondrial permeabilization and caspase activation within 3 h after drug treatment. Recently, in a comparative proteomics analysis performed on highly-enriched lysosomal extracts, we identified proteins whose translocation to lysosomes correlated with LLM induction after CPT treatment, including protein kinase C-δ (PKC-δ). In this study, we show that the PKC-δ translocation to lysosomes is required for LLM, as silencing its expression with RNA interference or suppressing its activity with the inhibitor, rottlerin, prevents CPT-induced LLM. PKC-δ translocation to lysosomes is associated with lysosomal acidic sphingomyelinase (ASM) phosphorylation and activation, which in turn leads to an increase in ceramide (CER) content in lysosomes. The accumulation of endogenous CER in lysosomes is a critical event for CPT-induced LLM as suppressing PKC-δ or ASM activity reduces both the CPT-mediated CER generation in lysosomes and CPT-induced LLM. These findings reveal a novel mechanism by which PKC-δ mediates ASM phosphorylation/activation and CER accumulation in lysosomes in CPT-induced LLM, rapidly activating the lysosomal pathway of apoptosis after CPT treatment.

A lysosomal pathway, characterized by partial rupture or labilization of lysosomal membranes and cathepsin activation, is evoked during camptothecin-induced apoptosis in human cancer cells, including human histiocytic lymphoma U-937 cells. These lysosomal events begin rapidly and simultaneously with mitochondrial permeabilization and caspase activation within 3 h after drug treatment. In this study, comparative and quantitative proteome analyses were performed to identify early changes in lysosomal protein expression/localization from U-937 cells undergoing apoptosis. In 2 independent experiments, among a total of more than 538 proteins putatively identified and quantitated by iTRAQ isobaric labeling and LC-ESI-MS/MS, 18 proteins were found to be upregulated and 9 downregulated in lysosomes purified from early apoptotic compared to control cells. Protein expression was validated by Western blotting on enriched lysosome fractions, and protein localization confirmed by fluorescence confocal microscopy of representative protein candidates, whose functions are associated with lysosomal membrane fluidity and dynamics. These include sterol-4-alpha-carboxylate 3-dehydrogenase (NSDHL), prosaposin (PSAP) and protein kinase C delta (PKC-delta). This comparative proteome analysis provides the basis for novel hypothesis and rationale functional experimentation, where the 3 validated candidate proteins are associated with lysosomal membrane fluidity and dynamics, particularly cholesterol, sphingolipid and glycosphingolipid metabolism.

Children who report sexual abuse (SA) have been found to display a range of internalizing and externalizing behavior problems. In the present study, a tree-based analysis was used to derive models predicting the variability of internalizing and externalizing behavior problems as well as dissociation symptoms in SA girls. Participants were 150 girls aged 4 to 12 years referred to a specialized pediatric clinic after disclosure of SA. The potential predictors taken into account included sociodemographic and abuse-related variables as well as maternal and family characteristics. The models obtained point to prior abuse as a salient variable in predicting outcomes of SA girls. Implications for the treatment for children disclosing SA are discussed.

A cluster analysis is used to explore differential outcomes in 123 French Canadian children reporting sexual abuse contrasted with 123 control children. Mothers' reports of behavioral problems on the Child Behavior Checklist, abuse-related variables, personal factors, and family characteristics are used as potential variables discriminating clusters. Results reveal four clusters: (a) anxiety constellation group refers to children displaying behavior problems on a subset of scales, (b) the severe distress group refers to children showing a broader array of behavior problems, (c) victims of less severe sexual abuse (SA) group consists of children disclosing mostly extrafamilial SA, and (d) resilient children refers to children who, while disclosing severe abuse, rely less on avoidance coping. Findings underscore the need to go beyond abuse-related variables to orient treatment for children disclosing sexual abuse and for tailoring interventions to distinct subgroups.

The purpose of this study was to evaluate the outcomes following participation in the ESPACE parents' workshop. A group of 55 parents who participated in the program, implemented in elementary schools in the Quebec city region, was compared to a group of 217 parents who did not attend the prevention workshop. The results revealed that attending parents suggested more adequate interventions to the vignette depicting a hypothetical situation of sexual abuse compared to nonattending parents. Attending parents are found to be more likely to suggest interventions sustaining the child in her own problem-solving process, seek help from specialized agencies, and attempt to offer emotional support to the victim. Data also reveal that the parents workshop has a positive outcome on knowledge. While the workshop is associated with beneficial outcomes, attendance rates are low. The findings are discussed in the context of identifying means to foster parent involvement in the prevention of child abuse.

Objectives: The purpose of this study was to determine whether vicarious experience, in which former patients exemplify the active lives they are leading, reduces anxiety and increases self-efficacy expectation and self-reported activity in patients after cardiac surgery., Design: A randomized, controlled trial was used to evaluate an intervention that linked volunteers who had recovered from cardiac surgery in dyadic support with patients about to undergo similar surgery. The linking was achieved by means of visits during the hospitalization and recovery period., Subjects: Fifty-six first-time male patients undergoing coronary artery bypass graft (CABG) surgery, with a mean age of 56.5 years, were randomly assigned to an experimental (n = 27) or control group (n = 29)., Outcome Measures: Anxiety was measured at 48 hours and 24 hours before surgery, and again at 5 days and 4 weeks after surgery. Self-efficacy expectation and self-reported activity were both evaluated at 5 days and 4 weeks after surgery., Results: Only the experimental group showed a significant decrease in anxiety during hospitalization. At all measurement times after the first intervention, the experimental group reported significantly lower levels of anxiety compared with the control group. The experimental group reported significantly higher levels of self-efficacy expectation and self-reported activity for general activities, walking, and climbing stairs evaluated at 5 days, and for general activities at 4 weeks after surgery., Conclusions: Vicarious experience provided through dyadic support is effective in helping patients undergoing cardiac surgery cope with surgical anxiety and in improving self-efficacy expectations and self-reported activity after surgery. Dyadic support is a valuable tool for recovery from cardiac surgery that needs to be maintained and explored through nursing practice and research.

The research aims at the acquisition of knowledge and its application in the practice. The knowledge which most interests the nurses is the one pertaining to the improvement of nursing practice. Before initiating a change in the clinical practice on the basis of the research results, it is important to consider some rigorous criteria which will provide guidance to an enlightened decision as to whether such results should be adopted or not. With the help of an example of nursing care concerning a support programme for the benefit of heart patients, this article presents the application of a model of use of research results. The model consists of six phases in support of a critical judgement on the value of a scientific work: preparation, validation, comparative evaluation, decision making, adoption/application and evaluation. Each of these phases states the application of the model criteria, not only to the results, but to the whole research processes followed by the author. This model of research use can provide the nurse with means of proposing changes in the practice, based on the knowledge issuing from research.

The objectives of this study were to determine whether vicarious experiences, in which expatients exemplify the active lives they are leading, can strengthen the belief in the restorability of cardiac functions. An experimental research design was used to evaluate an intervention designed to link volunteers who have successfully recovered from cardiac surgery in dyadic support with those individuals about to undergo similar surgery, by means of visits during the hospitalisation and recovery period. The intervention was intended to reduce anxiety and increase self-efficacy and activity performance. Through a randomised trial, 55 bypass surgery patients, aged 40-69 years, were allocated to either the experimental intervention (n = 27) or usual care (n = 28). The anxiety level was measured with the SPIELBERGER, GORSUCH and LUSHENE (1970) scale; self-efficacy and activity performance were measured with JENKIN's scales (1989). Data analysis with independent t tests revealed significant (p < 0.05) differences between groups in the anxiety level at 24 hours before surgery, and at 5 days and 4 weeks after surgery. Only the experimental group showed a significant (p < 0.02) decrease in anxiety during hospitalisation. Repeated analysis of variance showed significant (p < 0.05) differences between groups in perceived self-efficacy and performance of activities at 5 days and at 4 weeks after surgery. These results indicate that dyadic social support that volunteers offer cardiac surgery patients seems to be effective in helping the latter deal with cardiac events. Implications and recommendations for nursing practice and research were generated.

Purpose: During the past 14 months we conducted a prospective clinical trial to evaluate the efficacy of duplex-directed manual occlusion (DDMO) of iatrogenic femoral false aneurysms (FFAs) as an alternative to standard operative management., Methods: In all cases DDMO was performed with real-time color-flow imaging while steady, continuous external pressure was applied manually to the neck of the FFA by an experienced vascular technologist for a period of 10 minutes., Results: Ten of the 11 FFAs treated with DDMO in this series were thrombosed successfully, requiring a mean of 30 minutes of compression per aneurysm (three compressions of 10 minutes each). DDMO was unsuccessful in one patient, whose session was terminated because of severe discomfort as a result of the procedure. All 10 patients with successfully thrombosed FFAs are without recurrence at 1-month follow-up color-flow duplex examination, and there has been no morbidity attributable to DDMO., Conclusions: We conclude that DDMO of postcatheterization FFA can be performed safely and is an inexpensive, effective, nonoperative method of managing such lesions. The precise role of this technique would appear to be as a first-line treatment for uncomplicated iatrogenic FFAs.

The ability of 19 different Bordetella bronchiseptica isolates and 25 Pasteurella multocida isolates to adhere in vitro to porcine nasal and tracheal epithelial cells was examined. It was found that B. bronchiseptica adhered well to upper respiratory tract cells. In contrast the number of P. multocida organisms which adhered was four to six times less than the number of B. bronchiseptica adherent organisms. This difference was statistically significant (p less than 0.0001). Both microorganisms adhered in greater numbers to nasal cells than to tracheal cells (p less than 0.005). The data indicated that B. bronchiseptica possesses a greater ability than P. multocida to attach to porcine upper respiratory tract cells.